Clinical trials: Left Atrial Appendage, open to volunteers
Intracranial Hemorrhages, Atrial Fibrillation (AF)
Comparison of LAA-Closure vs Oral Anticoagulation in Patients With NVAF and Status Post Intracranial Bleeding.
Atrial fibrillation is the most common cardiac arrhythmia. In atrial fibrillation, there is a risk that clots can form in the heart, especially in the left atrium. If these clots come loose, there is a risk of stroke.
- Conditions
- Intracranial Hemorrhages, Atrial Fibrillation (AF), Atrial Flutter
- Trial name
- CLEARANCE (NCT04298723)
- Testing
- Percutaneous closure of the LAA (Watchman / Watchman FLX)
- Where
- 39 sites in Germany, Poland
- Volunteers
- 530 people
- Sponsor
- Jena University Hospital
Atrial Fibrillation, Left Atrial Appendage Closure
Austrian Left Atrial Appendage Closure Registry
Left atrial appendage (LAA) occlusion (LAAC) has been introduced to treat patients with indication of oral anticoagulation (OAC) for atrial fibrillation (AF) with contraindication to OAC.
- Trial name
- NCT03409159
- Testing
- LAAC
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Graz
Atrial Fibrillation (AF), Bleeding
Concomitant PFA Bsaed PVI Plus LAAC
A multicenter, prospective registry of concomitant Farapulse (Boston scientific) based PVI and Watchman Flx device (Boston scientific) based LAAC procedures was planned in order to assess the acute and mid-time safety, efficacy…
- Conditions
- Atrial Fibrillation (AF), Bleeding, Stroke
- Trial name
- COCONUT_2 (NCT07450755)
- Testing
- Interventional LAA Closure, Pulmonary vein isolation
- Volunteers
- 150 people
- Sponsor
- Asklepios proresearch
Left Atrial Appendage Closure
Oral Anticoagulation Versus Left Atrial Appendage Occlusion Added to Direct Oral Anticoagulation in Patients with Stroke Despite Oral
A total of 380 patients with ischemic stroke despite OAC will be included. Patients will be randomized 1:1 to the best medical treatment (control) or the combination of LAAO and DOAC or OAC.
- Trial name
- ADDLAAO (NCT06869811)
- Testing
- LAA Closurse
- Where
- Spain
- Volunteers
- 380 people
- Sponsor
- Hospital Clinic of Barcelona
Atrial Fibrillation
Optimal Antiplatelet Therapy Following Left Atrial Appendage Closure
SAFE-LAAC Trial has been designed to gather data on the most optimal strategy of antiplatelet therapy after transcatheter left atrial appendage occlusion with Amplatzer or WATCHMAN device
- Trial name
- SAFE-LAAC (NCT03445949)
- Testing
- short postimplantation dual antiplatelet therapy, extended postimplantation dual antiplatelet therapy, long-term treatment with a single antiplatelet agent
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Acute Ischemic Stroke AIS, Stroke Treatment
CardioLogical Interventions and Acute strOke Treatment sTudy
The study aims to investigate characteristics and prognosis of ischemic stroke cases following cardiological interventions, focusing on the effectiveness and safety of acute ischemic stroke treatments.
- Conditions
- Acute Ischemic Stroke AIS, Stroke Treatment, PCI Patients, Aortic Valve Replacement
- Trial name
- CLOT (NCT07314476)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University of L'Aquila
Atrial Fibrillation
Safety and Effectiveness of Short-Term Single AntiPlatelet Therapy After Left Atrial Appendage Closure With the LAmbre Device in Patients With Nonvalvular Atrial Fibrillation: A Multinational Real-world Registry
Brief Summary: A prospective, multicenter, single-arm, non-randomized study including consecutive patients with nonvalvular AF(Atrial Fibrillation), with a CHA2DS2-VASc score ≥2 (men) or ≥3 (women), and contraindication for…
- Trial name
- S-SAPT LAMBRE (NCT06620757)
- Testing
- Single antiplatelet therapy (SAPT)
- Where
- 22 sites in Spain
- Volunteers
- 234 people
- Sponsor
- Fundación EPIC
Cardiovascular Diseases, Arrhythmia
The Safety and Efficacy of Radiofrequency Ablation After Left Atrial Appendage Occlusion.
Objective: To evaluate the safety and efficacy of transcatheter atrial fibrillation ablation 1 month after WATCHMAN FLX left atrial appendage closure in patients with nonvalvular atrial fibrillation.
- Trial name
- NCT06984731
- Testing
- left atrial appendage closure, radiofrequency ablation
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Affiliated Hospital of Nantong University
Atrial Fibrillation (AF), Pulmonary Embolism (PE)
Exclusion of Left Atrial Appendage Thrombus in Emergency Department Patients With Atrial Fibrillation Undergoing CT to Assess for Pulmonary Embolus: A Feasibility Study
This study aims to investigate whether a quick, additional CT scan of the heart, performed immediately after a standard CT scan for pulmonary embolism, can effectively detect blood clots in the left atrial appendage (LAA) in…
- Conditions
- Atrial Fibrillation (AF), Pulmonary Embolism (PE), Left Atrial Appendage Thrombosis
- Trial name
- ELATE-AF (NCT07647939)
- Testing
- Delayed Un-gated CT Scan for Left Atrial Appendage Thrombus, Delayed Gated CT Scan for Left Atrial Appendage Thrombus
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwell Health
Left Atrial Appendage Thrombosis
The Left Atrial Appendage Closure by Surgery and the Incidence of Stroke in Patients Undergoing Open-heart Surgery.
This study aims to assess the efficacy and safety of prophylactic surgical closure of the left atrial appendage for stroke and cardiovascular death prevention in patients undergoing open heart surgery, regardless of their…
- Trial name
- NCT06172738
- Testing
- the left atrial appendage closure through surgery.
- Volunteers
- 100 people
- Sponsor
- Assiut University
Atrial Fibrillation (AF)
LA Function After PFA in Paroxysmal AF
A prospective study that investigates the changes in LA echocardiographic parameters after PFA for paroxysmal AF.
- Trial name
- NCT07439016
- Testing
- LA and LAA function measurements
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation (AF)
Shanghai Atrial Fibrillation Registry
Using the Shanghai Municipal Health Commission database and Shanghai Centers for Disease Control and Prevention database, patients with AF in Shanghai are included to construct the Shanghai AF registry to investigate clinical…
- Trial name
- SAFE (NCT06802965)
- Testing
- catheter ablation, left atrial appendage closure
- Where
- China
- Volunteers
- 400,000 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Atrial Fibrillation
Low-dose NOAC Versus GDMT After LAAO
The increased risk of Atrial fibrillation (AF) regarding thromboembolic stroke is predominantly due to the formation and embolization of clots from within the left atrial appendage (LAA).
- Trial name
- RECORD-III (NCT05960721)
- Testing
- Rivaroxaban 15mg, Aspirin 100mg, Clopidogrel 75mg
- Where
- China
- Volunteers
- 4,220 people
- Sponsor
- Xijing Hospital
Leadless Pacemaker, Left Atrial Appendage Occlusion
Combined Leadless Pacemaker and Left Atrial Appendage Occlusion Registry
Leadless pacemakers (LP) are safe and effective alternatives to transvenous pacemakers in selected patients. Implantation is performed with a large caliber delivery catheter.
- Trial name
- NCT06702865
- Where
- Hong Kong
- Volunteers
- 47 people
- Sponsor
- Chinese University of Hong Kong
Radiation Cystitis, Non-valvular Atrial Fibrillation
Study of the Effects of Anticoagulant Interruption Covered by Percutaneous Left Atrial Occlusion in Patients With Chronic Atrial Fibrillation and Radiation Cystitis at Risk of Bleeding
The etiology of the radiation cystitis is a pelvic irradiation generally performed as part of the treatment of prostate cancer. The incidence is 50,000 new cases per year.
- Trial name
- HEMOCC (NCT04701749)
- Testing
- Percutaneous left atrial closure, No Percutaneous left atrial closure
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Atrial Fibrillation (AF), Mitral Valve (MV) Regurgitation
EPX-HTG for Structural Heart Procedures
To investigate and evaluate the benefits of adding EchoPixel Holographic Therapy Guidance to the current standard of care in Structural Heart (SH) procedures.
- Trial name
- EPX-HTG-2026 (NCT07705425)
- Testing
- Left Atrial Appendage Occlusion, Mitral Valve Transcatheter Edge to Edge Repair
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- EchoPixel, Inc.
Atrial Fibrillation, Percutaneous Coronary Intervention
LAAO Versus NOAC in Patients with AF and PCI
Atrial fibrillation (AF) coincides with coronary artery disease (CAD) shared common risk factors and pathophysiologic pathways. CAD affects approximately 25% of AF patient according to the trial Atrial Fibrillation Follow-up…
- Trial name
- NCT05353140
- Testing
- The WATCHMAN/WATCHMAN FLX device, Rivaroxaban + Clopidogre, Aspirin + Clopidogrel
- Where
- China
- Volunteers
- 1,386 people
- Sponsor
- Xijing Hospital
Atrial Fibrillation, Stroke
Left Atrial Appendage Occlusion Versus Novel Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation
Atrial fibrillation (AF) is progressively common, and increases the risk of stroke five-fold. Oral anticoagulation is the mainstay therapy; however, it increases the risk of bleeding.
- Trial name
- Occlusion-AF (NCT03642509)
- Testing
- Left atrial appendage occlusion, NOAC
- Where
- 15 sites in Denmark, Finland and 3 more
- Volunteers
- 750 people
- Sponsor
- University of Aarhus
Cardiac Arrythmias, Left Atrial Appendage Closure
Agilis RF TSP Early Feasibility Study
This study is a prospective, acute, first-in-human, early feasibility study intended to assess the initial safety and performance of the Agilis™ Radiofrequency (RF) Transseptal (TSP) System in crossing the atrial septum for left…
- Trial name
- NCT07361445
- Testing
- Transseptal procedure with Agilis RF TSP System.
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Abbott Medical Devices
Nonvalvular Atrial Fibrillation, Aspirin
Non-antithrombotic Versus. Single Antiplatelet Therapy Following Left Atrial Appendage Closure
The goal of this clinical trial is to verify that Non-Antithrombotic Therapy (NAPT) followed by Oral Anticoagulants (OAC) monotherapy for 45 days after Left Atrial Appendage Closure (LAAC) is non-inferior to Single Antiplatelet…
- Conditions
- Nonvalvular Atrial Fibrillation, Aspirin, Non-Antithrombotic Therapy, High Bleeding Risk
- Trial name
- NCT07125417
- Testing
- Single Antiplatelet Therapy or No Therapy (Control), Non-Antithrombotic Therapy
- Where
- 21 sites in Japan
- Volunteers
- 500 people
- Sponsor
- OCEAN-SHD Study Group