Clinical trials: Left Atrial Appendage Occlusion
Non-valvular Atrial Fibrillation
The CONFORMAL Early Feasibility Study
An evaluation of the safety and performance of the Conformal Left Atrial Appendage Seal for Left Atrial Appendage Occlusion
- Trial name
- NCT03616028
- Testing
- left atrial appendage closure
- Where
- 11 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Conformal Medical, Inc
Evaluate the Safety and Efficacy of Apixaban
A Multi-center Study of Apixaban(APPROACH)
The aim of the study is to enroll approximately 200 cases from 10 research centers nationwide, completed left atrial appendage occlusion (LAAO) successfully, and give apixaban (5 mg bid) postoperatively.
- Trial name
- NCT04550637
- Testing
- Oral apixaban
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Cardiology
Comprehensive CT-guided vs Echo-fluoroscopy-guided Strategy in the Left Atrial Appendage Occlusion
Percutaneous left atrial appendage occlusion (LAAO) is an increasingly used alternative to oral anticoagulation in patients with nonvalvular atrial fibrillation (AF).
- Trial name
- NCT04913207
- Testing
- method of device size selection
- Where
- China
- Volunteers
- 310 people
- Sponsor
- RenJi Hospital
Atrial Fibrillation, Coronary Artery Disease
Safety and Efficacy of Left Atrial Appendage Closure Versus Antithrombotic Therapy in Patients With Atrial Fibrillation Undergoing Drug-Eluting Stent Implantation Due to Complex Coronary Artery Disease
Comparatively analyze the safety and validity of Amplazter Cardiac Plug (ACP) device-using percutaneous left atrial appendage closure, and the medical treatment with dabigatran plus aspirin or dabigatran plus clopidogrel after…
- Trial name
- NCT02606552
- Testing
- Dabigatrain plus aspirin, Dabigatrain plus clopidogrel, Amplazter Cardiac Plug (ACP)
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Yonsei University
Atrial Fibrillation, Left Atrial Appendage Ligation
Transatrial Pericardial Separation to Enhance Safety of Subxiphoid Pericardial Access for Left Atrial Appendage Ligation
We use a tiny catheter through the heart to separate the pericardium with gas. We expect this to improve the safety of the Lariat procedure.
- Conditions
- Atrial Fibrillation, Left Atrial Appendage Ligation, Pericardium, Epicardial Mapping
- Trial name
- NCT06584370
- Testing
- Pericardial insufflation with carbon dioxide through a transatrial microcatheter
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Henry Ford Health System
Left Atrial Appendage Occlusion
Use of Intracardiac Echocardiography or Left Atrial Appendage Radiography to Guide Implantation of a Left Atrial Appendage Occlusion Device.
A total of 60 patients with atrial fibrillation were scheduled to receive left atrial appendage occlusion, which were divided into two groups.
- Trial name
- NCT04524780
- Testing
- intracardiac echocardiography
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Hospital of Hebei Medical University
Stroke Prevention, Atrial Fibrillation
Stand-alone Totally Thoracoscopic Left Atrial Appendage Occlusion Using AtriClip® Device in Non-valvular Atrial Fibrillation.
Polish multicenter registry to assess safety and durability of totally thoracoscopic left atrial appendage occlusion for stroke prevention in atrial fibrillation.
- Conditions
- Stroke Prevention, Atrial Fibrillation, Safety Issues
- Trial name
- THORACS-LAAO (NCT03838341)
- Testing
- AtriClip™ LAA Exclusion System, Oral anticoagulation therapy
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
Atrial Fibrillation
Platelet-activation and Optimal Inhibition in Patients With Atrial Fibrillation Undergoing Left Atrial Appendage Occlusion
The POPULAR-LAAO registry is an open-label observational prospective registry to investigate hemostatic processes following left atrial appendage occlusion.
- Trial name
- POPULAR-LAAO (NCT04705688)
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- R&D Cardiologie
Left Atrial Appendage Closure
Intracardiac Versus Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion
This single-center, prospective, randomized study will evaluate the safety and feasibility of Intracardiac echocardiography (ICE)-guided Left atrial appendage closure (LAAC) when compared to the traditional Transesophageal…
- Trial name
- ICETEE (NCT06348394)
- Testing
- Intracardiac Echocardiography, Traditional transesophageal echocardiography
- Where
- United States
- Volunteers
- 444 people
- Sponsor
- Baylor Research Institute
Atrial Fibrillation
Safety and Efficacy of Left Atrial Appendage Occlusion Devices
Atrial fibrillation (AF) is the most common cardiac rhythm disorder in clinical practice. In the last two decades the number of hospitalizations for AF has increased two- to three-fold.
- Trial name
- NCT01695564
- Testing
- LARIAT LAA, WATCHMAN
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Kansas City Heart Rhythm Institute
Aortic Valve Disorder
Combined Transcatheter Aortic Valve Implantation and Percutaneous Closure of the Left Atrial Appendage
Atrial fibrillation (AF) is a common comorbidity of patients candidates to transcatheter aortic valve implantation (TAVI). The management of chronic oral anticoagulation (OAC) for the prevention of ischemic stroke is very…
- Trial name
- TAVI-LAAC (NCT02678871)
- Testing
- Lotus or ACURATE neo Heart valve system (or subsequent CE marked iterations), WATCHMAN
- Where
- 6 sites in Germany, Italy and 2 more
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Atrial Fibrillation, Coronary Artery Disease
LAAO With DAPT Versus Antithrombotic Therapy
This study will retrospectively review and compare clinical outcomes between left atrial appendage occlusion with dual antiplatelet therapy versus conventional antithrombotic therapy in patients with atrial fibrillation…
- Trial name
- NCT03310801
- Testing
- ACP or Watchman
- Volunteers
- 480 people
- Sponsor
- Korea University Anam Hospital
Left Atrial Appendage Velocity, Left Atrial Structure
Effect of Left Atrial Appendage Velocity on Left Atrial Structure and Function After Radiofrequency Ablation Combined With Left Atrial Appendage Occlusion
Radiofrequency ablation of atrial fibrillation combined with left atrial appendage closure can not only improve symptoms in patients with non-valvular atrial fibrillation, but also prevent left atrial appendage thrombosis.
- Conditions
- Left Atrial Appendage Velocity, Left Atrial Structure, Left Atrial Function
- Trial name
- NCT04693871
- Testing
- Transesophageal ultrasound
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Hospital of Hebei Medical University
Atrial Fibrillation
Russian National Registry of LAAO
The first Russian registry presents data from two hundred consecutive patients with nonvalvular atrial fibrillation, who undergone left atrial appendage occlusion (LAAO) using the Watchman device and the Amplatzer cardiac plug.
- Trial name
- NCT04322474
- Testing
- Catheter-based left atrial appendage occlusion
- Volunteers
- 200 people
- Sponsor
- National Research Center for Preventive Medicine
Non-valvular Atrial Fibrillation
The Conformal Prague Study
A prospective, single center, open-label, single arm, study to evaluate the safety and technical performance of the CLAAS system for closure of the left atrial appendage.
- Trial name
- NCT04193826
- Testing
- Left Atrial Appendage Closure
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Conformal Medical, Inc
Left Atrial Appendage Occlusion
LAmbre Versus AMPLATZER Amulet Left AtrIal Appendage Occluder for StRoke ProphylaxIs
The objective of this trial is to compare two different commercially available left atrial appendage occlusion (LAAO) devices in patients with non-valvular Atrial fibrillation/ atrial flutter (AF) at increased risk for stroke…
- Trial name
- AMPIRI (NCT06060912)
- Testing
- Left Atrial Appendage Occlusion
- Where
- Germany
- Volunteers
- 226 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Left Atrial Appendage Occlusion
Use of Intracardiac Echocardiography or Left Atrial Appendage Radiography to Guide Implantation of a Left Atrial Appendage Occlusion Device
A total of 40 patients with atrial fibrillation were scheduled to receive left atrial appendage occlusion, which were divided into two groups.
- Trial name
- NCT04524741
- Testing
- intracardiac echocardiography
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Second Hospital of Hebei Medical University
Atrial Fibrillation, Left Atrial Appendage Occlusion
RCT of Minimalist vs Standard Procedure for LAAC in NVAF Patients
Percutaneous left atrial appendage closure (LAAC) is an effective strategy for stroke prevention in patients with non-valvular atrial fibrillation (NVAF).
- Conditions
- Atrial Fibrillation, Left Atrial Appendage Occlusion, General Anesthesia, Local Anesthesia
- Trial name
- NCT06969118
- Testing
- Minimalism Transcatheter LAAC Group, Standard Transcatheter LAAC Group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Zhongshan Hospital
Evaluate the Safety and Efficacy of Bivalirudin in Decreasing Bleeding Risk
Multi-center Application of Bivalirudin in Left Atrial Appendage Occlusion
The study is an investigator-sponsored, prospective, multicenter, randomized, open-label study designed to compare efficacy and safety between bivalirudin and heparin in patients with non-valvular atrial fibrillation undergoing…
- Trial name
- NCT04195997
- Testing
- Bivalirudin, Heparin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Zhongshan Hospital
Atrial Fibrillation, Stroke
Left Atrial Appendage Occlusion Versus Novel Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation
Atrial fibrillation (AF) is progressively common, and increases the risk of stroke five-fold. Oral anticoagulation is the mainstay therapy; however, it increases the risk of bleeding.
- Trial name
- Occlusion-AF (NCT03642509)
- Testing
- Left atrial appendage occlusion, NOAC
- Where
- 15 sites in Denmark, Finland and 3 more
- Volunteers
- 750 people
- Sponsor
- University of Aarhus