Clinical trials: Left Heart Failure
Heart Failure, Low T3 Syndrome
Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF)
Purpose: The purpose of the study is to examine if treatment with liothyronine increases left ventricular ejection fraction (LVEF) in patients with stable, chronic heart failure.
- Trial name
- LIHFA (NCT01481402)
- Testing
- Liothyronine
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Jens Faber
Heart Failure, Noninvasive Ventilation
High Flow Nasal Oxygen and Acute Left Heart Failure
Acute left heart failure (ALHF) is a sudden attack or deterioration of abnormal left heart function, which may impair myocardial contractility and increase cardiac loading, further result in decreased cardiac output, abrupt…
- Conditions
- Heart Failure, Noninvasive Ventilation, Oxygen Therapy
- Trial name
- HFNO (NCT03607357)
- Testing
- High Flow Nasal Oxygen, Non-invasive Ventilation
- Where
- China
- Volunteers
- 123 people
- Sponsor
- Nanjing Jiangbei People's Hospital
Heart Failure, Ischemic Cardiomyopathy
Left Ventricular Assist Device Combined With Allogeneic Mesenchymal Stem Cells Implantation in Patients With End-stage Heart Failure.
The aim of the study is to investigate safety and efficacy of intramyocardial implantation of allogeneic mesenchymal stem cells in patients with end-stage ischemic cardiomyopathy undergoing left ventricular assist device…
- Trial name
- NCT01759212
- Testing
- Allogeneic stem cells implantation
- Where
- Greece
- Volunteers
- 1 people
- Sponsor
- AHEPA University Hospital
Cardiomyopathy, Heart Failure
Adaptive CRT Effect on Electrical Dyssynchrony
The purpose of this study is to better understand how adaptive cardiac resynchronization therapy (aCRT) might benefit patients. aCRT works by sometimes giving stimulation to only the left side of the heart, rather than to both…
- Conditions
- Cardiomyopathy, Heart Failure, Left Bundle Branch Block
- Trial name
- aCRT-ELSYNC (NCT02543281)
- Testing
- Adaptive cardiac resynchronization therapy, Conventional Cardiac Resynchronization Therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Larisa Tereshchenko
Heart Failure
Sacubitril/Valsartan in Left Ventricular Assist Device Recipients
The primary objective of this prospective randomised study is to assess the safety and tolerability of sacubitril/valsartan compared with standard of care used for treating BP in patients that have been implanted with the Heart…
- Trial name
- ENVAD-HF (NCT04103554)
- Testing
- Sacubitril-Valsartan, Standard of care
- Where
- 6 sites in Croatia, Czechia and 2 more
- Volunteers
- 60 people
- Sponsor
- University of Zagreb
Heart Failure
Improvement of Left Ventricular Ejection Fraction in ICD Patients Undergoing Therapy With Sacubitril/Valsartan
The study is aimed to evaluate the improvement of the left ventricular volumes and of the left ventricular ejection fraction in a population of ICD patients with heart failure and left ventricle systolic dysfunction undergoing…
- Trial name
- SAVE-ICD (NCT03935087)
- Testing
- two-dimensional echocardiogram
- Where
- 6 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Azienda Ospedaliera Cardinale G. Panico
Heart Failure, Left Ventricular Dysfunction
Effects of Viagra on Heart Function in Patients With Heart Failure
Sildenafil (Viagra) is known to reduce pulmonary hypertension. Heart failure patients also have pulmonary hypertension and several recent reports have shown that sildenafil leads to an improvement in their exercise capacity.
- Trial name
- NCT00781508
- Testing
- sildenafil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- MetroHealth Medical Center
Acute Heart Failure With Reduced Left Ventricular Ejection Fraction
Telemonitoring to Optimize Medication Titration for Heart Failure: a Feasibility Study
Problem: Aggressive titration of guideline-directed medical therapy is the cornerstone of heart failure management to reduce heart failure related hospitalization and mortality.
- Trial name
- TOM-HF (NCT07016815)
- Testing
- Wearable wrist heart rate and activity monitor, Bluetooth enabled body weight scale with bioimpedance analysis, Bluetooth enabled electronic blood pressure device
- Where
- 2 sites in Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Left Ventricular Dysfunction, Myocardial Infarction
St. Vincent's Screening To Prevent Heart Failure Study
The STOP-HF study is a prospective, randomized, controlled trial recruiting asymptomatic individuals with risk factors for left ventricular dysfunction from 50 primary care clinics in Dublin and south east Ireland.
- Conditions
- Left Ventricular Dysfunction, Myocardial Infarction, Hypertension, Diabetes
- Trial name
- STOP-HF (NCT00921960)
- Testing
- Intervention Care
- Where
- Ireland
- Volunteers
- 1,378 people
- Sponsor
- St Vincent's University Hospital, Ireland
Heart Failure
Prospective Randomized Evaluation of an Ultra Conservative Approach to Implantable Defibrillator (ICD) Programming in Patients With a Left Ventricular Assist Device (LVAD).
We propose to study a strategy empirically applied for the past 6 months at a high volume LVAD center (Vanderbilt Heart and Vascular Institute).
- Trial name
- NCT01977703
- Testing
- Ultra Conservative ICD Programming, Traditional ICD Programming
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Vanderbilt University Medical Center
Heart Failure, Congestive, Cardiomyopathy, Dilated
Progenitor Cell Therapy in Dilative Cardiomyopathy
Intracoronary infusion of bone marrow derived progenitor cells into the LAD in patients with non ischemic dilated cardiomyopathy.
- Conditions
- Heart Failure, Congestive, Cardiomyopathy, Dilated, Stem Cell Transplantation
- Trial name
- NCT00284713
- Testing
- intracoronary infusion of BMC
- Volunteers
- 30 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Congestive Heart Failure, Mitral Regurgitation
Speckle Tracking Imaging and Realtime 3 Dimensional Echocardiograhy to Study LV Function and Remodeling After Acute Myocardial Infarction (AMI)
Left ventricular (LV) remodeling after acute myocardial infarction (AMI) has been well described in previous studies. However, there is a paucity of data on the incidence of and risk factors for LV remodeling in modern clinical…
- Trial name
- NCT00745680
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Cardiac Pacing, Artificial, Cardiac Pacemaker, Artificial
BIO|MASTER.CSP Study
The goal of this clinical study is to test the clinical safety and performance of the Amvia pacemakers and the Solia CSP S lead when used for left bundle branch area pacing (LBBAP).
- Conditions
- Cardiac Pacing, Artificial, Cardiac Pacemaker, Artificial, Cardiac Resynchronization Therapy Devices, Bradycardia
- Trial name
- NCT06620237
- Testing
- Implantation of the Solia CSP S pacing lead for LBBAP
- Where
- 14 sites in Australia, Belgium and 3 more
- Volunteers
- 152 people
- Sponsor
- Biotronik SE & Co. KG
Atrial Fibrillation, Mitral Valve Failure
Atrial Fibrillation Registry 2017
Monocentric, prospective, randomized trial of cardiac surgical arrhythmia using endocardial radiofrequency atrial ablation compared with a cryo ablation system in the setting of cardiac surgery.
- Trial name
- NCT05023590
- Testing
- ablation of left atrium during mitral valve open chest intervention
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Herz- und Gefaesszentrum Bad Bevensen
Chronic Heart Failure
Efficacy and Safety of Allogeneic Mesenchymal Precursor Cells (Rexlemestrocel-L) for the Treatment of Heart Failure
The primary objective of this study is to determine whether transendocardial delivery of allogeneic human bone marrow-derived mesenchymal precursor cells (MPCs [rexlemestrocel-L]) is effective in the treatment of chronic heart…
- Trial name
- DREAM HF-1 (NCT02032004)
- Testing
- Rexlemestrocel-L
- Where
- 59 sites in United States, Canada
- Volunteers
- 565 people
- Sponsor
- Mesoblast, Inc.
Left Heart Failure
Visa-versa! Breaking Instead of Pushing the Pedals-C
Eccentric muscle work is defined as lengthening of a muscle while applying force. It was shown that with eccentric work, muscles are able to perform four times as much power compared to usual concentric work, which results in…
- Trial name
- NCT05204693
- Testing
- 15 minutes eccentric cycling, 15 minutes concentric (normal) cycling
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- University of Zurich
Left Ventricular Assist Device
Exercise Tolerance in Patients With Implanted Left Ventricular Assist Device
To evaluate the concept of dynamic pump speed optimization based on the echocardiographic assessment of aortic valve opening during cardiopulmonary exercise test.
- Trial name
- NCT05063006
- Testing
- Cardiopulmonary exercise tests with maintained baseline optimal pump speed settings., Cardiopulmonary exercise test with gradually increased pump speed depending on live echocardiographic imaging.
- Where
- Poland
- Volunteers
- 22 people
- Sponsor
- Karol Wierzbicki
Heart Failure With Preserved Ejection Fraction (HFPEF), Left Ventricular End Diastolic Pressure (LVEDP)
Evaluation of Left Ventricular Filling Pressures During Exercise
Heart failure with preserved ejection fraction (HFPEF) is common and is a real public health issue. Diagnosis, especially when there are no congestive signs, is difficult.
- Trial name
- PREFFORT (NCT01714752)
- Testing
- measure of left ventricular and diastolic pressure at exercise
- Where
- France
- Volunteers
- 60 people
- Sponsor
- French Cardiology Society
Heart Failure, Systolic, Left Bundle Branch Block
Optimal Coronary Sinus Lead Implantation Using Intracardiac Impedography and Magnetic Resonance Imaging
Despite the dramatic effect of cardiac resynchronization therapy (CRT) on survival and morbidity in people with congestive heart failure, 50-70% of eligible patients do not respond to this intervention.
- Trial name
- NCT01129635
- Testing
- Cardiac Resynchronization Therapy (CRT) implantation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Emory University
Diabetes Mellitus, Type 2, Heart Failure, Diastolic
Evaluating the Use of Exenatide in People With Type 2 Diabetes and Diastolic Heart Failure
People with type 2 diabetes experience heart failure more often than do people without diabetes. This may be due to increased stiffness in the heart as a result of diabetes.
- Trial name
- NCT00799435
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Baylor College of Medicine