Clinical trials: Left Heart Failure
Cardiomyopathy, Heart Failure, Congestive
Biventricular Pacing In Patients With Left Ventricular Dysfunction After Cardiovascular Surgery
Congestive heart failure (CHF) is a medical condition that is due to left ventricular systolic dysfunction (LVSD). LVSD is a decreased ability of the heart to pump blood forward.
- Conditions
- Cardiomyopathy, Heart Failure, Congestive, Thoracic Surgery
- Trial name
- NCT00321295
- Testing
- Atrial synchronous bi-ventricular pacing
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Corewell Health East
End-stage Heart Failure, Cardiomyopathies
VentrAssistTM LVAD for the Treatment of Advanced Heart Failure - Destination Therapy
The purpose of this study is to evaluate the safety and effectiveness of LVADs in providing long-term circulatory support for patients who have chronic stage D heart failure and are ineligible for a heart transplant.
- Trial name
- NCT00490321
- Testing
- VentrAssistTM Left Ventricular Assist Device
- Where
- 27 sites in United States
- Volunteers
- 225 people
- Sponsor
- Ventracor
Amyloid Cardiomyopathy, Congestive Heart Failure
Longitudinal Changes in Left and Right Ventricular Global Strain After Chemotherapy in Cardiac Light Chain Amyloidosis
The purpose of this study to assess the longitudinal changes in left and right ventricular global strain after chemotherapeutic strategies in cardiac light chain amyloidosis.
- Conditions
- Amyloid Cardiomyopathy, Congestive Heart Failure, Chemotherapy Effect
- Trial name
- NCT05452850
- Testing
- Left and Right Ventricular Global Strain Imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University - Cerrahpasa
Heart Failure, Congestive
Effect of 48 Hours of Treatment With the Natural Peptide-Hormone GLP-1 in Patients With Chronic Heart Failure
The purpose of this study is to determine whether 48 hours of glucagon-like-peptide-1 (GLP-1) infusion can improve heart function and alter substrate metabolism in non-diabetic patients with heart failure.
- Trial name
- NCT00264199
- Testing
- GLP-1
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aarhus University Hospital Skejby
Heart Failure
Multisite Pacing With a Quadripolar Lead
The purpose of this study is to evaluate the effects of multisite left ventricular (LV) biventricular (BiV) pacing on LV hemodynamics in CRT patients.
- Trial name
- NCT00964938
- Testing
- Quadripolar LV lead (pacing configurations)
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Abbott Medical Devices
ST Elevation Myocardial Infarction, Heart Failure
Effect of Levosimendan on Left Ventricular Systolic Function and Heart Failure After PCI in Patients With Acute Anterior Myocardial Infarction
Reperfusion therapy for acute ST segment elevation myocardial infarction (STEMI) can significantly reduce mortality, but patients may still have heart failure and adverse cardiovascular events due to massive myocardial loss.
- Trial name
- NCT04970238
- Testing
- Levosimendan
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhijun Sun
Heart Failure
The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure Patients
This is a phase IV, prospective, randomized, double-blind, double-dummy, parallel-group study. The study assessed the effects of 6 weeks of stable sacubitril/valsartan therapy, as compared with valsartan therapy, on the…
- Trial name
- TurkuPET (NCT03300427)
- Testing
- sacubitril/valsatran, valsartan
- Where
- Finland
- Volunteers
- 55 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure, Left Ventricle Remodeling
ALIVE Expended Access - Clinical Study
A prospective, multi-center, single-arm study. This study will enroll a maximum of 35 subjects treated with the Revivent TC System.
- Trial name
- ALIVE-EA (NCT05710042)
- Testing
- Revivent TC System
- Where
- 2 sites in United States
- Sponsor
- BioVentrix
Heart Failure
Attain Performa™ Left Ventricular (LV) Quadripolar Leads Chronic Performance Study
Lead survivability will be summarized.
- Trial name
- NCT02294331
- Where
- 100 sites in United States, Belgium and 6 more
- Volunteers
- 1,900 people
- Sponsor
- Medtronic
Heart Failure
Quartet Lead and Resynchronization Therapy Options III (QUARTO_III)
The purpose of the study is to assess prospectively at 6 months the percentage of responder patients implanted with a Cardiac Resynchronization Therapy (CRT-D) device and a Quartet Left Ventricular (LV) quadripolar lead and with…
- Trial name
- QUARTO_III (NCT02476201)
- Testing
- MPP ON
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Abbott Medical Devices
Cardiac Resynchronization Therapy, Chronic Heart Failure
Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment
The objective of this prospective, multicenter controlled study is to assess the feasibility of a patient-tailored implantation by creating a cloud-based pre-procedural multimodality CRT-roadmap by integration of 3D images from…
- Conditions
- Cardiac Resynchronization Therapy, Chronic Heart Failure, Left Bundle-Branch Block
- Trial name
- CRT-DRIVE (NCT05327062)
- Testing
- CRT implantation guided by XSpline, a non-invasive electrical and venous anatomy assessment
- Where
- 13 sites in United States, Austria and 5 more
- Volunteers
- 150 people
- Sponsor
- XSpline S.p.A.
Heart Failure
Influence of Individualized Training on Cardiopulmonary Exercise Capacity in LVAD Patients
The aim of this study is to examine the influence of an individualized, spiroergometry- guided training on cardiopulmonary fitness in patients with a left ventricular assist device (LVAD).
- Trial name
- NCT03984162
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Heart Failure
BAROSTIM® Hope for Heart Failure Study
The purpose of this clinical investigation is to assess the long-term safety and efficacy of the BAROSTIM NEO System in subjects currently participating in the BAROSTIM® HOPE4HF Trial (NCT01720160).
- Trial name
- HOPE4HF (NCT01720160)
- Testing
- BAROSTIM NEO® System, Standard of care medical managment therapy for heart failure
- Where
- 23 sites in United States
- Volunteers
- 98 people
- Sponsor
- CVRx, Inc.
Congestive Heart Failure, Left Ventricular Systolic Dysfunction
Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry
Objective target of the registry is to investigate the prevalence of SDB as well as the clinical characteristics of patients with and without SDB as well as the predominant type of sdb.
- Trial name
- SchlaHF (NCT01500759)
- Where
- 199 sites in Australia, Germany
- Volunteers
- 6,876 people
- Sponsor
- ResMed
Congestive Heart Failure, Ventricular Function, Left
Validation of the Gated Blood Pool SPECT: ERNA vs 3D Echo
This research study is designed to evaluate the accuracy of the techniques that are used to analyze heart function. The main purpose of this study is to analyze and compare three different methods of assessment of regional and…
- Trial name
- NCT00576186
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Cardiac Resynchronization Therapy, Heart Failure
Conduction System Pacing vs Biventricular Pacing in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant
Conduction system pacing vs biventricular resynchronization therapy in systolic dysfunction and wide QRS: mortality, heart failure hospitalization or cardiac transplant (CONSYST-CRT II trial).
- Trial name
- CONSYST-CRT II (NCT06105580)
- Testing
- Conduction system pacing, Biventricular pacing
- Where
- Spain
- Volunteers
- 320 people
- Sponsor
- Hospital Clinic of Barcelona
Hospitalization Rate, Mortality Rate
Efficacy of Multi-disciplinary Integrated Post-acute Care in Patients Admission for Heart Failure
Background: Clinical heart failure patients always suffering from (1) worsen symptoms such as decreased activity tolerance, end-to-end breathing and excessive body fluid volume; (2) high medical expenses results from…
- Conditions
- Hospitalization Rate, Mortality Rate, Functional Recovery, Left Ventricle Ejection Fraction
- Trial name
- NCT04638179
- Testing
- Not intervention.Use retrospective case contrl study.
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Heart Failure
A Phase II Trial to Assess Hemodynamic Effects of Istaroxime in Pts With Worsening HF and Reduced LV Systolic Function
The purpose of this study is to determine the minimum effective dose of Istaroxime, in patients requiring hospitalization for deterioration of chronic heart failure and left ventricular systolic dysfunction.
- Trial name
- HORIZON-HF (NCT00616161)
- Testing
- Istaroxime
- Volunteers
- 120 people
- Sponsor
- sigma-tau i.f.r. S.p.A.
Atrial Fibrillation, Heart Failure
The Impact of Atrial Pressure Change Before and After Combined Procedure
One-stop procedure combining catheter ablation (CA) and left atrial appendage closure (LAAC) has been a feasible treatment for patients with atrial fibrillation at high risk of stroke and/or bleeding.
- Trial name
- NCT05106270
- Testing
- Atrial pressure measurement using transseptal puncture sheath
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 10th People's Hospital
Cardiogenic Shock, Heart Failure
Veno-arterial Extracorporeal Membrane Oxygenation Prior to Left Ventricular Assist Device Implantation.
Cardiogenic shock is an uncommun pathology with a high mortatily rate around 45%. Veno arterial extracorporeal membrane oxygenation (VA-ECMO) is a temporary extracorporeal assist device which restore an adequate blood flow when a…
- Conditions
- Cardiogenic Shock, Heart Failure, Extracorporeal Membrane Oxygenation, Left Ventricular Assist Device
- Trial name
- LVAD-ECMO (NCT03583970)
- Testing
- Left Ventricular Assist Device Implantation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France