Clinical trials: Left Heart Failure
Heart Failure With Reduced Ejection Fraction
The ENVI Study: Effect of Entresto on Left Ventricular Remodelling on Cardiac MRI
A prospective, single centre, observational cohort study at University Hospital Southampton NHS Foundation Trust of 50 consecutive patients with Heart Failure with reduced Ejection Fraction and Ejection Fraction ≤35% who are…
- Trial name
- ENVI (NCT05348226)
- Testing
- Additional Cardiac Magnetic Resonance Scan
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Cardiac Insufficiency
Effects of Left Ventricular Assist Device Implantation on the Phenotype of Blood Platelets and Leucocytes
To compare in vivo platelet and leukocyte activation and phenotype before and after Left ventricular assist device (LAVD) implantation
- Trial name
- DAV-Hémo (NCT03306017)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Toulouse
Skeletal Muscle Changes After Crt
Effect of Cardiac Resynchronization Therapy (CRT) on Skeletal Muscle Histology, Neuroendocrine Activation and Inflammatory Response
Heart failure patients with left bundle branch block have a poor prognosis. Biventricular pacing which synchronize the heart pump action is associated with improved functional capacity.
- Trial name
- NCT01019915
- Testing
- CRT
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- Helse Stavanger HF
Chronic Heart Failure
Post-market Study of Multi-Vector Left Ventricular Lead Performance in Chinese Patients With Chronic Heart Failure
The purpose of this clinical study is to observe the safety and efficacy of the multi-vector left ventricular (LV) lead in Chinese patients that are indicated for Cardiac Resynchronization Therapy (CRT).
- Trial name
- MVLV (NCT02367716)
- Testing
- CRT
- Where
- 14 sites in China
- Volunteers
- 121 people
- Sponsor
- Abbott Medical Devices
Hypertrophic Cardiomyopathy
Role of Perhexiline in Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy (HCM) is the most common inherited heart muscle condition affecting up to 1 in 200 of the general population.
- Trial name
- RESOLVE-HCM (NCT04426578)
- Testing
- Perhexiline
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Flinders University
Dialysis, Chronic Kidney Disease (Stages 3b-5)
Left Atrial Appendage Occlusion in Dialysis Patients With Atrial Fibrillation: A Multicentre Pilot Study
Objectives: This pilot study aims to evaluate the safety and efficacy of left atrial appendage occlusion (LAAO) in dialysis patients and atrial fibrillation (AF) to establish a novel stroke prevention strategy and determine an…
- Conditions
- Dialysis, Chronic Kidney Disease (Stages 3b-5), Atrial Fibrillation, End Stage Kidney Failure
- Trial name
- LAAO-DAF (NCT07257614)
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
HFrEF - Heart Failure With Reduced Ejection Fraction, Cardiac Rehabilitation
Predictive Factors of Response to Phase II Cardiac Rehabilitation in Heart Failure With Reduced Ejection Fraction
Exercise intolerance, measured as peak oxygen consumption (VO₂peak) during exercise in patients with heart failure with reduced ejection fraction (HFrEF).
- Conditions
- HFrEF - Heart Failure With Reduced Ejection Fraction, Cardiac Rehabilitation, Exercise Training, Exercise Adaptations
- Trial name
- PrédicRéa (NCT07164911)
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier de Corbie
Dilated Cardiomyopathy
PREclinical Mutation CARriers From Families With DIlated Cardiomyopathy and ACE Inhibitors
This is a multicentre European double-blind,randomized and controlled trial with 2 parallel groups (1 study medication, 1 placebo) in order to analyse the impact of ACE inhibitors (ACEi) in subjects who carry a mutation but have…
- Trial name
- PRECARDIA (NCT01583114)
- Testing
- perindopril
- Where
- 7 sites in Denmark, France and 5 more
- Volunteers
- 6 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Left Bundle Branch Area Pacing, Biventricular Pacing
Clinical Efficacy of Left Bundle Branch Area Pacing for Patients With Permanent Atrial Fibrillation and Heart Failure
This is a multicenter, randomized controlled study. This study aims to compare the clinical efficacy of LBBAP with traditional biventricular pacing in patients with permanent atrial fibrillation and heart Failure
- Conditions
- Left Bundle Branch Area Pacing, Biventricular Pacing, Heart Failure, Permanent Atrial Fibrillation
- Trial name
- LBBAP-AFHF (NCT05549544)
- Testing
- Left bundle branch area pacing, Biventricular pacing
- Where
- 5 sites in China
- Volunteers
- 60 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Congestive Heart Failure
Device Evaluation of Contak Renewal 2and Easytrak 2 - DECREASE-HF
The purpose of this clinical investigation is to demonstrate the safety and effectiveness of the CONTAK® RENEWAL™ 2/4/4HE cardiac resynchronization therapy defibrillator (CRT-D) family and EASYTRAK® 2 lead in delivering LV-CRT or…
- Trial name
- NCT00158951
- Testing
- CONTAK RENEWAL 2/4/4HE CRT-D, EASYTRAK 2 Lead
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Boston Scientific Corporation
Heart Failure
EASYTRAK 3 Downsize Lead
The primary objective of this clinical investigation is to evaluate the safety and effectiveness of the EASYTRAK 3 Downsize Lead.
- Trial name
- NCT00384722
- Testing
- EASYTRAK 3 Downsize Lead
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Boston Scientific Corporation
Chronic Heart Failure
Drug Compliance and Quality of Life in Patients With Heart Failure Dosed With Either Once-daily or Twice-daily Coreg
The purpose of this study is to compare dosing compliance between study patients taking controlled release carvedilol once a day, and study patients taking immediate release carvedilol (Coreg) twice a day.
- Trial name
- NCT00272805
- Testing
- carvedilol
- Where
- 54 sites in United States
- Volunteers
- 400 people
- Sponsor
- Cardiovascular Clinical Sciences Inc
Heart Failure With Normal Ejection Fraction, Left Ventricular Hypertrophy
Imaging Histone Deacetylase in the Heart
The overall goal of this PET-MR imaging trial is to evaluate 11C-Martinostat, a histone deacetylase targeted radioligand, in patients with aortic stenosis, individuals with diabetes, and healthy volunteers.
- Conditions
- Heart Failure With Normal Ejection Fraction, Left Ventricular Hypertrophy, Aortic Valve Stenosis, Diabetes
- Trial name
- NCT03549559
- Testing
- 11C-Martinostat, PET-MRI
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Heart Failure, Central Sleep Apnea
Central Sleep Apnea Prevalence and Impact on Cognitive Function in Patients With Heart Failure With Reduced or Mildly Reduced Left Ventricular Ejection Fraction
Study to assess the prevalence of central sleep apnea in patients with heart failure with reduced or mildly reduced left ventricular ejection fraction (LVEF <50%) followed by case-control study to assess the link between central…
- Trial name
- COG01 (NCT06313840)
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Zoll Medical Corporation
Hyperglycemia, Chronic Heart Failure
The Effect of Liraglutide on Left Ventricular Function in Chronic Heart Failure Patients With and Without Type 2 Diabetes Mellitus
Type 2 diabetes (T2D) is a major risk factor of chronic heart failure (CHF). Glycemic control in patients with the combination of T2D and CHF is complicated and the currently available treatments have proven to be inadequate in…
- Trial name
- NCT01472640
- Testing
- liraglutide
- Where
- 4 sites in Denmark
- Volunteers
- 240 people
- Sponsor
- Flyvbjerg, Allan, DMSc
Heart Failure, Left Ventricular Assist Device
A Study of Metformin to Improve Cardiac Function After LVAD Implantation
This study investigates whether metformin, compared with placebo, improves cardiac function in patients after Left Ventricular Assist Device (LVAD) implantation.
- Trial name
- NCT07666698
- Testing
- Metformin Hydrochloride
- Where
- 5 sites in China
- Volunteers
- 108 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Congestive Heart Failure, Anemia
Impact of Darbepoetin Alfa on Exercise Tolerance and Left Ventricular Structure in Subjects With Symptomatic Congestive Heart Failure (CHF) and Anemia
The purpose of this study was to evaluate the effect of treatment with darbepoetin alfa on peak oxygen consumption (peak VO2) in subjects with symptomatic CHF and anemia.
- Trial name
- NCT00117234
- Testing
- darbepoetin alfa
- Sponsor
- Amgen
Cardiogenic Shock, Pulmonary Edema Cardiac Cause
Hemodynamic Evaluation of Left Atrial Pressure in Relationship to Pulmonary Capillary Wedge Pressure in Cardio Thoracic Patients
Accurate hemodynamic monitoring is critical in cardiothoracic surgery, where left atrial pressure (LAP) serves as the gold standard for assessing left-sided cardiac filling pressures.
- Trial name
- HEART (NCT07163052)
- Volunteers
- 136 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Heart Failure (HF), Ventricular Dysfunction, Left
Open-label, Test-retest Study Assessing Reproducibility of Quantitative Measurements of Myocardial Uptake of AdreView.
The aim of the study was to assess the reproducibility of quantitative measurements of myocardial uptake of Iobenguane I 123 on planar and single photon emission computed tomography (SPECT) imaging following intravenous (i.v.)…
- Trial name
- NCT01936649
- Testing
- AdreView (Iobenguane I 123 Injection)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- GE Healthcare
Heart Failure, Pulmonary Hypertension
Non-Invasive and Invasive Assessment of Heart Filling Pressure
This study evaluates how different non-invasive and invasive measurements reflect left ventricular filling pressure, an important indicator of cardiac function.
- Conditions
- Heart Failure, Pulmonary Hypertension, Ventricular Dysfunction, Left, Ventricular Dysfunction
- Trial name
- NIPRESS (NCT07512310)
- Where
- Germany
- Volunteers
- 623 people
- Sponsor
- University Hospital, Essen