Clinical trials: Left Side
LVAD (Left Ventricular Assist Device) Driveline Infection
A Silver Lining in the VAD Sky
The investigators propose to conduct a prospective randomized trail (RCT) of a driveline management protocol. The study will be initiated at UCSF from January 1st 2022 to December 31st 2022 as a pilot to be extended to other…
- Trial name
- LVAD-SilverD (NCT05163392)
- Testing
- Silverlon, Control
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Heart Failure, Left Bundle-Branch Block
Conventional Biventricular Versus Left Bundle Branch Pacing on Outcomes in Heart Failure Patients
Heart failure (HF) is the most common nosology encountered in clinical practice. Its incidence and prevalence increase exponentially with increasing age and it is associated with increased mortality, more frequent hospitalization…
- Conditions
- Heart Failure, Left Bundle-Branch Block, Ischemic Cardiomyopathy, Non-ischemic Dilated Cardiomyopathy
- Trial name
- RECOVER-HF (NCT05769036)
- Testing
- Implantation of Cardioverter-defibrillator with a Resynchronization Function Using Biventricular Pacing, Implantation of Cardioverter-defibrillator with a Resynchronization Function Using Left Bundle Branch Pacing
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Heart Failure
REDUCE LAP-HF RANDOMIZED TRIAL I
A study to evaluate the Corvia Medical, Inc. IASD® System II to REDUCE Elevated Left Atrial Pressure in Patients with Heart Failure.
- Trial name
- NCT02600234
- Testing
- Inter-Atrial Shunt Device, Intracardiac Echo
- Where
- 21 sites in United States, Australia and 3 more
- Volunteers
- 44 people
- Sponsor
- Corvia Medical
Stroke
Repetitive Transcranial Magnetic Stimulation in Spatial Attention After Stroke
Randomized Controlled Trial (RCT) aiming at assessing the efficacy of a novel rehabilitation protocol, based on repetitive transcranial magnetic stimulation (r- TMS) in combination with a conventional cognitive treatment (CCT).
- Trial name
- r-TMS (NCT04080999)
- Testing
- r-TMS
- Where
- 2 sites in Italy
- Volunteers
- 56 people
- Sponsor
- Azienda Usl di Bologna
Comparison of the Right and Left Internal Jugular Vein Using Ultrasound
Comparison of the Right and Left Internal Jugular Vein Using Ultrasound
The purpose of this study is to determine whether there is a difference between the diameter, and the cross-sectional area of the right internal in left internal jugular vein in preoperative, mechanically ventilated patients.
- Trial name
- NCT01599299
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Congestive Heart Failure
Post Approval Registry of Corox OTW, Endocardial, Left Ventricular Steroid Lead, Bipolar
The objective of this study is to confirm the long-term safety and reliability of the Corox OTW BP left ventricular (LV) pacing lead.
- Trial name
- CELESTIAL (NCT00810264)
- Testing
- CRT Therapy - LV Lead Registry
- Where
- 86 sites in United States
- Volunteers
- 2,499 people
- Sponsor
- Biotronik, Inc.
Heart Failure, Atrial Fibrillation
Cardiac Contractility Modulation in Patients With Chronic Heart Failure and the Various Forms of Atrial Fibrillation
Chronic heart failure (CHF) is a global pandemic which affects around 26 million people worldwide and develops in 10% of people over 70 years .
- Conditions
- Heart Failure, Atrial Fibrillation, Left Ventricular Ejection Fraction
- Trial name
- NCT05550792
- Testing
- optimizer smart
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Hypertension, Pulmonary Artery, Ventricular Dysfunction, Left
Characterization of LV Strain Patterns in Mildly Elevated PCWP and PAH.
The purpose of this study is to determine if patients with pulmonary hypertension and mildly elevated heart pressure known as PCWP will exhibit different patterns on echocardiography and that these patterns will predict treatment…
- Trial name
- LV strain (NCT01800292)
- Testing
- sildenafil
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Arizona
Advanced Heart Failure, Mechanical Circulatory Support
Palliative Care Intervention to Improve Health Related Quality of Life for Patients on Long-Term LVAD Support
Background: While left ventricular assist device (LVAD) therapy improves survival in patients with advanced heart failure (AHF), unique LVAD-related burdens may impact health-related quality of life (HRQoL).
- Conditions
- Advanced Heart Failure, Mechanical Circulatory Support, Left Ventricular Assist Device, Palliative Care
- Trial name
- PALL-VAD (NCT07445932)
- Testing
- Palliative care intervention
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Medstar Health Research Institute
Coronary Artery Disease, Chronic Kidney Disease
Clinical Feature and Outcome of Angiographic Coronary Artery Disease in Chronic Kidney Disease Patients
The prevalence and mortality rate of cardiovascular disease (CVD) in chronic kidney disease (CKD) patients is high. The prevalence of coronary artery disease (CAD) in CKD population ranges from 38 to 65%, with an average of 3.3…
- Trial name
- NCT00651521
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- Chang Gung Memorial Hospital
Post-TAVI
Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB)After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm
The replacement of the aortic valve by percutaneous approach (called TAVI) is a therapy which is booming in the management of aortic stenosis.
- Trial name
- LBBB-TAVI (NCT02482844)
- Testing
- pacemaker implantation, holter implantation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
Heart Failure
Prevention of Non-Surgical Bleeding by Management of HeartMate II Patients Without Antiplatelet Therapy
This study is a prospective, multi-center, randomized, double-blind placebo-controlled study of subjects receiving the HM II LVAD as per the current FDA approved indications for use.
- Trial name
- PREVENT II (NCT02836652)
- Testing
- HeartMate II (HMII), Warfarin, acetylsalicylic acid (ASA) therapy
- Where
- 35 sites in United States, Canada
- Volunteers
- 72 people
- Sponsor
- Abbott Medical Devices
Congestive Heart Failure
Effects of Pentoxiphylline on Left Ventricular (LV) Systolic Function Indices and Circulating Biomarkers in Patients With Chronic Congestive Heart Failure (CHF)
This is a prospective, double blinded randomized clinical study to evaluate the Effects of Pentoxifylline on left ventricular systolic function indices and circulating biomarkers in patients with chronic congestive heart failure.
- Trial name
- PENT-CHF (NCT01337349)
- Testing
- Pentoxifylline
- Where
- United States
- Sponsor
- Henry Ford Health System
Nail Psoriasis
Comparative Study of Intralesional Methotrexate Versus Intralesional Triamcinolone Acetonide in Treatment of Nail Psoriasis
The goal of this clinical trial is to compare methotrexate injections with triamcinolone acetonide injections for treating nail psoriasis.
- Trial name
- NCT07875608
- Testing
- Methotrexate, Triamcinalone Acetonide
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Tanta University
Coronary Artery Disease, Vascular Access Complication
Left Radial comparEd to Femoral Approach for CORonary Angiography in Patients With Previous CABG StuDy
This randomized, multicenter, prospective study seeks to compare left radial and femoral access during cardiac catheterization of patients with prior history of CABG surgery, with the primary objective of demonstrating that the…
- Trial name
- L-RECORD (NCT03393052)
- Testing
- Coronary Angiography
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University Hospital of Patras
Hypertrophy, Left Ventricular, Hypertension
Effect of a Targeted Notification and Clinical Support Pathway on Individuals With Left Ventricular Hypertrophy
The electronic health record contains vast amounts of cardiovascular data, including potential clues that an individual may have unrecognized cardiac conditions.
- Conditions
- Hypertrophy, Left Ventricular, Hypertension, Cardiomyopathies
- Trial name
- NOTIFY-LVH (NCT05713916)
- Testing
- Intervention: Population Health Coordinator
- Where
- United States
- Volunteers
- 648 people
- Sponsor
- Massachusetts General Hospital
Type 2 Diabetes Mellitus
Left Ventricular Functional Changes of Uncontrolled Diabetes by Dapagliflozin Treatment Trial
The primary purpose of this study is to evaluate the efficacy of the SGLT2 inhibitor dapagliflozin, as compared with standard care of diabetes, on left ventricular (LV) structural and functional change in asymptomatic type 2…
- Trial name
- ELUCIDATE (NCT03871621)
- Testing
- Diabetes Medicines, Dapagliflozin
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- Mackay Memorial Hospital
Coronary Artery Disease
Current Treatment Strategy of Patients With Multivessel Disease or Left Main Coronary Artery Disease Indicated for Coronary Artery Bypass Graft Surgery
According to 2011 ACCF/AHA guideline and 2014 ESC/EACTS guideline, CABG surgery was recommended for three-vessel coronary artery disease and left main coronary artery disease in the patients with stable ischemic heart disease as…
- Trial name
- NCT02410993
- Testing
- CABG surgery
- Where
- South Korea
- Volunteers
- 2,500 people
- Sponsor
- Yonsei University
Congestive Heart Failure
Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction
In congestive heart failure, cardiac output is low, blood pressure is high, and the body becomes congested with fluid. In normal people, when there is high blood pressure, the heart muscle cells secrete a hormone that excretes…
- Trial name
- PPG1 (NCT00387621)
- Testing
- Nesiritide, Saline
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Horng Chen
Paroxysmal Atrial Fibrillation, Pulsed Field Ablation
Pulsed Field Ablation for Paroxysmal Atrial Fibrillation: Clinical Efficacy and Left Atrial Function Protection
This is a prospective clinical study aiming to evaluate the clinical efficacy and safety of a novel domestic pulsed field ablation (PFA) system in the treatment of paroxysmal atrial fibrillation (PAF), and to specifically assess…
- Conditions
- Paroxysmal Atrial Fibrillation, Pulsed Field Ablation, Catheter Ablation, Left Atrial Function
- Trial name
- NCT07865221
- Testing
- Novel Pulsed Field Ablation System, Radiofrequency Ablation Catheter
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Tianjin Medical University General Hospital
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