Clinical trials: Left Side
Ventricular Dysfunction, Left
High-dose Selenium Supplementation in Patients With Left Ventricular Assist
This planned pilot study is a monocentric, prospective, double-blind randomized and placebo controlled clinical study. The SOS-LVAD Trial can be assigned to the clinical Phase III.
- Trial name
- SOS-LVAD (NCT02530788)
- Testing
- Selenium Supplement (sodium selenite)
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- RWTH Aachen University
Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation Sustained
Percutaneous Left Stellate Ganglion Block In Out-of-hospital Cardiac Arrest Due to Refractory VEntricular Arrhythmias (LIVE Study)
This is an observational, prospective study to verify the feasibility and practicability of percutaneous stellate ganglion block (PSGB) in patient suffering from a refractory out-of-hospital cardiac arrest (OHCA) due to a…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation Sustained, Shockable Rhythm, Medical Etiology
- Trial name
- LIVE (NCT04168970)
- Testing
- PSGB
- Where
- 2 sites in Italy
- Volunteers
- 62 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Primary Cardiomyopathy, Dilated Cardiomyopathy
Risk Stratification in Children and Adolescents With Primary Cardiomyopathy
RIKADA is a prospective study performing systematic family screening including clinical and genetic testing in pediatric patients with primary cardiomyopathy and their first-degree relatives with the aim to facilitate risk…
- Conditions
- Primary Cardiomyopathy, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Left Ventricular Noncompaction
- Trial name
- RIKADA (NCT03572569)
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- German Heart Institute
Atrial Fibrillation (AF)
Characterization of Left Atrial Substrate by Comparison of Bipolar Voltage Maps With Standard Focal 4.5 mm Tip Electrode, 1 mm Ring Electrode, and Microelectrode Catheters Using InTEllaMap Orion and IntellaNav MIFI O
This study is to investigate the correlation and to obtain the coefficient of correlation between the global and local bipolar signals (voltage maps) of the LA in sinus rhythm using a focal 4.5 mm irrigated-tip ablation catheter…
- Trial name
- CHAZESubstrate (NCT04095559)
- Testing
- multipolar mapping catheter, multielectrode circular catheter, irrigated ablation catheter
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- University Hospital, Basel, Switzerland
Mechanical Dyssynchrony, Heart Failure
Evaluating Effects of a Left Bundle Branch Block
A left bundle branch block (LBBB) is related to abnormal cardiac conduction and mechanical asynchrony and is associated with hypertension and coronary artery disease.
- Conditions
- Mechanical Dyssynchrony, Heart Failure, Bundle-Branch Block
- Trial name
- NCT00269659
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
AV Block
Left Septal Pacing or Left Bundle Branch Pacing to Avoid Left Ventricle Systolic Dysfunction
Right ventricular apical pacing (RVAP) can produce left ventricular dysfunction (LVD). Conduction system pacing (CSP) has been used successfully to reverse LVD in patients with left bundle branch block.
- Trial name
- STAY II (NCT06707662)
- Testing
- Pacemaker and defibrillator
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Parc de Salut Mar
Preeclampsia, Severe Preeclampsia
Diastolic Dysfunction 2025
This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregnant women.
- Trial name
- NCT07190846
- Testing
- No Intervention (Observational Echocardiographic Evaluation)
- Where
- Tunisia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Postoperative Pain, Postoperative Nausea
Autonomic Neural Field Block for Visceral Pain in Minimally Invasive Left-Sided Colectomy
Effective postoperative pain control is a core component of enhanced recovery after surgery (ERAS) pathways in colorectal surgery; however, postoperative pain following minimally invasive left-sided colectomy remains a persistent…
- Conditions
- Postoperative Pain, Postoperative Nausea, Opioid Use
- Trial name
- ANfiELD (NCT07351994)
- Testing
- Autonomic Neural Field Block
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Antonio Caycedo, MD
Atrial Fibrillation (AF), Pacemaker Therapy
Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF
This prospective, randomized controlled trial aims to evaluate the effect of left bundle branch pacing (LBBP) compared with conventional right ventricular (RV) pacing on the cumulative duration (total time) of atrial high-rate…
- Conditions
- Atrial Fibrillation (AF), Pacemaker Therapy, Atrioventricular Block, Preserved Ejection Fraction
- Trial name
- LBBP-AHRE (NCT07250529)
- Testing
- Right Ventricular Pacing, Left Bundle Branch Pacing
- Where
- Greece
- Volunteers
- 244 people
- Sponsor
- University Hospital of Patras
Depression, Major Depressive Disorder
Left vs. Right Non-Inferiority Trial
The aim of this study is to test the hypothesis that low-frequency rTMS (LFR) works as well as the established intermittent thetaburst rTMS (iTBS) treatment for treatment resistant depression (TRD).
- Conditions
- Depression, Major Depressive Disorder, Major Depressive Episode
- Trial name
- LeRNIT (NCT04999553)
- Testing
- Repetitive Transcranial Magnetic Stimulation, Intermittent Theta Burst Stimulation (iTBS), Low Frequency Right (LFR)
- Where
- 2 sites in Canada
- Volunteers
- 480 people
- Sponsor
- University of British Columbia
Athletes Heart
Semmelweis Sport Study
The aim of the present proposal is to investigate the development of distinct morphological, functional, biochemical and molecular aspects of short- and long-term sport-induced changes in the heart, to get a better understanding…
- Trial name
- NCT03025737
- Where
- Hungary
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Semmelweis University Heart and Vascular Center
Stroke, Aphasia
Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe
This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on lexicosemantic impairments, to enhance recovery.
- Trial name
- ATLAS (NCT07608588)
- Testing
- continuous Theta Burst Stimulation, intermittent Theta Burst Stimulation, Semantic Feature Analysis
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of South Carolina
Comparison of 3D Monitored Changes of Left Atrial Volume Before and After Ablation With Conventional Transesophageal Echocardiography
Assessment of Left Atrial Mechanical Function With a True 3D Ultrasouns Arry and Comparison With the Transthoracic and Transesophageal Echocardiography
Chronic atrial fibrillation is a challenging arrhythmia requiring additional radiofrequency ablation besides pulmonary vein isolation. Atrial contractility in these patients is often impaired.
- Trial name
- NCT03331029
- Testing
- transesophageal investigation
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Klinik Hirslanden, Zurich
Bipolar Depression
Transcranial Magnetic Stimulation for Bipolar Depression
This is a study to assess the effectiveness of repetitive transcranial magnetic stimulation (rTMS) as a treatment for depressed adults with bipolar disorder.
- Trial name
- NCT00470639
- Testing
- Transcranial Magnetic Stimulation
- Where
- 2 sites in Australia
- Sponsor
- The University of New South Wales
Left Main Coronary Artery Stenosis
Optical Coherence Tomography - Guided Protocol for Left Main Percutaneous Coronary Intervention
LEMON aim is to evaluate the feasibility, efficiency and security of a standardized Optical Coherence Tomography (OCT) - guided protocol for completion and optimization of Left Main (LM) Percutaneous Coronary Intervention (PCI).
- Trial name
- LEMON (NCT04248777)
- Testing
- standardised OCT-guided intervention
- Where
- 11 sites in France
- Volunteers
- 71 people
- Sponsor
- Institut Mutualiste Montsouris
HOCM, Hypertrophic Obstructive Cardiomyopathy, LVOTO - Left Ventricular Outflow Tract Obstruction
Reverse Remodeling After PTSMA in Severe But Asymptomatic LVOT Obstruction
Patients with HOCM and severe LVOT obstruction can remain asymptomatic while significant cellular and structural changes of the heart (adverse remodeling) may occur preceding heart failure and rhythm disorders.
- Conditions
- HOCM, Hypertrophic Obstructive Cardiomyopathy, LVOTO - Left Ventricular Outflow Tract Obstruction, Remodeling, Ventricular
- Trial name
- RASTA (NCT04230551)
- Testing
- PTSMA
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people
- Sponsor
- St. Antonius Hospital
Hypertension Arterial, Hypokinetic
Etiological DiagnOsis of caRdiac Diseases Based on echoCardiograpHIc Images and Clinical Data.
Research hypothesis - Recent studies have shown that high-dimensional descriptors of the cardiac function can be efficiently exploited to characterize targeted pathologies.
- Conditions
- Hypertension Arterial, Hypokinetic, Cardiomyopathies, Left Ventricular Hypertrophy
- Trial name
- ORCHID (NCT05942729)
- Testing
- Determine the etiology of hypokinetic and hypertrophic heart disease on transthoracic echocardiography data alone
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Hospices Civils de Lyon
Heart Failure
Left Ventricular MultiSpot Pacing for CRT (iSPOT)
The purpose of the iSPOT Study is to evaluate the contractility using positive left ventricular (LV) dP/dt max across LV pacing site(s) in patients indicated for cardiac resynchronization therapy (CRT).
- Trial name
- iSPOT (NCT01883141)
- Testing
- Electrophysiological Study
- Where
- 8 sites in Belgium, Israel and 2 more
- Volunteers
- 31 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Neck Pain
Left/Right Neck Judgment Performance in Individuals With Neck Pain
Neck pain is one of the leading causes of disability worldwide and ranks fourth among the pathologies that result in disability.
- Trial name
- NCT05750472
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Tricuspid Regurgitation
Minimally Invasive Tricuspid Surgery vs Medical Treatment for Severe TR
Late tricuspid regurgitation (TR) is a common complication after left-sided valve surgery (LSVS), which usually progresses slowly and results in right heart failure at terminal stage.
- Trial name
- NCT04339192
- Testing
- Minimally Invasive Tricuspid Surgery
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Zhongshan Hospital
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