Clinical trials: Left Side
Ulcerative Colitis
Faecal Bacteriotherapy for Ulcerative Colitis
The etiopathogenesis of ulcerative colitis (UC) is not fully understood. One of the theories of UC pathogenesis represents a pathological response of mucosal immunity to intestinal microbiota.
- Trial name
- FACTU (NCT03104036)
- Testing
- Faecal bacterial transplantation, Mesalazine 4G Enema
- Where
- 9 sites in Czechia
- Volunteers
- 61 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Coronary Artery Disease, Coronary Artery Disease (CAD)
Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)
This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (CAD), Multivessel Coronary Artery Disease, CABG
- Trial name
- STICH 3*0-NL (NCT07269366)
- Testing
- CABG, PCI
- Where
- Netherlands
- Volunteers
- 358 people
- Sponsor
- University Medical Center Groningen
Atrial Fibrillation
A Randomised Comparison of Left and Right Sided Approaches to Ablation of the Atrioventricular Junction
This study will compare right sided atrioventricular node ablation to left sided atrioventricular node ablation
- Trial name
- NCT05211453
- Testing
- atrioventricular node ablation
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- East Sussex Healthcare NHS Trust
Heart Failure, Asymptomatic Systolic Dysfunction
Human B-type Natriuretic Peptide (BNP) (Nesiritide) to Help Heart, Kidney, and Hormonal Functions in Persons With Lower Heart Pumping Function
The following are done for screening procedures to determine if patients are eligible for this study: blood count, kidney and liver blood tests. Patients will complete a 6-minute walk test.
- Trial name
- NCT00405639
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
T Acute Lymphoblastic Leukemia
Use of a New Medicine "Daratumumab" to Treat Left-over Cancer in a Blood Cancer Called "T Acute Lymphoblastic Leukemia"
T-ALL (T-acute lymphoblastic leukemia) is an aggressive blood cancer, wherein patients who are MRD positive after two courses of induction chemotherapy have poor outcomes.
- Trial name
- DARA_T_ALL (NCT07021677)
- Testing
- Daratumumab Injection
- Where
- India
- Volunteers
- 18 people
- Sponsor
- Tata Memorial Centre
Heart Failure, Heart Failure Systolic
Precision of AI-Based Cardiac Ultrasound for LVEF in the Elderly
Heart failure (HF) is common in older adults, especially those over 65. It is a leading cause of hospitalization and has high mortality rates.
- Conditions
- Heart Failure, Heart Failure Systolic, Elderly, Artificial Intelligence
- Trial name
- PRECISE AI (NCT06478901)
- Testing
- Echocardiography
- Where
- France
- Volunteers
- 129 people
- Sponsor
- Hôpital Broca APHP
Chronic Heart Failure
Study of the Effect of Serelaxin on High-sensitivity Cardiac Troponin I (Hs-cTnI) Release in Patients With Chronic Heart Failure
This was a multicenter, randomized, double-blind, crossover, placebo-controlled, Phase II clinical study that evaluated the effect of serelaxin versus placebo (both in addition to SoC) on the release of hs-cTnI, in patients with…
- Trial name
- RELAX-Cardio (NCT02625922)
- Testing
- Serelaxin
- Where
- 9 sites in Germany, Switzerland and 1 more
- Volunteers
- 26 people
- Sponsor
- Novartis Pharmaceuticals
Coronary Artery Bypass Grafting, Coronary Artery Disease
Comparison of RIMA-SVG and Ao-SVG Techniques in Coronary Artery Bypass Grafting
This randomized, double-blind, single-center clinical trial was divided into two groups, RIMA-SVG and Ao-SVG, according to the surgical method.
- Conditions
- Coronary Artery Bypass Grafting, Coronary Artery Disease, Saphenous Vein, Graft Patency
- Trial name
- NCT06787651
- Testing
- RIMA-SVG, Ao-SVG
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Jilin University
Pacemaker DDD
Comparison of Pacing Lead Design on Left Bundle Branch Pacing Outcomes: The LEAD_LBBP Randomized Clinical Trial
This trial seeks to evaluate the performance of the extendable helix, stylet-driven pacing lead (SDL) compared to the fixed helix, lumenless pacing lead (LLL) during left bundle branch pacing (LBBP), with respect to enduring left…
- Trial name
- LEAD-LBBP (NCT06318130)
- Testing
- Fixed helix, lumenless pacing lead., Extendable helix, stylet-driven pacing lead.
- Where
- Singapore
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Mitral Valve Surgical Approaches
Transseptal Approach Versus Conventional Left Atrial Approach for Mitral Valve Procedures
Study Objectives/Specific Aims Overall Goal: To compare between transseptal approach and the conventional left atrial approach for mitral valve procedures.
- Trial name
- NCT04078100
- Testing
- Transseptal approach.
- Volunteers
- 100 people
- Sponsor
- Assiut University
Essential Hypertension, Diabetes Mellitus
Effects Of Losartan On Myocardial Structure In Diabetic Hypertensive Patients With Left Ventricular
The anthypertensive treatment with Losartan may have benefits beyond blood pressure reduction on myocardial structure and function in hypertensive diabetic patients.
- Trial name
- NCT00659451
- Testing
- Losartan, Amlodipine
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Pavia
Metastatic Colorectal Cancer
Real-World Treatment Patterns and Effectiveness of Anti-EGFR- and Anti-VEGF-based Therapies in Left-sided RAS Wild-Type Metastatic Colorectal Cancer
The aim of this study is to learn how doctors treat a type of metastatic colorectal cancer in everyday medical practice. The study focuses on patients whose cancer started on the left side of the colon and does not have specific…
- Trial name
- NCT07909122
- Testing
- Anti-EGFR-Based Therapy, Anti-VEGF-Based Therapy
- Volunteers
- 1 people
- Sponsor
- Pfizer
ST Elevation (STEMI) Myocardial Infarction of Anterior Wall
CD-NP (Cenderitide) Therapy for the Preservation of Left Ventricular Function
The primary endpoint is to assess the safety and tolerability of Cenderitide (CD-NP) with the incidence of symptomatic hypotension being one of the key safety variables.
- Trial name
- BELIEVE III (NCT02071602)
- Testing
- CD-NP
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Coronary Artery Disease, Heart Failure
Clinical Trial of Ventiflow LP Supporting High-risk Percutaneous Coronary Intervention(PCI)
The purpose of this prospective, multicenter, randomized controlled clinical trial is to evaluate the effectiveness of the transcatheter left ventricular assist system (Ventiflow LP) in providing circulatory support to patients…
- Conditions
- Coronary Artery Disease, Heart Failure, High-risk PCI
- Trial name
- NCT06754839
- Testing
- Percutaneous left ventricular assist device(Ventiflow LP), VA-ECMO
- Volunteers
- 250 people
- Sponsor
- Suzhou Hearthill Medical Technology Co.,LTD
Thrombus of Left Ventricle
Cohort of Patients With Left Ventricular Thrombus: Management and Outcomes in the Direct Oral Anticoagulants Era
The investigators' primary objective is to assess whether a difference in the occurrence of bleeding events exist between patients with LVT treated with DOACs as compared to those treated with VKAs.
- Trial name
- LV-Thrombus (NCT05028777)
- Where
- Switzerland
- Volunteers
- 98 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Heart Failure With Preserved Ejection Fraction
Mechanisms of LV Remodeling in Hypertensive Patients Working on a Rotational Expeditionary Basis in the Arctic
The main goal of our investigation is to study the mechanisms of formation of left ventricular remodeling in patients with hypertension, working on a rotational expedition basis in the Arctic.
- Trial name
- NCT05839028
- Where
- Russia
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Left Bundle Branch Pacing
Feasibility of Simplified Permanent Left Bundle Branch Pacing Without Electrophysiological Recording System
This is a prospective, single-center study of patients with an indication for ventricular pacing who attempted LBBP without electrophysiology recording system (EP system).
- Trial name
- NCT05553431
- Testing
- Left bundle branch pacing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Left Atrial Appendage Occluder, Device Embolisation
Therapy Strategies After LAA Occluder Device Embolization
The investigators thought to evaluate risk factors, therapeutic approaches and outcomes after left atrial appendage occluder device embolization (LAAO, either surgical or interventional).
- Conditions
- Left Atrial Appendage Occluder, Device Embolisation, Therapy Strategies, Risk Factors
- Trial name
- LAAODE (NCT05014477)
- Testing
- Removal or leaving of LAA occluders
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Cardiovascular Center Frankfurt
Cardiac Insufficiency
Cardiac Resynchronization Therapy: Relevance of the Surgical Approach in the Implantation of the Left Ventricular Probe
Heart failure is very common and reaches more than 56 million people worldwide. 17 to 45 percent die in the first year of hospitalization. The most affected populations live in Western countries like Europe or the USA.
- Trial name
- NCT03083301
- Testing
- Medical Files data extraction
- Where
- Belgium
- Volunteers
- 155 people
- Sponsor
- Pierre Wauthy
Healthy
tDCS of the Left dlPFC: Effects on Information Processing
This study investigates how a non-invasive form of brain stimulation, called transcranial direct current stimulation (tDCS), affects brain activity and information processing in younger and older adults.
- Trial name
- NCT07168031
- Testing
- Active Transcranial Direct Current Stimulation (tDCS)
- Where
- Switzerland
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of Bern
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