Clinical trials: Left Side
Covid19, Cardiac Disease
COvid-19 LongitUdinal Multiethnic BioImaging Assessment of CARDiovascular Sequelae Registry
COLUMBIA CARDS is a pilot study to understand how COVID-19 affects the heart. It is known that COVID-19 can affect the heart in different ways.
- Conditions
- Covid19, Cardiac Disease, Cardiac Arrhythmia, Myocarditis
- Trial name
- NCT04661657
- Testing
- Transthoracic echocardiogram (TTE), Cardiovascular Magnetic Resonance (CMR) Imaging
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Columbia University
Grief, Grief Disorder, Prolonged
Families Left Behind
The United States is facing unprecedented rates of drug overdose deaths, profoundly impacting millions of families who are left to navigate their grief.
- Conditions
- Grief, Grief Disorder, Prolonged, Overdose Accidental, Substance Use Disorders
- Trial name
- NCT06854757
- Testing
- RIVER, Enhanced care as usual
- Where
- 4 sites in United States
- Volunteers
- 340 people
- Sponsor
- RAND
Hypoplastic Left Heart Syndrome, Single Ventricle
Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single Ventricle Physiology
Hypoplastic left heart syndrome (HLHS) and related anomalies involved a single ventricle are characterized by hypoplasia of the left heart and the aorta with compromised systemic cardiac output.
- Conditions
- Hypoplastic Left Heart Syndrome, Single Ventricle, Heart Failure
- Trial name
- TICAP (NCT01273857)
- Testing
- Autologous cardiac progenitor cell transplantation, staged shunt procedure
- Where
- Japan
- Volunteers
- 14 people
- Sponsor
- Okayama University
Silent Myocardial Ischemia, Type 2 Diabetes
Detection no Invasive of a Silent Myocardial Ischemia
The pathophysiological features of myocardial diabetic subject combined with cardiac autonomic neuropathy were behind the quietness of myocardial ischemia, known as silent myocardial ischemia (IMS).
- Trial name
- NCT02885428
- Testing
- echography
- Where
- France
- Volunteers
- 47 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Myocardial Infarction: Rehabilitation Phase, Coronary Artery Bypass Graft Triple Vessel
Cardiopulmonary and Metabolic Responses to Early Exercise in Patients After Coronary Arterial Bypass Grafting
Coronary arterial bypass graft surgery (CABG) is proven safe with improved survival and greater quality of life in patients with coronary arterial disease.
- Conditions
- Acute Myocardial Infarction: Rehabilitation Phase, Coronary Artery Bypass Graft Triple Vessel, Physical Activity
- Trial name
- NCT02758600
- Testing
- Cycle ergometer exercise rehabilitation protocol
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Heart Failure
Left Ventricular Pacing Vectors Effectiveness to Narrow Phrenic Nerve Stimulation
Evaluation of three left ventricular pacing polarities effectiveness to narrow phrenic nerve stimulation.
- Trial name
- ORPHEE (NCT03127202)
- Testing
- Cardiac Resynchronization Therapy -Defibrillator (range PARADYM, LivaNova, Clamart, France)
- Where
- 12 sites in France
- Volunteers
- 90 people
- Sponsor
- LivaNova
Coronary Disease
Drug-eluting-stents for Unprotected Left Main Stem Disease (ISAR-LEFT-MAIN)
The purpose of this study is to evaluate the efficacy of sirolimus- and paclitaxel-eluting stents for treatment of unprotected left main coronary artery disease.
- Trial name
- NCT00133237
- Testing
- Sirolimus-eluting stent, Paclitaxel-eluting stent
- Where
- 2 sites in Germany
- Volunteers
- 607 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Transcatheter Aortic Valve Replacement (TAVR), Left Ventricular Hypertrophy
Angiotensin Receptor Blocker After TAVR in Severe Aortic Stenosis With Left Ventricular Hypertrophy (ARBITAR)
This is a multicenter, prospective, open-label, randomized, investigator-initiated trial evaluating whether angiotensin receptor blocker (ARB) therapy improves clinical outcomes in patients with severe aortic stenosis (AS) and…
- Conditions
- Transcatheter Aortic Valve Replacement (TAVR), Left Ventricular Hypertrophy, Severe Aortic Stenosis
- Trial name
- ARBITAR (NCT07735130)
- Testing
- Angiotensin Receptor Blocker (ARB)
- Where
- South Korea
- Volunteers
- 632 people
- Sponsor
- Seoul National University Hospital
Colorectal Anastomosis, Left-sided Colon Resection
Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections
The purpose of this study is to evaluate the safety and performance of the Signia™ power handle, Signia™ circular adapter, and Signia™ Tri-Staple™ 2.0 circular reloads (hereafter referred to as Signia™ circular stapler) in…
- Conditions
- Colorectal Anastomosis, Left-sided Colon Resection, Anastomotic Leak, Anastomotic Complication
- Trial name
- SECURE (NCT07351071)
- Testing
- Signia™ circular stapler with Tri-Staple™ Technology (Signia™ Circular Stapling system)
- Where
- 10 sites in United States
- Volunteers
- 137 people
- Sponsor
- Medtronic - MITG
Mitral Valve Insufficiency, Left Ventricular Dysfunction
Pharmacological Reduction of Functional, Ischemic Mitral REgurgitation
Functional MR is caused by adverse left ventricular remodeling after myocardial injury and associated with an increased incidence of heart failure and death.
- Trial name
- PRIME (NCT02687932)
- Testing
- LCZ696, Valsartan
- Where
- 4 sites in South Korea
- Volunteers
- 118 people
- Sponsor
- Asan Medical Center
Cardiac Failure
The Efficacy and Safety of Pirfenidone in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction
This randomised, double-blind, placebo-controlled, phase 2 study aims to evaluate the efficacy and safety of the anti-fibrotic drug pirfenidone in the treatment of patients with heart failure and preserved left ventricular…
- Trial name
- PIROUETTE (NCT02932566)
- Testing
- Pirfenidone
- Where
- United Kingdom
- Volunteers
- 129 people
- Sponsor
- Manchester University NHS Foundation Trust
Cardiac Function
Evaluation of Whole-body CZT Camera in Gated Tomographic Radionuclide Angiography
Tomographic radionuclide angiography (or blood pool) is a reproducible method to evaluate left ventricular ejection fraction that is needed during oncological treatments or to evaluate cardiopathies.
- Trial name
- STARGAC (NCT04629937)
- Testing
- SPECT acquisitions
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Dilated Cardiomyopathy
Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy
The purpose of this study is to determine the safety and clinical effectiveness of umbilical cord mesenchymal cells transplanted by intravenous infusion in patients with heart failure.
- Trial name
- RIMECARD (NCT01739777)
- Testing
- ucMSC, Controls
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad de los Andes, Chile
Hypertension; Heart Disease, Hypertensive
Effect of Aterial Stiffness on Myocardial Work in Patients With Hypertension
Hypertension is a serious threat to human health and a major global economic burden.Chronic hypertension can cause left ventricular remodeling and loss of function, eventually leading to heart failure.Exploring the early changes…
- Trial name
- NCT04573257
- Testing
- Echocardiography and pulse wave velocity measurement
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
Left Ventricular Dysfunction, Heart Failure
Effects of Left Ventricular Pacing Optimilization on Cardiac Perfusion, Contractile Force, and Clinical Performance in Patients With Ventricular Dysfunction and Heart Failure
To compare a surgical approach of LV lead placement for BIV pacing with the conventional transvenous approach by assessment of differences on the effects on cardiac perfusion and relate this to the clinical cardiac function.
- Trial name
- CONTRACT (NCT00551681)
- Testing
- biventricular pacemaker with epicardial left ventricular lead, transvenous left ventricular lead placement
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- R&D Cardiologie
Heart Failure, Diastolic, Heart Failure, Systolic
Network Medicine Approaches to Classify Heart Failure With PReserved Ejection Fraction by Signatures of DNA Methylation and Point-of-carE Risk calculaTors (PRESMET)
Heart failure (HF) is a syndrome, resulting from structural or functional impairment of ventricular filling or ejection of blood.
- Conditions
- Heart Failure, Diastolic, Heart Failure, Systolic, Pulmonary Hypertension, Atrial Fibrillation
- Trial name
- PRESMET (NCT05475028)
- Testing
- RRBS
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
Heart Failure With Reduced Ejection Fraction
Effects of Preferential Left Ventricular Pacing on Ventriculoarterial Coupling and Clinical Course of Heart Failure
Randomized trial of adult patients to study the effects of preferential left ventricular pacing on ventriculoarterial coupling of both systemic and pulmonary circulation, indices of systolic and diastolic function of both…
- Trial name
- READAPT (NCT04420065)
- Testing
- Preferential left ventricular pacing, Biventricular pacing
- Where
- Greece
- Volunteers
- 220 people
- Sponsor
- National and Kapodistrian University of Athens
Chronic Heart Failure
Omega-3-Polyunsaturated Fatty-Acids (N3-Pufa) In Patients With Severe Chronic Heart Failure
To investigate whether n3-fatty acids have beneficial effects in chronic heart failure as regards circulatory function.
- Trial name
- NCT00149409
- Testing
- Omacor
- Where
- Austria
- Sponsor
- Medical University of Vienna
Left Ventricular Thrombus, Myocardial Infarction
Anticoagulation in Post MI LV Thrombus Trial in Nepal
Introduction: The prevalence of left ventricular(LV) thrombus after acute myocardial infarction has decreased with thrombolysis and primary angioplasty intervention worldwide.
- Trial name
- WaRMIN (NCT05794399)
- Testing
- Rivaroxaban, Warfarin
- Where
- Nepal
- Volunteers
- 196 people
- Sponsor
- Shahid Gangalal National Heart Centre
Left Ventricular Diastolic Dysfunction
Assessment of the Possible Association Between Left Ventricular Diastolic Dysfunction and Carotid Atherosclerosis and Brain White Matter Damage
Left ventricular diastolic dysfunction is caused by impaired relaxation and increased left ventricular stiffness with a consequent increase in filling pressures.
- Trial name
- NCT04549298
- Testing
- No interventions
- Volunteers
- 88 people
- Sponsor
- Neuromed IRCCS
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