Clinical trials: Left Side
Heart Failure
QUAD-HF - Prospective Registry of Patients With Incident Heart Failure and Left Ventricular Ejection Fraction <50%
The QUAD-HF registry is an observational study that would enroll patients in the United Kingdom, who have been newly diagnosed with heart failure and a left ventricular ejection fraction <50%.
- Trial name
- QUAD-HF (NCT07174362)
- Where
- 2 sites in United Kingdom
- Volunteers
- 4,000 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Atrial Fibrillation
Age Related D-dimer Evaluation for the Exclusion of a Left Atrium Thrombus in Patients With Atrial Fibrillation (ADDIT-AF)
Patients with atrial fibrillation are at increased risk of thrombus formation in the left heart, especially in the auricula and the atrium.
- Trial name
- NCT02802488
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 142 people
- Sponsor
- Brugmann University Hospital
Ventricular Dysfunction, Left
High-dose Selenium Supplementation in Patients With Left Ventricular Assist
This planned pilot study is a monocentric, prospective, double-blind randomized and placebo controlled clinical study. The SOS-LVAD Trial can be assigned to the clinical Phase III.
- Trial name
- SOS-LVAD (NCT02530788)
- Testing
- Selenium Supplement (sodium selenite)
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- RWTH Aachen University
Depression - Major Depressive Disorder, Depression Bipolar
Right-sided 1-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Versus Left-sided Intermittent Theta Burst Stimulation (iTBS) in Patients With Depression
Aim: The purpose of the study is to establish the non-inferiority of right-sided inhibitory 1 Hz stimulation compared to left-sided intermittent theta burst stimulation (iTBS) in unipolar and bipolar depression.
- Trial name
- NCT07026461
- Testing
- repetitive transcranial magnetic stimulation, intermittent theta burst stimulation
- Where
- 2 sites in Sweden
- Volunteers
- 350 people
- Sponsor
- Region Örebro County
Ischemia, Myocardial Infarction
Evaluating a New Echocardiography Imaging Procedure for Evaluating Heart Function
Magnetic resonance imaging (MRI) and echocardiography are two imaging methods that are used to obtain pictures of the heart and assess heart function.
- Conditions
- Ischemia, Myocardial Infarction, Ischemic Heart Disease
- Trial name
- NCT00661323
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetes Mellitus
Diabetic Autonomic Neuropathy and Left Ventricular Function
Purpose: To investigate the effect of Quinapril (Q) or Losartan (L) or their combination on definite Diabetic Autonomic Neuropathy (DAN) and left ventricular systolic and diastolic function (LVF) over a period of 4 years.
- Trial name
- DANEL (NCT05713396)
- Testing
- Quinapril, Losartan, Quinapril + Losartan
- Where
- Greece
- Volunteers
- 59 people
- Sponsor
- AHEPA University Hospital
Atrial Fibrillation, Anticoagulants and Bleeding Disorders
Left Atrial Appendage Occlusion for AF Patients Unable to Use Oral Anticoagulation Therapy
Up to 5% of Atrial Fibrillation (AF) patients may have or develop contraindications to use oral anticoagulation (OAC). Randomized controlled trial (RCT) data suggest that Left Atrial Appendage Occlusion (LAAO) may provide a…
- Trial name
- COMPARE-LAAO (NCT04676880)
- Testing
- Left atrial appendage occlusion (Watchman FLX or Amplatzer Amulet)
- Where
- 14 sites in Netherlands
- Volunteers
- 609 people
- Sponsor
- R&D Cardiologie
Congestive Heart Failure, Ventricular Function, Left
Validation of the Gated Blood Pool SPECT: ERNA vs 3D Echo
This research study is designed to evaluate the accuracy of the techniques that are used to analyze heart function. The main purpose of this study is to analyze and compare three different methods of assessment of regional and…
- Trial name
- NCT00576186
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Oesophageal Reflux
Determination of the Left Paratrachéal Force Required to Occlude the Esophageal Entrance
Determine the force required to occlude the esophagus with a left paratracheal pressure
- Trial name
- NCT05214079
- Testing
- Left paratracheal pressure
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Liege
Heart Failure
Triple-site Biventricular Stimulation in the Optimization of CRT
Cardiac resynchronization is a recommended therapy for patients with advanced heart failure, under optimized medical treatment with reduced left ventricular ejection fraction and prolonged QRS, nevertheless, still 30% of the…
- Trial name
- TRIUMPH-CRT (NCT02350842)
- Testing
- triple-site biventricular pacing with peri-operative echo guidance, standard biventricular pacing
- Where
- 14 sites in France, Germany and 4 more
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- MicroPort CRM
Ulcerative Colitis
An Efficacy and Safety Study of PENTASA in Chinese Patients With Left-sided Active Ulcerative Colitis Followed by a 24-Week Open-Label Extension Phase
The purpose of this study is to investigate the efficacy and safety of 4-week double-blind treatment with PENTASA enema compared with placebo enema in Chinese patients with mild to moderate active left-sided ulcerative colitis…
- Trial name
- NCT02368717
- Testing
- Mesalazine Enema
- Where
- China
- Volunteers
- 281 people
- Sponsor
- Ferring Pharmaceuticals
Maxillary Sinus Left
Magnetic Mallet and Densah Bur for Crestal Sinus Left
Background: Implant placement in the posterior maxilla is problematic procedure, not only due to inferior properties of bone but also due to loss of vertical bone height, which happens after extraction of posterior teeth.
- Trial name
- NCT06677125
- Testing
- Electrical Mallet, Densah bur
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Hams Hamed Abdelrahman
Subcutaneous Fat Disorder
Safety and Efficacy Study of 10XB-101 in Adults With Bilateral Flank Adiposity
The goal of this clinical trial is to test the safety and effectiveness of an injection study drug in decreasing bilateral flank adiposity.
- Trial name
- NCT05760248
- Testing
- 10XB-101 Solution for Injection, 6.0%
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- 10xBio, LLC
HCC, Liver Cirrhosis
SALT for Liver Cirrhosis With HCC
HCC is the third leading cause of cancer deaths worldwide. Although surgical treatment may be effective in patients with HCC, the five-year survival rate is only 50-70%.
- Trial name
- NCT06069947
- Testing
- sequential adult left lateral lobe liver transplantation (SALT)
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Heart Failure, Cardiac Resynchronisation Therapy
Effects of Endurance Training on Patients With Reduced Left Ventricular Ejection Fraction (LVEF) and Cardiac Resynchronisation Therapy Especially for Cardiac Arrhythmias
A severely reduced left ventricular ejection fraction is associated with increased mortality due to pump failure as well as to malignant ventricular arrhythmia.
- Conditions
- Heart Failure, Cardiac Resynchronisation Therapy, Sudden Cardiac Death
- Trial name
- NCT00472238
- Testing
- endurance training, exercise training
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
Congestive Heart Failure
Effects of Pentoxiphylline on Left Ventricular (LV) Systolic Function Indices and Circulating Biomarkers in Patients With Chronic Congestive Heart Failure (CHF)
This is a prospective, double blinded randomized clinical study to evaluate the Effects of Pentoxifylline on left ventricular systolic function indices and circulating biomarkers in patients with chronic congestive heart failure.
- Trial name
- PENT-CHF (NCT01337349)
- Testing
- Pentoxifylline
- Where
- United States
- Sponsor
- Henry Ford Health System
Fetal Left Heart Hypoplasia
Trial of Maternal Oxygen for Fetal Left Heart Hypoplasia
The purpose of this study is to determine if maternal hyperoxygenation is an effective treatment for fetal left heart hypoplasia versus room air (placebo).
- Trial name
- P-RCT-MHO (NCT02965638)
- Testing
- Oxygen
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Shaine Morris
Left-Sided Ulcerative Colitis, Proctosigmoiditis
Safety, Tolerability, Efficacy Study of PUR 0110 Rectal Enema in Mild-to-Moderate Distal Ulcerative Colitis
PUR 0110 is a 100% natural novel investigational medicinal product that has been demonstrated in several in vitro and in vivo pharmacology studies to have potent anti-inflammatory, anti-oxidative and immunomodulatory effects.
- Trial name
- NCT01149707
- Testing
- PUR 0110 Rectal Enema 250 mg, PUR 0110 Rectal Enema 500 mg, PUR 0110 Rectal Enema 1000 mg
- Where
- 6 sites in Germany
- Volunteers
- 34 people
- Sponsor
- PurGenesis Technologies Inc.
Heart Attack, Enlarged Heart
Sodium Glucose Co-Transporter 2 (SGLT2) and STEMI
The purpose of the research is to determine whether a class of medication called SGLT2 inhibitor will improve the heart's function and reduce its enlargement after a heart attack.
- Trial name
- NCT05305911
- Testing
- SGLT-2 inhibitors
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Minneapolis Heart Institute Foundation
Heart Failure, Cardiac Failure
Clinical Trial to Evaluate the the ReliantHeart HeartAssist 5® VAD System in Patients Awaiting Heart Transplantation
The purpose of the study is to evaluate the safety and effectiveness of the ReliantHeart HeartAssist 5® VAD System in patients listed for heart transplantation and at risk of death from refractory end-stage heart failure.
- Conditions
- Heart Failure, Cardiac Failure, Congestive Heart Failure, Heart Failure, Left-sided
- Trial name
- NCT02205411
- Testing
- HeartAssist 5® VAD System, Control VAD
- Where
- 14 sites in United States
- Volunteers
- 17 people
- Sponsor
- ReliantHeart Inc.
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