Clinical trials: Left Side
His Bundle Pacing, Heart Failure, Systolic
His-bundle Pacing vs. Right Ventricular Apical Pacing in Patients With Reduced Ejection Fraction
The study compares standard right ventricle apical pacing with so called His-bundle pacing, for patients with slightly or moderately reduced ejection fraction and atrioventricular block requiring pacemaker therapy.
- Trial name
- HIS-PrEF (NCT04529577)
- Testing
- His-bundle pacing
- Where
- 3 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Atrial Fibrillation, Stroke
Use of 4D-ICE in Conjunction With TEE for Left Atrial Appendage Closure
This is a prospective, single center, non-randomized study with two parallel arms intended to study if 4D Intracardiac echocardiography (4D-ICE) (Nuvision, Nuvera TM) will provide better visualization of the anatomical landmarks…
- Trial name
- NCT06061757
- Testing
- Imaging guidance with TEE and ICE for Left atrial appendage closure
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Macular Degeneration Exudative Eye Left, Macular Degeneration Exudative Eye Right
OCTA (Optical Coherence Angiography Tomography) Versus Structural OCT(Optical Coherence Tomography) in Neovascular AMD (Age Macular Degeneration)
The objective is to find if there is a relationship between the Fractal Dimension, the gap, vascular density (VD), the surface, the span ratio and the status of the choroidal neovessels to adjust the interval between 2…
- Trial name
- QUAOBARE (NCT03939195)
- Testing
- Follow-up
- Where
- 3 sites in France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Coronary Microvascular Dysfunction, Obstructive Coronary Heart Disease
The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease
The study was designed to evaluate the left ventricular longitudinal strain and strain rate assessed by 2D-STI in patients with coronary microvascular dysfunction (CMD) or obstructive coronary artery disease (CAD) , to…
- Trial name
- NCT04959357
- Testing
- Two dimensional speckle tracking imaging
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Peking University Third Hospital
Heart Failure
Hemodynamically Guided Home Self-Therapy in Severe Heart Failure Patients (HOMEOSTASIS)
This study is a feasibility study of the HeartPOD™ Heart Failure Management System with DynamicRx® (HeartPOD system) in patients with severe chronic congestive heart failure.
- Trial name
- HOMEOSTASIS (NCT00547729)
- Testing
- HeartPOD™ System
- Where
- 7 sites in United States, Australia and 1 more
- Volunteers
- 71 people
- Sponsor
- Abbott Medical Devices
Chronic Kidney Disease (CKD) Stage 5, Hypertrophy, Left Ventricular
The PRIMO II Study: Paricalcitol Injection Benefits in Renal Failure Induced Cardiac Morbidity in Subjects With Chronic Kidney Disease (CKD) Stage 5
To evaluate the effects of paricalcitol injection on cardiac structure and function over 48 weeks in subjects with Stage 5 Chronic Kidney Disease (CKD) receiving hemodialysis who have left ventricular hypertrophy (LVH).
- Trial name
- PRIMO II (NCT00616902)
- Testing
- paricalcitol injection 4 mcg/mL
- Where
- 76 sites in United States, Australia and 11 more
- Volunteers
- 12 people
- Sponsor
- Abbott
Cardiac Rehabilitation, Heart Failure
Cardiac REhabilitation COhort at the Medicine Campus DaVos to invEstigate Recovery
The RECOVER study, titled Cardiac Rehabilitation Cohort at the Medicine Campus Davos for Exploration of Recovery, is a prospective, non-interventional, monocentric cohort study conducted at the Hochgebirgsklinik Davos.
- Conditions
- Cardiac Rehabilitation, Heart Failure, Cardiac Arrest (CA), ACS (Acute Coronary Syndrome)
- Trial name
- RECOVER (NCT07096973)
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- Hochgebirgsklinik Davos
Coronary Artery Disease, Coronary Artery Disease (Left Main)
µQFR for Branch Stenosis After Single Stent in Bifurcation Lesions
Murray-law based single-view quantitative flow ratio (µQFR) has been recommended for guiding percutaneous coronary intervention (PCI) in selective patients.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (Left Main), Obstructive Coronary Artery Disease, Stent Implantation
- Trial name
- NCT07116083
- Where
- China
- Volunteers
- 290 people
- Sponsor
- Shanghai Zhongshan Hospital
Atrial Fibrillation
Evaluating the Safety and Effectiveness of the Laminar Left Atrial Appendage Closure System
The objective of this study is to demonstrate safety and effectiveness using a percutaneous Delivery System of the Laminar Left Atrial Appendage Closure System to treat patients with NVAF to reduce the risk of thromboembolism…
- Trial name
- NCT04807283
- Testing
- Left Atrial Appendage Closure
- Where
- 4 sites in Georgia, Paraguay
- Volunteers
- 29 people
- Sponsor
- Laminar, Inc.
Contrast Nephropathy
Renal Insufficiency Following Contrast Media Administration Trial III
The urine flow rate (UFR)-guided and the left-ventricular end-diastolic pressure (LVEDP)-guided hydration regimens have been proposed to prevent contrast-induced acute kidney injury (CI-AKI).
- Trial name
- REMEDIALIII (NCT02489669)
- Testing
- RenalGuard system™® (PLC Medical Systems, Inc. Franklin, MA, USA)
- Volunteers
- 700 people
- Sponsor
- Clinica Mediterranea
Metastatic Colorectal Cancer With Left-sided Primary Tumor, Immunotherapy
Efficacy and Safety of FOLFOX+Cetuximab vs. FOLFOXIRI+Bevacizumab Both With QL1706 in First-Line Treatment of Left-Sided mCRC
This is a two-arm, randomized phase II clinical study. It is planned to enroll 44 patients with primary left-sided, RAS and BRAF wild-type metastatic colorectal cancer.
- Trial name
- NCT07070713
- Testing
- FOLFOXIRI + QL1706 + Bevacizumab, FOLFOX+QL1706+Cetuximab
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Fujian Cancer Hospital
Liver Transplant; Complications
Left Lobe Versus Right Lobe in Adult Living Donor Liver Transplantation in Borderline GRWR
a prospective cohort study comparing outcomes of left lobe and right lobe adult living donor liver transplantation
- Trial name
- LDLT (NCT06542913)
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Atrial Fibrillation
Safety and Efficacy of Workflows of High Volume Single Operators in a LAAO Device Implant Procedural Day
SAFE HV is an observational, prospective, multi-center, non-randomized study evaluating real-world clinical experience of centers where a single procedural physician schedules eight or more left atrial appendage occlusion (LAAO)…
- Trial name
- NCT06436924
- Testing
- Left Atrial Appendage Device Implant
- Where
- 7 sites in United States
- Volunteers
- 569 people
- Sponsor
- Heart Rhythm Clinical and Research Solutions, LLC
Emergencies, Trauma
Comparison of Two Resuscitative Thoracotomy Techniques
Resuscitative thoracotomy (RT) is a life saving procedure for patients who have suffered cardiac arrest or are at significant risk of cardiac arrest following significant trauma.
- Conditions
- Emergencies, Trauma, Procedural Training, Thoracotomy
- Trial name
- NCT04242160
- Testing
- Modified Clamshell Thoracotomy, Left Anterolateral Thoracotomy
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Heart Failure, Cardiac Resynchronization Therapy
LVSP Based CRT vs. RVAP Based CRT
To find out whether left ventricular septal pacing (LVSP)-based cardiac resynchronization therapy (CRT) is superior to right ventricular apical pacing (RVAP)-based CRT in patients with failed left bundle branch pacing at the…
- Conditions
- Heart Failure, Cardiac Resynchronization Therapy, Left Ventricular Septal Pacing, Right Ventricular Septal Pacing
- Trial name
- NCT05985408
- Testing
- left ventricular septal pacing, right ventricular apical pacing
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Coronary Stenosis, Coronary Artery Disease
Percutaneous Coronary Intervention (PCI) With Drug-Eluting Stents (DES) Versus Coronary Artery Bypass Graft (CABG) for Patients With Significant Left Main Stenosis
Recent technical advances in percutaneous coronary interventions have made it possible to approach patients with coronary lesions formerly considered to be classical candidates for bypass surgery, e.g.
- Trial name
- NCT00176397
- Testing
- Percutaneous coronary intervention (left main)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Leipzig
Atrial Fibrillation, Stroke
Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI: A Pilot Study
Demonstrating the pathophysiological link between Left Atrial (LA) and Left Atrial Appendage (LAA) pathology and embolic strokes in non-Atrial Fibrillation (AF) individuals represents a major advance in stroke prevention…
- Conditions
- Atrial Fibrillation, Stroke, Stroke, Cardiovascular, Vascular Cognitive Impairment
- Trial name
- NCT04769310
- Testing
- Cardiac and Brain MRI
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Tulane University
Atrial Fibrillation
Comparison of Different Ablation Surgeries on Left Atrial Reverse Remodeling in Patients With Atrial Fibrillation
The goal of this Ambispective cohort Study is to compare in patients with paroxysmal atrial fibrillation undergo pulse field ablation and radiofrequency ablation, respectively.
- Trial name
- NCT06307860
- Testing
- pulsed field ablation, radiofrequency ablation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Yun Wan
Anterior Acute Myocardial Infarction, Left Ventricular Systolic Dysfunction
STem cElls Mobilization in Acute Myocardial Infarction Outcome Trial
The purpose of this study is to demonstrate that granulocyte colony-stimulating factor (G-CSF) therapy in addition to state-of-the-art treatment (pharmacological and non pharmacological) is safe and significantly improves…
- Trial name
- STEM-AMI (NCT01969890)
- Testing
- G-CSF administration
- Where
- 53 sites in Italy
- Volunteers
- 532 people
- Sponsor
- Heart Care Foundation
Tricuspid Valve Insufficiency, Sick Sinus Syndrome
Left Ventricular Pacing to Prevent Iatrogenic TR Pilot Study
Background and Aims Pacemaker implantation for treating bradyarrhythmias typically involves placing a pacing lead through the tricuspid valve (TV) into the right ventricular (RV) apex.
- Trial name
- NCT02314897
- Testing
- LV pacing, RV pacing
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- National University Hospital, Singapore
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