Clinical trials: Left Side
Hypoplastic Left Heart Syndrome, Tricuspid Atresia
Sildenafil After the Fontan Operation
In this study, the investigators will evaluate the effect of sildenafil on exercise tolerance in patients with a single cardiac ventricle who have undergone the Fontan operation.
- Trial name
- SAFO (NCT00507819)
- Testing
- Sildenafil
- Volunteers
- 28 people
- Sponsor
- Children's Hospital of Philadelphia
Heart Failure, Ventricular Fibrillation
Italian Registry On Multipoint Left Ventricular Pacing
The IRON-MPP is a prospective multicenter, observational registry designed to collect clinical and device data from a large cohort of HF patients treated in clinical practice with a CRT-D device with the ability to deliver Multi…
- Conditions
- Heart Failure, Ventricular Fibrillation, Ventricular Tachycardia
- Trial name
- IRON-MPP (NCT02606071)
- Testing
- CRT-D
- Where
- 3 sites in Italy
- Volunteers
- 436 people
- Sponsor
- University of Rome Tor Vergata
Left Ventricular Dysfunction
Use of Adult Autologous Stem Cells in Treating People 2 to 3 Weeks After Having a Heart Attack (The Late TIME Study)
More than 1 million Americans suffer heart attacks each year. Although current treatments are able to stabilize the condition of the heart, none is able to restore heart function as it was prior to the heart attack.
- Trial name
- NCT00684060
- Testing
- Adult stem cells
- Where
- 5 sites in United States
- Volunteers
- 87 people
- Sponsor
- The University of Texas Health Science Center, Houston
Mitral Valve Insufficiency, Atrial Fibrillation
Left Atrial Distensibility to Predict Left Ventricular Filling Pressure and Prognosis in Patients With Severe Mitral Regurgitation
A large left atrial (LA) volume, which represents chronic diastolic dysfunction, is associated with a poor outcome, regardless of systolic function.
- Conditions
- Mitral Valve Insufficiency, Atrial Fibrillation, Heart Failure
- Trial name
- NCT01172184
- Testing
- Cardiac catheterization
- Where
- Taiwan
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.
Ischemic Stroke, Systemic Embolism
Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial
This trial is a prospective, randomized, multicenter, multinational, blinded, superiority trial. The objective of this trial is to evaluate the effectiveness of left atrial appendage exclusion (LAAE) for the prevention of…
- Trial name
- LeAAPS (NCT05478304)
- Testing
- AtriClip LAA Exclusion System
- Where
- 138 sites in United States, Australia and 8 more
- Volunteers
- 6,573 people
- Sponsor
- AtriCure, Inc.
End-stage Heart Failure
Corheart 6 Left Ventricular Assist System Prospective, Multicenter, Single-arm Clinical Evaluation Trial
This study is to evaluate the safety and effectiveness of the Corheart 6 Left Ventricular Assist System (Corheart 6 LVAS) used for the treatment of end-stage heart failure.
- Trial name
- NCT05353816
- Testing
- Corheart 6 Left Ventricular Assist System
- Where
- 11 sites in China
- Volunteers
- 50 people
- Sponsor
- Shenzhen Core Medical Technology CO.,LTD.
Coronary Artery Disease (CAD), Chronic Coronary Syndrome
"Expert IVUS-Eye" vs. IVUS-guided Left Main Bifurcation PCI
This is a prospective, randomized, controlled trial comparing two strategies for optimizing stent implantation during bifurcation stenting of the left main coronary artery (LM): an intravascular ultrasound (IVUS)-guided approach…
- Conditions
- Coronary Artery Disease (CAD), Chronic Coronary Syndrome, Left Main Coronary Artery Disease, Coronary Bifurcation Lesion
- Trial name
- EYE-IVUS LM (NCT07711106)
- Testing
- IVUS-Guided LM PCI, "Trained Eye" (Angiography-Guided) LM PCI
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Liver Cirrhosis, Liver
SALT for Patients With Hepatic Cirrhosis
Hepatitis B virus (HBV) infection is a very difficult public health problem in the world. Patients often experience the trilogy of "hepatitis-cirrhosis-liver cancer".
- Trial name
- NCT06153914
- Testing
- Sequential Adult Left Lateral Liver Transplantation
- Volunteers
- 47 people
- Sponsor
- RenJi Hospital
Ventricular Tachycardia
Efficacy and Safety of Multisite Cardiac Resynchronization Therapy
Cardiac resynchronization therapy (CRT) is a proven therapy in patients with severe left ventricular (LV) dysfunction with ejection fraction (EF)<35%., moderate to severe congestive heart failure and wide QRS in ECG.
- Trial name
- NCT01966016
- Testing
- Pacing
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Barzilai Medical Center
Coronary Artery Disease, Decreased Left Ventricular Function
Glucagon-like Peptide 1 Agonist Exenatide for Improved Glucose Control and Cardiac Function in Patients With Aortocoronary Bypass
GLP-1 has not only beneficial effects on glucose metabolism but also direct positive effects on cardiac function and metabolism in both experimental models and in patients with type 2 diabetes mellitus.
- Trial name
- Executive (NCT01373216)
- Testing
- Exenatide
- Where
- Czechia
- Volunteers
- 38 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation
Assessment of Left Ventricular Diastolic Function in Patients With Atrial Fibrillation
This study is a single-center, prospective cohort study to investigate non-invasive method to assess left ventricular diastolic function using echocardiography.
- Trial name
- DIAAF (NCT04654806)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Nail Psoriasis
Efficacy of Combined Fractional Carbon Dioxide Laser and Topical Tazarotene in the Treatment of Psoriatic Nail Disease
Nail psoriasis has a high incidence amongst patients with psoriasis.It is estimated to affect 80% of psoriatic patients at some time during their lives and has a significant adverse influence on their quality of life.
- Trial name
- NCT03263624
- Testing
- fractional carbon dioxide laser, Tazarotene Cream 0.1%
- Volunteers
- 30 people
- Sponsor
- Assiut University
Left Atrial Appendage Occlusion, Antiplatelet Therapy
Head-to-head Comparison of Single Versus Dual Antiplatelet Treatment Strategy After Percutaneous Left Atrial Appendage Closure: a Multicenter, Randomized Study
The study will perform a randomized, head-to-head comparison between SAPT (aspirin) and DAPT (aspirin plus clopidogrel) after percutaneous LAA closure with implantation of the Amulet device (AbbottTM, Abbott Park, Illinois, US)…
- Trial name
- ARMYDA-AMULET (NCT05554822)
- Testing
- Aspirin 100mg, Aspirin 100 mg OD plus clopidogrel 75 mg OD
- Where
- 19 sites in Italy
- Volunteers
- 574 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Cardiac Disease
MyoVista wavECG Clinical Validation Study Versus Low e' on Echocardiogram
Clinical validation study of the MyoVista wavECG.
- Trial name
- NCT04804969
- Testing
- MyoVista wavECG Test
- Where
- 5 sites in United States
- Volunteers
- 575 people
- Sponsor
- Heart Test Laboratories, Inc.
Acute Coronary Syndrome, Cardiogenic Shock
Left Ventricular Physiological Effects of Veno-Arterial Extracorporeal Membrane Oxygenation Support During Cardiogenic Shock
A Clinical Events Committee (CEC) will include Cardiac Surgery Professor and chief of cardiac surgery Rose Kelly MD, Professor of Medicine Ganesh Raveendran MD at the University of Minnesota who is the direction of Interventional…
- Trial name
- NCT05426083
- Testing
- Physiological Assessment
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Coronary Artery Disease
Observational Study for Left Main Disease Treatment
The purpose of this study is to observe clinical courses for long-term in patients with unprotected LMCA disease and to evaluate comparative results of medical treatment, coronary stenting with drug-eluting stents, and CABG for…
- Trial name
- IRIS-MAIN (NCT01341327)
- Where
- 42 sites in China, Malaysia and 3 more
- Volunteers
- 10,000 people
- Sponsor
- Seung-Jung Park
Atrial Fibrillation
Surgical vs Percutaneous LAAO
Atrial fibrillation is the most common cardiac arrythmia globally. Its prevalence ranges between 2-4% worldwide. It is associated with significant morbidity and mortality.
- Trial name
- NCT05420701
- Testing
- TEE
- Volunteers
- 260 people
- Sponsor
- Chinese University of Hong Kong
Cannabis
Excitatory rTMS to the Left Dorsolateral Pre-Frontal Cortex to Reduce Cannabis-Cue Induced Craving
This is a double-blind, crossover trial that will recruit a cohort of non-treatment seeking Cannabis use disordered participants.
- Trial name
- NCT02567344
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Volunteers
- 18 people
- Sponsor
- Medical University of South Carolina
Ventricular Fibrillation, Ventricular Tachycardia
Left Ventricular Capture Management Study
Primary Objective: To characterize left ventricular (LV) threshold behavior over time using daily left ventricular capture management (LVCM) measurements.
- Conditions
- Ventricular Fibrillation, Ventricular Tachycardia, Bradyarrhythmia
- Trial name
- LEARN (NCT01089634)
- Where
- Canada
- Volunteers
- 151 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Congestive Heart Failure
A Study Investigating the Safety, Tolerability, and Pharmacokinetics of MTP-131 in Subjects With Congestive Heart Failure
This is a Phase 1, single-center, randomized, double-blind, single ascending dose, placebo-controlled study, in subjects aged 45-80 years with stable mild to moderate heart failure due to left ventricular systolic dysfunction, to…
- Trial name
- NCT02388464
- Testing
- MTP-131
- Where
- Bulgaria
- Volunteers
- 36 people
- Sponsor
- Stealth BioTherapeutics Inc.
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