Clinical trials: Left Sided Breast Cancer
Left Ventricular Function Systolic Dysfunction, Cardiotoxicity
Usefulness of Myocardial Deformation Imaging for Trastuzumab-induced Cardiotoxicity
Trastuzumab prolongs survival in patients with human epidermal growth factor receptor type 2-positive breast cancer. Sequential left ventricular (LV) ejection fraction (EF) assessment has been mandated to detect myocardial…
- Trial name
- NCT01665300
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Seoul National University Hospital
Breast Cancer, Cardiac Event
Deep Inspiration Breath-hold Radiotherapy for Left-sided Breast Cancer
Postoperative breast radiotherapy (RT) has been associated with increased risk of heart toxicity. However, there is a lack of knowledge for radiation-induced early cardiovascular injury, especially for hypofractionated RT.
- Trial name
- NCT05200078
- Testing
- Deep inspiration breath-hold technique
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Shu lian Wang
Lung Cancer, Left Sided Breast Cancer
A Prospective Study to Evaluate Continuous Positive Airway Pressure Devices to Reduce Pulmonary Dose
Data collection and assessment on patients with left-sided breast cancer or undergoing lung stereotactic body radiation therapy (SBRT) utilizing continuous positive airway pressure (CPAP) devices.
- Trial name
- NCT05142358
- Testing
- Continuous Positive Airway Pressure, Deep inspiratory breath hold, Free Breath
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Whole Breast RT on Prone Position in Korean Women
It is well known fact that postoperative whole breast radiation therapy (RT) in left breast cancer patient can cause cardiac problem according to the exposed dose.
- Trial name
- NCT02231112
- Testing
- Whole breast RT on prone position
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Samsung Medical Center
Breast Cancer, HER2-positive Breast Cancer
Study of Cardiopulmonary Exercise Testing in Women Who Have HER2-Positive Breast Cancer With Mild Cardiotoxicity
The purpose of this study is to find out how much oxygen is used during a cardiopulmonary exercise test (CPET) in women who have mild cardiotoxicity after standard treatment for HER2-positive breast cancer, and to see whether the…
- Conditions
- Breast Cancer, HER2-positive Breast Cancer, HER2-positive Metastatic Breast Cancer, Breast Cancer Stage I
- Trial name
- NCT05036252
- Testing
- Cardiopulmonary Exercise Test, Echocardiogram, Echocardiography
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Left-Sided Breast Cancer, Radiation Toxicity
Hybrid PET/MR Imaging of Acute Cardiac Inflammation After Left-Sided Breast Cancer Radiotherapy
Radiation therapy (RT) of the breast is a critical component of modern breast cancer treatment. RT treatments have led to improved local control and overall survival of breast cancer patients.
- Trial name
- RICT-BREAST (NCT03748030)
- Testing
- Confirmed Left-Sided Breast Cancer
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Breast Cancer
Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease
The purpose of this study is to determine the safety and efficacy of PF-07220060 with letrozole compared to approved treatments (ie, palbociclib, ribociclib or abemaciclib with letrozole) in people with breast cancer: HR-positive…
- Trial name
- FourLight-3 (NCT06760637)
- Testing
- PF-07220060, letrozole, abemaciclib
- Where
- 460 sites in United States, Argentina and 28 more
- Volunteers
- 1,035 people
- Sponsor
- Pfizer
Breast Cancer, Optical Surface Monitoring Technology
Optical Surface Monitoring Technology-Guided Large-Segment Radiotherapy for Breast Cancer
This study is a single-center,blinded, efficacious, phase III randomized clinical trial initiated by investigators. The primary objective is to investigate the use of Surface Guided Radiation Therapy (SGRT) in combination with…
- Conditions
- Breast Cancer, Optical Surface Monitoring Technology, Large-segment Radiotherapy
- Trial name
- NCT05804916
- Testing
- Surface Guided Radiation Therapy (SGRT)
- Where
- China
- Volunteers
- 556 people
- Sponsor
- Peking Union Medical College Hospital
Cardiotoxicity, Cancer
Monitoring for CardioToxicity Using WeArable deVices While Undergoing cancEr Treatments (MCT-WAVE)
This pilot study will evaluate the validity and feasibility of ambulatory cardiac monitoring to identify markers of cardiotoxicity in adults undergoing cancer treatment.
- Conditions
- Cardiotoxicity, Cancer, Cardiac Arrhythmia, Left Ventricular Dysfunction
- Trial name
- NCT07776964
- Testing
- Mobile Cardiac Telemetry, Wearable Cardiac Monitor
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Minnesota
Breast Cancer
Study of Cardiac MRI in Patients With Left-Sided Breast Cancer Receiving Radiation Therapy
This is a pilot study to determine if there are changes in heart function following completion of radiation therapy for breast cancer as measured by cardiac magnetic resonance imaging (cardiac MRI) scans.
- Trial name
- NCT02199366
- Testing
- Cardiac magnetic resonance (cardiac MRI)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Radiotherapy, Breast Cancer
Respiratory Training and Relaxation Techniques to Improve Adjuvant Radiation Therapy in DIBH in Breast Cancer
The goal of this prospective clinical trial is to improve patient compliance and performance of deep inspiration breath hold (DIBH) to further reduce the cardiac dose from left breast radiation, and to improve cooperation and…
- Conditions
- Radiotherapy, Breast Cancer, Relaxation, Breathholding
- Trial name
- B-REST (NCT05975190)
- Testing
- Respiratory training and relaxation techniques under adjuvant radiation therapy in DIBH in breast cancer
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Technical University of Munich
Thoracic Cancer, Left Sided Breast Cancer
Hyperpolarized Carbon 13-Based Metabolic Imaging to Detect Radiation-Induced Cardiotoxicity
Patients enrolled in the study will receive standard of care adjuvant or definitive breast, chest wall or thoracic radiation therapy.Cardiac mitochondrial dysfunction is a hallmark of radiation-induced cardiac injury.
- Trial name
- NCT04044872
- Testing
- [1-13C]pyruvate along with MRI imaging
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Texas Southwestern Medical Center
Breast Cancer, Heart Failure
Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction
Trastuzumab is an important treatment for HER 2 positive breast cancer. But trastuzumab can cause injury to the heart, and this is one of the main reasons it cannot be administered as planned.
- Trial name
- SCHOLAR-2 (NCT04680442)
- Testing
- Trastuzumab, Pertuzumab, Trastuzumab emtansine
- Where
- 8 sites in Brazil, Canada and 1 more
- Volunteers
- 130 people
- Sponsor
- Population Health Research Institute
Breast Neoplasm Female, Lymphoma
Cancer Adverse Effects PReventIon With Care & Exercise: the CAPRICE Study
Breast cancer is the most common cancer among women worldwide. Similarly, Hodgkin and non- Hodgkin lymphomas make up two of the most prevalent cancers in men and women.
- Conditions
- Breast Neoplasm Female, Lymphoma, Cardiotoxicity, Anthracyclines
- Trial name
- NCT03850171
- Testing
- Exercise Training
- Where
- 4 sites in Switzerland
- Volunteers
- 57 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Breast Cancer, Adverse Effect of Radiation Therapy
Study to See Whether Breath-Hold Techniques During RT Are Effective in Helping to Improve Sparing of the Heart
The study hopes to determine whether patients with left-sided breast cancer are at an increased risk of cardiac changes due to radiation to the breast +/- Anthracycline-based chemotherapy +/- Herceptin and whether a deep…
- Trial name
- NCT02052102
- Testing
- Radiation therapy
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- AHS Cancer Control Alberta
HER2 Positive Breast Cancer, Left Ventricular Function Systolic Dysfunction
Cardiac Safety Study in Patients With HER2 + Breast Cancer
HER2 positive breast cancer cells have more HER2 receptor (a protein on the surface of cells) than normal breast cells. Approximately 30% of patients with breast cancer have HER2 positive breast cancer.
- Trial name
- SAFE-HEaRt (NCT01904903)
- Testing
- Trastuzumab, Pertuzumab, Ado Trastuzumab Emtansine
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Medstar Health Research Institute
Breast Cancer
MindVybe tVNS/APS for Wellbeing in Breast Cancer Survivors
This study tests whether a gentle, non-invasive device called mindvybe can help improve feelings of wellbeing in people who have had breast cancer.
- Trial name
- NCT07782866
- Testing
- Transcutaneous vagus nerve and acupuncture point stimulation
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- The Healing Consciousness Foundation
Breast Cancer
Assessment of Ability of Breath Hold for Left-sided Breast Cancer Radiation Therapy to Reduce Side Effects to Heart
The purpose of this research study is to demonstrate that Deep Inspiration Breath Hold (DIBH), the technique used at the University of North Carolina (UNC) for left-side breast cancer radiation therapy, can reduce side effects to…
- Trial name
- NCT01849614
- Testing
- Cardiac SPECT perfusion scan
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Large Segmentation Radiotherapy ± Deep Inspiration Breath Hold(DIBH) for Left Breast Cancer
The study is a single-center, prospective, non-randomized controlled study. The primary objective is to examine the clinical outcomes of utilizing Deep Inspiration Breath Hold (DIBH) in conjunction with hypo-fractionated…
- Trial name
- DLLEB (NCT06660628)
- Testing
- Large Segmentation Radiotherapy, DIBH, Surface guided radiation therapy
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Peking Union Medical College Hospital
Breast Cancer
Active Breathing Coordinator-based vs VisionRT-based Deep Inspiration Breath-hold for Radiation for Breast Cancer
Female patients treated with radiation for left-sided breast malignancy will undergo alternate fractions of Active Breathing Coordinator (ABC)-assisted and VisionRT-assisted Deep Inspiration Breath-Hold (DIBH).
- Trial name
- VisionRT (NCT02694029)
- Testing
- Active Breathing Coordinator (ABC), VisionRT
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Texas Southwestern Medical Center