Clinical trials: Left Ventricle Remodeling
Heart Failure, Heart Failure With Reduced Ejection Fraction
AI-ECG for Time-Resolved Prediction of HFrEF
This study aims to develop and validate a deep learning-based electrocardiogram (ECG) model for predicting the future risk of heart failure with reduced ejection fraction (HFrEF).
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Left Ventricular Dysfunction, Cardiac Remodeling
- Trial name
- NCT07519434
- Where
- China
- Volunteers
- 286,709 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Mitral Regurgitation (MR)
Quantification of Mitral Regurgitation Using 4D MRI Flow : Comparison With 2D MRI Flow and Echocardiography Using the Evolution of Left Ventricular Remodeling as a Reference
The goal of this study is to evaluate whether 4D MRI provides a better assessment of mitral regurgitation quantification and associated ventricular remodeling than standard imaging techniques: echocardiography and 2D MRI, in…
- Trial name
- FLAME (NCT07066904)
- Testing
- Standard echocardiography, 2D phase-contrast magnetic resonance imaging, 4D flow magnetic resonance imaging
- Where
- 3 sites in France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension
Clinical Efficacy of Telmisartan in Reducing Cardiac Remodeling Among Obese Patients With Hypertension
Hypertension is closely related to metabolic abnormalities such as obesity, dyslipidemia and diabetes. When hypertension is complicated with metabolic abnormalities, target organ damage is more serious, the risk of cardiovascular…
- Trial name
- NCT03956823
- Testing
- telmisartan, amlodipine
- Where
- China
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Myocardial Infarction, Anterior Wall, Myocardial Remodeling, Ventricular
Effect of Methotrexate Carried by a Lipid Nanoemulsion on Left Ventricular Remodeling After STEMI
Prospective, randomized, double-blind, placebo-controlled, proof of concept study. Patients with first anterior wall STEMI will be randomized with 4±2 days after symptoms beginning to receive ddMTX-LDE at the dose of 40 mg/m2 IV…
- Trial name
- NCT03516903
- Testing
- Methotrexate, Folic Acid
- Where
- Brazil
- Volunteers
- 35 people
- Sponsor
- University of Sao Paulo
Ppm, Cardiomyopathy
Effect of Melatonin on Left Ventricular Reverse Remodeling and Inflammation in Peripartum Cardiomyopathy
This randomized, controlled clinical trial investigates the potential cardioprotective effects of melatonin in women diagnosed with peripartum cardiomyopathy (PPCM).
- Trial name
- MEL-PPCM (NCT07334197)
- Testing
- Melatonin 10 MG, Selenium
- Volunteers
- 25 people
- Sponsor
- Tanta University
Acromegaly Cardiomyopathy
Endocrine Cardiomyopathy: Response to Cyclic GMP PDE5 Inhibitors in Acromegaly Cardiomyopathy
Pathophysiology of acromegaly cardiomyopathy is yet unclear and a specific treatment have not been indicated. It was already demonstrated the positive impact of phosphodiesterase type 5A (PDE5A) inhibition in several models of…
- Trial name
- SUM (NCT02611336)
- Testing
- Tadalafil
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Andrea M. Isidori
Aortic Valve Stenosis
Aortic Stenosis: Determinants and Prognostic Value of Preoperative Left Ventricular Remodeling After Valvular Replacement
Aortic stenosis (AS) is the most frequent valvulopathy in Western countries. The prevalence of AS is constantly increasing due to the aging of the population.
- Trial name
- NCT03411304
- Where
- France
- Volunteers
- 440 people
- Sponsor
- University Hospital, Rouen
Dilated Cardiomyopathy
Effect of Rosuvastatin on Left Ventricular Remodeling
The purpose of this study is to examine the the effect of the HMG-CoA reductase inhibitor Rosuvastatin on left ventricular remodeling in patients with dilated cardiomyopathy.
- Trial name
- NCT00505154
- Testing
- Rosuvastatin
- Where
- Norway
- Volunteers
- 75 people
- Sponsor
- Oslo University Hospital
Congestive Heart Failure
Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease
Hypothesis: Tissue and serum samples collected from end-stage heart failure patients receiving left ventricular assist device implantation (LVAD) or heart transplantation will provide information regarding the basic science of…
- Trial name
- NCT01099982
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Utah
Abdominal Aortic Aneurysm, Arterial Stiffness
EndoVascular Aneurysm Repair: Heart Remodeling and Aortic Stiffness Study
Abdominal aortic aneurysm (AAA) is associated with a high burden of cardiovascular morbidity and mortality. Although endovascular aneurysm repair (EVAR) has become the preferred treatment for many patients with infrarenal AAA…
- Conditions
- Abdominal Aortic Aneurysm, Arterial Stiffness, Left Ventricle Remodeling
- Trial name
- EVAR-HRAS (NCT07722793)
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Aortic Valve Stenosis
Hemodynamic Comparison of Tissue Aortic Valves
The purpose of this study is to: 1. Assess for hemodynamic differences at rest and with exercise between three clinically available tissue aortic valves. 2.
- Trial name
- NCT01635244
- Testing
- Aortic valve replacement
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Acute Coronary Syndrome, Left Ventricle Remodeling
Predictive Value of Risk Scores in Acute Coronary Syndrome
role of different risk scores in acute coronary syndrome to predict left ventricular remodeling
- Conditions
- Acute Coronary Syndrome, Left Ventricle Remodeling, Risk Scores
- Trial name
- NCT03549481
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- shaimaa Mostafa
Tetralogy of Fallot With Pulmonary Stenosis
Right and Left Ventricle Remodeling Predictors After Pulmonary Valve Replacement in Patients With Repaired Tetralogy of Fallot
Long term survival of patients with repaired tetralogy of Fallot is excellent (about 85% at 35 year-old). However these patients are exposed to residual pulmonary stenosis (PS) and/or pulmonary regurgitation (PR).
- Trial name
- NCT02186691
- Testing
- MRI
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Myocardial Infarction, Left Ventricular Remodeling
Tetracycline (Doxycycline) and Post Myocardial Infarction Remodeling
The aim of the study is to assess the efficacy of an antibiotic treatment with tetracycline (doxycycline) in the early stage of large reperfused acute myocardial infarction (AMI), in preventing left ventricular (LV) remodeling.
- Trial name
- TIPTOP (NCT00469261)
- Testing
- Doxycycline, Current medical therapy for AMI
- Volunteers
- 110 people
- Sponsor
- Careggi Hospital
Type 2 Diabetes Mellitus
Left Ventricular Functional Changes of Uncontrolled Diabetes by Dapagliflozin Treatment Trial
The primary purpose of this study is to evaluate the efficacy of the SGLT2 inhibitor dapagliflozin, as compared with standard care of diabetes, on left ventricular (LV) structural and functional change in asymptomatic type 2…
- Trial name
- ELUCIDATE (NCT03871621)
- Testing
- Diabetes Medicines, Dapagliflozin
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- Mackay Memorial Hospital
Cushing's Syndrome Cardiomyopathy
Endocrine Cardiomyopathy in Cushing Syndrome: Response to Cyclic GMP PDE5 inhibitOrs
Pathophysiology of Cushing's Syndrome (CS) cardiomyopathy is yet unclear and a specific treatment have not been indicated. It was already demonstrated the positive impact of phosphodiesterase type 5A (PDE5A) inhibition in several…
- Trial name
- ERGO (NCT02611258)
- Testing
- Tadalafil
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Andrea M. Isidori
STEMI
ReModeling in ST-elevation myocARrdial Infarction: a Comparison of Left VEntricuLar Functions in Long-term Follow-up Among STEMI Patients
Patients diagnosed with STEMI who underwent pPCI were included in this study. The investigators collected comprehensive data on each patient's status, including laboratory findings such as NT-proBNP, troponin levels, and…
- Trial name
- MARVEL (NCT07041840)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Pisa