Clinical trials: Left Ventricular Mass
Arterial Hypertension, Kidney Transplant; Complications
StOPping Hypertension and imprOving Children's Lives After KidnEy TranSplantation
Cardiovascular (CV) disease is a major morbidity in children after kidney transplantation (KTx), limiting life expectancy and impairing graft function.
- Trial name
- SOPHOCLES (NCT06589947)
- Testing
- Intensified BP control, Standard Treatment
- Volunteers
- 170 people
- Sponsor
- Hannover Medical School
Renal Insufficiency, Chronic, Cardio-Renal Syndrome
Comparing the Effects of Spironolactone With Chlortalidone on LV Mass in Patients With CKD
In stage 3 chronic kidney disease (CKD) the risk of death due to cardiovascular causes is high and greatly exceeds the risk of progression to end stage renal failure.
- Trial name
- SPIRO-CKD (NCT02502981)
- Testing
- Spironolactone, Chlortalidone
- Where
- 4 sites in United Kingdom
- Volunteers
- 154 people
- Sponsor
- University Hospital Birmingham
Anemia, Kidney Failure
A Safety and Efficacy Study for Epoetin Alfa in Pre-dialysis Subjects.
The purpose of this study is to determine if using Eprex, to maintain hemoglobin within the normal range, will prevent or delay the progression of left ventricular mass growth.
- Conditions
- Anemia, Kidney Failure, Left Ventricular Hypertrophy
- Trial name
- NCT00364260
- Testing
- epoetin alfa
- Volunteers
- 172 people
- Sponsor
- Janssen-Ortho Inc., Canada
Cardiovascular Disease
Decreasing Dialysis Cardiovascular Risk: Daily Versus Longer Treatments
Given the known increased risk of heart disease in hemodialysis patients, this study aims to evaluate the change in both size and function of the heart by using cardiac magnetic resonance imaging (MRI) in patients undergoing…
- Trial name
- NCT00925483
- Testing
- dialysis
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Dallas VA Medical Center
LVM, Type 2 Diabetic Patients With IHD
Pioglitazone Regress Left Ventricular Mass in Type 2 Diabetes With Ischeamia Heart Disease
Cardiovascular complications account for the highest mortality in type 2 diabetic patients, mainly due to ischeamia heart disease (IHD).
- Conditions
- LVM, Type 2 Diabetic Patients With IHD, Endothelial Function
- Trial name
- NCT01947790
- Testing
- pioglitazone group, Metformin group
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Xiang Guang-da
Chronic Renal Failure (CRF), Graft Failure
Renal Transplantation in the Elderly - nEverOld Study
An exploratory study of the efficacy and safety of a regimen consisted of Everolimus plus low tacrolimus for the immunosuppression in renal transplantation in the elderly.
- Conditions
- Chronic Renal Failure (CRF), Graft Failure, Transplant; Failure, Kidney, Renal Transplant Rejection
- Trial name
- NCT01631058
- Testing
- Everolimus
- Where
- 2 sites in Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo General Hospital
Amyloidosis
Multiple Treatment Session Study to Assess GSK2398852 Administered Following and Along With GSK2315698
The study is intended to evaluate whether monthly repeated courses of administration of GSK2315698 followed by GSK2398852 is associated with a reduction in cardiac amyloid load in patients with cardiac amyloidosis, monitored by…
- Trial name
- NCT03044353
- Testing
- GSK2315698 (CPHPC), GSK2398852 (anti-SAP mAb)
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 7 people
- Sponsor
- GlaxoSmithKline
Coronary Artery Disease, Coronary Arteriosclerosis
Influence of EPICardial Adipose Tissue in HEART Diseases: EPICHEART Study
This translational study was designed to explore the association of the quantity and quality of epicardial adipose tissue (EAT) with coronary artery disease (CAD), left atrial remodeling and postoperative atrial fibrillation in a…
- Conditions
- Coronary Artery Disease, Coronary Arteriosclerosis, Atrial Fibrillation, Left Atrial Abnormality
- Trial name
- EPICHEART (NCT03280433)
- Testing
- Aortic valve replacement
- Where
- 2 sites in Portugal
- Volunteers
- 500 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Suspected Arterial Hypertension
Central Blood Pressure Over 24 Hours (ABPM) and Left Ventricular Mass
The investigators aim to investigate whether central systolic blood pressure, as measured during regular 24 hour ambulatory blood pressure monitoring (ABPM), is a better predictor of left ventricular mass than peripheral systolic…
- Trial name
- NCT01278732
- Testing
- no intervention performed
- Where
- 10 sites in Austria, Germany and 5 more
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Klinikum Wels-Grieskirchen
Renal Transplant Donor of Left Kidney, Renal Transplant Donor of Right Kidney
Lowering Uric Acid in Live Kidney Donors
Recently there was described an increase in left ventricular mass after kidney donation. It is uncertain whether this is reversible or not.
- Trial name
- AL-DON (NCT03353298)
- Testing
- Allopurinol 300 mg
- Where
- Norway
- Volunteers
- 71 people
- Sponsor
- Oslo University Hospital
Aortic Valve Stenosis, Valsartan
Efficacy of Angiotensin Receptor Blocker Following aortIc Valve Intervention for Aortic STenOsis: a Randomized mulTi-cEntric Double-blind Phase II Study
Aortic stenosis (AS) is the most frequent valvular heart disease in Western countries, with increasing prevalence. Recent guidelines recommend aortic valve intervention (surgical aortic valve replacement [SAVR] or transcatheter…
- Conditions
- Aortic Valve Stenosis, Valsartan, Angiotensin Receptor Antagonists, Transcatheter Aortic Valve Replacement
- Trial name
- ARISTOTE (NCT03315832)
- Testing
- Valsartan
- Where
- France
- Sponsor
- University Hospital, Limoges
End-stage Renal Disease, Left Ventricular Hypertrophy
In-Centre Nocturnal Hemodialysis (INHD): A Long-Term Follow-Up Study
Background: In 2010, approximately 39000 Canadians had end-stage renal disease (ESRD), and the prevalence rate of dialysis has increased by 189% over the past 2 decades.
- Trial name
- INHD (NCT02684773)
- Testing
- Conventional Hemodialysis, In-centre Nocturnal Hemodialysis
- Where
- 2 sites in Canada
- Volunteers
- 67 people
- Sponsor
- Unity Health Toronto
Hypertrophic Cardiomyopathy, Left Ventricular Hypertrophy
Factors Contributing to Increased Left Ventricle Size in Patients With Abnormally Enlarged Hearts
The human heart is divided into four chambers. One of the four chambers, the left ventricle, is the chamber mainly responsible for pumping blood out of the heart into the circulation.
- Trial name
- NCT00001878
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Kidney Disease
Loop Diuretics in Chronic Kidney Disease
The purpose of this study is to verify the efficacy of diuretic therapy on blood pressure control and left ventricular mass in patients affected by chronic kidney disease
- Trial name
- NCT00478543
- Testing
- Furosemide
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Campania Luigi Vanvitelli
Fibroblast
Fibroblast Growth Factor-23 (FGF-23) is Independently Associated With Left Ventricular Mass Index (LVMI) and Myocardial Performance Index (MPI) in Haemodialysis Patients
Serum FGF-23 levels will be measured in patients with a history of coronary artery disease and aortic valve calcifications.It will be searched whether patients with MPI>0.47 had higher or lower serum FGF-23 levels than those with…
- Trial name
- NCT01154842
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Diskapi Teaching and Research Hospital
Arterial Hypertension
Cumulative Blood Pressure Load and Left Ventricular Mass
Delay in the diagnosis of systemic arterial hypertension (SAH) causes morbid hypertensive status with target organ damage (TOD).
- Trial name
- NCT05465746
- Testing
- 24-hour ambulatory blood pressure monitoring (ABPM), Three-dimensional transthoracic echocardiography
- Where
- Ecuador
- Volunteers
- 80 people
- Sponsor
- Instituto Ecuatoriano del Corazón
Chronic Kidney Disease
Effects of a Reduction in Kidney Function on Cardiovascular Structure and Function: A Prospective Study of Kidney Donors
Studies of patients with established kidney disease, even when this is mild, appear to show that they are at high risk of heart failure, stroke and sudden cardiac death.
- Trial name
- NCT01028703
- Where
- United Kingdom
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Fabry Disease
A Study to Evaluate the Effect of Venglustat Tablets on Left Ventricular Mass Index in Male and Female Adult Participants With Fabry Disease
This is an 18-month, multicenter, randomized, active-control, parallel-group Phase 3 study, in which participants will be randomized to venglustat versus standard of care therapy (agalsidase alfa, agalsidase beta, or migalastat)…
- Trial name
- CARAT (NCT05280548)
- Testing
- Venglustat (GZ402671), Agalsidase alfa, Agalsidase beta (GZ419828)
- Where
- 54 sites in United States, Austria and 17 more
- Volunteers
- 104 people
- Sponsor
- Sanofi
Hypertension
Can Nebivolol Reverse Inappropriate Left Ventricular Mass in Hypertensive Patients?
The purpose of this study is to evaluate if a drug called nebivolol can reverse inappropriate left ventricular mass (LVM) when compared to the standard of care drug metoprolol.
- Trial name
- Inapprop (NCT01605370)
- Testing
- Nebivolol, Metoprolol succinate
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Diabetes Mellitus Type 2
SGLT2 Inhibition and Left Ventricular Mass
Patients with type 2 diabetes mellitus are exposed to an excessive heart failure risk secondary to left ventricular hypertrophy and impaired diastolic filling, a condition not addressed by currently available treatments.
- Trial name
- EMPATROPHY (NCT02728453)
- Testing
- Empagliflozin, Glimepiride
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Hannover Medical School