Clinical trials: Left Ventricular Systolic Dysfunction (Disorder)
Left Ventricular Systolic Dysfunction
AI-ECG Screening for Left Ventricular Systolic Dysfunction
The purpose of the current study is to verify the effectiveness of the artificial intelligence algorithm applied to the electrocardiogram as a potential screening tool for left ventricular systolic dysfunction.
- Trial name
- NCT06231797
- Testing
- AI algorithm conducted on 12-lead ECG and transthoracic echocardiography
- Volunteers
- 1,530 people
- Sponsor
- Seoul National University Hospital
HF - Heart Failure
AI ECG Algorithm for Detecting LV Systolic Dysfunction
This prospective observational cohort study aims to evaluate the clinical performance of a deep learning-based electrocardiography (ECG) algorithm (DeepECG LVSD) for detecting left ventricular systolic dysfunction (LVSD), defined…
- Trial name
- NCT07636759
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Ajou University School of Medicine
Congestive Heart Failure
A Study Investigating the Safety, Tolerability, and Pharmacokinetics of MTP-131 in Subjects With Congestive Heart Failure
This is a Phase 1, single-center, randomized, double-blind, single ascending dose, placebo-controlled study, in subjects aged 45-80 years with stable mild to moderate heart failure due to left ventricular systolic dysfunction, to…
- Trial name
- NCT02388464
- Testing
- MTP-131
- Where
- Bulgaria
- Volunteers
- 36 people
- Sponsor
- Stealth BioTherapeutics Inc.
Left Ventricular Systolic Dysfunction, Myocardial Infarction
Adherence to Cied Implantation Guidelines and Cardiac Rehabilitation
There are limited data on how the guideline indications for ICD implantation are applied in clinical practice across Europe. Moreover, the impact of "time-dependence" of some indications to implantation on the guidelines…
- Trial name
- ANGELICA (NCT05764109)
- Where
- Italy
- Volunteers
- 488 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Lymphoma, Non-Hodgkin, Lymphoma, Hodgkin
Early Detection of Patients at Risk of Developing Anthracycline Cardiotoxicity With TEP/CT -FDG
Management of patients with lymphoma is based on the administration of a chemotherapy containing anthracyclines (ATC), and allows cure rates of 65% to 80% at 5 years.
- Trial name
- DETECT (NCT04892667)
- Testing
- Intervention
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Myocardial Infarction
Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI
The purpose of this study is to evaluate the efficacy and safety of LCZ696 titrated to a target dose of 200 mg twice daily, compared to ramipril titrated to a target dose of 5 mg twice daily.
- Trial name
- PARADISE-MI (NCT02924727)
- Testing
- LCZ696 (sacubitril/valsartan), Ramipril, Valsartan
- Where
- 486 sites in United States, Argentina and 39 more
- Volunteers
- 5,669 people
- Sponsor
- Novartis Pharmaceuticals
Inflammatory Arthritis, Rheumatoid Arthritis
The Relationship Between Inflammatory ARTritis and CArdiac DIseAse
The goal of this prospective cohort study is to investigate cardiac comorbidity in a random sample of approximately 1200 patients from a population of outpatients with rheumatoid arthritis and axial spondyloarthritis referred to…
- Conditions
- Inflammatory Arthritis, Rheumatoid Arthritis, Spondylitis, Ankylosing, Axial Spondyloarthritis
- Trial name
- ARTCADIA (NCT05647577)
- Where
- Denmark
- Volunteers
- 1,285 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Hypertension
Predictive Factors of Systolic Dysfunction in Non-complicated Hypertensive Patients
Hypertension is a major cardiovascular risk factor. Heart failure is one of its main complications but the factors that influence its development are still insufficiently known.
- Trial name
- GLOBAL-HTN (NCT02841696)
- Testing
- Cardiac echography
- Where
- France
- Volunteers
- 183 people
- Sponsor
- University Hospital, Bordeaux
Left Ventricular Systolic Dysfunction, Sudden Cardiac Death
Heart Rate Response to Regadenoson and Sudden Cardiac Death
The purpose of this study is to determine whether a blunted heart rate response to regadenoson is an independent predictor of sudden cardiac death.
- Trial name
- NCT01842035
- Testing
- regadenoson
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Alabama at Birmingham
Hypovolemia, Heart Failure
Prevalence of Hypovolemia and Heart Failure in Non-cardiac Surgery
Prevalence of biventricular function of the heart and preoperative level of venous return is not known in non-cardiac non-morbid obese population.
- Conditions
- Hypovolemia, Heart Failure, Diastolic Dysfunction, Systolic Dysfunction
- Trial name
- NCT03349593
- Testing
- Echocardiography
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Umeå University
Cardiomyopathies, Dilated Cardiomyopathy
Pediatric Cardiomyopathy Mutation Analysis
The goal of this protocol is to obtain information from individuals with cardiomyopathy and from their families in order to elucidate the molecular genetics of this disorder.
- Conditions
- Cardiomyopathies, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathy
- Trial name
- NCT02432092
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Septic Shock, Left Ventricular Systolic Dysfunction
Cardiac Stress in Septic Shock - Biomarkers, Echocardiography and Outcome
Septic shock is a major cause of death in intensive care. Septic shock is often dominated by profound changes in organ functions, of which cardiac failure is one of the most severe.
- Conditions
- Septic Shock, Left Ventricular Systolic Dysfunction, Left Ventricular Diastolic Dysfunction
- Trial name
- Septic Heart (NCT01747187)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- University Hospital, Linkoeping
Heart Failure
The Product Surveillance Registry REVERSE Post Approval Study
The purpose of the REVERSE Post Approval Study (PAS) is to confirm the benefit observed in the REVERSE and RAFT pivotal studies in "real-world" clinical practice.
- Trial name
- PSR-REVERSE (NCT01660035)
- Where
- 123 sites in United States, Belgium and 8 more
- Volunteers
- 155 people
- Sponsor
- Medtronic
Dysfunction, Left Ventricular
Ultrasound and Left Ventricular Systolic Function
The aim of this study is to evaluate, in an intensive care unit, the reproducibility between two non-cardiologists operators and a cardiologist expert in echocardiogram, of the Simpson method and of the calculation of GLS for the…
- Trial name
- EFESE (NCT02381756)
- Testing
- Ultrasound
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Heart Diseases, Cardiac Arrhythmias
Reversal of Cardiomyopathy by Suppression of Frequent Premature Ventricular Complexes
Frequent monomorphic premature ventricular complexes (PVCs) may cause a cardiomyopathy (CMP) that is reversible by suppression of the ectopic focus.
- Conditions
- Heart Diseases, Cardiac Arrhythmias, Ventricular Premature Complexes, Systolic Heart Failure
- Trial name
- NCT01566344
- Testing
- PVC suppression therapy
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Maastricht University Medical Center
Heart Failure
A Safety Study of Sacubitril/Valsartan in Japanese Pediatric Patients With Heart Failure Due to Systemic Left Ventricle Systolic Dysfunction Who Have Completed CLCZ696B2319E1 Study
The purpose of this open-label study was to collect additional safety information of sacubitril/valsartan and to provide post-trial access to sacubitril/valsartan for the eligible Japanese patients who completed…
- Trial name
- NCT06149104
- Testing
- sacubitril/valsartan
- Where
- 6 sites in Japan
- Volunteers
- 8 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure
Phase IIb Safety and Efficacy Study of BAY94-8862 in Subjects With Worsening Chronic Heart Failure and Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Moderate Chronic Kidney Disease Alone
This study will be conducted in subjects with clinical diagnosis of worsening chronic heart failure and either type 2 diabetes mellitus (DM) with or without chronic kidney disease (CKD) or moderate CKD alone treated with…
- Trial name
- ARTS-HF Japan (NCT01955694)
- Testing
- BAY94-8862, Eplerenone
- Where
- 29 sites in Japan
- Volunteers
- 72 people
- Sponsor
- Bayer
Myocardial Infarction Type 2
Targeting Investigation and Treatment in Patients With Type 2 Myocardial Infarction
Type 2 myocardial infarction (MI) is common and associated with poor clinical outcomes, with as many as one in ten experiencing recurrent MI within one year, and only one in three alive at five years.
- Trial name
- TARGET-Type 2 (NCT05419583)
- Testing
- Coronary computed tomography angiography, Invasive coronary angiography, Transthoracic echocardiography
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Heart Failure, Systolic
Patient and Physician Survey Determinants of Appropriate ICD Utilization
To better understand the reasons for underutilization of defibrillator therapy in selected populations, the investigators propose a study to assess heart failure patient knowledge and attitudes toward device therapy.
- Trial name
- NCT01514773
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- Todd M Koelling, MD
Cognitive Impairment, Cognitive Change
How is COGNItive Function Affected by Cardiac Resynchronisation Therapy?
The primary objective of COGNI-CRT is to assess whether Cardiac Resynchronisation Therapy (CRT) can improve cognitive function in patients with systolic HF (LVEF ≤35%), when compared to a control group of patients implanted with…
- Conditions
- Cognitive Impairment, Cognitive Change, Heart Failure, Systolic, Heart Failure
- Trial name
- COGNI-CRT (NCT03755570)
- Testing
- Repeatable Assessment of Neuropsychological Status, Hospital Anxiety and Depression Scale, Frontal Assessment Battery
- Where
- United Kingdom
- Volunteers
- 198 people
- Sponsor
- Royal Cornwall Hospitals Trust