Clinical trials: Leg Injuries and Disorders
Chronic Venous Disease, Varicose Ulcer
Effects of Local Insulin on Varicose Ulcers for Wound Healing
A randomized, split-plot, double-blind, placebo-controlled trial. The varicose ulcer is divided into two (side A and B). Half of the wound's surface is treated locally with insulin (Glargine) applied at an approx depth of 3-4 mm.
- Conditions
- Chronic Venous Disease, Varicose Ulcer, Wound Healing, Insulin
- Trial name
- NCT04310280
- Testing
- Insulin Glargine, Saline
- Where
- Mexico
- Volunteers
- 13 people
- Sponsor
- Hospital Central "Dr. Ignacio Morones Prieto"
Heart Failure, Hip Fracture
Preoperative Levosimendan and Heart Failure
The purpose of this study is to investigate the safety and efficacy of Levosimendan given preoperative to patients with heart failure undergoing noncardiac surgery.
- Trial name
- PELS (NCT01022983)
- Testing
- Levosimendan
- Where
- 4 sites in Norway, Sweden
- Sponsor
- Sykehuset i Vestfold HF
Osteomyelitis Tibia, Surgical Site Infection
Acute Posttraumatic Osteomyelitis in Patients With High-energy Tibial Fractures and Biomarkers
The present trial was aimed to identify which biomarkers could be associated in perioperative period after surgical treatment of tibial fracture to the development of POM.
- Trial name
- POMTIBIAL (NCT03459261)
- Testing
- blood sample on admission (ADD), first postoperative day (POD1) and fourth postoperative day (POD4)
- Volunteers
- 86 people
- Sponsor
- University Medical Centre Ljubljana
Spinal Cord Injuries, Stroke
Evaluation of an Advanced Lower Extremity Neuroprostheses
The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate exercise, standing, stepping and/or balance in people with various degrees of paralysis.
- Conditions
- Spinal Cord Injuries, Stroke, Paralysis, Tetraplegia
- Trial name
- LE-IST (NCT00623389)
- Testing
- IST (Implanted Stimulator-Telemeter)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Case Western Reserve University
Sport Injury, Osteoarthritis, Knee
Biometric Recognition and Rehabilitation Assessment of Lower Extremity Sports Injury Based on Gait Touch Information
The current common clinical methods cannot truly reflect the biomechanical status of the knee joint. Based on the foot-knee coupling mechanism, the simple and practical dynamic gait touch information provided by the 3D force…
- Trial name
- NCT04462913
- Testing
- no intervention
- Where
- China
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Spinal Cord Injuries
Functional Electrical Stimulation During Cycling in People With Spinal Cord Injury
Neuroscience research that has identified potential for recovery (neuroplasticity) following incomplete SCI has changed clinical practice away from compensation strategies towards optimizing recovery.
- Trial name
- iCycle (NCT03834324)
- Testing
- FES
- Volunteers
- 11 people
- Sponsor
- University of Southampton
Overuse Injuries, Musculoskeletal Make-up in the Lower Extremities
Knowledge of Predicting Increased Risk for an Overuse Injury in Runners
The purpose of this study is to examine the skeleton of the legs and the running style in order to predict a possible overuse injury.
- Trial name
- NCT01979562
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northern Orthopaedic Division, Denmark
Diabetic Foot Ulcer Outcome, Quality of Patient Care
The Diabetic Foot Ulcer Registry
This is an observational, longitudinal real world registry of diabetic foot ulcers created from electronic health record data obtained in the course of clinical care.
- Trial name
- DFUR (NCT02813161)
- Testing
- cellular and tissue based therapy, negative pressure wound therapy, debridement
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- U.S. Wound Registry
Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Virtual Reality Treatment for Phantom Limb Pain
Patients with limb amputations experience the sensation of the missing extremity, which is sometimes coupled with a persistent and debilitating pain in the missing limb, a condition known as phantom limb pain (PLP).
- Conditions
- Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Phantom Limb Pain
- Trial name
- NCT03338842
- Testing
- Distractor and Lower limb VR
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tibial Fractures, Pain
Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial
Two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial evaluating the efficacy of standard pain management without NSAIDs (Group 1) vs.
- Trial name
- NSAID (NCT07006675)
- Testing
- 600 mg Ibuprofen
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,000 people
- Sponsor
- Major Extremity Trauma Research Consortium
Sarcopenia, Hip Fracture
Hyperprotein Nutritional Intervention in Elderly Patients With Hip Fracture and Sarcopenia
1. RATIONALE The unique characteristic of our study lies in the attempt to reverse the functional impairment experienced by sarcopenic patients with hip fracture using nutritional intervention.
- Trial name
- HIPERPROT (NCT01404195)
- Testing
- Ensure Plus Advance
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Hospital Viamed Valvanera, Spain
Knee Osteoarthritis, Knee Injuries
Clinical Study of Novel Diagnostic Techniques for Knee Osteoarthritis
The purpose of this study is to clarify the potential of intra-articular ultrasound imaging, non-invasive ultrasound imaging, quantitative MRI imaging, contrast-enhanced CT imaging and arthroscopy for diagnostics of knee…
- Trial name
- NCT01359553
- Testing
- Intra-articular ultrasound imaging of knee joint during arthroscopy, Non-invasive ultrasound imaging of knee, Quantitative MRI imaging of knee
- Where
- Finland
- Volunteers
- 12 people
- Sponsor
- University of Oulu
Diabetes Foot Care
Therapeutic Effect of Electroacupuncture at Zusanli (ST-36) on Diabetic Foot Wounds
The goal of this clinical trial is to learn if electroacupuncture at the Zusanli (ST-36) can assist in the treatment of diabetic foot ulcers.
- Trial name
- EA for DFU (NCT07482137)
- Testing
- Electroacupuncture at Zusanli (ST-36)
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Zhongda Hospital
Diabetes, Diabetic Foot Ulcer
Medico-economical Assessment of Telemedicine During Chronic Diabetes-related Foot Wound Management
The aim of the study is to assess the cost-effectiveness of telemedicine in the care of chronic diabetic foot ulcers. Patients will be randomized into 2 groups: 1/conventional care group with iterative visits to diabetes…
- Trial name
- AIRPEDIA (NCT01814267)
- Testing
- telemedicine, conventional
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Grenoble
Sarcopenia
Sarcopenia and Its Associated Factors Among Hip Fractures Patients
1. Asses the prevalence of sarcopenia in hip fracture patients in Truama hospital at Assuit University 2. To study the associated factors of sarcopenia in hip fracture patients in Trauma hospital at Assuit University
- Trial name
- NCT05141981
- Testing
- inbody device
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Assiut University
Hip Fractures, Gait Disorders in Old Age
Clinical Study of the Effects of a SWalker II and VR for Hip Fracture Rehabilitation in the Elderly
This project is structured in two distinct phases. The first phase deals with the recovery of the hip fracture in the acute phase up to ambulation, and the second is understood as the continuation of functional improvement of…
- Trial name
- SWalker-VR (NCT06025981)
- Testing
- Preliminary Phase, Phase I - Early gait rehabilitation, Phase II - Maintenance gait function ( with VR)
- Where
- 2 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Werium Assistive Solutions
Hip Fracture
Fascia Iliaca Compartment Blockade as Analgesia for Hip Fractures in the Acute Phase
To evaluate the analgesic potential of an neural blockade (Fascia iliaca compartment) with local anaesthetics in patients with hip fracture immediately after arrival in the emergency department.
- Trial name
- NCT00162630
- Testing
- Fascia Iliaca Compartment Blockade
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Hvidovre University Hospital
Diabetic Foot Ulcer
Longitudinal Study of Chronic Wounds Using Novel Wound Measurement Technologies
An open, non-randomised longitudinal study of diabetic foot ulcers receiving standardised treatment, over a 16 week period conducted at out-patient level, utilising novel optical wound measurement technologies.
- Trial name
- NCT02967900
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Michelson Diagnostics Ltd.
Ischemic Preconditioning, Acute Kidney Injury
Remote Ischemic Preconditioning During Lower Limb Revascularization
The aim of this study is to evaluate the role of remote ischemic preconditioning (RIPC) in preventing acute kidney injury after lower limb revascularization.
- Conditions
- Ischemic Preconditioning, Acute Kidney Injury, Limb Ischemia
- Trial name
- NCT04016857
- Testing
- RIPC, Control
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Messina
Ankle Fractures, Post-traumatic Osteoarthritis
Custom Dynamic Orthoses to Reduce Articular Contact Stress
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle. Research suggests that ankle arthritis develops following ankle fracture due, in part, to elevated forces on the cartilage.
- Conditions
- Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
- Trial name
- PRMRP FPA CT (NCT05209347)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Sponsor
- University of Iowa
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