Clinical trials: Leg Injuries and Disorders
Lower Extremity Chronic Ulcers in Diabetics
Evaluation of CureXcell® in Treating Lower Extremity Chronic Ulcers in Adults With Diabetes
Chronic foot ulcers are particularly prevalent in patients with underlying diabetes mellitus. These ulcers are reported to be the leading cause of hospitalization among people with diabetes.
- Trial name
- NCT01421966
- Testing
- CureXcell®
- Where
- 37 sites in United States, Canada and 1 more
- Volunteers
- 285 people
- Sponsor
- Macrocure Ltd.
Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis
Gait Rehabilitation to Treat FastOA
The purpose of this study is to determine the effects of real-time gait biofeedback delivered over a 6-week period on early markers of FastOA and conduct 6-week and 6-month follow-up assessments in anterior cruciate ligament…
- Conditions
- Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Knee Osteoarthritis, Osteo Arthritis Knee
- Trial name
- NCT05848622
- Testing
- Real-time gait biofeedback
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of North Carolina, Chapel Hill
Anterior Cruciate Ligament Rupture
Pain Relief Results After Anterior Cruciate Ligament (ACL) Reconstruction
Anterior cruciate ligament (ACL) reconstruction is surgery that is done to repair a damaged ligament in the knee. In this study we will look at whether the femoral nerve block, a commonly used method for pain relief after ACL…
- Trial name
- NCT00022854
- Testing
- Single-injection femoral nerve block, Femoral nerve block 60-hour continuous injection, Saline (control) injection into femoral nerve envelope
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Pittsburgh
Anterior Cruciate Ligament Injuries, Knee Osteoarthritis
Optimizing Movement After Anterior Cruciate Ligament Injury
Fifty percent of teenagers and young adults who suffer an anterior cruciate ligament (ACL) injury develop knee osteoarthritis (OA) within 15 years.
- Trial name
- NCT05363683
- Testing
- Squat Biofeedback, Standard Care
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Nebraska
Diabetic Foot Ulcer
Matrix Metalloproteinase-1/Tissue Inhibitor of Metalloproteinase-1 (MMP-1/TIMP-1) Ratio and Diabetic Foot Ulcers
The primary objective of this study is to assess the sensitivity and specificity of a MMP-1/TIMP-1 ratio equal to 0.24 at study entry to predict wound healing at 12 weeks' follow up visit.
- Trial name
- DIAB-MMP2 (NCT00935051)
- Testing
- Picture + MMPs and TIMP1 at week 0 and week 4
- Where
- 2 sites in France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Grenoble
Burns, Gait Disorder, Sensorimotor
Effects of Robot-assisted Gait Training in Patients Burn Injury on Lower Extremity
Gait enables individuals to move forward and is considered a natural skill. However, gait disturbances are very common in patients with burn injury. Major causes of functional impairment are pain and joint contractures.
- Trial name
- NCT04281394
- Testing
- Robot assisted gait training, conventional gait training
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Hangang Sacred Heart Hospital
Recurrent Patellar Dislocation, Patellar Instability
The Comprehensive Assessment in Children After Surgical Treatment of Patellar Recurrent Dislocation.
The aim of this prospective study is to assess extension apparatus function of the knee based on clinical, radiological, isokinetic and gait analysis data in patients after surgical treatment.
- Trial name
- NCT03983213
- Testing
- mpfl reconstruction
- Where
- Poland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Chronic Venous Insufficiency
Neuromuscular Electrical Therapy in Venous Ulcers
The use of neuromuscular electrical stimulation in the treatment of venous ulcers with difficulty of repair could be an alternative therapeutic favoring devitalized tissues and hence the pain.
- Trial name
- NCT01372020
- Testing
- neuromuscular electrical stimulation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Faculdade Evangelica do Parana
Shift-Work Sleep Disorder, Insomnia
Fire Fighter Fatigue Management Program: Operation Healthy Sleep
Firefighters work some of the most demanding schedules known under highly stressful and demanding conditions. The need to work frequent extended shifts and long work weeks leads to acute and chronic partial sleep deprivation as…
- Conditions
- Shift-Work Sleep Disorder, Insomnia, Restless Leg Syndrome, Obstructive Sleep Apnea
- Trial name
- NCT01988129
- Testing
- Sleep disorders education and screening
- Where
- United States
- Volunteers
- 1,189 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Lung Edema, Hip Fractures
Ultrasound in Evaluation of Preoperative Fluid Management of Hip Fracture Surgery Patients
Goal directed fluid therapy is a new standard surgical procedure which is successful in patients undergoing hip revision arthroplasty, There has been a reduction of postoperative complications, most importantly surgery with a…
- Trial name
- NCT05916599
- Testing
- ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Delirium - Postoperative, Delirium Prevention
Dexmedetomidine for Prevention of Delirium After Hip Fracture Surgery
Postoperative delirium is common after hip fracture surgery and is associated with delayed recovery and serious postoperative complications.
- Conditions
- Delirium - Postoperative, Delirium Prevention, Dexmedetomidine, Dexmedetomidine Infusion
- Trial name
- DEXLIR (NCT07867899)
- Where
- Denmark
- Volunteers
- 242 people
- Sponsor
- Peter Gaarsdal Uhrbrand
Diabetic Foot, Regional Anesthesia
Efficacy of Continuous Sciatic Nerve Block in Diabetic Foot Patients
Patients who underwent surgery for diabetic foot were divided into three groups: sciatic nerve block (Group B), continuous nerve catheter (Group C) .
- Conditions
- Diabetic Foot, Regional Anesthesia, Catheter Blockage, Wound Heal
- Trial name
- NCT04212325
- Testing
- Group C (Continuous sciatic nerve block), Group S (sciatic nerve block)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gulhane School of Medicine
Spinal Cord Injury
Safety Study of Outdoor and Indoor Mobility in People With Spinal Cord Injury (ROBOtics Spinal Cord Injury EKSO).
The aim of this study will be to evaluate the safety and the efficacy of a new robotic exoskeleton device in subjects with Spinal Cord Injury (SCI) and in subjects with other neurological disease with an impairment of lower limbs.
- Trial name
- ROBOSCIEKSO (NCT02065830)
- Testing
- EKSO
- Where
- 2 sites in Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Diabetic Foot Ulcers
Randomized, Controlled Multicenter Trial of Vacuum Assisted Closure Therapy™ in Diabetic Foot Ulcers
To determine if topical negative pressure therapy delivered by the V.A.C.® device is clinically efficacious and cost effective in the treatment of diabetic foot ulcers.
- Trial name
- NCT00432965
- Testing
- Moist Wound Therapy, VAC Therapy
- Where
- 25 sites in United States, Canada
- Volunteers
- 335 people
- Sponsor
- KCI USA, Inc
Venous Leg Ulcer, Leg Injuries and Disorders
Clinical Trial Enzyme Application Targeting Venous Leg Ulcers
This is an adaptive open-label, first-in-human (Phase IIa) study designed to assess the safety (and efficacy) of Aurase Wound Gel, an enzymatic debridement product, intended for topical application to sloughy venous leg ulcers…
- Trial name
- CLEANVLU (NCT04956900)
- Testing
- Aurase Wound gel
- Where
- 8 sites in United States, Hungary and 1 more
- Volunteers
- 43 people
- Sponsor
- SolasCure Limited
Hip Fractures, Anesthesia
Delirium in Elderly Patients With Trauma of the Hip
A broken hip occurs frequently in elderly patients and is often very painful. Side effects of inadequately treated pain as well as the traditional drugs (administered through intravenous catheter) used to treat pain are, among…
- Trial name
- DEPTHip (NCT02689024)
- Testing
- Bupivacaine, Acetaminophen, Diclofenac
- Where
- 5 sites in Netherlands
- Volunteers
- 239 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hallux Limitus
Kinetic Control Versus Dynamic Taping on First Metatarsophalangeal Joint in Athletes With Functional Hallux Limitus
This study is conducted to investigate and compare the effect of adding either kinetic control retraining or dynamic taping to the standard treatment program on first metatarsophalangeal joint dorsiflexion active range of motion…
- Trial name
- NCT07692113
- Testing
- the standard treatment, Dynamic taping, kinetic control
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Cognitive Impairment, Femoral Fractures
Sedation and Postoperative Cognitive Functions
Patients over the age of 65 who underwent elective surgery for a hip fracture and were sedated during spinal anesthesia were included in the study.
- Trial name
- NCT05737459
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Izmir Ataturk Training and Research Hospital
Diabetic Foot Ulcer, Diabetes
Inforatio Technique to Promote Wound Healing of Diabetic Foot Ulcers
This randomized clinical trial will examine the effect of inforatio technique on healing of diabetic foot ulcers (DFUs). Inforatio technique is a novel procedure developed by the research group.
- Conditions
- Diabetic Foot Ulcer, Diabetes, Foot Ulcer, Diabetic Foot
- Trial name
- NCT05189470
- Testing
- Inforatio technique, Usual care of the respective outpatient clinics
- Where
- 4 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Zealand University Hospital
ACL Injury, Knee Injuries
Association Between 4-Month Isokinetic Testing Measures and Second Knee Injuries After Primary Anterior Cruciate Ligament Reconstruction
Anterior cruciate ligament (ACL) is a frequent and disabling injury in athletes. Most of the time, ACL reconstruction (ACLR) is consider for regaining function and returning to preinjury sports while reducing the risk of…
- Conditions
- ACL Injury, Knee Injuries, Muscle Weakness
- Trial name
- PREDICT-ACLv2 (NCT05897970)
- Testing
- Return-to-sport (RTS) follow-up
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
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