Clinical trials: Leg Injuries and Disorders
Instability, Joint, Ankle Sprains
Italian Version of The Cumberland Ankle Instability Tool (CAIT)
Study Design: Evaluation of the psychometric properties of a translated, culturally adapted questionnaire. Objective: Translating, culturally adapting, and validating the Italian version of the Cumberland Ankle Instability Tool…
- Conditions
- Instability, Joint, Ankle Sprains, Ankle Injuries, Sport Injury
- Trial name
- CAIT-I (NCT04644601)
- Where
- Italy
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Peripheral Arterial Disease, Intermittent Claudication
A New Heat Therapy Device for Home-based Leg Heating in Patients With Lower-extremity Peripheral Artery Disease
The goal of the proposed pilot study is to evaluate the feasibility of a new leg heat therapy system treatment for patients with lower extremity PAD.
- Trial name
- NCT05335161
- Testing
- Home-based leg heat therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Purdue University
Hip Fractures, Malnutrition
Postoperative Dietary Intake of Hip Fracture Patients
The goal of this observational study is to observe the postoperative dietary intake in older adult hip fracture patients from their day of surgery (day zero) until day three inclusive.
- Conditions
- Hip Fractures, Malnutrition, Comorbidities and Coexisting Conditions, Postoperative Complications
- Trial name
- NCT06451679
- Testing
- Observational
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Teesside University
Healthy, Osteopenia
Clinical Study to Estimate Bone Mineral Density With the POROUS Ultrasound Device
Osteoporosis is a widespread medical condition among older people. It causes the bones to weaken and become more likely to break.
- Conditions
- Healthy, Osteopenia, Osteoporosis
- Trial name
- POROUS-BMD (NCT07187518)
- Testing
- Measurements with the POROUS R4C ultrasound device at the midshaft tibia, DXA measurement of the hip and lumbar spine
- Where
- 2 sites in Germany
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- POROUS GmbH
Diabetic Foot Disease, Diabetic Foot Infection
Intraosseous Versus Intravenous Vancomycin in Below-Knee Amputation for Ischemic Diabetic Foot
This randomized clinical trial compared two routes of vancomycin administration in patients undergoing below-knee amputation for ischemic diabetic foot infection.
- Conditions
- Diabetic Foot Disease, Diabetic Foot Infection, Diabetic Amputation Foot Wound
- Trial name
- NCT07338773
- Testing
- Intraosseous Vancomycin, Intravenous Vancomycin
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Venous Leg Ulcer
Assessment of the Evolution of Wound Biomarkers in Venous Leg Ulcers Treated With KLOX Biophotonic System
The main purpose of the study is to evaluate the effect of KLOX BioPhotonic System (composed of KLOX LumiHeal Gel and KT-L Lamp) on the expression of wound biomarkers in the treatment of venous leg ulcers (VLU).
- Trial name
- NCT03593369
- Testing
- KLOX BioPhotonic System (single treatment)+SOC, KLOX BioPhotonic System (consecutive treatments)+SOC, Standard of Care (SOC)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- KLOX Technologies Inc.
Spinal Cord Injuries
Clinical Investigation on Safety, Feasibility and Usability of the ABLE Exoskeleton Device With Spinal Cord Injured Patients in a Hospital Setting
The loss of the ability to walk and the associated restriction of mobility presents a major challenge to people with spinal cord injury in an everyday environment designed for pedestrians.
- Trial name
- NCT04876794
- Testing
- ABLE Exoskeleton
- Where
- 2 sites in Germany, Spain
- Volunteers
- 24 people
- Sponsor
- ABLE Human Motion S.L.
Osteomyelitis, Bone Infection
Clinical Effectiveness of S53P4 Bioactive Glass in Treatment of Long-bone Chronic Osteomyelitis
This clinical trial studies the clinical effectiveness of S53P4 bioactive glass (BAG) as a bacterial growth inhibiting bone graft substitute in a one-stage or two-stage surgical procedure for treatment of chronic long bone…
- Conditions
- Osteomyelitis, Bone Infection, Non-Union Fracture, Bone Infection of Lower Leg
- Trial name
- NCT04945434
- Testing
- S53P4 bioactive glass (BonAlive)
- Volunteers
- 78 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Osteoporosis
RCT: Added Value of Coordinator for the Management of Hip Fracture Patients
Introduction: Hip fracture due to osteoporosis is associated with an extremely high mortality morbidity and loss of quality of life. The risk of future fracture after a first hip fracture is increased.
- Trial name
- NCT01785381
- Testing
- Added value of coordinator
- Where
- Belgium
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Pressure Ulcers, Venous Ulcers
Use of Fish Skin Extracellular Matrix (ECM) to Facilitate Chronic Wound Healing
The clinical study is designed to assess the effectiveness, safety and non-immunogenicity of fish skin wound dressing extracellular matrix (ECM) in treating chronic wounds.
- Conditions
- Pressure Ulcers, Venous Ulcers, Diabetic Ulcers, Chronic Ulcer of Foot
- Trial name
- NCT01348581
- Testing
- Marigen Wound Dressing
- Where
- Iceland
- Volunteers
- 37 people
- Sponsor
- Kerecis Ltd.
Nerve Pain, Peripheral Nerve Injuries
The Effectiveness of Neurodynamic Techniques in Patients With Nerve-Related Leg Pain
This study aims to verify if patients with nerve-related leg pain benefits from neurodynamic treatment over two weeks.
- Conditions
- Nerve Pain, Peripheral Nerve Injuries, Peripheral Nervous System Diseases, Sciatica
- Trial name
- NCT01954199
- Testing
- Neurodynamic Group
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Cervical Cancer, Endometrial Cancer
Pelvic Fractures and Radiation Therapy for Cervical Cancer
The goal of this study is to estimate how often pelvic fractures occur in women treated with radiation therapy for either newly diagnosed or recurrent cervical, endometrial, or vaginal cancer.
- Conditions
- Cervical Cancer, Endometrial Cancer, Vaginal Cancer
- Trial name
- NCT00800644
- Testing
- CT or MRI + Blood Test
- Where
- United States
- Volunteers
- 239 people
- Sponsor
- M.D. Anderson Cancer Center
Hip Fractures, Muscle Atrophy
The Role of Blood Flow Restriction Therapy in Postoperative Elderly Patients With Hip Fracture
The investigators aim to study the use of blood flow restriction therapy (BFR) to augment routine post-operative physical therapy in elderly patients (age >= 65) after recovering from surgical treatment of hip fractures.
- Trial name
- NCT04809714
- Testing
- Blood Flow Restriction with Delfi Tourniquet System Cuff, Routine Post-operative Physical Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Pressure Injury, Venous Ulcer
MicroMatrix® Flex in Tunneling Wounds
To evaluate the safety and performance of MicroMatrix® Flex in subjects with wounds complicated by tunneling and/or undermining features.
- Conditions
- Pressure Injury, Venous Ulcer, Necrotizing Soft Tissue Infection, Diabetic Ulcers
- Trial name
- NCT06629506
- Testing
- MicroMatrix® Flex, MicroMatrix® UBM Particulate, Cytal® Wound Matrix 2-Layer
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Integra LifeSciences Corporation
Ankle Sprain
Effects of Talocrural Joint Mobilizations in the Treatment of Subacute Lateral Ankle Sprains
The goal is to determine if standard therapy including joint mobilizations of the ankle performed 3 times per week for 2 weeks will increase self-reported function and decrease pain in patients with mild lateral ankle sprains.
- Trial name
- NCT01117909
- Testing
- Mobilization therapy in addition to standard therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Diabetic Foot Ulcer
Pilot Study of PHOENIX Wound Matrix® Impact on Chronic DFU Wound Microbiome
A Pilot Study to Determine the Impact of the Phoenix Wound Matrix® on the Wound Microbiome in Chronic Diabetic Foot Ulcers
- Trial name
- NCT04437537
- Testing
- Bioresorbable 3D electrospun synthetic matrix
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- RenovoDerm
Diabetic Foot Ulcer
Iontophoresis of Treprostinil to Enhance Wound Healing in Diabetic Foot Skin Ulcers
Assess the effect of iontophoresis of treprostinil on wound closure over 12 weeks, in patients with DFU. In the present study the investigators aim at establishing the proof-of-concept of iontophoresis of treprostinil as a…
- Trial name
- InTREPiD (NCT03654989)
- Testing
- Treprostinil iontophoresis
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Grenoble
Proprioceptive Disorders, Knee Injuries
Effectiveness of an Exercise Protocol on Alteration of Knee Joint Position Sense in Futsal Players
This research presents a randomized clinical trial which evaluates the effectiveness of an exercise protocol on the knee-joint repositioning in futsal players related to a post-match muscle fatigue.
- Conditions
- Proprioceptive Disorders, Knee Injuries, Athletic Injuries
- Trial name
- NCT02804685
- Testing
- exercise protocol
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Hip Fracture, Delirium - Postoperative
Effectiveness of the Delirium Zero Protocol to Prevent the Onset of Delirium in Patients Undergoing Hip Fracture Surgery
The main objective of this research will be to investigate whether the control of care provided by the family/caregiver can prevent the incidence of delirium in individuals undergoing surgical intervention for hip fracture.
- Trial name
- DZ (NCT07202208)
- Testing
- "Delirium Zero" protocol, Standard of Care to prevent Delirium.
- Where
- 2 sites in Spain
- Volunteers
- 112 people
- Sponsor
- Cardenal Herrera University
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Reconstruction
Effect of Intraoperative Live Video Viewing on Kinesiophobia After ACL Reconstruction
The purpose of this randomized controlled trial is to investigate whether intraoperative live arthroscopic video viewing improves postoperative psychological and functional outcomes in patients undergoing primary anterior…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Reconstruction, Kinesiophobia, Anxiety
- Trial name
- VIDEO-ACLR (NCT07540715)
- Testing
- Intraoperative Live Video Viewing, Standard ACL Reconstruction
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Konya City Hospital
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