Clinical trials: Leg Injuries and Disorders
Diabetes Mellitus, Leg Injuries
Prosthetic Components and Stability in Amputee Gait
The biomechanics of changing direction while walking has been largely neglected despite its relevancy to functional mobility. In addition, an increased risk of injury can be associated with turning due to a decrease in stability.
- Conditions
- Diabetes Mellitus, Leg Injuries, Traumatic Amputation
- Trial name
- NCT00167778
- Testing
- Transverse plane rotation adaptor pylon, Rigid pylon
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Type 2 Diabetes, Foot Wound
Study of the Psychological Profile of Type 2 Diabetic Patients With Foot Wounds, Compared to Diabetic Patients Without Foot Wounds
Several studies have highlighted the value of analyzing a patient's psychological profile with the Bortner scale questionnaire (defined as type A or B personality).
- Trial name
- Bortner Pied (NCT04159922)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Osteoarthritis, Avascular Necrosis
PMCF Study of the CLS Brevius Stem With Kinectiv Technology
This study is a multi-center, prospective, non-controlled post-market surveillance study. The primary objective of this study is to confirm the safety and performance of the CLS Brevius stem with Kinectiv technology by obtaining…
- Conditions
- Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Femoral Neck Fractures
- Trial name
- NCT03410940
- Testing
- CLS Brevius stem with Kinectiv technology
- Where
- 4 sites in Italy, Poland and 1 more
- Volunteers
- 223 people
- Sponsor
- Zimmer Biomet
Amputation, Diabetes Complications
Study to Determine if Different Prosthetic Sockets Effect How Much Oxygen is in the Tissue of Lower Limb Amputees While They Are Walking
Amputee gait produces periodic occlusion of residual limb blood vessels. During the stance phase of gait, body weight cause the prosthesis to compresses the soft tissue of the residual limb and occlude blood flow.
- Conditions
- Amputation, Diabetes Complications, Leg Injuries, Traumatic Amputation
- Trial name
- NCT00985842
- Testing
- Pe-Lite and sleeve suspension socket, Total Surface bearing a socket with a sleeve suspension but without suction, Total surface bearing suction socket with a pin lock suspension
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- VA Office of Research and Development
Knee Injuries and Disorders
Evaluation of Long-term Isokinetic Training of Knee Joint
The goal of this clinical trial is to assess the effectiveness of isokinetic rehabilitation training under optimal stiffness in patients undergoing knee joint rehabilitation.
- Trial name
- NCT06674473
- Testing
- With robot assistance, traditional rehabilitation
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Peking University Third Hospital
Deep Vein Thrombosis of the Lower Extremities
AI-Based Prediction Model for Iliofemoral DVT Thrombolysis
This prospective single-arm cohort study aims to develop an AI-powered prediction model for treatment outcomes in patients with acute extensive iliofemoral deep vein thrombosis (IF-DVT) undergoing stent-free pharmacomechanical…
- Trial name
- NCT07181083
- Testing
- Rheolytic thrombectomy
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Sarcopenia in Elderly, Sarcopenic Obesity
Comparative Analysis of Sarcopenia in Rehabilitation Outcomes Following Femoral Neck Fracture: a Study in Normal Weight and Obese Study Cohort
Impact of Obesity on Sarcopenia Prevalence and Severity in Elderly Adults Recovering from Femoral Neck Fractures: A Prospective Study Introduction Age-related muscle loss, or sarcopenia, which includes reductions in both muscle…
- Conditions
- Sarcopenia in Elderly, Sarcopenic Obesity, Frailty, Femoral Fractures
- Trial name
- NCT06705166
- Volunteers
- 300 people
- Sponsor
- Shmuel Harofeh Hospital, Geriatric Medical Center
Peripheral Artery Disease
Leg Heat Therapy in Peripheral Artery Disease
The goal of this randomized, double-blind, sham-controlled clinical trial is to evaluate the benefits of home-based, leg heat therapy (HT) on lower-extremity functioning and quality of life in patients who suffer from…
- Trial name
- NCT05465070
- Testing
- Leg heat therapy
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Indiana University
Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries
Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury
The goal of this randomized clinical trial is to evaluate the effects of vibration on factors related to the risks of post-traumatic knee osteoarthritis and secondary anterior cruciate ligament (ACL) injury in individuals who…
- Conditions
- Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Quadriceps Muscle Atrophy
- Trial name
- NCT04875052
- Testing
- Experimental: Whole Body Vibration, Experimental: Local Muscle Vibration, Standard ACL Rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- University of North Carolina, Chapel Hill
Hip Fractures
Ultrasound Assessment of Gastric Contents in Fasted Elderly Patients With Hip Fracture
Evaluation of gastric contents in fasted elderly patients with hip fracture. The gastric contents will be examined by using ultrasonography in fasted elderly patients scheduled for hip fracture surgery.
- Trial name
- NCT03242733
- Testing
- Ultrasound assessment of gastric contents
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- SMG-SNU Boramae Medical Center
Hip Fractures, Acute Pain
PENG Block for Traumatic Hip Fracture in the Emergency Department
The study is a multicenter single-blinded randomized comparative trial. Adult patients older than 20 years of age presenting with acute hip fracture in emergency department between January 1st, 2021 and December 31st, 2021 will…
- Conditions
- Hip Fractures, Acute Pain, Emergency Department
- Trial name
- NCT04997785
- Testing
- Ultrasound-guided Pericapsular Nerve Group (PENG) Block
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- Dalin Tzu Chi General Hospital
Sarcopenia in Elderly, Frailty
Safety and Efficacy of Isomyosamine in Reducing Inflammation and Treating Muscle Loss in Older Adults After Hip or Thigh Bone Fractures
This Phase II clinical study investigates the safety and effectiveness of a new drug, Isomyosamine, in patients with sarcopenia or frailty, conditions associated with aging and muscle weakness.
- Conditions
- Sarcopenia in Elderly, Frailty, Frailty/Sarcopenia, Frailty in Older Adults
- Trial name
- NCT06942182
- Testing
- Isomyosamine 250mg
- Volunteers
- 60 people
- Sponsor
- TNF Pharmaceuticals, Inc.
Wounds and Injuries, Burns
Clinical Registry Collecting Real World Evidence on Wound Care Treatments
The proposed registry Sponsor (Siddhey LLC) will collect data on various wound treatments in real life settings. Data collection will facilitate the analysis of the safety and efficacy of wound treatments.
- Conditions
- Wounds and Injuries, Burns, Mohs Surgery, Diabetic Foot Ulcer Mixed
- Trial name
- SIDDX (NCT06328010)
- Testing
- Various types of wound care treatments
- Where
- 12 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- Siddhey LLC
Diabetic Wound
EUSOL vs. PDGF Dressing for Diabetic Foot Ulcers
Diabetic foot ulcers are a major cause of morbidity and amputation. This randomized controlled trial will compare the efficacy of a traditional antiseptic dressing (EUSOL) with a modern biologic dressing containing…
- Trial name
- NCT07493343
- Testing
- EUSOL Dressing, Platelet-Derived Growth Factor (PDGF) Dressing
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Services Hospital, Lahore
Chronic Wounds, Diabetic Foot Ulcer
Subcutaneous Dexpanthenol Administration and Wound Epithelialization
Chronic wounds are wounds that do not heal properly over time and can significantly reduce quality of life. Common types include diabetic foot ulcers, venous leg ulcers, and arterial ulcers.
- Conditions
- Chronic Wounds, Diabetic Foot Ulcer, Venous Leg Ulcers, Arterial Ulcer
- Trial name
- DEXPAN-WOUND (NCT07395674)
- Testing
- Dexpanthenol, Standard Wound Care
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Dilara CANBAY OZDEMIR
Anterior Cruciate Ligament Injuries, Sports Injury
Neuromusculoskeletal Alterations After ACL Injury
This study investigated how anterior cruciate ligament (ACL) injuries affect not only the knee joint but also brain activity, reaction speed, and psychological readiness to return to sports.
- Conditions
- Anterior Cruciate Ligament Injuries, Sports Injury, Neurocognitive Function
- Trial name
- NEURO-ACL (NCT07163468)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duzce University
Spinal Cord Injury, Paraplegia
Spinal Cord Injury Leg Rehabilitation
The purpose of this study is to determine if individuals with incomplete spinal cord injury (SCI) who remain unable to walk normally 1 year after their SCIs are able to sense and move the affected legs better after 10-13 weeks of…
- Conditions
- Spinal Cord Injury, Paraplegia, Quadriplegia, Tetraplegia
- Trial name
- AMES (NCT01498991)
- Testing
- AMES Treatment
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Oregon Health and Science University
Painful Hip, Fonctional Impotence After Minor Trauma (Fall)
Radiologist Diagnostic Performance Versus Artificial Intelligence (AI)
In France, femoral neck fracture is mainly detected with interpretation of pelvis/hip X-ray imaging (French Health Authority recommandation).
- Trial name
- RAVIA (NCT04304742)
- Testing
- hip standard radiography/ CT scan/ MRI
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Montpellier
Dementia, Hip Fractures
PERFECTED: Caring for Patients With Hip-fracture & Memory Difficulties
This qualitative study is part of the 5-year long (2013-18) PERFECTED (Peri-operative Enhanced Recovery hip-fracture Care of paTiEnts with Dementia) National Institute for Health Research (NIHR) funded research programme.
- Trial name
- PERFECTED (NCT03308123)
- Testing
- Observational study, not interventional
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Diabetic Foot Ulcer
Prospective, Multicenter, RCT of the Tenex Ultrasound System
The goal of this multicenter randomized controlled trial is compare standard of care (SOC) to Tenex MicroTip ultrasound therapy plus SOC in patients with Wagner 1-2 diabetic foot ulcers.
- Trial name
- NCT06137222
- Testing
- Tenex TXB MicroTip Ultrasound system plus SOC, Standard of Care for diabetic foot ulcer
- Where
- 2 sites in United States
- Volunteers
- 148 people
- Sponsor
- Tenex Health Inc.
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