Clinical trials: Leg Injuries and Disorders
Diabetic Foot Ulcer (DFU), Chronic Foot Ulcers
Rising Tide - Amniotic Tissue(s) Treatments for Chronic Diabetic Foot Ulcers
The purpose of this clinical investigation is to evaluate the safety and efficacy of Amnion/Chorion/Amnion allograft , Amnion/Chorion allograft, and/or Amnion/Amnion allograft, plus Standard of Care (SOC) each versus SOC alone in…
- Trial name
- NCT06681428
- Testing
- Allograft
- Where
- 9 sites in United States
- Volunteers
- 240 people
- Sponsor
- Tides Medical
Primary Osteoarthritis, Post-Traumatic Arthritis
AVANTAGE® RELOAD Double Mobility Acetabular Cup -Clinical Study
This is a Post Marketing Clinical Follow Up study (PMCF) on the AVANTAGE RELOAD dual mobility system cup.
- Conditions
- Primary Osteoarthritis, Post-Traumatic Arthritis, Inflammatory Joint Disease, Femoral Neck Fracture
- Trial name
- NCT03357445
- Testing
- Avantage Reload cup
- Where
- 4 sites in France, Slovenia
- Volunteers
- 500 people
- Sponsor
- Zimmer Biomet
Atherosclerosis, Stable Angina
Remote Ischemic Preconditioning as a Method Against Subclinical Renal Injury and Contrast-induced Nephropathy
Contrast-induced nephropathy (CIN) has remained significant and severe complication of angiographic procedures despite the increasing use of preventative methods.
- Conditions
- Atherosclerosis, Stable Angina, Peripheral Artery Disease, Contrast-induced Nephropathy
- Trial name
- NCT02700958
- Testing
- Remote ischemic preconditioning
- Where
- Estonia
- Volunteers
- 160 people
- Sponsor
- Tartu University Hospital
Anterior Cruciate Ligament Tear
The Effect of Perioperative and Postoperative Music Reduces Pain Perception After Anterior Cruciate Ligament Reconstruction
study the effect of music therapy in pre-operative and post operative period and measure the out come by the visual analog scale (pain score) and analgesic drug use such as morphine and the anxiety score
- Trial name
- NCT06275828
- Testing
- slow beat mesic listening by headphone
- Where
- Thailand
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Police General Hospital, Thailand
Knee Injuries, Knee Arthritis
Kinematic Parameters to Predict Knee Diseases.
There is no study to explore the prediction of knee diseases using kinematic parameters of knee during gait. The aim of this study is to explore the possibility of predicting knee diseases by gait parameters.
- Trial name
- NCT03130400
- Testing
- Observational gait analysis procedure
- Where
- China
- Volunteers
- 1,914 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Left Ventricular Dysfunction, Femoral Fracture
Optimization Study of Cardiac Risk Patients With Hip Fracture
Elderly patients undergoing surgery for proximal hip fracture have a high risk of morbidity and mortality (M\&M) postoperatively.
- Trial name
- NCT01219712
- Testing
- Colloids, dobutamin, levosimendan
- Where
- 3 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- University Hospital, Linkoeping
Hip Dysplasia, Hip Injuries
PENG Block vs. ESP Block for Pediatric Hip Surgery
The study compares the effectiveness and safety of the pericapsular nerve blockade vs. ESPB in pediatric patients who underwent hip surgeries.
- Conditions
- Hip Dysplasia, Hip Injuries, Hip Fractures, Hip Disease
- Trial name
- NCT06087549
- Testing
- Pericapsular nerve group block using 0.2% ropivacaine, Erector Spinae Plane Block using 0.2% ropivacaine, Standard care
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Degenerative Osteoarthritis, Rheumatoid Arthritis
Non-Interventional, Multicenter Bicontact® E PMCF Study
Prospective observational (non-interventional) cohort study, multi-centric in 5 study Centers in Japan to collect short term clinical and radiological results of the cementless Bicontact® E stem in a standard patient population…
- Conditions
- Degenerative Osteoarthritis, Rheumatoid Arthritis, Femoral Neck Fractures, Femoral Head Necrosis
- Trial name
- NCT03442855
- Where
- 5 sites in Japan
- Volunteers
- 73 people
- Sponsor
- Aesculap AG
Spinal Cord Injuries, Paraplegia
Brain Controlled Spinal Cord Stimulation In Participants With Spinal Cord Injury For Lower Limb Rehabilitation
The purpose of this clinical study is to evaluate the preliminary safety and effectiveness of using a cortical recording device (ECoG) combined with lumbar targeted epidural electrical stimulation (EES) of the spinal cord to…
- Trial name
- Think2Go (NCT06243952)
- Testing
- ARC-BSI Lumbar system
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Ischemia Reperfusion Injury, Peripheral Artery Disease
Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion
In this study, we are trying to see if vitamin B6 can minimize the amplified blood pressure response to exercise following ischemia-reperfusion injury.
- Trial name
- NCT06369350
- Testing
- Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Rupture of Anterior Cruciate Ligament, Complete Tear, Knee, Anterior Cruciate Ligament
Comparison of Dynamic Knee Stability and Functional Outcomes in Anatomical ACL Reconstruction at AM or Central Position
This is a prospective, randomized and double-blind clinical trial about anatomical single-bundle anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT02074917
- Testing
- Anatomical ACL reconstruction
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Total Knee Arthroplasty, Osteo Arthritis Knee
In Vivo Kinematics for Subjects Implanted With Klassic Total Knee Arthroplasty (TKA)
In vivo knee kinematics will be assessed for 20 subjects that have been implanted with a Total Joint Orthopedics Klassic knee system by Dr.
- Conditions
- Total Knee Arthroplasty, Osteo Arthritis Knee, Knee Implant, Knee Injuries
- Trial name
- TKA (NCT04113785)
- Testing
- Klassic Knee System
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The University of Tennessee, Knoxville
Ulcer Healing, Diabetic Foot Ulcer
Evaluating The Efficacy Of A Keratin Graft In Treating Non-Healing Diabetic Foot Ulcers
The goal of this clinical pilot is to collect patient outcome data on a commercially available, keratin-based skin substitute matrix: ProgenaMatrix®.
- Trial name
- NCT05797285
- Testing
- human keratin graft
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- ProgenaCare Global, LLC
Endothelial Dysfunction
Artery Function Responses to Heat Therapy and Exercise Training
This study will explore the effects of 8 weeks of local leg heat therapy, exercise training, or both on measures of vascular function, cardiorespiratory fitness, and muscle strength in young, healthy individuals.
- Trial name
- NCT04588103
- Testing
- Heat therapy, Exercise training
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Diabetic Foot Ulcer (DFU), Diabetic Symmetrical Polyneuropathy
Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients and Its Effect on Wound Healing
Diabetic symmetrical polyneuropathy (DSPN) is a common complication of diabetes that affects the nerves, especially in the legs and feet. It can cause pain, numbness, tingling, weakness, and loss of sensation.
- Trial name
- NCT07877948
- Testing
- Alpha-Lipoic Acid, Vitamin B1, Vitamin B6, Vitamin B12, Vitamin E, Vitamin B1, Vitamin B6, Vitamin B12
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- BREGO Life Sciences
Hip Fracture, Anemia
IRONCARE: Iron Treatment in Older Patients With Hip Fractures
The aim of this study is to investigate the effects of intravenous (IV) iron therapy compared to alternate-day oral iron treatment and no supplementation in older patients with hip fractures.
- Conditions
- Hip Fracture, Anemia, Iron, Placebo - Control
- Trial name
- NCT07659184
- Testing
- Ferric Derisomaltose, Oral Iron (Ferrous sulphate)
- Where
- 5 sites in Denmark
- Volunteers
- 528 people
- Sponsor
- University of Aarhus
Ulcer, Leg, Heal Wound
Wound Dressing With Moisture Sensor
Explorative study of function of a moisture sensor on top of a superabsorbent wound dressing on exuding leg ulcers.
- Trial name
- NCT03468816
- Testing
- Sensor activation (on DryMax Extra Soft)
- Where
- 2 sites in Sweden
- Volunteers
- 5 people
- Sponsor
- Vårdcentralen Åby
Hip Fracture, Delirium
Incidence of Delirium in Hip Fracture Patients Randomized to Regular Hypnotics vs Placebo
To examine the influence of regular hypnotic therapy on the incidence of delirium after hip fracture surgery
- Trial name
- NCT00286936
- Testing
- Zolpidem
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Hvidovre University Hospital
Patella Dislocation
Conservative Versus Operative - First Time Patella Dislocations
There is no consensus regarding whether rehabilitation or surgical management is best for the management of a primary patellar dislocation.
- Trial name
- NCT05533671
- Testing
- medial patellofemoral reconstruction, Non-operative group
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Pressure Ulcer, Diabetic Foot Ulcer
Efficacy of Wound Dressings With Copper Oxide
Thirty patients of 18-85 years of age, with 2-30 cm2 pressure ulcers or post-op wounds, will be recruited and treated with either wound dressing containing silver or wound dressings containing copper oxide microparticles.
- Trial name
- NCT04634838
- Testing
- MedCu Antibacterial Wound Dressings with Copper Oxide
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- MedCu Technologies Ltd.
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