Clinical trials: Leg Injuries and Disorders
Osteoarthritis, Knee, Post-traumatic Osteoarthritis
Preventing Injured Knees From osteoArthritis: Severity Outcomes
This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction.
- Conditions
- Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear
- Trial name
- PIKASO (NCT06096259)
- Testing
- Metformin
- Where
- 9 sites in United States
- Volunteers
- 512 people
- Sponsor
- Brigham and Women's Hospital
Fracture of Hip, Ileus
Peripheral Perfusion Index in Acute Surgical Patients
Introduction Perioperative haemodynamic instability is associated with postoperative morbidity and mortality. Macrocirculatory parameters, such as the conventionally obtained mean arterial blood pressure and cardiac output, may…
- Conditions
- Fracture of Hip, Ileus, Perforated Viscus, Anastomotic Leak
- Trial name
- NCT03757442
- Where
- Denmark
- Volunteers
- 1,338 people
- Sponsor
- Hvidovre University Hospital
Delirium, Hip Fractures
Prevention of Delirium Among Elderly Patients With Hip Fractures
Objective: To evaluate the effect of care bundle on prevention of delirium among elderly patients with hip fractures. Methods: A prospective randomized case control study was performed for 80 patients (≥65 years) with hip…
- Trial name
- NCT03470662
- Testing
- Care bundle
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhoupu Hospital, Pudong New Area, Shanghai, China
Hip Fracture, Pain Management
Comparison of the Efficacy of Ultrasound-guided Supra-inguinal Fascia Iliaca and Lumbar Erector Spina Plan Block in Hip Fractures
The aim of our study was to evaluate the efficacy and patient satisfaction level of SI-FIB and lumbar ESPB for positioning and postoperative analgesia during spinal anesthesia in patients undergoing hip fracture surgery.
- Conditions
- Hip Fracture, Pain Management, Multimodal Analgesia, Peripheral Nerve Block
- Trial name
- NCT07639762
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Diabetic Foot Ulcers, Venous Ulcers
Registry Trial of the Effectiveness of Platelet Rich Plasma for Chronic Non-Healing Wounds
This study will examine differences in the process of wound-healing in patients treated with platelet rich plasma (a concentration of proteins derived from a patients own blood) applied to the wound as a gel; injected into the…
- Conditions
- Diabetic Foot Ulcers, Venous Ulcers, Pressure Ulcers
- Trial name
- CMS (NCT02071979)
- Testing
- Autologous PRP Gel, Autologous PRP Injections, Autologous PRP Gel plus PRP Injections
- Where
- 6 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Arteriocyte, Inc.
Hip Fractures
Dietary Patterns and Hip Fracture Risk in the UK Biobank
Hip fracture is a common serious injury in older adults that reduces mobility, independence, and quality of life, and can lead to premature death.
- Trial name
- NCT05554549
- Testing
- Dietary pattern observed
- Where
- United Kingdom
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Surgical Incision, Ulcer Foot
Study to Evaluate the PICO 14 Negative Pressure Wound Therapy System in the Management of Acute and Chronic Wounds
This is a prospective, multi-center, open label study evaluating the performance of PICO14 Negative Pressure Wound Therapy (NPWT) in the management of chronic open wounds (pressure ulcers, venous leg ulcers, diabetes related foot…
- Conditions
- Surgical Incision, Ulcer Foot, Ulcer Venous, Ulcer, Leg
- Trial name
- PICO14 (NCT05234632)
- Testing
- PICO 14 single-use Negative Pressure Wound Therapy System
- Where
- 6 sites in Germany, United Kingdom
- Volunteers
- 45 people
- Sponsor
- Smith & Nephew, Inc.
Foot Ulcer
Photoacoustic Imaging of Foot Wound
This pilot device trial aims to test the feasibility of using photoacoustic images to monitor tissue perfusion and to guide post-surgical wound treatment.
- Trial name
- NCT07216599
- Testing
- Photoacoustic imaging and multispectral imaging
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- State University of New York at Buffalo
Osteoporosis, Frailty
Spitex-SpiTal-Autonomie-Reha-Kraft
The primary purpose of this study is to test if the STARK comprehensive autonomy health care package improves lower extremity function over time at 6 weeks, 3, 6 and 12 months after hip or pelvis fracture compared to the standard…
- Conditions
- Osteoporosis, Frailty, Hip Fractures
- Trial name
- STARK (NCT03154684)
- Testing
- STARK intervention, Standard of Care
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- University of Zurich
Muscle Strain, Neuromuscular Diseases
Posterior Chain EMG Patterns in Athletes With and Without Hamstring Injury
This cross-sectional observational study investigated posterior chain muscle activation patterns in football players with and without a history of hamstring strain injury.
- Conditions
- Muscle Strain, Neuromuscular Diseases, Athletic Injuries
- Trial name
- NCT07171385
- Testing
- Nordic Hamstring Curl (NHC), Kettlebell Swing (KS), Supine Sliding Single-Leg Curl (SSLC)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Venous Leg Ulcer (VLU)
Nonhealing Venous Leg Ulcers Treated With a Standard of Care (SoC) Alone or Standard of Care and Dehydrated Human Placenta Tissue (dHPT) With Crossover
The purpose of this study is to determine how well our dHPT (Dehydrated Human Placental Tissue) Product and Standard of Care work when compared to Standard of Care alone in achieving complete closure of venous leg ulcers.
- Trial name
- EVOLVE (NCT07230340)
- Testing
- Amnion-Intermediate-Chorion, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Cellution Biologics
Negative-Pressure Wound Therapy, Amputation
The Effect of Negative Pressure Wound Therapy on Wound Healing in Major Amputations of the Lower Limb
The socioeconomic costs of problematic and delayed wound healing following lower limb amputations are enormous to the society. Lower limb amputations is one of the longest known surgical treatments, but also one of the least…
- Conditions
- Negative-Pressure Wound Therapy, Amputation, Wound Heal
- Trial name
- NCT04618406
- Testing
- PICO VAC, Standard care
- Where
- Denmark
- Volunteers
- 158 people
- Sponsor
- University of Southern Denmark
Magnetic Resonance Imaging, Hip Fractures
fMRI Feasibility Older Hip Fracture Surgery
An assessment of the feasibility of structural and functional magnetic resonance imaging (MRI) brain scans in older people who have recovered from and older people who never had delirium after hip fracture surgery
- Conditions
- Magnetic Resonance Imaging, Hip Fractures, Postoperative Delirium
- Trial name
- NCT05081726
- Testing
- Functional MRI
- Volunteers
- 10 people
- Sponsor
- University of Nottingham
Sports Physical Therapy, Multi-Tasking Behavior
A New Dual Task Test Method for Football Players
Multitasking (Dual Task) is a measurement method to evaluate cognitive ability to execute multiple functions at the same time. To perform this test, while participant/patient performing a main skill (for example, walking), a…
- Conditions
- Sports Physical Therapy, Multi-Tasking Behavior, ACL Injury, Kinesiophobia
- Trial name
- NCT05218993
- Testing
- A new dual-task measurement method with images, A new dual-task measurement method with cards
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Diabetic Foot Ulcer
Diabetic Foot Ulcers-Comparing Transforming Powder to Standard of Care
Phase IV, randomized, prospective, multi-center, open-label, comparison of transforming powder dressing to standard of care dressing for healing diabetic foot ulcers.
- Trial name
- NCT05046158
- Testing
- Transforming Powder Dressing, Standard of care topical wound agents and dressings
- Where
- 12 sites in United States
- Volunteers
- 135 people
- Sponsor
- ULURU Inc.
Toenail Fungal Infection, Cellulitis
A Subjective Observational Study of Patients Using Medicated Footbath/Footwash Treatment in Podiatry Care
The purpose of this study is to evaluate the level of relief perceived by patients using medicated footbath/footwash with or without an oral medication for the treatment of podiatry issues.
- Conditions
- Toenail Fungal Infection, Cellulitis, Pitted Keratolysis, Diabetic Foot Ulcer
- Trial name
- NCT03781024
- Testing
- Footwash
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Data Collection Analysis Business Management
Lower Limb Amputation Below Knee (Injury)
Effects of Prosthesis Training on Pain, Prosthesis Satisfaction and Ambulatory Status of Lower Limb Amputees
The objective of the study is to assess the effects of prosthesis training with and without phantom exercises on pain, prosthesis satisfaction and ambulatory status of lower limb amputees treated with prosthesis training, phantom…
- Trial name
- NCT06013631
- Testing
- Prosthesis Training, Phantom Exercises
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- University of Lahore
Hip Osteoarthritis, Leg Length Discrepancy
An Intelligent Instrument for Improved Leg Length and Hip Offset Accuracy in Total Hip Arthroplasty
Leg length discrepancies following total hip arthroplasty have been associated with nerve palsies, gait abnormalities, and lower back pain.
- Conditions
- Hip Osteoarthritis, Leg Length Discrepancy, Dislocation
- Trial name
- NCT02095093
- Testing
- Intellijoint HIP, Outrigger
- Where
- Canada
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Foot Ulcers, Diabetic, Foot Ulcer Unhealed
SALACIA: SALvesAn vs Conventional Management of dIAbetic Foot Wounds
Increasing prevalence of diabetes mellitus has led to increasing numbers of chronic non-healing foot ulcers (wounds). Electrolysed water is a novel antiseptic which reduces bacterial load and appears to encourage wound healing.
- Trial name
- SALACIA (NCT06908148)
- Testing
- Electrolysed water, Conventional irrigant
- Volunteers
- 200 people
- Sponsor
- NHS Lanarkshire
Diabetic Foot, Ulcer Foot
SDRM® vs. Collagen for Diabetic Foot Ulcers
Supra SDRM® is FDA-cleared as a dressing for treating partial and full-thickness wounds. It is a dermal substitute that provides a barrier and an ECM-like structure to help accelerate wound healing.
- Conditions
- Diabetic Foot, Ulcer Foot, Wound Heal
- Trial name
- NCT05883098
- Testing
- Wound debridement, Wound closure matrix application
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Polymedics Innovations Inc.
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