Clinical trials: Leg Injuries and Disorders
Leg Ulcer
Efficacy of Kerecis Omega 3 in Comparison to Clinical Standard Procedures
Chronic leg ulcerations are a great burden for patients and the medical system alike. Frequent outpatient consultations with associated treatment costs and travel costs for the patient as well as psychosocial burdens remain an…
- Trial name
- NCT06036485
- Testing
- Kerecis Omega 3, Surgical debridement
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetic Foot Ulcers
Omeza Products in Combination With Standard of Care for the Treatment of Diabetic Foot Ulcers
This study is to evaluate the efficacy of OCM™ used in combination with off-loading devices for the treatment of diabetic foot ulcers.
- Trial name
- NCT05417425
- Testing
- Omeza collagen matrix, Omeza lidocaine lavage, Omeza skin protectant
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Omeza, LLC
Pain, Acute, Pain, Chronic
Evaluation of the Effect of the AI500™ SINGLE-DOSE GEL Medical Device in Patients With Reduced Knee Function
Evaluation of the effect of the AI500™ SINGLE-DOSE GEL medical device in patients with reduced knee function
- Conditions
- Pain, Acute, Pain, Chronic, Knee Injuries, Knee Osteoarthritis
- Trial name
- NCT05886608
- Testing
- AI 500™ SINGLE-DOSE GEL
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Contrad Swiss SA
Diabetic Foot Ulcer
Comparative Study of Two Application Regimens of Amniotic Membrane Wound Graft In the Management of Diabetic Foot Ulcers
The purpose of this study is to determine whether a weekly application of EpiFix human amniotic membrane is more effective than a biweekly application (every two weeks) in the treatment of diabetic foot ulcers.
- Trial name
- NCT01657474
- Testing
- Weekly application of EpiFix plus standard of care, Biweekly application of EpiFix plus standard of care
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- MiMedx Group, Inc.
Osteogenesis Imperfecta
Management of Combined Fracture Neck of Femur and Femoral Deformity in Osteogenesis Imperfecta Patient
O.I with NOF fixed by Wagner technique and telescoping nail
- Trial name
- OI (NCT05878548)
- Testing
- corrective osteotomy and intramedullary telescoping nail for deformed femur and Wagner technique to fix NOF fracture
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Assiut University
Medial Tibial Stress Syndrome
Effect of Functional Strength Training of Hip Abductors in Runners With Medial Tibial Stress Syndrome
This study will be the first project to investigate the effect of functional strength training of hip abductors on pain, function, hip, and knee kinematics including contra-lateral pelvic drop angle (hip frontal plane projection…
- Trial name
- MTSS (NCT05637476)
- Testing
- Functional strength training of hip abductors, A selected physical therapy exercise program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Shin Splint, Fascial Manipulation
Observing the Effect of Fascial Manipulation in Athletes With Shin Splits.Tibial Stress Syndrome.
Aims \& objectives: 1. The aim of the study is to find out the influence of fascial manipulation on running kinematics among athletes with medial tibial stress syndrome (MTSS). 2. The objectives of our study are i.
- Conditions
- Shin Splint, Fascial Manipulation, Running Kinematics
- Trial name
- MTSS (NCT03198260)
- Testing
- Fascial manipulation
- Where
- India
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Manipal University
Osteopenic Women, Proximal Femur Fracture
Copley II: Long-term Outcome Follow-up Study of Osteoporotic Women Who Underwent a Local Osteo-Enhancement Procedure (LOEP) in the Proximal Femur
To evaluate longer-term (5-7 years) outcomes of the twelve (12) subjects treated with AGN1 Femoral LOEP in the clinical study "A Prospective Pilot Evaluation of Percutaneous Osteo-supplementation in the Proximal Femur of…
- Trial name
- NCT06799143
- Volunteers
- 12 people
- Sponsor
- AgNovos Healthcare, LLC
Limb Salvage, Diabetes Complication
This Observational Study Evaluates the Clinical Outcomes of Patients With Diabetes Who Utilize a Specialized Dietary Supplements for Foot Ulcer Healing. The Study Documents the Rate of Complete Wound Closure and the Prevention of Lower Extremity Amputations in a Real-world, At-home Setting.
This observational study evaluates the clinical outcomes of patients with diabetes who utilize a specialized dietary supplements for foot ulcer healing.
- Conditions
- Limb Salvage, Diabetes Complication, Dietary Supplements, Healed Ulcer
- Trial name
- NCT07442110
- Testing
- Diabetic foot ulcer treatment by dietary supplements
- Where
- Algeria
- Volunteers
- 35 people
- Sponsor
- Amar h Zireg
Ankle Disease, Ankle Injuries and Disorders
Dexmedetomidine Vs Dexamethasone in Popliteal Nerve Block
Effect of Perineural Dexmedetomidine vs. Dexamethasone on the duration of popliteal nerve block for Anesthesia After Pediatric ankle/foot surgery.
- Conditions
- Ankle Disease, Ankle Injuries and Disorders, Foot Injury, Foot Diseases
- Trial name
- NCT06304324
- Testing
- 0.9% Sodium chloride, 0.1mg/kg Dexamethasone, 0.05ug/kg Dexmedetomidine
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Foot Ulcer, Varicose Ulcer
Skin Ulcers Treatment With an Handicraft Topical Device
The aim of this study was to evaluate the efficacy of a handicraft topical device of negative pressure versus traditional healing treatment for skin ulcers in lower limbs; in patients with diabetes mellitus, venous stasis and…
- Trial name
- NCT02512159
- Testing
- drenovac handcrafted, Healing
- Volunteers
- 144 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Diabetes, Diabetic Foot
Diabetic Foot Ulcer Study Comparing Cytal Wound Matrix 1-Layer to Standard of Care
This is a two-armed randomized controlled trial (RCT) primarily aimed at determining if application of Cytal Wound Matrix 1-Layer intervention to diabetic foot ulcers shows improved wound closure rates when compared to standard…
- Conditions
- Diabetes, Diabetic Foot, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT03626623
- Testing
- Cytal Wound Matrix 1-Layer, Standard of Care (SOC)
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Integra LifeSciences Corporation
Blood Flow Restriction Training, Eccentric Training
BFR Training on Muscle Morphology
This randomized clinical trial study compares high-load eccentric training (HL-Et), sham LL-BFRt, and low-load blood flow restriction (LL-BFRt) in sportsmen.
- Conditions
- Blood Flow Restriction Training, Eccentric Training, Muscle Morphology, Patellofemoral Pain Syndrome
- Trial name
- NCT06566950
- Testing
- Low load-BFRt, High load-Eccentric training
- Where
- Indonesia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Udayana University
Diabetic Foot Ulcer
Clinical Evaluation of the Combined Use of Apligraf® and the SNaP® Pressure Wound Therapy System
The primary purpose of this study is to evaluate the safety and efficacy of the concurrent use of Apligraf® and the SNaP® Wound Care System for the treatment of diabetic and venous stasis lower extremity ulcers.
- Trial name
- OG/SNaP (NCT01623882)
- Sponsor
- KCI USA, Inc
Ankle Sprains, Instability, Joint
Arthroscopic Versus Open Brostrom for Ankle Instability
Background: Ankle sprains are among the most prevalent lesions in primary care. A substantial number of these ligament lesions will develop ankle instability and require a surgical procedure.
- Conditions
- Ankle Sprains, Instability, Joint, Ligament Injury, Surgery
- Trial name
- NCT03643926
- Testing
- Arthroscopic Brostrom, Open Brostrom
- Where
- 2 sites in Brazil
- Volunteers
- 98 people
- Sponsor
- Federal University of São Paulo
Knee Injury, Knee Osteoarthritis
Monitoring Of Helsingborg Acute Knee Injuries (MOHAK)
Using magnetic resonance imaging (MRI), laboratory analyses and patient reported outcomes, the overall aim of this study is to investigate structural injuries and biochemical alterations in the acutely injured knee and to relate…
- Trial name
- NCT01382173
- Where
- Sweden
- Volunteers
- 192 people
- Sponsor
- Lund University
Hip Arthropathy, Hip Dysplasia
Mid-Term Natural Course Postoperative of Crowe Type III-IV Hip Dysplasia
Comparison of preoperative and postoperative mid-term course of patients with Crowe Type 3 and Type 4 hip dysplasia.
- Trial name
- NCT05149729
- Testing
- Shortened hip arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Bezmialem Vakif University
Diabetic Foot Ulcer, Wound
Investigation of the Effects of Different Exercise on Wound Healing in Patients wıth Diabetic Foot Wounds
Diabetic foot ulcers are a common complication of diabetes mellitus and are associated with delayed wound healing, impaired quality of life, and an increased risk of lower extremity amputation.
- Trial name
- NCT05422846
- Testing
- standard treatment, aerobic exercise, exercise protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Harran University
Diabetes Mellitus, Foot Ulcer
REOXCARE Dressing to Improve Healing in Diabetic Foot Ulcers (DFU)
It has been shown that diabetic patients present a significant increase in markers related to oxidative stress, which increases even more in those with diabetic foot ulcers and gradually depending on the severity of the injury…
- Conditions
- Diabetes Mellitus, Foot Ulcer, Neuroischemic Foot Ulcer
- Trial name
- REOXDFU (NCT05413746)
- Testing
- Reoxcare antioxidant dressing
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Histocell, S.L.
Diabetic Foot Ulcer
Ultrasound Assisted Wound Debridement (UAW) Versus Standard Wound Treatment in Complicated Diabetic Foot Ulcers (DFU)
The investigators aimed to elucidate the effects of UAW debridement on cellular proliferation and dermal repair in complicated diabetic foot ulcers as compared to diabetic foot ulcers receiving surgical/sharp wound debridement.
- Trial name
- NCT04633642
- Testing
- Ultrasound group, Surgical group
- Where
- 2 sites in Spain
- Volunteers
- 51 people
- Sponsor
- Universidad Complutense de Madrid
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