Clinical trials: Leg Injuries and Disorders
Endothelial Dysfunction
Effect of Local Heat Stress Via Leg Bath on Artery Function
Arteries are flexible in their structure and function and change in response to a variety of factors. Endothelial cells, are the skin type cells that form a layer inside arteries, and they are very important for arterial health.
- Trial name
- HEAT (NCT03618524)
- Testing
- Lower limb hot water immersion
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Leg Ulcer, Diabetic Foot Ulcer
Proof of Concept (Design Validation) in Patient With Hard to Heal Wounds Such as Pressure Ulcer, Diabetic Foot Ulcer and Leg Ulcer, Leia
The purpose of this reseach study is to determine Mölnlycke Health Care´s Leia dressing performance properties is fulfilled and that the dressing is safe when used on wound types such as pressure ulcer, leg ulcer, and diabetic…
- Conditions
- Leg Ulcer, Diabetic Foot Ulcer, Pressure Ulcer
- Trial name
- NCT01966380
- Testing
- Leia
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Molnlycke Health Care AB
Knee Osteoarthritis, Knee Injuries
The Relationship Between Disease Severity and Various Lower Extremity Parameters in Individuals With Knee Osteoarthritis
This study perform to investigate the relationship between quadriceps femoris (QF) strength, QF thickness, femoral cartilage thickness, knee function, balance, kinesiophobia and gait of the patients with knee osteoarthritis.
- Trial name
- NCT05294224
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Dilara Özen Oruk
Diabetic Foot
Nutritional Supplement on Wound Healing in Diabetic Foot
Diabetic foot ulcer (DFU) is the leading cause of non-traumatic limb loss in adult worldwide. One of the major causes of limb loss in patients with DFU is poor wound healing.
- Trial name
- NCT03679273
- Testing
- Abound
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Chang Gung Memorial Hospital
Wound, Diabetic Foot
Effect of the Use of Low Intensity Therapeutic LASER
Diabetes mellitus consists of a heterogeneous group of metabolic disorders that have hyperglycemia in common, resulting from defects in insulin action, insulin secretion, or both.
- Conditions
- Wound, Diabetic Foot, LTBI
- Trial name
- NCT05530486
- Testing
- CC, LG1, LG2
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of Piaui
Anemia, Cardiac Event
Restrictive vs Liberal Transfusion Strategy on Cardiac Injury in Patients Undergoing Surgery for Fractured Neck Of Femur
The investigator wishes to see if it is possible to undertake a study comparing blood transfusion at two different levels of anaemia to see which is best for patients.
- Conditions
- Anemia, Cardiac Event, Kidney Injury, Fractured Hip
- Trial name
- RESULT-NOF (NCT03407573)
- Testing
- Administration of Red Cell
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- NHS Lothian
Wounds, Diabetic Foot Ulcers
Safety and Exploratory Efficacy Study of Collagen Membrane With Mesenchymal Stem Cells in the Treatment of Skin Defects
The purpose of the present study is to evaluate the safety and exploratory efficacy of the medical collagen membrane with umbilical cord derived mesenchymal stem cells in the treatment of patients with skin defects.
- Conditions
- Wounds, Diabetic Foot Ulcers, Burns
- Trial name
- SEESCMMSCTSD (NCT02672280)
- Testing
- Medical Collagen Membrane with MSC, Medical Collagen Membrane
- Volunteers
- 30 people
- Sponsor
- South China Research Center for Stem Cell and Regenerative Medicine
Delirium in Old Age, Hip Fractures
The Efficacy of Music in Preventing Delirium in Elderly Patients With Hip Fracture
The aim of this trial is to explore the efficacy of music in preventing delirium in elderly patients with hip fracture. The main aims of this research are: 1.
- Trial name
- NCT06209788
- Testing
- experimental group
- Volunteers
- 102 people
- Sponsor
- Chang Gung Memorial Hospital
Bone Diseases, Infectious, Musculoskeletal Diseases
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health.
- Conditions
- Bone Diseases, Infectious, Musculoskeletal Diseases, Joint Diseases, Osteoarthritis
- Trial name
- MVMS_MRI (NCT04536103)
- Testing
- MRI
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Xiaojuan Li
Knee Pain, Hip Pain
Effects of Lumbosacral Joint Mobilization/Manipulation on Lower Extremity Muscle Neuromuscular Response
The purpose of this study is to gain a better understanding of the effects of lumbopelvic manual therapy on lower extremity biomechanics and arthrogenic muscle response.
- Conditions
- Knee Pain, Hip Pain, Ankle Pain, Lumbopelvic Pain
- Trial name
- NCT00601341
- Testing
- lumbosacral joint manipulation, lumbar passive range of motion, No active intervention
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Neck of Femur Fracture, Fractures, Bone
A Quality Improvement Project to Assess and Refine the Handover Process at Morning Trauma Meetings
This project was intended to observe the handover of trauma and orthopaedic patients at a district general hospital in the UK. Following the implementation of a standard operating protocol, the handover of patient information…
- Conditions
- Neck of Femur Fracture, Fractures, Bone, Orthopedic Disorder
- Trial name
- NCT04514601
- Testing
- Standard Operating Protocol
- Where
- United Kingdom
- Volunteers
- 317 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Osteoporosis, Osteopenia
A Randomized, Double-Blind Study to Compare the Efficacy of Treatment With Denosumab Versus Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density.
The purpose of this study is to determine whether in postmenopausal women with low bone mineral density, the mean percent change in total hip BMD in subjects receiving denosumab is not less than that observed in subjects…
- Trial name
- NCT00330460
- Testing
- Alendronate, Denosumab
- Volunteers
- 1,189 people
- Sponsor
- Amgen
Tranexamic Acid, Trauma
Tranexamic Acid in Trauma Surgery Tranexamic Acid in Trauma Surgery Tranexamic Acid in Trauma Surgery
This study was done to evaluate the efficacy of Tranexamic Acid (TXA) in reducing blood transfusion requirement in patients of lower limb trauma undergoing surgery.
- Conditions
- Tranexamic Acid, Trauma, Lower Extremity Fracture
- Trial name
- NCT04986813
- Testing
- Tranexamic acid injection, Normal Saline
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Jaspreet Singh
Osteoporosis, Osteoarthritis, Hip
Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)
Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations.
- Conditions
- Osteoporosis, Osteoarthritis, Hip, Hip Fractures, Clonal Hematopoiesis of Indeterminate Potential
- Trial name
- NCT05246813
- Testing
- Blood and bone marrow cell collection
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Imelda Hospital, Bonheiden
Diabetes, Wound Infection
Tissue Penetration of Ceftolozane/Tazobactam in Diabetic Patients With Lower Limb Infections
This study will determine the tissue penetration of ceftolozane/tazobactam (Zerbaxa, Merck \& Co.), a novel β-lactam/β-lactamase combination antibiotic, into the extracellular, interstitial fluid of soft tissue in diabetic…
- Conditions
- Diabetes, Wound Infection, Healthy Volunteers
- Trial name
- NCT02620774
- Testing
- Ceftolozane/tazobactam, Microdialysis Catheter Insertion
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Spinal Cord Injury
Functional Electrical Stimulation (FES) Cycling for Children With Spinal Cord Injuries (SCI)
The overall objective of this research project is to examine the clinical efficacy of lower extremity cycling with functional electrical stimulation to improve the health and fitness of children with spinal cord injuries (SCI).
- Trial name
- NCT00245726
- Testing
- FES Cycle, ES therapy, Passive (Motor Assist) Cycle
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Shriners Hospitals for Children
Diabetic Foot Ulcer, Wound Healing
Systemic Biochemical Signature and Functional Quality Index of Calcaneal Bone Marrow Aspirate in Adults Undergoing Foot or Ankle Surgery
This observational prospective cohort study will evaluate whether routine blood tests are associated with the functional quality of calcaneal bone marrow aspirate mesenchymal stem cells in adults undergoing clinically indicated…
- Conditions
- Diabetic Foot Ulcer, Wound Healing, Foot Ulcer Due to Type 2 Diabetes Mellitus, Diabetes Mellitus Type 2
- Trial name
- IQF-BMA (NCT07802106)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Sao Francisco
Post-Traumatic Osteoarthritis of Ankle, Ankle Osteoarthritis
Indications for Osteochondral Allograft Transplantation
With IRB approval, a prospective single-cohort clinical trial will be performed to assess safety and efficacy of total biologic arthroplasty of the ankle.
- Conditions
- Post-Traumatic Osteoarthritis of Ankle, Ankle Osteoarthritis, Ankle Injuries
- Trial name
- NCT03711747
- Testing
- Osteochondral allograft ankle
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Missouri-Columbia
Lower Limb Injury, Pulmonary Embolism
Assessment of the Impact of TIP Score on Thromboprophylaxis in Patients With Non-surgical Lower Leg Trauma.
Traumatic lesions are the leading causes of admission to the emergency center (39%), isolated non-surgical lower limbs trauma are in the foreground.
- Conditions
- Lower Limb Injury, Pulmonary Embolism, Venous Thromboses
- Trial name
- EvaTIP (NCT03089255)
- Where
- France
- Volunteers
- 196 people
- Sponsor
- University Hospital, Angers
Medial Tibial Stress Syndrome
Comparison of ESWT and Deep Tissue Massage in Individuals With Medial Tibial Stress Syndrome
This study, titled "Comparison of the Effectiveness of Extracorporeal Shock Wave Therapy and Deep Tissue Massage in Individuals with Medial Tibial Stress Syndrome (MTSS)," is designed as a prospective, randomized controlled trial…
- Trial name
- NCT07056426
- Testing
- Exercises, ESWT, Deep Tissue Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Ankara Yildirim Beyazıt University
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