Clinical trials: Leg Lymphoedema
Uterine Cervical Neoplasms, Endometrial Neoplasms
Early Intervention to Prevent Lower Limb Lymphedema of Gynecological Malignancy
This study is a prospective, randomized, controlled clinical trial of a single center in China and plans to enroll 400 patients. 1.
- Conditions
- Uterine Cervical Neoplasms, Endometrial Neoplasms, Lymphedema, Treatment Effectiveness
- Trial name
- NCT05793749
- Testing
- Prophylactic lymphedema treatment
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chongqing University Cancer Hospital
Lymphoedema of Leg, Lymphedema Arm
Added Value of Reconstructive Lymphatic Surgery to Usual Care in Lymphoedema
The primary objective of this research proposal is to investigate in patients with lymphoedema of the upper limb or lower limb (P) the added value of reconstructive lymphatic surgery (I) to the decongestive lymphatic therapy…
- Conditions
- Lymphoedema of Leg, Lymphedema Arm, Lymphedema
- Trial name
- SurLym (NCT05064176)
- Testing
- Usual care, Reconstructive lymphatic surgery
- Where
- 3 sites in Belgium
- Volunteers
- 180 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Endometrial Cancer, Lymphedema
Prevalence of Self Reported Lymphedema in Patients With Endometrial Cancer
The investigators are interested in understanding how the patient has been doing since their surgery for endometrial cancer and if they are experiencing any symptoms related to lymphedema (swelling) in the your lower body.
- Trial name
- NCT02912767
- Testing
- questionnaire
- Where
- United States
- Volunteers
- 625 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lymphoedema
Intermittent Pneumatic Compression for Treating Lower Limb Lymphoedema
The treatment of lymphoedema and its associated complications represent a considerable drain on increasingly limited NHS resources.
- Trial name
- IMPRESS (NCT03825263)
- Testing
- Intermittent Pressure Compression
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of South Wales
Lymphedema, Lymphoedema
Effect of Lymphovenous Anastomosis on Lower Limb Lymphedema: Pragmatic Randomized Controlled Trial
This multicentre pragmatic randomised controlled trial evaluates lymphovenous anastomosis (LVA) for lower-limb lymphedema (LLL) in Denmark.
- Conditions
- Lymphedema, Lymphoedema, Lymphoedema of Leg, Lymphedema of Leg
- Trial name
- NCT07073586
- Testing
- Lymphovenous Anastomosis, Complete Decongestive Therapy
- Where
- 2 sites in Denmark
- Volunteers
- 66 people
- Sponsor
- Herlev and Gentofte Hospital
Gynecologic Cancer-related Lower Extremity Lymphedema, Lymphedema
Comparative Efficacy of 3L and 2L Integrated Techniques for Gynecologic Cancer-related Lower Extremity Lymphedema: a Retrospective Study
The goal of this retrospective study is to evaluate the long-term efficacy of 3L versus 2L integrated techniques in patients with gynecologic cancer-related lower extremity lymphedema (GCR-LEL).
- Trial name
- NCT06920732
- Testing
- VLNT（Vascularized Lymph Node Transfer）, LVA（Lymphaticovenular Anastomosis）, LS（Liposuction）
- Where
- China
- Volunteers
- 125 people
- Sponsor
- Zunyi Medical College
Gynecologic Cancer
Cross-sectional and Questionnaire Study for Leg Lymphedema
The purpose of this study is to identify the incidence,feature,clinical significance for leg lymphedema after gynecologic cancer treatment.
- Trial name
- NCT02069171
- Volunteers
- 333 people
- Sponsor
- National Cancer Center, Korea
Lymphedema
Pedal Pump and Leg Lymphedema
Chronic lymphedema in the lower extremities is a common problem found in older adults that can result in cellulitis, poor wound healing, venous stasis ulcers, and other comorbidities.
- Trial name
- NCT06235463
- Testing
- Osteopathic Pedal Pump, Light Touch Treatment
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Rowan University
Lymphedema of Leg
Establishing Guidelines for Manual Lymphatic Drainage
The purpose of this study is to establish optimal guidelines for Manual Lymphatic Drainage in participants with lower extremity lymphedema.
- Trial name
- MLD (NCT05509062)
- Testing
- Pressure
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Colorado, Denver
Lower Limb Lymphedema, Fibrosis
Effect of Modified Complete Decongestive Therapy on Lower Limbs Fibrosis Post Cellulitis
this study will be designed to investigate the therapeutic benefits of kinesio tape in combination to complete decongestive therapy on limb volume , skin fibrosis, functional capacity ,ankle range of motion, lymphedema associated…
- Conditions
- Lower Limb Lymphedema, Fibrosis, Cellulitis of Leg
- Trial name
- NCT05661123
- Testing
- Complete decongestive therapy
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Lymphedema Lower Extremity
Assessment of the Efficacy of the Dynamic Decongestive System in the Maintenance Phase of Lower Limb Lymphedema
The trial aims to determine whether the dynamic compression device, used in combination with elastic compression garments, is non-inferior to currently available compression devices (CACD) during the maintenance phase of…
- Trial name
- EDYDES-maint (NCT07603531)
- Testing
- Control group: Currently available compression devices, DDS group: Dynamic compression device (DDS)
- Where
- 3 sites in France, Germany
- Volunteers
- 98 people
- Sponsor
- Jean-Paul Belgrado
Lymphedema Lower Extremity
Psychometric Properties of a Lymphedema-specific Quality of Life Questionnaire in Lower Limb Lymphedema
The goal of this observational study is to cross-validate the Lymphedema Functioning, Disability and Health Questionnaire for Lower Limb Lymphedema (Lymph-ICF-LL) in French and to investigate the responsiveness of the original…
- Trial name
- NCT07075549
- Testing
- Maintenance phase of Decongestive Lymphatic Therapy, Intensive phase of Decongestive Lymphatic Therapy
- Where
- 3 sites in Belgium, France
- Volunteers
- 451 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lower Extremity Lymphoedema, Leg Lymphoedema
Treatment Response to Different Lymphoedema Compression Programs Using a Pneumatic Compression Device
Proof of principle study in order to determine if there is a difference in treatment effect across the 3 study groups when treating lower extremity lymphoedema using a pneumatic compression device.
- Trial name
- NCT02031627
- Testing
- pneumatic compression - 1 hour per day, pneumatic compression - 2 hours per day, pneumatic compression - 4 hours per day
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Tactile Medical
Lymphedema, Musculoskeletal Complications
Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg
RATIONALE: Image-guided radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a lower dose of radiation directly to the tumor may kill more tumor cells and cause less damage to…
- Conditions
- Lymphedema, Musculoskeletal Complications, Radiation Fibrosis, Radiation Toxicity
- Trial name
- NCT00589121
- Testing
- Chemotherapy, Radiation therapy, Surgery
- Where
- 17 sites in United States, Canada
- Volunteers
- 98 people
- Sponsor
- Radiation Therapy Oncology Group
Lymphedema, Stage 0 Cervical Cancer
Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer
This randomized phase III trial is studying Flexitouch® home maintenance therapy to see how well it works compared with standard home maintenance therapy in treating patients with lower-extremity lymphedema caused by treatment…
- Conditions
- Lymphedema, Stage 0 Cervical Cancer, Stage 0 Uterine Corpus Cancer, Stage 0 Vulvar Cancer
- Trial name
- NCT00577317
- Testing
- Management of Therapy Complications, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gynecologic Oncology Group
Leg Lymphedema
Comparative Trial in Compression Therapy in Leg Lymphedema
The purpose of this trial is to study the effect of the 3M Coban 2 Layer Compression System (hereafter C2L) in the treatment of leg lymphedema compared to the traditional treatment with Trico bandages.
- Trial name
- NCT00665379
- Testing
- Regular Compression therapy (Trico bandages), New Compression therapy (C2L bandages)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Nij Smellinghe Hosptial
Lymphedema, Obesity & Overweight
TECAR and ESWT in Obesity-Related Lower Limb Lymphedema
This randomized controlled trial evaluates the effectiveness of adding TECAR therapy or extracorporeal shock wave therapy (ESWT) to complex decongestive therapy (CDT) in the treatment of bilateral lower-limb lymphedema in…
- Trial name
- NCT07520942
- Testing
- Complex Decongestive Therapy, TECAR Therapy, Extracorporeal Shock Wave Therapy
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Applied Science Private University
Lower Limb Lymphedema
Development of a Clinical Screening, Diagnostic and Evaluation Tool for Patients With Lower Limb Lymphedema: Aim 2
Lymphedema is a chronic, debilitating disorder characterized by abnormal tissue swelling, adipose deposition and tissue fibrosis, resulting from disruption, blockage, or genetic abnormalities of the lymphatic system.
- Trial name
- EvaLymph-Leg2 (NCT05421377)
- Testing
- clinical assessment
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- KU Leuven
Post Thrombotic Syndrome
Treatment Trial for Post-Thrombotic Syndrome
The purpose of this study is to determine if complex lymphedema therapy is effective in decreasing disease severity and improving quality of life in patients with post thrombotic syndrome.
- Trial name
- NCT00633971
- Testing
- complex lymphedema therapy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Vermont
Urogenital Cancer, Lower Limb Lymphedema
Lymphoedema and Nocturia/Nocturnal Polyuria After Pelvic LND for Urogenital Cancer
After the treatment of urogenital cancer, a person may develop lymphoedema of the leg(s) and/ or midline region. Clinical symptoms include abnormal tissue swelling, sensation of limb heaviness, erythema, pain, and impaired limb…
- Conditions
- Urogenital Cancer, Lower Limb Lymphedema, Nocturia, Nocturnal Polyuria
- Trial name
- UroLymph (NCT05300308)
- Testing
- usual care
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven