Clinical trials: Leg Lymphoedema
Lymphedema
Comfort Subcutaneous Drainage: a Descriptive Study Among Palliative Phase Cancer Patients
Physical embarrassment, pain and psychological impact linked to the body image distortion are often associated to these lymphedemas.
- Trial name
- NCT02494115
- Testing
- subcutaneous drainage
- Where
- 3 sites in France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Lower Extremity Lymphedema
Lipid Peroxidation and Options Antioxidant Therapy for Secondary Lymphedema of the Lower Extremities
A single-center, open, prospective, randomized, controlled clinical trial will include 120 patients with lower limb lymphedema who undergo treatment in an office-based vascular lab at the Ryazan regional clinical cardiology…
- Trial name
- NCT04360889
- Testing
- Micronised purified flavonoid fraction (diosmin+flavonoids expressed as hesperidin), Tocopherol, Elastic compression
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ryazan State Medical University
Primary Lower Limb Lymphedema, Secondary Lower Limb Lymphedema
Pilot Efficacy Study of the Stendo Pulsating Suit in Patient With Leg Lymphoedema
This study aims at evaluating the efficacy of the Stendo pulsating suit in patients with a leg lymphedema hospitalized for intensive Complex Decongestive Physiotherapy (CDP).
- Trial name
- NCT02234674
- Testing
- Current intensive CDP, intensive CDP where Stendo pulsating suit replaces pressotherapy
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Stendo
Lower Limb Lymphedema
Development of a Clinical Screening, Diagnostic and Evaluation Tool for Patients With Lower Limb Lymphedema: Aim 3
The current best practice is a three-stage classification consensus guideline as published by the International Society of Lymphology (ISL).
- Trial name
- EvaLymph-Leg3 (NCT05757284)
- Testing
- Lower Limb Lymhedema assessment
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 140 people
- Sponsor
- KU Leuven
Lymphedema of Leg, Lymphedema
Inspiratory and Calf Muscles Training in Patients With Leg Lymphedema
Lymphedema results in the accumulation of protein-rich fluid in the subcutaneous tissue as a result of the failure of the lymphatic system, which returns water and protein in the interstitial spaces to the bloodstream.
- Conditions
- Lymphedema of Leg, Lymphedema, Exercise
- Trial name
- NCT05609526
- Testing
- Compression Therapy, Inspiratory muscle training, Calf muscle exercise training
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Lymphedema of Leg, Gynecologic Cancer
Effectiveness of Two Exercises in Preventing Lower-Limb Lymphedema After Gynecological Cancer Surgery
Background: Lower-limb lymphedema is one of the complications after gynecological cancer surgery. Patients with lymphedema are more likely to limit their daily life activities and become inactive, leading to negative influences…
- Conditions
- Lymphedema of Leg, Gynecologic Cancer, Exercise
- Trial name
- NCT05666947
- Testing
- Home-based exercise
- Volunteers
- 60 people
- Sponsor
- Yu-Yun Hsu
Cellulitis/Erysipelas of the Leg
RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg
To assess whether a period of prophylactic penicillin after an episode of cellulitis of the leg reduces the risk of repeat episodes. Participants are randomised to receive 12 months of prophylaxis (penicillin VK 250mg b.d.
- Trial name
- PATCH1 (NCT00552799)
- Testing
- Penicillin VK
- Where
- 25 sites in Ireland, United Kingdom
- Volunteers
- 274 people
- Sponsor
- University of Nottingham
Lymphedema of Leg, Sensitisation
Effects of Complex Decongestive Therapy on Proprioception, Balance and Tactile Sense
The aim of this study is to investigate the effects of complex decongestive physiotherapy (CDP) on propriseception, balance and sensation in patients with secondary lymphedema that develops in the lower extremities after cancer…
- Conditions
- Lymphedema of Leg, Sensitisation, Balanced, Therapy-Associated Cancer
- Trial name
- NCT06204510
- Testing
- complex decongestive therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Selcuk University
Primary Lymphedema, Aerobic Exercise
The Effects of Aerobic Exercise in Patients With Primary Lower Extremity Lymphedema
Our aim in this study is to evaluate the effects of lymphedema on exercise capacity, body composition, functional level and quality of life in lymphedema patients with primary lower extremity involvement.
- Trial name
- NCT06327412
- Testing
- Aerobic exercise on the treadmill, Walking between 12-13 RPE (The Borg Rating of Perceived Exertion) according to the Modified Borg Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Kayseri City Hospital
Lower Limb Lymphedema
Development of a Clinical Screening, Diagnostic and Evaluation Tool for Patients With Lower Limb Lymphedema: Aim 4
Research investigating measurement properties for evaluating the decongestive treatment effect on different edema characteristics (e.g.
- Trial name
- EvaLymph-Leg4 (NCT06038864)
- Testing
- 2 clinical evaluations with 1 month in between
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 120 people
- Sponsor
- KU Leuven
Lymphedema, Lymphedema Lower Extremity
Study to Evaluate the Safety and Effectiveness of Dayspring for Lower Extremity Lymphedema
A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of Koya Dayspring Active Wearable Compression Technology for Treating Lower Extremity Lymphedema
- Conditions
- Lymphedema, Lymphedema Lower Extremity, Chronic Venous Insufficiency, Secondary Lymphedema
- Trial name
- TIBER (NCT04897035)
- Testing
- Dayspring Active Wearable Compression System
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Koya Medical, Inc.
Lower Extremity Lymphedema
Aerobic Exercise Effects in Lower Extremity Lymphedema
Lower extremity lymphedema negatively affects patients' functional status, quality of life, and activities of daily living. Complete decongestive therapy (CDT) is considered the gold-standard conservative treatment for patients…
- Trial name
- NCT07726277
- Testing
- aerobic exercise program, complet decongestive therapy
- Volunteers
- 50 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Lymphedema of Leg
Hydrophobic Tubes for the Treament of Lower and Upper Limb Lymphedema
Lymphedema is a chronic condition causing fluid buildup in affected limbs. Traditional treatments often fall short, but subcutaneous implantation of hydrophobic silicone tubes shows promise, creating artificial drainage pathways.
- Trial name
- NCT05970068
- Testing
- implantation of hydrophobic tubes for edema fluid drainage, Best Medical Treatment
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- Universidade do Porto
Lymphedema, Lower Limb Lymphedema
Tissue Elastography Assessement and Cuteous and Cubcutaneous Thickness Measurement Following Manual Lymph Drainage in Legs With Lymphedema
Tissue Elastography Assessement and Cuteous and Cubcutaneous Thickness Measurement Following Manual Lymph Drainage in Legs With Lymphedema Hence the importance of evaluating the impact of an intensive five-day decongestive…
- Trial name
- ELASTOLYMPH (NCT05186142)
- Testing
- Ultrasonography / Ultrasound elastography
- Where
- France
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier