Clinical trials: Leg Pain, open to volunteers
Chronic Insomnia, Chronic Pain
Lemborexant vs Clonidine vs Sedatives to Treat Insomnia in Chronic Pain Patients
Prospective observational crossover study of 250 adults undergoing chronic pain management. For insomnia treatment, patients alternate their usual prescribed sedative versus Lemborexant or Clonidine; on alternate nights.
- Conditions
- Chronic Insomnia, Chronic Pain, Restless Leg Syndrome (RLS), Substance Abuse
- Trial name
- NCT05618002
- Testing
- Lemborexant
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Salem Anaesthesia Pain Clinic
Leg Ulcer
Topical Sevoflurane for Treatment of Chronic Leg Ulcers
Patients with painful non-healing leg ulcer will be enrolled in the clinical single-blinded randomized study. The active treatment group will have sevoflurane applied at approximately 1 ml/cm2 at the start of wound treatment, the…
- Trial name
- NCT05303805
- Testing
- Sevoflurane, Cyteal
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Chemotherapy-induced Peripheral Neuropathy, Chemotherapy-induced Neuropathic Pain
Analgesic Efficacy and Safety of Topical VMD-3866 Gel in Management of Pain Induced by Chemotherapy (CIPN)
Peripheral neuropathy is a disorder caused by damage to the peripheral nerves. Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of certain chemotherapy drugs, such as platinum-based compounds, taxanes…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Chemotherapy-induced Neuropathic Pain, CIPN - Chemotherapy-Induced Peripheral Neuropathy, Peripheral Neuropathic Pain
- Trial name
- NCT07072468
- Testing
- VMD-3866 Gel
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- VM Therapeutics LLC
Lumbosacral Radicular Pain, Sciatic Radiculopathy
Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy
The purpose of this study is to evaluate the safety and tolerability of C-1101 administered as a single dose, transforaminal epidural injection compared to sterile saline
- Conditions
- Lumbosacral Radicular Pain, Sciatic Radiculopathy, Sciatic Leg Pain, Sciatica
- Trial name
- NCT07264270
- Testing
- C-1101
- Where
- 6 sites in United States, Australia
- Volunteers
- 24 people
- Sponsor
- Consano Bio
Chronic Pain, Chronic Pain Due to Injury
Virtual Pain Education for Spinal Cord Stimulation Patients
Chronic pain is a leading cause of disability in the United States. When standard treatments fail, many patients develop treatment resistant pain and undergo Spinal Cord Stimulation (SCS) therapy.
- Conditions
- Chronic Pain, Chronic Pain Due to Injury, Failed Back Syndrome, Persistent Spinal Pain Syndrome
- Trial name
- SCS-PNE (NCT07743905)
- Testing
- SCS-PNE intervention
- Volunteers
- 50 people
- Sponsor
- University of Arkansas
Degenerative Disc Disease, Spine Fusion
MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion
This is a phase IV post-marketing study for MagnetOs Flex Matrix. MagnetOs Flex Matrix is a synthetic bone graft extender product that is routinely used by surgeons as a treatment for patients with degenerative disc disease and…
- Conditions
- Degenerative Disc Disease, Spine Fusion, Leg Pain and/or Back Pain
- Trial name
- PRECISE (NCT05037968)
- Testing
- MagnetOs Flex Matrix, Trinity Elite
- Where
- 9 sites in United States
- Volunteers
- 100 people
- Sponsor
- Kuros Biosurgery AG
Chronic Pain, Intractable Pain
Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control
Study to evaluate the effectiveness of time variant pulse (TVP)-SCS in patients with chronic pain using commercially approved Boston Scientific SCS Systems per local Instructions for use (IFU).
- Conditions
- Chronic Pain, Intractable Pain, Low Back Pain, Chronic Low-back Pain
- Trial name
- MOSAIC (NCT07190807)
- Testing
- Boston Scientific WaveWriter Alpha™ SCS Systems
- Where
- 7 sites in United States
- Volunteers
- 70 people
- Sponsor
- Boston Scientific Corporation
Achilles Injuries Tendon, Achilles Tendinopathy (AT)
Extracorporeal Shockwave Therapy and Platelet-Rich Plasma for Midportion Achilles Tendinopathy
Midportion Achilles tendinopathy is a common cause of pain and functional limitation in both athletes and the general population.
- Conditions
- Achilles Injuries Tendon, Achilles Tendinopathy (AT), Achilles Tendinitis, Left Leg, Achilles Tendinitis, Right Leg
- Trial name
- NCT07483320
- Testing
- Platelet Rich Plasma, Extracorporeal Shockwave Therapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Spaulding Rehabilitation Hospital
Lumbosacral Radicular Pain, Lumbar Radiculopathy
Determination of Sensitivity and Specificity of Straight Leg Raise Test Via Transforaminal Nerve Root Block
This study aims to evaluate the diagnostic accuracy of the straight leg raise test in patients with suspected lumbosacral radicular pain.
- Conditions
- Lumbosacral Radicular Pain, Lumbar Radiculopathy, Straight Leg Raise
- Trial name
- NCT07696312
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Marmara University
Edema Leg, Pain
Does Edema Affect the Adjustment of TENS Amplitude
The goal of this pre-post clinical trial is to compare the amplitude settings of three different frequency TENS modes (Conventional TENS, LF TENS, HF TENS) in patients who had undergone total knee arthroplasty, both with the…
- Trial name
- NCT06153277
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people
- Sponsor
- Karamanoğlu Mehmetbey University
Sciatic Leg Pain, Hamstring Muscle Tightness
Acute Effects of Neurodynamics on Strength and Endurance in Athletes
This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population.
- Conditions
- Sciatic Leg Pain, Hamstring Muscle Tightness, Hamstring Muscle Strain, Hamstring Muscle Strength
- Trial name
- NCT07721220
- Testing
- Sciatic Slider, Sciatic Tensioner, Mechanically loaded neurodynamic sciatic floss
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- High Point University
Lumbar Adjacent Spinal Stenosis, Chronic Low Back and Leg Pain
The Lumbar Adjacent Segment Stenosis Trial
The goal of this clinical trial is to learn if there are differences in the effectiveness of decompression surgery alone versus decompression combined with extended fusion in patients with a previous lumbar spinal fusion who now…
- Trial name
- LASS (NCT07670533)
- Testing
- Decompression alone, Decompression with extended fusion
- Where
- 3 sites in Norway
- Volunteers
- 192 people
- Sponsor
- Oslo University Hospital
Restless Leg Syndrome in Pregnancy
Comparative Effects of Aerobic and Muscle Relaxation Exercises in Pregnant Women With Restless Leg Syndrome
This study will be a randomized controlled trial and will be conducted in the Gynecology and Physiotherapy departments of Valencia Health Clinic, Lahore. Non-probability purposive sampling will be used to collect data.
- Trial name
- NCT07628387
- Testing
- aerobic exercises, progressive muscle relaxation
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Sciatica, Lumbar Radiculopathy
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments.
- Conditions
- Sciatica, Lumbar Radiculopathy, Lower Back Pain, Degenerative Disc Disease
- Trial name
- NCT04982965
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cellulitis of Leg
Cellulitis Optimal Antibiotic Treatment
To determine whether a short course of oral flucloxacillin (5 days) is non-inferior to a standard course (7 days) in terms of pain over days 6-14 (indicative of persistence or recurrence associated with the symptoms of most…
- Trial name
- COAT (NCT05584007)
- Testing
- Flucloxacillin Only Product in Oral Dose Form
- Where
- United Kingdom
- Volunteers
- 334 people
- Sponsor
- University of Southampton
Low Back Pain, Leg Pain and/or Back Pain
Sciatic Neural Mobilization in Lumbar-Related Leg Pain
Low back pain is one of the most prevalent musculoskeletal disorders worldwide and significantly reduces individuals' quality of life, functional capacity, and productivity.
- Trial name
- NCT07588919
- Testing
- Sciatic neural mobilization
- Volunteers
- 52 people
- Sponsor
- Istinye University
Varicose Veins Leg, Great Saphenous Vein Insufficiency
Calcium Dobesilate After Radiofrequency Ablation for Varicose Veins
This study evaluates whether calcium dobesilate, a venoactive drug, improves recovery after radiofrequency ablation (RFA) for varicose veins.
- Conditions
- Varicose Veins Leg, Great Saphenous Vein Insufficiency, Chronic Venous Insufficiency
- Trial name
- NCT07390097
- Testing
- calcium dobesilate
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Oguz Arslanturk
Pain, Procedural, Analgesia
Procedural Sedation and Analgesia for Treatment of Adults With Fractures and Dislocations in the Emergency Department
The goal of this observational study is to evaluate the effectiveness and safety of different procedural sedation and analgesia methods used for adults with painful fractures requiring reduction treatment in the emergency…
- Conditions
- Pain, Procedural, Analgesia, Extremity Injury, Patient Satisfaction
- Trial name
- PAINEX (NCT07314450)
- Testing
- Usual Care
- Where
- 3 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Region Zealand
Restless Leg Syndrome (RLS)
Combined Effects of Near-Infrared Light and Vibration on Diabetic Patients With Restless Leg Syndrome
This Randomized Clinical Trial, titled "Combined Effects of Near-Infrared Light and Vibration on Pain, Sleep Quality and Symptom Severity in Diabetic Patients with Restless Leg Syndrome," aims to evaluate a non-pharmacological…
- Trial name
- NCT07308080
- Testing
- Near-Infrared Light Therapy, Vibration, Conventional Physical Therapy
- Volunteers
- 42 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Debridement Care, Leg Ulcer
Effectiveness of Musicotherapy in Reducing Pain Induced by Leg Ulcer Care
Venous leg ulcer is the final stage of chronic venous disease and only develops due to advanced chronic venous insufficiency. The problems caused by venous disease are initially minor and often neglected, but can impact the…
- Conditions
- Debridement Care, Leg Ulcer, Leg Ulcers Venous, Pain
- Trial name
- MUS-ICAT (NCT06153589)
- Testing
- Musicotherapy
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital Center of Martinique