Clinical trials: Leiomyomas, active
Infertility, In Vitro Fertilization (IVF)
The Impact of Myomectomy on IVF Outcomes: A Multicenter Randomized Controlled Trial
Uterine fibroids are the most common benign tumors of the female reproductive system and are frequently encountered in women of reproductive age.
- Conditions
- Infertility, In Vitro Fertilization (IVF), Uterine Myomas, Leiomyomas, or Fibromas
- Trial name
- MIO (NCT07578623)
- Testing
- Myomectomy
- Volunteers
- 792 people
- Sponsor
- Peking Union Medical College Hospital
Abnormal Uterine Bleeding, Unspecified, Benign Gynecological Disease
The Learning Curve of a Gynecology and Obstetrics Resident Performing Vaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) Hysterectomy in a University Hospital
This prospective observational study aims to evaluate the learning curve of obstetrics and gynecology residents performing Vaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) hysterectomy in a university hospital…
- Conditions
- Abnormal Uterine Bleeding, Unspecified, Benign Gynecological Disease, Adenomyosis of Uterus, Uterine Leiomyomas
- Trial name
- LC of V-NOTES (NCT07465822)
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people
- Sponsor
- Cukurova University
Advanced Kidney Carcinoma, Advanced Renal Cell Carcinoma
Mercaptopurine for the Treatment of Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC), Uterine/Cutaneous Leiomyomas, and Kidney Cancer
This phase I/II trial studies the side effects and best dose of mercaptopurine, and to see how well it works in treating patients with hereditary leiomyomatosis and renal cell carcinoma (HLRCC).
- Conditions
- Advanced Kidney Carcinoma, Advanced Renal Cell Carcinoma, Hereditary Leiomyomatosis and Renal Cell Carcinoma, Metastatic Kidney Carcinoma
- Trial name
- NCT07716735
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Pregnancy Related, Pregnancy Complications
MYFEMBREE®: A Retrospective Cohort Study Using an Administrative Healthcare Database to Assess Pregnancy Outcomes in Women Treated With Relugolix Combination Therapy
This is a retrospective cohort study that will be conducted using secondary de-identified electronic healthcare data (EHD) that originally were collected for the purposes of health insurance billing and/or routine patient care…
- Conditions
- Pregnancy Related, Pregnancy Complications, Pregnancy, High Risk
- Trial name
- NCT05739136
- Testing
- Relugolix + Estradiol + Norethindrone Acetate
- Where
- United States
- Volunteers
- 530 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
Postoperative Pain After Uterine Fibroid Embolization, Uterine Fibroids (UF)
Transmucosal Uterosacral Electrical Stimulation for Pelvic Pain Relief
This study will test whether gentle electrical stimulation to nerves near the uterus can reduce pelvic pain after uterine fibroid embolization.
- Conditions
- Postoperative Pain After Uterine Fibroid Embolization, Uterine Fibroids (UF), Uterine Fibroids, Pelvic Pain
- Trial name
- TUNES (NCT07501676)
- Testing
- TUNES (Transmucosal Uterosacral Electrical Stimulation)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Weill Medical College of Cornell University
Leiomyoma, Uterine, Leiomyoma
Prescription of Letrozole for Uterine Myoma
The PLUM Study is a randomized, double-blinded, 2-arm, parallel-group, placebo-controlled trial is designed to compare the efficacy of letrozole versus placebo on leiomyoma-related symptoms and quality of life as well as…
- Conditions
- Leiomyoma, Uterine, Leiomyoma, Fibroid, Fibroid Uterus
- Trial name
- PLUM (NCT06143631)
- Testing
- Letrozole 2.5mg
- Where
- 5 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Leiomyoma, Uterine
FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea
The objective of this study is to determine the effect of low caffeine green tea extract containing 45% epigallocatechin gallate (EGCG) on fibroids and subsequent pregnancy and live births in women seeking fertility treatment.
- Trial name
- FRIEND (NCT05364008)
- Testing
- Green Tea Extract
- Where
- 4 sites in United States
- Volunteers
- 33 people
- Sponsor
- Yale University
Menstrual Irregularity
Sonographic Evaluation Of Uterine Fibroids At Different Locations In Patient With Irregular Menstrul Cycle
Uterine fibroids are a major cause of illness in women of a reproductive age. There are many factors involved in the growth and reduction of these common tumors.
- Trial name
- NCT06768879
- Testing
- Ultrasound
- Where
- Pakistan
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Superior University
Pregnancy Related, Pregnancy Complications
Relugolix Pregnancy Registry: An Observational Study of the Safety of Relugolix-Containing Therapy Exposure in Pregnant Women and Their Offspring
The Relugolix Pregnancy Registry is a prospective, observational cohort study designed to evaluate the association between relugolix-containing therapy exposure during pregnancy and subsequent maternal, fetal, and infant…
- Conditions
- Pregnancy Related, Pregnancy Complications, Pregnancy, High Risk
- Trial name
- NCT05739123
- Testing
- Relugolix-Containing Product
- Where
- United States
- Volunteers
- 728 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
Menorrhagia, Uterine Fibroids
to Evaluate the Efficacy and Safety of KLH-2109 in Patients With Uterine Fibroids and Menorrhagia
The goal of this clinical trial was to determine whether the investigational drug KLH-2109 is effective for treating excessive menstrual bleeding in patients with uterine fibroids.
- Trial name
- NCT07378098
- Where
- South Korea
- Volunteers
- 254 people
- Sponsor
- JW Pharmaceutical
Fibroid Uterus
The Effects of One-time Intraoperative Methadone During Laparoscopic Hysterectomy in Reducing Opioid Prescription.
Currently, there is a nationwide epidemic of opioid abuse and overdose deaths. One source of excess opioids is overprescribing in the postoperative period.
- Trial name
- NCT06536517
- Testing
- Methadone
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Uterine Fibroids, Hysterectomy
Predictors of Success and Failure of v-NOTES Hysterectomy for Large and Very Large Uteri
Uterine fibroids are the most common benign tumors in women of reproductive age and are a major indication for hysterectomy. This retrospective, single-center observational study aims to identify factors associated with the…
- Conditions
- Uterine Fibroids, Hysterectomy, Vaginal Natural Orifice Transluminal Endoscopic Surgery (v-NOTES)
- Trial name
- PRE v-NOTES (NCT07895953)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Surgery
LapBox® Manual Containment System
This study to evaluate the leak integrity of the LapBox Manual Containment System for laparoscopic hysterectomy and myomectomy. The goal is to determine the integrity of this containment system in order to increase surgical…
- Trial name
- NCT07767968
- Testing
- LapBox Manual Containment System, Standard of Care Specimen Bag
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Wisconsin, Madison
Uterine Fibroids
Phase III Study of MR-Guided Focused Ultrasound Surgery for the Treatment of Uterine Fibroids Compared to Myomectomy
The aim of the study is to answer the question, whether in patients with symptomatic and medically not sufficiently treatable uterine fibroids (population) the "Magnetic-Resonance-Guided Focused Ultrasound Surgery" short…
- Trial name
- NCT03948789
- Testing
- Magnetic Resonance Imaging-controlled high-focussed ultrasound therapy, Myomectomy (laparoscopic or open surgical)
- Where
- 4 sites in Germany
- Volunteers
- 127 people
- Sponsor
- Krankenhaus Nordwest
Fibroid, Uterine Corpus Smooth Muscle Neoplasm
Evaluation of Ultrasound-guided Transuterine Vaginal Biopsy Technique in Uterine Fibromatous Disease
The goal of this diagnostic, prospective study is to evaluate an innovative, minimally invasive surgical technique for diagnosing uterine smooth muscle tumors by biopsy, in women aged 18 and more, and to evaluate complications…
- Trial name
- EFIBIA (NCT06576362)
- Testing
- Echoguided transuterine vaginal biopsy performed before myomectomy or hysterectomy
- Volunteers
- 250 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Postoperative Pain, Fibroid Uterus
QL Block in Laparoscopic Myomectomy
This study aims to determine the efficacy of a quadratus lumborum (QL) block in decreasing postoperative pain in patients undergoing myomectomy for uterine fibroids.
- Trial name
- NCT05979493
- Testing
- Bupivacain, Saline
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Joseph Findley MD
Uterine Fibroid
Epidemiology and Risk Factors of Uterine Fibroids in China
Uterine fibroids are the most common form of benign uterine tumors in the uterine muscle layer, which had a certain rate of malignancy, but it is rare.
- Trial name
- NCT05840042
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Wenwen Wang
Leiomyoma (Uterine Fibroids)
Prospective Study of TVRFA Treatment for FIGO Type 3-5 Uterine Fibroids
This study evaluates the effectiveness and safety of transvaginal radiofrequency ablation of myomas (TVRFAM), a minimally invasive treatment for uterine fibroids performed at our clinic as part of the study.
- Trial name
- NCT07923253
- Testing
- Radiofrequency ablation alone
- Where
- Serbia
- Volunteers
- 50 people
- Sponsor
- University of Novi Sad
Adenomyosis, Fibroid Uterus
Fertility Limiting Diseases of Pelvic Organs and Their Influence on Receptivity of Endometrial Cavity: Prospective Clinical Trial
In this project, we will characterize the effects of fertility limiting diseases of pelvic organs on the receptivity of the endometrium.
- Conditions
- Adenomyosis, Fibroid Uterus, Endometriosis
- Trial name
- REAdME (NCT06991595)
- Testing
- cytoreductive resection of adenomyosis, myomectomy, resection of endometriosis, hysteroscopy
- Where
- Czechia
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Cervical Cancer, Endometrial Cancer
Specimen and Data Study for Ovarian Cancer Early Detection and Prevention
RATIONALE: To improve strategies for detection and prevention of early-stage disease. PURPOSE: This research study is collecting specimens and data to develop better methods for early detection and prevention of ovarian cancer…
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Hereditary Breast/Ovarian Cancer (brca1, brca2)
- Trial name
- NCT00005095
- Testing
- Ca-125, screening questionnaire administration, Surgery
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Northwestern University