Clinical trials: Leishmaniasis, Cutaneous
Leishmaniasis
Topical Liposomal Amphotericin B Gel Treatment for Cutaneous Leishmaniasis
Comparison between placebo gel treatment to topical liposomal amphotericin B gel treatment for cutaneous leishmaniasis of Leishmania species major and tropica.
- Trial name
- NCT02656797
- Testing
- Topical Amphotericin-B 0.4% liposomal gel
- Where
- Israel
- Volunteers
- 13 people
- Sponsor
- Soroka University Medical Center
Cutaneous Leishmaniasis
Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis
Cutaneous leishmaniasis is a worldwide disease, endemic in 88 countries, that has shown an increasing incidence over the last two decades.
- Trial name
- NCT00317629
- Testing
- controlled nitric oxide releasing patch, meglumine antimoniate
- Where
- Colombia
- Volunteers
- 178 people
- Sponsor
- Fundación Cardiovascular de Colombia
Cutaneous Leishmaniases
Cutaneous Leishmaniasis Diagnostic Study
The performance of the CL Detect Rapid test will be tested in individuals with suspected cutaneous leishmaniasis in Ethiopia using both skin slit and dental broach samples against a combined reference of microscopy and PCR.
- Trial name
- NCT03837431
- Testing
- Skin slit, Dental broach, Tape disc
- Where
- Ethiopia
- Volunteers
- 351 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Cutaneous Leishmaniasis
Safety and Efficacy of Azithromycin to Treat Cutaneous Leishmaniasis
The adequate treatment of the American tegumentary leishmaniasis is crucial since the disease, differently from the caused by the Old World species, is painful and not self-healing and may lead to the disfiguring mucosal…
- Trial name
- PCL01 (NCT00682656)
- Testing
- Glucantime®, Zithromax ®
- Where
- 3 sites in Brazil
- Volunteers
- 48 people
- Sponsor
- Ana Rabello
Leishmaniasis, Cutaneous, Leishmania Braziliensis Complex
Topical Paromomycin for Cutaneous Leishmaniasis in Bolivia
This protocol will compare topical paromomycin to standard intralesional (IL) antimony (Sb) to placebo for L braziliensis in Bolivia.
- Conditions
- Leishmaniasis, Cutaneous, Leishmania Braziliensis Complex, Leishmaniasis, American, Leishmaniasis; American, Cutaneous
- Trial name
- NCT03096457
- Testing
- Paromomycin Sulfate, Pentamidine Isethionate
- Where
- 2 sites in Bolivia
- Volunteers
- 80 people
- Sponsor
- Fundacion Nacional de Dermatologia
Cutaneous Leishmaniasis
Efficacy and Safety of Miltefosine or Thermotherapy for Cutaneous Leishmaniasis in Colombia.
Cutaneous leishmaniasis (CL) is a worldwide disease, endemic in 88 countries, that has shown an increasing incidence the last two decades. It is estimated that in 2005, about of 20,000 new cases of CL were diagnosed in Colombia.
- Trial name
- NCT00471705
- Testing
- Miltefosine, Thermotherapy, Glucantime®
- Where
- Colombia
- Volunteers
- 437 people
- Sponsor
- Universidad de Antioquia
Cutaneous Leishmaniases
Efficacy and Safety of Pentamidine (7mg/kg) for Patients With Cutaneous Leishmaniasis Caused by L. Guyanensis
Introduction: Up to the present, have been few studies with pentamidine in the Americas; and there is no consensus regarding the dose used.
- Trial name
- NCT02919605
- Testing
- Single dose of Pentamidine, Two doses of Pentamidine, Three doses of Pentamidine
- Volunteers
- 159 people
- Sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Cutaneous Leishmaniasis
Phase 3 Study of Walter Reed (WR) 279,396 and Paromomycin Alone for the Treatment of Cutaneous Leishmaniasis in Panama
This study is a pivotal Phase 3, randomized, double-blind, 3-site, two-group trial assessing the efficacy and safety of WR 279,396 Topical Cream and Paromomycin Alone Topical Cream in subjects with CL in Panama.
- Trial name
- NCT01790659
- Testing
- WR 279,396, Paromomycin
- Where
- Panama
- Volunteers
- 399 people
- Sponsor
- U.S. Army Medical Research and Development Command
Cutaneous Leishmaniases, Treatment Adherence
Study of Cases of Cutaneous Leishmaniasis Treated With Miltefosine in French Guiana, Retrospective Study
Miltefosine is the only oral treatment currently available for Cutaneous Leishmaniasis. Despite several reports of good efficiency in other countries of South America, miltefosine remains limited to a compassionate use in France.
- Conditions
- Cutaneous Leishmaniases, Treatment Adherence, Primary Health Care, Drug Evaluation
- Trial name
- MILT2022 (NCT05493059)
- Testing
- Data collection, Questionnaires
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier de Cayenne
Leishmaniasis, Cutaneous
A Study of a New Leishmania Vaccine Candidate ChAd63-KH
This is a study to assess the safety of a new candidate Leishmania vaccine ChAd63-KH in patients with persistent post kala azar dermal leishmaniasis (PKDL).
- Trial name
- Leish2a (NCT02894008)
- Testing
- ChAd63-KH
- Where
- Sudan
- Volunteers
- 24 people
- Sponsor
- University of York
Leishmaniasis, Leishmaniasis, Mucocutaneous
Clinical Trial of Miltefosine to Treat Mucosal Leishmaniasis
The purpose of this study is to determine whether miltefosine is effective in the treatment of mucosal leishmaniasis compared to meglumine antimoniate, the standard treatment.
- Trial name
- NCT01377974
- Testing
- Miltefosine, Standard Treatment Meglumine antimoniate
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Brasilia University Hospital
Cutaneous Leishmaniasis, American
Tofacitinib Associated With Meglumine Antimoniate in Cutaneous Leishmaniasis
Phase 2/3 randomized and controlled clinical trial, which will evaluate the effectiveness of the association meglumine antimoniate (Glucantime) with tofacitinib in the cure of CL and the capacity of this association to reduce the…
- Trial name
- CLTofa23 (NCT06011343)
- Testing
- Oral tofacitinib, Parenteral meglumine antimoniate
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- Hospital Universitário Professor Edgard Santos
Leishmaniasis, Cutaneous
Evaluation of a Diagnostic Device, CL Detect™ Rapid Test, for the Diagnosis of Cutaneous Leishmaniasis in Peru
Determine the sensitivity and specificity of the FDA-cleared CL Detect™ Rapid Test in Peru, using a test procedure that was modified from that described in the device instructions to optimize these parameters for the detection of…
- Trial name
- NCT03762070
- Testing
- CL Detect™ Rapid Test
- Where
- 2 sites in Peru
- Volunteers
- 200 people
- Sponsor
- Naval Medical Research Center
Leishmaniasis, Cutaneous
Study to Evaluate the Leish-111F + MPL-SE Vaccine in the Treatment of Cutaneous Leishmaniasis
This study will evaluate the safety of the Leish-111f + MPL-SE vaccine in adult patients with cutaneous leishmaniasis.
- Trial name
- NCT00111553
- Testing
- Leish-111f + MPL-SE vaccine
- Where
- 2 sites in Brazil
- Volunteers
- 45 people
- Sponsor
- Access to Advanced Health Institute (AAHI)
Cutaneous Leishmaniasis
Efficacy of Topical Liposomal Form of Drugs in Cutaneous Leishmaniasis
Leishmaniasis with diverse clinical manifestations is caused by different species of Leishmania and is endemic in many countries. Although Cutaneous Leishmaniasis (CL) is a self-healing disease, but it takes a long time to heal.
- Trial name
- NCT01050777
- Testing
- Liposomal meglumine antimoniate (Glucantime), Liposomal meglumine antimoniate, Liposomal Paromomycin
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Tehran University of Medical Sciences
Mucosal Leishmaniasis, Mucocutaneous Leishmaniasis
Low Antimonial Dosage in American Mucosal Leishmaniasis
"Phase III clinical trial for mucosal or mucocutaneous leishmaniasis. Equivalence between the standard and alternative schemes with meglumine antimoniate" has begun in October 2008 at the Laboratory of Leishmaniasis Surveillance…
- Trial name
- NCT01301937
- Testing
- Meglumine antimoniate
- Where
- Brazil
- Volunteers
- 76 people
- Sponsor
- Oswaldo Cruz Foundation
Leishmaniasis, Cutaneous
Development of Topical Herbal Formulations for Treatment of Cutaneous Leishmaniasis
Infections due to protozoa of the genus Leishmania are a major worldwide skin problem, with high endemicity in developing countries including Pakistan.
- Trial name
- NCT04841239
- Testing
- Herbal topical formulation
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Jinnah Sindh Medical University
Skin Diseases
Evaluation of CL Detect™ Rapid Test to Detect Cutaneous Leishmaniasis
This study is a single-site trial assessing the specificity of CL Detect™ Rapid Test versus the gold standard for Leishmania diagnosis in the US which is microscopic identification of Leishmania amastigotes in a stained lesion…
- Trial name
- NCT01865032
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- U.S. Army Medical Research and Development Command
Leishmaniasis, Cutaneous
Investigation of an Outbreak Situation of Cutaneous Leishmaniasis Among Military Personnel in French Guiana (CEFELEISH)
Clinical, epidemiological, therapeutic and microbiological investigation of an outbreak of cutaneous Leishmaniasis that occurred among military personnel in French Guiana in 2020.
- Trial name
- CEFELEISH (NCT04888130)
- Testing
- Phylogenetic Analysis, Data collection
- Where
- French Guiana
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cayenne
Post Kala Azar Dermal Leishmaniasis
Ivermectin Repurposed for the Treatment of PKDL
Background (brief): 1. Burden: Post-Kala-Azar Dermal Leishmaniasis (PKDL) commonly follows visceral leishmaniasis (VL) caused by Leishmania donovani.
- Trial name
- NCT07286604
- Testing
- Ivermectin 6 MG Oral Tablet (2 tablets)
- Where
- Bangladesh
- Volunteers
- 10 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh