Clinical trials: Lens Disease
Cataract, Astigmatism
Observational Prospective Clinical Investigation on Monofocal Toric Intraocular Lens
Evaluation, at least one-year long-term, of the clinical performance and safety of Mini Toric Ready Intraocular Lens (IOL), a monofocal toric intraocular lens.
- Trial name
- NCT06250855
- Testing
- Mini Toric IOL
- Where
- 2 sites in Romania
- Volunteers
- 105 people
- Sponsor
- SIFI SpA
Cataract
Evaluate the Safety and Effectiveness of the enVista® One-Piece Hydrophobic Acrylic Trifocal Intraocular Lens
The objective of the study is to evaluate the safety and effectiveness of the enVista trifocal intraocular lens when implanted in the capsular bag.
- Trial name
- NCT03603600
- Testing
- enVista MX60E, enVista MX60EF
- Where
- 23 sites in United States
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Cataracts
A Real-World Study for the TECNIS Synergy™ Intraocular Lens
This is a prospective and retrospective, single-center, single-arm, open-label clinical study of the TECNIS Synergy™ IOL. The study will enroll up to 100 subjects from a single site in China.
- Trial name
- NCT05090826
- Testing
- Model ZFR00V
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Johnson & Johnson Surgical Vision, Inc.
Aphakia
Clinical Investigation of the AcrySof IQ Vivity Extended Vision Intraocular Lens (IOL)
The purpose of this study is to compare the visual disturbance profile of an intraocular lens (IOL) using nondiffractive optics, the VIVITY IOL, to two diffractive IOLs in subjects requiring bilateral cataract surgery.
- Trial name
- NCT04098367
- Testing
- VIVITY, SYMFONY, AT LARA
- Where
- 12 sites in Australia, New Zealand
- Volunteers
- 222 people
- Sponsor
- Alcon Research
Visual Disorders
Clinical Long-Term Evaluation of Approved and Investigational Contact Lenses
This is a multi-site, dispensing, 4-visit, 2-arm parallel group, randomized, double-masked clinical trial using a Vistakon investigational contact lens (test) and a marketed monthly replacement contact lens (control).
- Trial name
- NCT02625233
- Testing
- senofilcon C, comfilcon A
- Where
- 6 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Glaucoma
GTS400 Stent Implantation in Conjunction With Cataract Surgery in Subjects With Open-angle Glaucoma
The purpose of this study is to evaluate the safety and efficacy of the GTS400 trabecular micro-bypass stent in reducing intraocular pressure (IOP) in subjects with open-angle glaucoma or ocular hypertension and co-existing…
- Trial name
- NCT01052558
- Testing
- iStent Inject (GTS400), Cataract Surgery
- Where
- 22 sites in United States
- Volunteers
- 164 people
- Sponsor
- Glaukos Corporation
Refractive Error
Comparison of Lotrafilcon B Lenses With Different Packaging Solutions
The purpose of this study is to evaluate AIR OPTIX® plus HYDRAGLYDE® (AOHG) contact lenses compared to AIR OPTIX® AQUA (AOA) contact lenses in overall lens fit.
- Trial name
- NCT02699684
- Testing
- Lotrafilcon B contact lenses with EOBO-41, Lotrafilcon B contact lenses, Hydrogen peroxide-based lens care solution
- Volunteers
- 82 people
- Sponsor
- Alcon Research
Aphakia, Cataract
Exploratory Study to Evaluate the Use of the RxSight Light Adjustable Lens (LAL) and the Light Delivery Device (LDD) to Improve Visual Outcomes
The objective of this study is to evaluate, for the visual correction of aphakia, whether the RxSight Light Adjustable Lens (LAL) and Light Delivery Device (LDD) can be used to improve visual outcomes after performing adjustments…
- Trial name
- NCT03895034
- Testing
- Light Adjustable lens (LAL) and Light Delivery Device (LDD)
- Where
- Mexico
- Volunteers
- 66 people
- Sponsor
- RxSight, Inc.
Astigmatism, Myopia
Vision Stability and Preference for Soft Toric vs. Soft Spherical Contact Lenses
The principal hypothesis is to be tested in this work is that vision stability (the primary outcome measure) with a spherical contact lens correction vs. a toric contact lens correction will be the same.
- Trial name
- NCT04536571
- Testing
- Test Contact lens, Control Contact lens
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Astigmatism
Clinical Performance of Atypical Contact Lens Powers on Subjects With Astigmatism
This study will evaluate the fitting characteristics and physiological response of two toric lenses manufactured by Vistakon.
- Trial name
- NCT00697190
- Testing
- senofilcon A toric, galyfilcon A toric
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Myopia, Myopic Astigmatism
A Clinical Trial Assessing the Safety and Effectiveness of Orthokeratology Lenses in Patients With Myopia and Myopic Astigmatism
This is a prospective, multi-centre, single-arm clinical trial to evaluate the effectiveness and safety of MCOK-01 lenses in patients with myopia and myopic astigmatism who need dioptric correction.
- Trial name
- SEMOA (NCT07047924)
- Testing
- MCOK-01
- Where
- 4 sites in Australia
- Volunteers
- 220 people
- Sponsor
- Menicon Co., Ltd.
Cataract
Observational, Prospective Clinical Investigation on Mini 4 Ready Intraocular Lens
Cataract surgery presents an extremely high success rate in improving vision and quality of life and it is currently the most commonly performed ophthalmic surgery, especially considering its growing utility in the aging…
- Trial name
- NCT06093880
- Testing
- monofocal intraocular lens
- Where
- Italy
- Volunteers
- 125 people
- Sponsor
- SIFI SpA
Lid Wiper Epitheliopathy
Lid Wiper Epitheliopathy Trial
The purpose of this study is to evaluate the effect of contact lens lubricity on lid wiper epitheliopathy (LWE) in symptomatic contact lens wearers.
- Trial name
- NCT01870856
- Testing
- Spectacles, Delefilcon A contact lenses, Etafilcon A contact lenses
- Volunteers
- 187 people
- Sponsor
- Alcon Research
Cataract, Nuclear Progressive
The Post-Vitrectomy Lenstatin™ Study
To determine the efficacy of Lenstatin™, an over-the-counter nutritional supplement, in inhibiting the progression of nuclear cataract in eyes after pars plana vitrectomy.
- Trial name
- NCT02131194
- Testing
- Lenstatin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Lenstatin LLC
Astigmatism
Effect of Eye Movement on Toric Lens Orientation and Visual Acuity
The relative performance of a new toric soft contact lens against toric contact lenses currently available in market, specifically for visual acuity and lens orientation.
- Trial name
- NCT00584831
- Testing
- senofilcon A, balafilcon A, omafilcon A
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Disorders of the Eye Following Cataract Surgery
Microbiological Evaluation of the Ocular Flora Before Cataract Surgery
The purpose of the present study is to elucidate the spectrum of ocular flora and their antimicrobial susceptibility profiles in patients undergoing routine cataract surgery.
- Trial name
- NCT02124603
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- SIFI SpA
Cataract
Clinical Safety and Efficacy of Hydrophilic Acrylic Intraocular Lenses
Clinical safety and efficacy of CT ASPHINA 409 IOLs after implantation
- Trial name
- UVEA409 (NCT03145103)
- Testing
- CT ASPHINA 409
- Where
- Sweden
- Volunteers
- 282 people
- Sponsor
- Carl Zeiss Meditec AG
Astigmatism
Clinical Performance of Habitual Wearers of Avaira Toric When Refitted With Clariti Toric Lenses
The aim of this dispensing study is to evaluate the clinical performance of existing wearers of Avaira toric lenses following a refit with Clariti toric over 1 month of daily wear.
- Trial name
- NCT02248766
- Testing
- somofilcon A
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- CooperVision, Inc.
Non-Proliferative Diabetic Retinopathy, Cataract
Nepafenac Once Daily for Macular Edema - Study 1
The purpose of this study is to demonstrate superiority of Nepafenac Ophthalmic Suspension, 0.3% dosed once daily relative to Nepafenac Vehicle based upon clinical outcomes among diabetic subjects following cataract surgery.
- Trial name
- NCT01853072
- Testing
- Nepafenac Ophthalmic Suspension, 0.3%, Nepafenac vehicle, Prednisolone acetate
- Volunteers
- 881 people
- Sponsor
- Alcon Research
Myopia
Lens Fitting Evaluation of CooperVision MyDay™ Compared With 1-DAY ACUVUE® TruEye® and DAILIES TOTAL1®
Lens Fitting Evaluation of CooperVision MyDay™ Compared with 1-DAY ACUVUE® TruEye® and DAILIES TOTAL1®
- Trial name
- NCT02341859
- Testing
- stenfilcon A, delefilcon A, narafilcon A
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- CooperVision, Inc.
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