Clinical trials: Lens Disease
Cataract
Topical 0.1% Bromfenac Sodium and Prostaglandin E2 Inhibition in Cataract Surgery
Since a new generation of femtosecond lasers became available for cataract surgery in 2009, the use of this image-guided system has provided several benefits, including a reduction in phacoemulsification energy by…
- Trial name
- NCT02681679
- Testing
- 0.1% bromfenac ophthalmic solution, femtosecond laser cataract surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-sen University
Cataracts
Comparison of Two Phacoemulsification-methods: EasyTip 2.2mm vs. Infusion Assisted EasyTip 2.2mm
The aim of this study was to compare the intraoperative efficiency, safety and postoperative outcomes of cataract surgery with two different "high-fluidic" settings.
- Trial name
- NCT01936727
- Testing
- cataract surgery
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Cataract Congenital, Astigmatism
Toric Intraocular Lens Implantation in Pediatric Cataract
To evaluate the visual and refractive outcomes after an intraocular lens (IOL) implantation in pediatric eyes with cataract and preexisting corneal astigmatism
- Conditions
- Cataract Congenital, Astigmatism, IOL
- Trial name
- TILIPC (NCT06294795)
- Testing
- congenital/pediatric cataract surgery, Non-Toric IOLs, Toric IOLs
- Where
- 2 sites in Kazakhstan
- Volunteers
- 40 people
- Sponsor
- Kazakh Eye Research Institute
Aphakia, Presbyopia
Evaluation of AcrySof IQ Vivity Extended Vision Intraocular Lenses
The purpose of this post-market study is to describe the long-term safety and performance of AcrySof IQ Vivity and AcrySof IQ Vivity Toric intraocular lens (IOL) models in a real-world setting through routine clinical practice.
- Conditions
- Aphakia, Presbyopia, Residual Refractive Cylinder
- Trial name
- NCT06541795
- Testing
- AcrySof IQ Vivity Extended Vision IOL
- Where
- United States
- Sponsor
- Alcon Research
Meibomian Gland Dysfunction, Dry Eye
Treatment of Meibomian Gland Dysfunction and Dry Eye in Contact Lens Wearers
The pilot study objective is to evaluate the potential benefits of LipiFlow® System treatment of contact lens wearers with meibomian gland dysfunction and evaporative dry eye by assessing for improvement in meibomian gland…
- Trial name
- NCT02102464
- Testing
- LipiFlow treatment
- Where
- 6 sites in United States, Canada
- Volunteers
- 55 people
- Sponsor
- TearScience, Inc.
Refractive Errors, Ametropia
Clinical Comparison of Two Daily Wear Frequent Replacement Silicone Hydrogel Soft Contact Lenses
The primary objective of this study is to evaluate the overall performance of an investigational silicone hydrogel lens when compared to ACUVUE OASYS® with HYDRACLEAR® PLUS (AOHP).
- Trial name
- NCT04532099
- Testing
- Lehfilcon A contact lenses, Senofilcon A contact lenses, Comfilcon A contact lenses
- Where
- 4 sites in United States
- Volunteers
- 132 people
- Sponsor
- Alcon Research
Primary Open Angle Glaucoma (POAG), Cataract
Study of an Implantable Device for Lowering Intraocular Pressure in Glaucoma Patients Undergoing Cataract Surgery
The purpose of this study is to evaluate the safety and efficacy of the CyPass Implant for lowering intraocular pressure (IOP) in patients with glaucoma who undergo cataract surgery.
- Trial name
- COMPASS (NCT01085357)
- Testing
- Cataract Surgery, CyPass Micro-Stent
- Volunteers
- 897 people
- Sponsor
- Transcend Medical, Inc.
Myopia, Myopia Progression, Lag of Accommodation, Hyperopic Retinal Blur, Reduction in Contrast
Lag of Accommodation With DOT Spectacle Lenses
The objective of the study is to measure the difference in the lag of accommodation between DOT spectacle lenses and control spectacles.
- Trial name
- ASH (NCT04700111)
- Testing
- DOT Pattern, Control Spectacles
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Myopia, Astigmatism
On-Eye Evaluation of Contact Lens Axis Location
The purpose of this study was to evaluate the axis location of toric contact lenses after 3 minutes of wear. During this 1-visit study, each participant wore 3 pairs of study lenses of various design iterations (2-87-1, 2-87-2…
- Conditions
- Myopia, Astigmatism, Refractive Error
- Trial name
- NCT02100410
- Testing
- Delefilcon A toric contact lens T1, Delefilcon A toric contact lens T2, Delefilcon A toric contact lens T3
- Volunteers
- 50 people
- Sponsor
- Alcon Research
Aphakia
Clinical Evaluation of the Lenstec Softec HP1 Intraocular Lens
The study is designed as a post market evaluation of the Softec HP1 IOL for continuance of the CE certificate. The primary effectiveness endpoint is to evaluate the safety and performance levels produced by this IOL in patients…
- Trial name
- NCT03900260
- Testing
- Softec HP1 Intraocular Lens
- Where
- 3 sites in United Kingdom
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Lenstec Incorporated
Presbyopia, Myopia
Comparison of Two Multifocal Contact Lenses Worn on a Daily Disposable Basis
The purpose of this trial is to evaluate and compare the clinical performance of two multifocal contact lenses.
- Trial name
- NCT01254760
- Testing
- Nelfilcon A multifocal contact lens, investigational, Nelfilcon A multifocal contact lens, commercial
- Volunteers
- 79 people
- Sponsor
- CIBA VISION
Cataract, Astigmatism
Safety and Effectiveness of the Akreos Toric Intraocular Lens.
The purpose of this study is to evaluate the safety and effectiveness of the Akreos Toric IOL following cataract surgery.
- Trial name
- NCT00825513
- Testing
- Akreos Toric IOL, Akreos Advanced Optics Aspheric Intraocular Lens (Akreos AO)
- Where
- Sweden
- Volunteers
- 198 people
- Sponsor
- Bausch & Lomb Incorporated
Refractive Errors
Clinical Evaluation of a Daily Wear Frequent Replacement Silicone Hydrogel Lens
The purpose of this clinical study is to demonstrate the safety and performance of an investigational soft contact lens compared to a commercially available soft contact lens when worn in a daily wear modality.
- Trial name
- NCT03920280
- Testing
- LID015385 contact lenses, Comfilcon A soft contact lenses, CLEAR CARE
- Where
- 8 sites in United States
- Volunteers
- 120 people
- Sponsor
- Alcon Research
Myopia
Variation of Orthokeratology Lens Treatment Zone (VOLTZ) Study
This project aims to study the effects of treatment characteristics on myopia control in orthokeratology by investigating the effects of modified treatment zone by reducing the lens back optic zone diameter on the effect of…
- Trial name
- NCT03191942
- Testing
- Modified ortho-k lenses, Ortho-k lenses
- Where
- 2 sites in Hong Kong
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Cataract
Imaging and Spectral Analysis of the Crystalline Lens Using the "HYPERLAF" Slit Lamp
Cataract is the leading cause of reversible blindness and the first surgery worldwide. It corresponds to the crystalline lens opacification.
- Trial name
- HYPERLAF (NCT07875205)
- Testing
- Non-contact observation of the crystalline lens nucleus
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cataract
Visual Outcomes of Vivity in Patients With High Axial Length
The objective is to assess the visual outcomes and quality of vision of patients receiving the AcrySof® Vivity Intraocular lens (IOL), when implanted in eyes with high ocular axial length (≥24.5mm), after uneventful cataract…
- Trial name
- NCT05210569
- Testing
- Vivity
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Dr. James J. Wiens Medical Corporation
Absence of Capsule Support, Aphakia
Clinical Observation of the Transscleral Suture Fixation of Posterior Chamber Intraocular Lens in Eyes With Inadequate Capsule Support
To present the follow-up outcomes of transscleral suture fixation of posterior chamber intraocular lens (PCIOL) in eyes with inadequate capsule support.
- Trial name
- NCT03817151
- Testing
- posterior chamber intraocular lens implantation
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Myopia
A Study to Evaluate the Product Performance of a New Silicone Hydrogel Contact Lens
The objective of this study is to evaluate the product performance of a new silicone hydrogel soft contact lens when worn by current soft contact lens wearers on a daily wear basis.
- Trial name
- NCT01873846
- Testing
- Silicone Hydrogel Contact Lens
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Bausch & Lomb Incorporated
Cataract
Post-Approval Study of the Tecnis® Toric IOL
This study is a prospective, multicenter, bilateral, non-randomized, open-label, comparative clinical study conducted at up to 80 sites in the USA.
- Trial name
- NCT02566083
- Testing
- non-toric intraocular lens, toric intraocular lens
- Where
- 44 sites in United States
- Volunteers
- 365 people
- Sponsor
- Abbott Medical Optics
Myopia
A Clinical Comparison of Three Soft Daily Disposable Contact Lenses
This study aims to compare the clinical performance of the somfilcon A, nelfilcon A II 2 and omafilcon A II 2 daily disposable contact lenses.
- Trial name
- NCT02920983
- Testing
- somofilcon A, nelfilcon A II 2, omafilcon A ll 2
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
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