Clinical trials: Lens Disease
Glaucoma, Cataract
Phaco vs. Phaco-ELT vs. Phaco-Trabectome 12m
This study compares efficacy (i.e. IOP and hypotensive medications) of phaco alone vs. combined phaco plus excimer laser trabeculotomy vs. combined phaco plus trabectome.
- Trial name
- NCT01194310
- Testing
- phaco, phaco-ELT, phaco-Trabectome
- Where
- Switzerland
- Volunteers
- 245 people
- Sponsor
- University of Zurich
Lens Diseases, Cataract
Multicenter Study on the Use of Intraoperative OCT in the Diagnosis and Management of Lens Diseases
This multicenter retrospective study will collect clinical data to investigate the associations between preoperative and intraoperative anterior segment structural changes and postoperative surgical outcomes in patients with lens…
- Conditions
- Lens Diseases, Cataract, Age-related Cataract, Complicated Cataract
- Trial name
- NCT07741370
- Testing
- Intraoperative Optical Coherence Tomography
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cataract
Clinical Investigation of Omega Refractive Capsule Model V With Use of an FDA Approved IOL
The objective of this study is to evaluate the safety and effectiveness of the investigational Omega Refractive Capsule (model V)
- Trial name
- ORCV (NCT04574102)
- Testing
- Omega Refractive Capsule with FDA approved Intraocular Lens, FDA approved Intraocular lens
- Where
- Costa Rica
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Omega Ophthalmics
Glaucoma, Cataract
Observational Study to Evaluate Long Term Outcomes for Ocular Hypertension and Glaucoma Patients Treated With the SpyGlass Bimatoprost Implant System / IOL Combination
The goal of this clinical trial is to further observe and learn if the SpyGlass Pharma Bimatoprost Implant System / IOL Combination works to treat cataracts and either ocular hypertension or glaucoma.
- Conditions
- Glaucoma, Cataract, Ocular Hypertension
- Trial name
- NCT07154810
- Where
- Honduras
- Volunteers
- 23 people
- Sponsor
- SpyGlass Pharma, Inc.
Cataracts
Clinical Research of Femtosecond Laser-Assisted Cataract Surgery
Since femtosecond laser was approved for cataract surgery by FDA in 2010, femtosecond laser assisted cataract surgery (FLACS) has demonstrated high precision of capsulotomy, reduced phacoemulsification power and time, and…
- Trial name
- FLACS (NCT02492659)
- Testing
- femtosecond laser-assisted cataract surgery, conventional phacoemulsification
- Where
- China
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Wenzhou Medical University
Cataract
Comparison of Visual Outcomes With Mini-Monovision Between a Monofocal and an Adjustable Intraocular Lens
This study is a single center, multi-surgeon, prospective, randomized, comparative study of binocular corrected distance visual acuity (CDVA) after successful bilateral cataract surgery.
- Trial name
- NCT06122103
- Testing
- Clareon Monofocal, Light-Adjustable Lens
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Gainesville Eye Associates
Drug Action Increased
A Randomized Controlled Trial Comparing Urea Loaded Nanoparticles to Placebo: a New Concept for Cataract Management
Cataract is the leading cause of vision loss and blindness in the world,surgery is the only available option to correct the problem and the major reasons for low cataract surgical rates include low demand because of fear of…
- Trial name
- NCT03001466
- Testing
- urea-loaded nanoparticles eye drops, Balance Salt Solution eye drops
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Juvenile Myopia, Myopia
Assessment of DOT Spectacles in Chinese Children
This is a randomized, controlled, evaluator-blinded, multicenter, two-arm parallel group clinical trial to evaluate the continued safety and efficacy of Diffusion Optics Technology (DOT) spectacle lenses by comparing to single…
- Trial name
- CATHAY (NCT05562622)
- Testing
- Novel spectacle lens design, Spectacle lenses
- Where
- 5 sites in China
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Cataract, Lens Opacity
Comparison of Clinical Outcomes POD L GF vs POD F GF (PHY1707)
Prospective, randomised, controlled, single-surgeon, single-center clinical study to compare the clinical outcomes of two trifocal IOLs differing in the dominance of additional power.
- Conditions
- Cataract, Lens Opacity, Presbyopia
- Trial name
- NCT03688399
- Testing
- IOL implantation experimental, IOL implantation comparator
- Where
- Hungary
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Beaver-Visitec International, Inc.
Cataract
Clinical Evaluation of Modified 2.2mm Microincision Phacoemulsification for Age-related Cataract
This study is a single-center, parallel-group, randomized controlled trial with the following objectives: to compare the incidence of post-operative descemet membrane detachment (DMD) in phacoemulsification surgery between…
- Trial name
- NCT04014699
- Testing
- modified 2.2mm microincision, conventional 2.2mm microincision
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Cataract
Pseudophakic Eyes With Presbyopia-correcting IOLs: OCT Biometry and Pyramid Aberrometry
To correlate ocular morphology from anterior segment OCT and pyramid wavefront sensing in order to comprehensively analyze pseudophakic in vivo image quality of presbyopia-correcting IOLs in cataract patients.
- Trial name
- NCT07436247
- Testing
- Osiris-T Pyramid Wavefront Sensor - (CSO, Italy)
- Where
- 2 sites in Austria
- Volunteers
- 80 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Astigmatism
Rotational Stability of Two Soft Toric Contact Lens Designs
This study compared the rotational behavior of two commercially available soft toric contact lenses with different stabilization designs and explored whether ocular biometric and refractive characteristics were associated with…
- Trial name
- NCT07795671
- Testing
- Acuvue Oasys for Astigmatism, Air Optix for Astigmatism
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bozok University
Cataract
Spectacle Independence and Overall Satisfaction With AcrySof® Panoptix® Toric Intraocular Lens
The study was designed to assess the spectacle independence and satisfaction of patients receiving the AcrySof® Panoptix® Toric intraocular lens (IOL) after uneventful cataract surgery.
- Trial name
- NCT04128514
- Testing
- Panoptix Toric
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Eye Center of North Florida
Marfan's Syndrome With Ocular Manifestations, Pseudoexfoliation Syndrome
The Oscillation of Crystalline and Intraocular Lenses
The crystalline lens of the human eye helps to sharpen vision. There can be issues with the support/stability of the lens. This could be seen with the naked eye of an external observer or with the use of a slit lamp.
- Conditions
- Marfan's Syndrome With Ocular Manifestations, Pseudoexfoliation Syndrome, Cataract, Phakodonesis
- Trial name
- NCT04274634
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Hyperopia, Myopia
Clinical Study of Visibility Tinted Clariti Contact Lens
The purpose of this study was to investigate the safety and efficacy of the Sauflon Clariti Monthly silicone hydrogel contact lenses with handling tint (Sauflon Pharmaceuticals Limited) by comparison with Air Optix Aqua silicone…
- Trial name
- NCT01996787
- Testing
- Air Optix Aqua, Clariti with Handling Tint
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Sauflon Pharmaceuticals Ltd
Primary Open Angle Glaucoma and Cataracts
A Clinical Trial of Phacoemulsification Versus Phacoemulsification & the iStent Implantation in POAG Patients
This was a prospective, double-masked, 15-month clinical trial comparing efficacy of phacoemulsification alone to combined phacoemulsification and implantation of the iStent® trabecular micro-bypass stent in patients with primary…
- Trial name
- NCT00847158
- Testing
- phacoemulsification alone, iStent Trabecular Micro-Bypass Stent
- Volunteers
- 36 people
- Sponsor
- University of Turin, Italy
Presbyopia
Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Multifocal Contact Lenses
The primary objective of this study is to demonstrate noninferiority in visual acuity at distance when wearing the test contact lenses (LID210464) compared to the control contact lenses (AOHG MF) after 30 days of wear.
- Trial name
- NCT05338333
- Testing
- Lehfilcon A multifocal contact lenses, Lotrafilcon B multifocal contact lenses, CLEAR CARE®
- Where
- 8 sites in United States
- Volunteers
- 101 people
- Sponsor
- Alcon Research
Cataract, Lenses, Intraocular
Effect of Intraocular Lens (IOL) Centration and Tilt on Visual Performance With Clareon® Vivity® IOL Implantation
The goal of this observational study is to assess the effect of intraocular lens (IOL) movement in patients who have undergone Clareon® Vivity® IOL implantation.
- Trial name
- NCT05827133
- Testing
- No intervention
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- East Coast Institute for Research
Cataract
Refractive Accuracy of Argos in Conjunction With the Alcon Vision Suite Following Implantation of Presbyopia Correcting IOLs
The objective is to assess refractive accuracy of the Alcon Vision Suite (with Argos biometer) following Clareon PanOptix and AcrySof Vivity IOL implantation.
- Trial name
- NCT05901597
- Testing
- Clareon PanOptix and AcrySof Vivity IOL implantation Alcon Vision Suite and Argos biometer
- Where
- Canada
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Valley Laser Eye Centre
Myopia, Myopia Progression
Comparing Myopia Control Spectacle Lenses and Standard Single Vision Spectacle Lenses in Children With Myopia
The purpose of this clinical trial is to compare a new myopia control spectacle lens with a standard single vision spectacle lens in slowing the progression of myopia (nearsightedness) in healthy children aged 6 to under 11…
- Trial name
- PEARL (NCT07839091)
- Testing
- Investigational Myopia Control Spectacle Lens, Single Vision Spectacle Lens
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- Essilor International
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