Clinical trials: Lenses
Cataract
Safety and Efficacy of a Violet Visible Light Blocking Intraocular Lens (IOL)
The purpose of this study is to evaluate the safety and effectiveness of a new investigational modified light transmission monofocal intraocular lens compared to a conventional intraocular lens (IOL).
- Trial name
- NCT00747227
- Testing
- modified light transmission intraocular lens, monofocal acrylic intraocular lens
- Where
- 11 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Cataract, Presbyopia
Clinical Investigation of a Small Aperture Extended Depth of Focus Intraocular Lens in Patients With Complex Corneas
The objective of this study is to evaluate the clinical outcomes of the IC-8 IOL implanted in patients with complex corneas after crystalline lens removal.
- Conditions
- Cataract, Presbyopia, Irregular Astigmatism
- Trial name
- NCT05574270
- Testing
- IC-8 Intraocular Lens (IOL)
- Where
- 2 sites in Philippines, Singapore
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- AcuFocus, Inc.
Migraine
Use of the Avulux® Lenses as an Aid in Reducing the Impact of Migraine Headaches
The purpose of this research is to assess how well the Avulux® migraine lenses work in reducing the impact of migraine headaches as measured by improvement in an 11-point pain scale after two and four hours of device application…
- Trial name
- NCT04341298
- Testing
- 11-point pain scale, Headache diary, Avulux®
- Where
- 3 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Avulux, Inc.
Juvenile Myopia
Control of Myopia Using Novel Spectacle Lens Designs
Randomized, controlled, multisite, subject-and observer-masked, 3-arm parallel group clinical trial of 36-month duration to evaluate the safety and efficacy of a novel spectacle lens design in reducing the progression of juvenile…
- Trial name
- CYPRESS (NCT03623074)
- Testing
- Novel spectacle lens design, Spectacle lenses
- Where
- 14 sites in United States, Canada
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Myopia
Lens Wear Schedules and End-of-Day Comfort
The purpose of this study was to assess the impact of lens-free (recovery) intervals of varying lengths on end-of-day comfort and tear film changes with daily contact lens wear.
- Trial name
- INVERMERE (NCT01433549)
- Testing
- Lotrafilcon B, Senofilcon A
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- CIBA VISION
Myopia
Multi-Centre Clinical Evaluation of Two Reusable Soft Contact Lenses
The aim of this study is to compare the subjective performance of the comfilcon A contact lens against lotrafilcon B contact lens after 4 weeks of reusable lens wear.
- Trial name
- NCT02815735
- Testing
- comfilcon A, lotrafilcon B
- Where
- 9 sites in United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Refractive Error
DAILIES TOTAL1® - Comparative Assessment of Tear Film Evaporation
The purpose of this study is to evaluate the tear film evaporation of symptomatic soft contact lens wearers in the absence of contact lens wear and after at least 8 hours of contact lens wear.
- Trial name
- NCT02517567
- Testing
- Delefilcon A contact lenses, Narafilcon A contact lenses, Somofilcon A contact lenses
- Volunteers
- 37 people
- Sponsor
- Alcon Research
Study Focus is Healthy Contact Lens Wearers
Evaluation of an Investigational Multi-Purpose Solution (MPS)
The purpose of this study is to evaluate the safety and effectiveness of an investigational multi-purpose contact lens solution.
- Trial name
- NCT00961051
- Testing
- Investigational MPS, Opti-Free
- Where
- 9 sites in United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Visual Acuity
Clinical and Laboratory Study of Lysozyme Deposition on Daily Disposable Contact Lenses
In vitro studies show that some hydrogel materials uptake more lysozyme than other hydrogel materials and that this protein remains largely active and promotes reduced cytokine response in an in vitro culture of human corneal…
- Trial name
- NCT02365298
- Testing
- etafilcon A, nelfilcon A
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Visual Acuity
Short-Term Clinical Comparison of Two Silicone Hydrogel Daily Disposable Contact Lenses
This will be a 2 period one-day, double-masked, randomized, repeated measures, non-dispensing, cross-over study where the main purpose of this study is to compare the performance of a new daily disposable silicone hydrogel lens…
- Trial name
- NCT03139578
- Testing
- Test 8.5BC, Test 9.0BC, Control 8.5BC
- Where
- 2 sites in United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Cataract, Inflammation
Indomethacin Eyedrops Compared With Ketorolac Eyedrops for Ocular Inflammation Following Cataract Surgery
This study is being conducted to show that indomethacin is at least as effective as ketorolac for the prevention of ocular inflammation following cataract surgery.
- Trial name
- NCT00904904
- Testing
- Indomethacin ophthalmic solution, Ketorolac Ophthalmic Solution
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Bausch & Lomb Incorporated
Presbyopia
CLEAR CARE® PLUS for Presbyopic Contact Lens Wearers
The purpose of this study is to evaluate CLEAR CARE® PLUS (CCP) compared to non-HYDRAGLYDE® multi-purpose contact lens solutions in presbyopes currently wearing soft contact lenses and experiencing symptoms of dryness.
- Trial name
- NCT02965833
- Testing
- 3% hydrogen peroxide solution with HydraGlyde® Moisture Matrix, Habitual Multi-Purpose Contact Lens Solution, Habitual Contact Lenses
- Volunteers
- 126 people
- Sponsor
- Alcon, a Novartis Company
Astigmatism, Myopia
Short-term Study of Two Soft Contact Lenses in Wearers With Low Astigmatism
The primary objective of the study is to evaluate and compare the performance of two soft contact lens.
- Conditions
- Astigmatism, Myopia, Hyperopia
- Trial name
- NCT06873048
- Testing
- Control Contact Lens (stenfilcon A Sphere), Test Contact Lens (stenfilcon A Toric)
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- CooperVision International Limited (CVIL)
Contact Lens Care
7-Day, Multi-Site Study of an Investigational Multi-Purpose Disinfecting Solution for Contact Lens Wearers
The purpose of this study is to clinically evaluate solution-related corneal staining with an investigational multi-purpose disinfecting solution (MPDS) in hydrogel and silicone hydrogel contact lens wearers.
- Trial name
- NCT00884806
- Testing
- FID 114675A Multi-Purpose Disinfecting Solution (MPDS), Etafilcon A contact lens (ACUVUE® 2™), Senofilcon A contact lens (ACUVUE® OASYS™)
- Volunteers
- 110 people
- Sponsor
- Alcon Research
Pseudophakia
Corrected VA With Long-Term Follow-Up After AcrySof® Intraocular Lens (IOL) Implantation
The purpose of this study is to compare the long-term visual acuity (VA) with an acrylic IOL to a silicone or polymethylmethacrylate (PMMA) IOL in cataract patients. This study will take place in Japan.
- Trial name
- NCT02450799
- Testing
- Acrylic IOL, Silicone IOL, PMMA IOL
- Volunteers
- 104 people
- Sponsor
- Alcon, a Novartis Company
Presbyopia
Visual Outcomes After Presbyopic Lens Exchange
Evaluation of mean preoperative and postoperative Corrected distance visual acuity (CDVA) after Refractive Lens Exchange in presbyopic patients
- Trial name
- RELAX (NCT03790592)
- Testing
- trifocal IOL
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Carl Zeiss Meditec AG
Dry Eye
A Study to Evaluate Concomitant Perfluorohexyloctane Use With Contact Lens Wear
Assess the impact of concomitant Miebo use while wearing contact lenses
- Trial name
- NCT07054606
- Testing
- Perfluorohexyloctane ophthalmic solution
- Where
- 6 sites in United States
- Volunteers
- 104 people
- Sponsor
- Bausch & Lomb Incorporated
Contact Lens Care
OPTI-FREE Family STUDY
The purpose of this post-market clinical follow-up (PMCF) study is to evaluate the long-term safety and performance of 3 commercially available contact lens cleaning and disinfecting solutions in a pediatric population.
- Trial name
- NCT06592521
- Testing
- OPTI-FREE EXPRESS MPDS and Alcon contact lens case, OPTI-FREE PureMoist MPDS and Alcon contact lens case, OPTI-FREE REPLENISH MPDS and Alcon contact lens case
- Where
- United States
- Sponsor
- Alcon Research
Cataract
Comparative Study of 2 Multifocal Intraocular Lenses in Heidelberg
The goal of this clinical trial is to compare the performance of 2 intraocular lenses (IOLs): ARTIS SYMBIOSE (study lenses) vs PANOPTIX (comparator) through binocular Distance Corrected Intermediate Visual Acuity (DCIVA) assessed…
- Trial name
- C2H (NCT06327347)
- Testing
- intraocular lens implantation in cataract surgery
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Cristalens Industrie
Myopia
Daily Disposable Silicone Hydrogel Contact Lens, Stenfilcon A, Clinical Study
Clinical evaluation of stenfilcon A compared with narafilcon A and delefilcon A This is a total 120 subject, randomized, open label, bilateral wear, two week crossover study (each lens for 1 week) evaluating the clinical…
- Trial name
- NCT02637804
- Testing
- stenfilcon A, narafilcon A, delefilcon A
- Volunteers
- 106 people
- Sponsor
- CooperVision, Inc.
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