Clinical trials: Lenses
Cataract, Astigmatism
Rotational Stability of the Acrysof, Tecnis and Envista Intraocular Lenses
Brief Summary: Age-related cataract is the main cause of impaired vision in the elderly population worldwide. In the UK, more than half of people who are over 65 years old have some cataract development in one or both eyes.
- Trial name
- NCT04345380
- Testing
- Implantation of an Alcon Acrysof SN60WF intraocular lens, Implantation of an AMO Tecnis ZCB00 intraocular lens, Implantation of an Envista MX60 intraocular lens
- Where
- Austria
- Volunteers
- 199 people
- Sponsor
- Medical University of Vienna
Cataract
AMO's Tecnis™ Multifocal Intraocular Lenses (Tecnis MF), Alcon's ReStor Multifocal IOL
The purpose of this study is to compare the visual outcomes with bilateral implantation of Tecnis MF and ReSTOR IOLs Six months post cataract surgery.
- Trial name
- NCT01278420
- Testing
- Tecnis MF, ReSTOR
- Where
- 6 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Myopia, Hyperopia
DAILIES TOTAL1® Soft Contact Lenses - Post-Market Clinical Follow-up Study
The purpose of this study is to continuously assess the visual performance and safety of DAILIES TOTAL1 soft contact lenses in a real world setting and broader patient base through routine clinical practices.
- Conditions
- Myopia, Hyperopia, Presbyopia, Astigmatism
- Trial name
- NCT06483113
- Testing
- Delefilcon A spherical soft contact lenses, Delefilcon A toric soft contact lenses, Delefilcon A multifocal soft contact lenses
- Where
- 12 sites in United States
- Volunteers
- 192 people
- Sponsor
- Alcon Research
Cataract
A Randomized Controlled Study of Phacoemulsification by the Enlarged Internal Incision and the Regular 2.2mm Incision
Objective and Principle: To evaluate whether enlarging the incision can reduce corneal complications associated with phacoemulsification with regular 2.2 mm incision.
- Trial name
- NCT03976791
- Testing
- enlarged internal incision, regular 2.2mm incision
- Where
- China
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Keratoconus, Irregular Astigmatism
Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism
Aberrations are the spreading of light from a point focus. Aberrations of the eyes can be objectively evaluated with a wavefront aberrometer.
- Conditions
- Keratoconus, Irregular Astigmatism, Corneal Ectasia, Aberration, Corneal Wavefront
- Trial name
- WFG Sclerals (NCT04698590)
- Testing
- Wavefront Guided Scleral Lenses, Traditional Scleral Lenses
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Intraocular Lens Dislocation, Aphakia - No Lens Capsule
Horizontal vs Vertical Scleral Tunnels in Flanged IOL Fixation
This study compares the 2-year outcomes of horizontal versus vertical scleral tunnel orientation in flanged intrascleral intraocular lens (IOL) fixation surgery.
- Trial name
- HORVER (NCT07701980)
- Testing
- Flanged Intrascleral IOL Fixation (Yamane Technique)
- Where
- Turkey (Türkiye)
- Volunteers
- 107 people
- Sponsor
- Yuzuncu Yil University
Myopia
Defocus (DIMS) Spectacles Versus Ortho-K Lenses (OKL) for Slowing Myopia Progression in Children Aged 6-12 Years.
The goal of this non-inferiority randomized clinical trial is to compare the myopia control efficacy of Ortho-K lenses (OKL) and Defocus (DIMS) spectacles in myopic children aged 6-12 years.
- Trial name
- NISDO (NCT05134935)
- Testing
- Defocus Incorporated Multiple Segment (DIMS) Spectacles, Orthokerathology lenses (OKL)
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Vejle Hospital
Cataract
Comparison of Visual Outcomes With Mini-Monovision Between a Monofocal and an Adjustable Intraocular Lens
This study is a single center, multi-surgeon, prospective, randomized, comparative study of binocular corrected distance visual acuity (CDVA) after successful bilateral cataract surgery.
- Trial name
- NCT06122103
- Testing
- Clareon Monofocal, Light-Adjustable Lens
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Gainesville Eye Associates
Dry Eye Disease, Dry Eye Syndrome
Comprehensive Study on Dry Eye and Ocular Surface Disease Prior and After Cataract Surgery
Ocular surface disease (OSD), particularly dry eye, is one of the most common conditions seen by ophthalmologists. Dry eye (DE) is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort…
- Conditions
- Dry Eye Disease, Dry Eye Syndrome, Evaporative Dry Eye, Cataract
- Trial name
- NCT04711642
- Testing
- The study will include three arms, one non interventional and 2 interventions. The intervention arms will include two commercially available sodium hyaluronate 0.1% (Systane ultra plus and Hylo-comod)
- Volunteers
- 100 people
- Sponsor
- Fundación Oftalmológica Los Andes
Cataract, Dry Eye
Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Cataract Surgery
To study the efficacy of an ocular bandage contact lens for the treatment of dry eye after cataract surgery
- Trial name
- NCT04100031
- Testing
- bandage contact lenses, phacoemulsification
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pterygium, Cataract
Surgical Treatment of Concurrent Cataract and Primary Pterygium
Pterygium is known to induce with-the-rule astigmatism. The corneal curvature along the long axis of the pterygium body is flattened. The excision of pterygium will result in steepening of the cornea and reduction of astigmatism.
- Conditions
- Pterygium, Cataract, Lenses, Intraocular
- Trial name
- NCT00563277
- Testing
- combined pterygium and cataract operation, pterygium excision followed by cataract operation
- Where
- 3 sites in China
- Volunteers
- 75 people
- Sponsor
- Hospital Authority, Hong Kong
Myopia
Clinical Evaluation of a Myopia Control Lens in Slowing Myopia Progression (CSL)
This is a mono-centre, prospective, one-arm, unmask clinical trial to evaluate the effectiveness of test lens in slowing myopia progression with respect to axial length elongation compared to a single vision spectacle lens from…
- Trial name
- NCT05724186
- Testing
- Test myopia control lenses (CSL)
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Essilor International
Cataract, Ocular Inflammation
Safety and Effectiveness of Drop-free Small Incision Cataract Surgery
This is a randomized control trial comparing the effects of subconjunctival triamcinolone administration during surgery to topical prednisolone drops on the development of post-operative inflammation and macular edema in manual…
- Conditions
- Cataract, Ocular Inflammation, Ocular Hypertension, Post-Op Complication
- Trial name
- NCT05248139
- Testing
- Intraoperative delivery of medication, Kenalog (Triamcinolone), Topical post-operative eyedrops, Prednisolone acetate
- Volunteers
- 100 people
- Sponsor
- Visualiza
Cataract
EDoF IOLs vs Monofocal IOL
prospective, comparative (3 arms), randomized, multicentric clinical trial
- Trial name
- NCT03172351
- Testing
- EDoF1, Monofocal, EDoF2
- Where
- Germany
- Volunteers
- 216 people
- Sponsor
- Carl Zeiss Meditec AG
Myopia
Clinical Comparison of Two Soft Contact Lenses
This study was designed to gather short-term clinical performance data for 2 soft contact lenses.
- Trial name
- NCT06251154
- Testing
- Lens 1, Lens 2
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- CooperVision, Inc.
Cataract Surgery
A Study to Compare Ocular Safety and Tolerability of Eye Drops Containing Prednisolone Acetate in Patients With Intraocular Inflammation After Cataract Surgery
The primary objective was to demonstrate that two days of treatment with 0.5% prednisolone acetate eye-drops after cataract surgery are superior to vehicle in reducing the flare in the anterior chamber of the operated eye.
- Trial name
- NCT00170729
- Testing
- Prednisolone acetate
- Volunteers
- 62 people
- Sponsor
- Novartis
Presbyopia
Clinical Validation Study of Comfilcon A Multifocal Toric Contact Lenses
This is a study to evaluate the clinical performance and subjective acceptance of an investigational contact lens (test), compared to a marketed lens (control) in an in-office setting.
- Trial name
- NCT03417557
- Testing
- Comfilcon A lens (test), Omafilcon B lens (control)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- CooperVision, Inc.
Cataract
Yellow Versus White Study
Blue-light-filtering IOLs are implanted increasingly often in cataract surgery. Several studies examined the effect of blue-light-filters on contrast and colour vision. However, the study outcomes were varying.
- Trial name
- YeWhi (NCT00612781)
- Testing
- cataract surgery (Hoya AF-1 [UY] YA-60BB), cataract surgery (Hoya AF-1 [UV] VA-60BB lens)
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Hospital Hietzing
Myopia Progression, Myopia
Inhibition of Myopia Progression With Optical Devices
This observational study aims to determine whether optical devices designed to slow myopia progression and/or environmental factors can prevent myopia progression in the pediatric and adolescent myopic population.
- Conditions
- Myopia Progression, Myopia, Myopia, Child Myopia Progression
- Trial name
- NCT07698977
- Testing
- Wearing myopia-control D.I.M.S. glasses while awake, DIMS (Defocus Incorporated Multiple Segments) lenses
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Refractive Error, Myopia
A Comparison of Two Daily Disposable Contact Lenses
This study seeks to evaluate the clinical performance of a new CE marked daily disposable contact lens that contains a wetting agent to a recently improved daily disposable contact lens.
- Trial name
- NCT00634101
- Testing
- nelfilcon A, narafilcon A
- Where
- 20 sites in United Kingdom
- Volunteers
- 129 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
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