Clinical trials: Leprosy
Leprosy
The Use of Low Level Laser Therapy for Wound Healing in Leprosy Patients
Neuropathic ulcers are common sequelae of leprosy. The objectives of this study are to analyze the clinic-epidemiological characteristics of patients attended at one specialized dressing service from a leprosy-endemic region of…
- Trial name
- NCT00860717
- Testing
- Routine treatment, Low level laser therapy (LLLT)
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Para Federal University
Leprosy
Molecular and Immunological Tools for Detection of Strain Diversity, Drug Resistance and Immunological Responses
The purpose of this study is to determine what factors contribute to the continued incidence of leprosy in Colombia. Study participants will include volunteering and consenting individuals, older than 4 years of age, representing…
- Trial name
- NCT00138437
- Where
- 2 sites in Colombia
- Volunteers
- 1,554 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Erythema Nodosum Leprosum
Methotrexate and Prednisolone Study in Erythema Nodosum Leprosum
Erythema Nodosum Leprosum (ENL) is a painful, debilitating complication of leprosy. Patients often require high doses of corticosteroids for prolonged periods. Thalidomide is expensive and not available in most countries.
- Trial name
- MaPs (NCT03775460)
- Testing
- Methotrexate, Prednisolone
- Where
- 7 sites in Bangladesh, Brazil and 4 more
- Volunteers
- 550 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Lepromatous Leprosy
Microcirculatory Impairment in Patients With Leprosy
In this study the investigators have aimed to evaluate morphology and reactivity of cutaneous microcirculation in patients with lepromatous leprosy.
- Trial name
- NCT02085317
- Testing
- acetylcholine Iontophoresis, sodium nitroprusside Iontophoresis
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Curt Treu
Leprosy
Prednisolone Monotherapy Versus Prednisolone Plus Methotrexate in ENL
Erythema nodosum leprosum (ENL) is characterized by painful nodules and systemic compromising. It is usually recurrent and/or chronic and has both physical and economic impact on the patient, being a very important cause of…
- Trial name
- NCT07806357
- Testing
- Efficacy and Safety of Prednisolone Monotherapy Versus Prednisolone Plus Methotrexate in Erythema Nodosum Leprosum (Type 2 Lepra Reaction)
- Where
- Bangladesh
- Volunteers
- 19 people
- Sponsor
- Chittagong Medical College
Allergic Cutaneous Vasculitis, Urticaria
Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome
This Study is to evaluate the utility of prospective HLA-B*1301 screening on the incidence of dapsone hypersensitivity syndrome (DHS) in 3130 previously Dapsone(DDS)-naive patients.
- Conditions
- Allergic Cutaneous Vasculitis, Urticaria, Psoriasis, Acne
- Trial name
- NCT02550080
- Testing
- Dapsone, HLA-B*1301
- Where
- China
- Volunteers
- 3,130 people
- Sponsor
- Shandong Provincial Institute of Dermatology and Venereology
Leprosy, Hansen's Disease
The Effects of Traditional Chinese Medicine Mouthwash Solutions on the Oral Health of Leprosy Patients
The purpose of this study is to treat with traditional Chinese medicine mouthwash, and through the research of dental plaque detection and xerostomia questionnaire and traditional Chinese medicine treatment mechanism.
- Conditions
- Leprosy, Hansen's Disease, Xerostomia, Plaque
- Trial name
- NCT05091216
- Testing
- Traditional Chinese Medicine mouthwash, Dilute 50 times of Traditional Chinese Medicine mouthwash
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- Lo-Sheng Sanatorium
Leprosy
Serum Irisin Level In Leprosy Patients
Measurement of plasma irisin level in leprosy patients. Correlation of plasma irisin level between leprosy patients and healthy controls. Correlation of plasma irisin level in different leprosy types.
- Trial name
- NCT06416033
- Testing
- Serum Irisin
- Where
- Egypt
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Aswan University
Leprosy
Ciclosporin in the Management of Steroid Resistant Type 1 Reactions in Leprosy
Study 1B: Ciclosporin in the management of steroid resistant Type 1 Reactions in Leprosy Objective: A pilot study assessing the efficacy and safety of Ciclosporin as a second -line drug in patients with Type 1 Reactions who have…
- Trial name
- NCT00919451
- Testing
- ciclosporin
- Where
- Ethiopia
- Volunteers
- 16 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Leprosy
Leprosy Skin Test Antigens Phase 1
This is a small Phase I trial to evaluate the safety of the use as skin test antigens of the immunologically active proteins from the soluble/cytosol and insoluble cell wall of Mycobacterium leprae.
- Trial name
- NCT01920750
- Testing
- MLCwA, MLSA-LAM, Mock Antigen
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Leprosy
Ciclosporin in the Management of Chronic or Recurrent Erythema Nodosum Leprosum
Study 2B: Ciclosporin in the management of chronic or recurrent Erythema Nodosum Leprosum Aim: To assess the safety, tolerability and efficacy of Ciclosporin in the treatment of patients whose ENL is not controlled with standard…
- Trial name
- NCT00919776
- Testing
- prednisolone, ciclosporin
- Where
- Ethiopia
- Volunteers
- 20 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Leprosy, Leprosy, Multibacillary
Efficacy and Tolerability of Adjunct Metformin for Multibacillary Leprosy
This trial aims to evaluate the efficacy, tolerability and safety of adjunct metformin added to standard-of-care multi-drug therapy (MDT) in patients with multibacillary leprosy, and explore its effects on immunological…
- Conditions
- Leprosy, Leprosy, Multibacillary, Neglected Tropical Diseases
- Trial name
- MetLep (NCT05243654)
- Testing
- Metformin
- Where
- 6 sites in Indonesia
- Volunteers
- 166 people
- Sponsor
- Oxford University Clinical Research Unit Indonesia
Borderline Lepromatous Leprosy, Lepromatous Leprosy
Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in Leprosy
This study is a double-blind, randomized controlled trial examining the effect on ENL reactions of giving an additional year of clofazimine after completion of MDT in leprosy.
- Trial name
- NCT01290744
- Testing
- Clofazimine
- Where
- Philippines
- Volunteers
- 100 people
- Sponsor
- Paul Saunderson
Leprosy
Improved Understanding of Ongoing Transmission of Leprosy in the Hyperendemic Comoros (ComLep)
Despite decades of a solid leprosy control program, including active case finding and follow-up on therapeutic outcome, the Comoros islands of Anjouan and Moheli continue to be hyperendemic for leprosy, with leprosy case…
- Trial name
- ComLep (NCT03526718)
- Where
- Comoros
- Volunteers
- 889 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Erythema Nodosum Leprosum, Leprosy
CC-11050 Trial in Nepalese Patients With Erythema Nodosum Leprosum
This study will be a single center, Phase 2, open-label trial to evaluate the safety and efficacy of 200mg CC-11050 administered twice daily taken with food for patients with moderate to severe ENL.
- Trial name
- NCT03807362
- Testing
- CC-11050
- Where
- 2 sites in Nepal
- Volunteers
- 50 people
- Sponsor
- The Leprosy Mission Nepal
Leprosy
TGF β 1 Expression Related Gene Polymorphism
Leprosy is one of the oldest human infectious diseases. It is a chronic infectious contagious, granulomatous disease caused by intracellular bacillus.
- Trial name
- NCT06683690
- Testing
- Measurement of TGF- β1 in leprosy patients
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aswan University
Leprosy, Hansen's Disease
The Effect of "Jinchuang Ointment" (JCO) on the Treatment of Wounds in Patients With Hansen's Disease.
This study aimed to evaluate the effect of a Chinese herb complex "Jinchuang ointment" (JCO) on the treatment of chronic nonhealing wounds in patients with Hansen's disease and its mechanism.
- Conditions
- Leprosy, Hansen's Disease, Wounds
- Trial name
- NCT05047809
- Testing
- "Jingchuang Ointment"(JCO), Regular Treatment
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Lo-Sheng Sanatorium
Leprosy
Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy
There will be two study arms. Arm 1 will be the intervention arm in which there will be provided BE-PEP to all persons residing within 100 meters of an index case, to be repeated after four weeks for household contacts.
- Trial name
- BE-PEOPLE P3 (NCT05597280)
- Testing
- BE-PEP Bedaquiline, SDR-PEP Rifampicin, BE-PEP Rifampicin
- Where
- Comoros
- Volunteers
- 124,000 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Discrimination, Perceived
Trauma-Informed Motivational Interviewing in Rural Dwelling Samples
Leprosy remains a profoundly stigmatized condition in many rural communities worldwide, fostering social exclusion, body image dissatisfaction, and diminished mental health outcomes.
- Trial name
- NCT06909734
- Testing
- Trauma-Informed Motivational Interviewing
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Alexandria University
Leprosy
Treatment Protocol for Clofazamine in the Long Term Treatment of Leprosy
Clofazimine has shown effectiveness in the treatment of leprosy for many years. The World Health Organization and the National Hansen's Disease Program consider clofazamine to be standard therapy for treatment of multibacillary…
- Trial name
- NCT00852345
- Testing
- clofazamine
- Where
- United States
- Sponsor
- Kaiser Permanente