Clinical trials: Leprosy, open to volunteers
Skin and Connective Tissue Diseases, Neglected Tropical Diseases
Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers
Skin-related Neglected Tropical Diseases (Skin NTDs) affect about 1.8 billion people worldwide, particularly in poor and rural communities where healthcare access is limited.
- Conditions
- Skin and Connective Tissue Diseases, Neglected Tropical Diseases, Leprosy, Buruli Ulcer
- Trial name
- SkincAIr (NCT07506967)
- Testing
- A mobile app with AI functionality for diagnosing skin-related NTDs
- Where
- 5 sites in Democratic Republic of the Congo, Ethiopia and 3 more
- Volunteers
- 2,420 people
- Sponsor
- Kenya Medical Research Institute
Discrimination, Perceived
Trauma-Informed Motivational Interviewing in Rural Dwelling Samples
Leprosy remains a profoundly stigmatized condition in many rural communities worldwide, fostering social exclusion, body image dissatisfaction, and diminished mental health outcomes.
- Trial name
- NCT06909734
- Testing
- Trauma-Informed Motivational Interviewing
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Alexandria University
Leprosy, Lymphatic Filariases
Integrating Mental Health Into Neglected Tropical Disease Care in Ghana
Background Neglected Tropical Diseases (NTDs) are a group of diseases that are more common among the poorest people in the poorest countries.
- Conditions
- Leprosy, Lymphatic Filariases, Buruli Ulcer, Onchocerciasis
- Trial name
- IMAGINE (NCT07248462)
- Testing
- WHO Essential Care package for mental health and NTDs
- Volunteers
- 200 people
- Sponsor
- Liverpool School of Tropical Medicine
Leprosy, Mycobacterium Leprae Infection
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients
Mycobacterium leprae is a slow-growing bacillus that causes leprosy. the infection may take two to ten years to incubate. While the exact mechanism of infection transmission is unknown, direct bacillus absorption through the…
- Trial name
- NCT06819449
- Testing
- Dapsone
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- South Valley University
Leprosy, Leprosy, Multibacillary
Efficacy and Tolerability of Adjunct Metformin for Multibacillary Leprosy
This trial aims to evaluate the efficacy, tolerability and safety of adjunct metformin added to standard-of-care multi-drug therapy (MDT) in patients with multibacillary leprosy, and explore its effects on immunological…
- Conditions
- Leprosy, Leprosy, Multibacillary, Neglected Tropical Diseases
- Trial name
- MetLep (NCT05243654)
- Testing
- Metformin
- Where
- 6 sites in Indonesia
- Volunteers
- 166 people
- Sponsor
- Oxford University Clinical Research Unit Indonesia
Leprosy, Multibacillary
Telacebec in Adults With Multibacillary Leprosy (TEBULA Leprosy Trial)
The goal of this clinical trail is to evaluate whether short-course telacebec-based regimens can induce rapid and measurable reductions in M.
- Trial name
- TEBULA LEPROSY (NCT07918573)
- Testing
- Telacebec 300 mg, Telacebec 600 mg, Telacebec + Rifampicine
- Where
- Benin
- Volunteers
- 120 people
- Sponsor
- Fondation Raoul Follereau
Leprosy
Novel Interventions and Diagnostic Tests for Leprosy
Contact with Mycobacterium leprae (M. leprae) infected individuals is a risk factor for development of leprosy. Thus, detection of asymtomatically M.
- Trial name
- INDIGO#2 (NCT06222372)
- Testing
- Rifampin
- Where
- Bangladesh
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Annemieke Geluk
Erythema Nodosum Leprosum
Efficacy and Safety Study of Dovramilast in People With Leprosy Type 2 Reaction
Dovramilast has not been approved for leprosy type 2 reaction (erythema nodosum leprosum, ENL) or any other disease anywhere in the world.
- Trial name
- NCT07172659
- Testing
- Dovramilast, Prednisolone, Thalidomide
- Where
- 6 sites in United States, Benin and 4 more
- Volunteers
- 45 people
- Sponsor
- Medicines Development for Global Health
Leprosy, Leprosy Neuropathy
Accuracy of the Polymerase Chain Reaction of Ulnar Perineural Subcutaneous Aspirate Guided by Ultrasound for the Diagnosis and Monitoring of Leprosy Cure
Brief Summary Leprosy is a chronic granulomatous infectious disease caused by *Mycobacterium leprae* or *Mycobacterium lepromatosis*, characterized by peripheral nerve involvement that may lead to progressive neurological damage…
- Conditions
- Leprosy, Leprosy Neuropathy, Leprosy, Multibacillary, Leprosy--Patients
- Trial name
- Does not exist (NCT07515989)
- Testing
- Ultrasound-Guided Ulnar Perineural Subcutaneous Aspirate
- Where
- Brazil
- Volunteers
- 108 people
- Sponsor
- University of Brasilia
Leprosy, Hansen's Disease
Epidemiological, Clinical, Diagnostic, and Therapeutic Characteristics of Hansen's Disease in Costa Rica (2018-2025)
The goal of this observational retrospective study is to characterize the epidemiologic, clinical, diagnostic, and therapeutic features of Hansen's disease cases in Costa Rica between 2018 and 2025.
- Conditions
- Leprosy, Hansen's Disease, Leprosy--Patients, Lepromatous Leprosy
- Trial name
- NCT07448389
- Where
- Costa Rica
- Volunteers
- 130 people
- Sponsor
- Caja Costarricense de Seguro Social
Leprosy
Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy
There will be two study arms. Arm 1 will be the intervention arm in which there will be provided BE-PEP to all persons residing within 100 meters of an index case, to be repeated after four weeks for household contacts.
- Trial name
- BE-PEOPLE P3 (NCT05597280)
- Testing
- BE-PEP Bedaquiline, SDR-PEP Rifampicin, BE-PEP Rifampicin
- Where
- Comoros
- Volunteers
- 124,000 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Atopic Dermatitis, Psoriasis
Identification of Cutaneous and Blood Biomarkers Predictive of Response to Systemic Treatments During Chronic Inflammatory Skin Diseases
Chronic inflammatory skin diseases constitute a heterogeneous group of pathologies. They affect the skin but also other organs (joints, lungs, muscles, etc.). Their prognosis and response to treatments is extremely variable.
- Conditions
- Atopic Dermatitis, Psoriasis, Hidradenitis Suppurativa, Lichen Planus
- Trial name
- ImmuneSkinBank (NCT06599411)
- Testing
- Sampling
- Where
- France
- Volunteers
- 830 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris