Clinical trials: Lesion
de Novo or Restenosis Lesions
MedJ-01 Ridaforolimus Eluting Coronary Stent System Trial (JNIR)
MedJ-01 Ridaforolimus Eluting Coronary Stent System is a single use device/drug combination product comprising: A mounted Cobalt Chromium (CoCr) alloy based stent A Rapid Exchange (RX) Coronary System Delivery System A Poly…
- Trial name
- JNIR (NCT02828917)
- Testing
- MedJ-01 Ridaforolimus Eluting Coronary Stent System
- Where
- Japan
- Volunteers
- 104 people
- Sponsor
- Medinol Ltd.
Cardiac Surgical Procedures, Hemorrhage
A Premarket, Prospective, Randomized, Single-Blind Study to Compare the Veriset™ Hemostatic Patch to TachoSil® as an Adjunct to Hemostasis in Subjects Undergoing Cardiovascular Surgery
The objective of this study is to assess the safety and effectiveness of Veriset™ Hemostatic Patch in cardiovascular procedures by comparing Veriset™ Hemostatic Patch to TachoSil® in subjects undergoing open cardiovascular…
- Trial name
- NCT01639833
- Testing
- Veriset Hemostatic Patch, TachoSil®
- Where
- 12 sites in Belgium, Germany and 1 more
- Volunteers
- 90 people
- Sponsor
- Medtronic - MITG
Solitary Pulmonary Nodule, Biopsy, Fine-Needle
iNod System Human Feasibility Assessment
The purpose of this study is to demonstrate feasibility to access, visualize, and obtain specimens adequate for cytology of lung lesions in subjects with suspected lung cancer when using the iNod System.
- Trial name
- iNod (NCT02832284)
- Testing
- iNod System
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Boston Scientific Corporation
Central Nervous System Infections, Pseudotumor Cerebri
A Study to Test Performance of Needle Placements for Neuraxial Procedures Using Tactile Imaging vs Control
This study will compare the VerTouch device to the conventional palpation technique for performing diagnostic and therapeutic neuraxial procedures.
- Conditions
- Central Nervous System Infections, Pseudotumor Cerebri, Neurological Disorder, Cancer
- Trial name
- NCT04796935
- Testing
- Tactile Imaging (VerTouch), Control (palpation)
- Where
- 3 sites in United States
- Volunteers
- 95 people
- Sponsor
- IntuiTap Medical, Inc
Alzheimer's Disease
A 24-Week Efficacy, Safety and Tolerability of Rivastigmine Patch Study in Patients With Probable Alzheimer's Disease
The purpose of this study is to assess the efficacy, safety, and tolerability of Exelon® patch in patients with probable AD (MMSE 10-20), in order to support a planned regulatory submission and registration of Exelon transdermal…
- Trial name
- NCT01399125
- Testing
- Rivastigmine Patch, Rivastigmine Capsules
- Where
- 16 sites in China
- Volunteers
- 501 people
- Sponsor
- Novartis Pharmaceuticals
Pancreatic Cancer, Pancreatitis
TOF-18F-FDG-PET/CT in Patients With Suspected Pancreatic Cancer
Aim of the prospective study is a better differentiation of benign and malignant lesions in the pancreas in patients with suspected pancreatic cancer using images 30 and 90 min p.i.
- Conditions
- Pancreatic Cancer, Pancreatitis, IPMN
- Trial name
- TOF-P (NCT03914950)
- Testing
- PET/CT results with TOF/without TOF
- Volunteers
- 174 people
- Sponsor
- Medical University of Graz
Rosacea
A Study to Assess the Efficacy, Safety and Tolerability of DFD-04
The purpose of this exploratory study is to assess the efficacy, safety and tolerability of DFD-04 Ointment for topical treatment of rosacea over 12 weeks of treatment.
- Trial name
- NCT02828241
- Testing
- DFD-04 Ointment
- Where
- 8 sites in Germany
- Volunteers
- 61 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Psoriasis
Study to Evaluate Psoriasis Severity and Its Psychosocial Impact Using the Simplified Psoriasis Index (SPI), as Well as Long-term Safety, Tolerability and Efficacy of Secukinumab Administered Subcutaneously in Patients With Moderate to Severe Psoriasis
Evaluate psoriasis severity and its psychosocial impact using a novel Patient Reported Outcome (the Simplified Psoriasis Index SPI) at 16 weeks, as well as long-term safety, tolerability and efficacy of secukinumab administered…
- Trial name
- IPSI-PSO (NCT02595970)
- Testing
- Secukinumab
- Where
- 17 sites in France
- Volunteers
- 120 people
- Sponsor
- Novartis Pharmaceuticals
Type 1 Diabetes
Transdermal Basal Insulin Patch Study in Type 1 Diabetes
This study is designed to evaluate the pharmacokinetics/pharmacodynamics of an investigational basal insulin patch in type 1 diabetes patients.
- Trial name
- NCT00519623
- Testing
- PassPort(R) Transdermal Insulin Delivery System
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Altea Therapeutics
Nicotine Dependence
Adaptive Pharmacotherapy for Smoking Cessation
The purpose of this study is to assess an "adaptive" approach to smoking cessation pharmacotherapy. The protocol is designed to compare adaptive vs.
- Trial name
- NCT02501265
- Testing
- Varenicline Standard Protocol, Nicotine Patch Standard Protocol, Varenicline Adaptive Protocol
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- Duke University
Spinal Fusion Acquired, Spinal Stenosis
Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion
Major lumbar spine surgery causes inflammation, soreness and swelling that can delay discharge from the hospital. Dexmedetomidine (DEX) has been shown to have anti-inflammatory effects.
- Conditions
- Spinal Fusion Acquired, Spinal Stenosis, Lesions of Lumbosacral Intervertebral Disc, Spinal Diseases
- Trial name
- DEXREDLOS (NCT00808665)
- Testing
- Dexmedetomidine, 0.9% Saline
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Vanderbilt University Medical Center
Diarrhea
Safety and Immunogenicity Study of Traveler's Diarrhea Vaccine Patch
The purpose of this study is to evaluate and compare the safety and immune responses following a two vaccination regimen by transcutaneous immunization with heat-labile enterotoxin of E.
- Trial name
- NCT01067781
- Testing
- Heat-Labile Enterotoxin of E. coli (LT)
- Where
- 5 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Intercell USA, Inc.
Eosinophilic Esophagitis
Value of Patch Testing in Direct Diet Therapy for Eosinophilic Esophagitis
This study is being done to see if allergy patch testing (APT) can help predict effective dietary therapy in patients with eosinophilic esophagitis.
- Trial name
- EoE (NCT02227836)
- Testing
- Allergy Patch Testing
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Oral Cancer
Erlotinib Prevention of Oral Cancer (EPOC)
The goal of this clinical research study is to learn if erlotinib hydrochloride (Tarcevaâ (OSI-774 ) can prevent cancer in the mouth of people with a high risk of developing cancer in the mouth.
- Trial name
- NCT00402779
- Testing
- Erlotinib
- Where
- 4 sites in United States
- Volunteers
- 303 people
- Sponsor
- M.D. Anderson Cancer Center
Dental Caries in Children, Dental Caries Class II
Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective…
- Conditions
- Dental Caries in Children, Dental Caries Class II, Dental Caries
- Trial name
- NCT03770286
- Testing
- 5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Lung Biopsy
Effect of Autologous Blood Patch Injection Versus BioSentry Hydrogel Tract Plug in the Reduction of Pneumothorax Risk Following Lung Biopsy Procedures
The purpose of this study is to compare two methods that are currently used at the end of a CT guided lung biopsy to close the hole on the surface of the lung in order to minimize the chance of air leaking out of the hole.
- Trial name
- NCT02224924
- Testing
- ABPI, BioSentry (formerly known as Bio-Seal) hydrogel Tract Plug
- Where
- 2 sites in United States
- Volunteers
- 454 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pancreatic Cystic Lesions
Evaluation of PCLs Using Three EUS-FNA Needles
To document impact of EUS-FNA needle size and flexibility on effectiveness of pancreatic cystic lesions (PCL) aspiration, on ability to obtain sufficient material for standard diagnostic testing, and on diagnostic accuracy of…
- Trial name
- NCT01711294
- Testing
- 19 G Flex Needle, 22 G Needle, 19 G Needle
- Where
- 8 sites in United States, China and 1 more
- Volunteers
- 250 people
- Sponsor
- Boston Scientific Corporation
Meniscus Disorder, Meniscus, Torn Tibial
Blood Flow Restriction After Meniscus Repair
The purpose of this study is to evaluate post-operative outcomes after meniscus surgery in participants undergoing blood flow restriction training as a rehabilitative adjunct compared to those with standard rehabilitation.
- Conditions
- Meniscus Disorder, Meniscus, Torn Tibial, Meniscus Lesion, Meniscus Tear, Tibial
- Trial name
- NCT04436523
- Testing
- Blood flow restriction (Delfi Personalized Tourniquet System), Standard rehabilitation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, San Francisco
Gastric Ulcer, Duodenal Ulcer, Acute Stress Gastritis, and Acute Gastric Mucosal Lesions
Lansoprazole Intravenous 30 mg Specified Drug-use Survey [Hemostatic Effect/Rebleeding Rate]
The purpose of this survey is to evaluate the safety (i.e., frequency of adverse events) and efficacy (i.e., hemostatic effect, rate of rebleeding after confirmation of hemostasis) of administration of lansoprazole intravenous 30…
- Trial name
- NCT02151786
- Testing
- Lansoprazole
- Volunteers
- 1,120 people
- Sponsor
- Takeda
Colon Adenoma, Colon Polyp
Gastroenterology Artificial INtelligence System for Detecting Colorectal Polyps (The GAIN Study)
This is a prospective, multicenter, randomized controlled study to evaluate the effect of the Computer-Assisted Detection (CADe) Device on Adenomas Per Colonoscopy and Positive Percent Agreement for routine colonoscopies.
- Conditions
- Colon Adenoma, Colon Polyp, Colon Lesion
- Trial name
- GAIN (NCT05275556)
- Testing
- Computer-Assisted Detection (CADe) Device
- Where
- 7 sites in United States, Israel
- Volunteers
- 1,410 people, healthy volunteers welcome
- Sponsor
- Verily Life Sciences LLC