Clinical trials: Lesion
Endobronchial Lesions
Safety and Diagnostic Yield of Cryobiopsy Versus Forceps Biopsy in Endobronchial Lesions:Assiut University Experience
The purpose of this study is to assess the diagnostic yield and show the feasibility and safety of endobronchial biopsies using the flexible cryoprob and to assess the sensitivity of cryobiopsy compared with forceps biopsy
- Trial name
- NCT04227743
- Testing
- cryobiopsy
- Volunteers
- 300 people
- Sponsor
- Assiut University
Adnexal Lesion
Role of Magnetic Resonance Imaging in Diagnosis of Adnexal Cystic Lesions
This prospective study aims to evaluate the diagnostic accuracy of magnetic resonance imaging (MRI) in characterizing adnexal cystic lesions and differentiating benign from malignant lesions.
- Trial name
- NCT07334184
- Testing
- Magnetic Resonance Imaging
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
HSIL, High Grade Squamous Intraepithelial Lesions, Anal Cancer
A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand
The purpose of this research is to assess the safety and effectiveness of circumferential radiofrequency ablation (RFA) to the anal canal using the BarrxTM Ablation System to destroy anal high-grade squamous intraepithelial…
- Conditions
- HSIL, High Grade Squamous Intraepithelial Lesions, Anal Cancer, HPV-Related Squamous Cell Carcinoma, Human Papilloma Virus
- Trial name
- NCT03302858
- Testing
- BARRX™ Anorectal Wand
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stephen E. Goldstone
Chondral or Osteochondral Lesion of Talus
Efficacy and Safety of Allogenic Stem Cell Product(CARTISTEM®) for Osteochondral Lesion of Talus
The purpose of this study is to evaluate the efficacy and safety of adding CARTISTEM®(allogenic umbilical cord blood-derived stem cell product) on microfracture, a currently standard treatment for OLT, in patients with talar…
- Trial name
- NCT04310215
- Testing
- CARTISTEM®, Microfracture
- Where
- 6 sites in South Korea
- Volunteers
- 102 people
- Sponsor
- Hyundai Bioland Co., Ltd.
Angioplasty, Cardiovascular Disease
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS) China Single-Arm Study
Abbott Vascular (AV) obtained marketing approval for the XIENCE PRIME Everolimus Eluting Coronary Stent System (XIENCE PRIME EECSS) in China from the China Food and Drug Administration (CFDA) on August 10th, 2011.
- Conditions
- Angioplasty, Cardiovascular Disease, Coronary Artery Disease, Coronary Heart Disease
- Trial name
- XP China SAS (NCT01894152)
- Testing
- XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
- Where
- United States
- Volunteers
- 2,002 people
- Sponsor
- Abbott Medical Devices
Colon Lesions
A Phase I In-Vivo Peptide Applied in the Right Colon
You are invited to participate in a research study to develop new ways to look for abnormal areas/tissues of the colon. The current endoscopes used to look at the colon are very good, but if the area doesn't look different to the…
- Trial name
- NCT01722058
- Testing
- Peptide application
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cardiac Arrhythmia, Brain Lesion
Berlin Beat of Running Study
This prospective observational study will investigate the frequency of new onset atrial fibrillation (AF) and of further cardiac arrhythmias as well as of (clinically silent) cerebral lesions in endurance runners before, during…
- Conditions
- Cardiac Arrhythmia, Brain Lesion, Stroke
- Trial name
- NCT01428778
- Where
- Germany
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Dental Restoration Failure
Evaluation of Adhering Flowable Composite With and Without Adhesive Vs Flowable in Cervical Lesions
With limited evidence-based information in literature about using self-adhering flowable composite in conservative class V restorations, it was found beneficial to evaluate the newly introduced material using a randomized…
- Trial name
- NCT03859284
- Testing
- flowable resin composite, self adhering flowable, self adhering flowable with adhesive
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Lesion With Known or Suspected F-choline Uptake
Choline-PET: Exploratory Study Assessing the Potential Role of F-choline PET Imaging in New and Emerging Indications
Choline is an important building block of phospholipids in cell membranes. Certain cancers and medical conditions are known to demonstrate increased absorption and incorporation of choline into their cell membranes.
- Trial name
- F-choline (NCT04999215)
- Testing
- F-choline intravenous injection
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Bone Lesions
Role of SPECT/CT of Bone Scan in Charactarization of Bone Lesions
This observational study aims to assess the diagnostic value of SPECT/CT of 99mTc-MDP bone scintigraphy in differentiating begnin from malignant bone lesions.
- Trial name
- NCT07248033
- Testing
- SPECT/CT
- Volunteers
- 120 people
- Sponsor
- MennaTalla Saber Sabet Mohamed
Colo-rectal Cancer
Efficacy of a Hemostatic Agent (PuraStat®) in Reducing Delayed Bleeding After Endoscopic Submucosal Dissection
The problem of delayed bleeding after endoscopic resection is becoming important due to the growing number of indications for anti-aggregation or anticoagulant treatment for cardiovascular reasons in the aging populations.
- Trial name
- NCT05031325
- Testing
- Endoscopic submucosal dissection with Purastat
- Where
- France
- Volunteers
- 288 people
- Sponsor
- Mathieu Pioche
Helicobacter Pylori Infection, Premalignant Lesion
Application of Artificial Intelligence on the Diagnosis of Helicobacter Pylori Infection and Premalignant Gastric Lesion
The aim of this study is to evaluate the impact of artificial intelligence (AI) assistance during routine upper endoscopy on gastric cancer-specific mortality.
- Trial name
- NCT05762991
- Testing
- Routine endoscopy with artificial intelligence-assisted interpretation
- Where
- Taiwan
- Volunteers
- 6,000 people
- Sponsor
- National Taiwan University Hospital
Cerebral White Matter Lesions
MRI,Gene And Cognitive Performance Study of Patients With Cerebral White Matter Lesions(WMLs)
The purpose of this study is:1)to observe topological organization in brain structural and functional networks in cerebral white matter lesion patients and to evaluate the association between impairment of cognitive function and…
- Trial name
- NCT02276976
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wei Wang
Prostate Adenocarcinoma, Prostate Cancer
Hypofractionated Focal Lesion Ablative Microboost in prostatE Cancer 2.0
The hypo-FLAME 2.0 study is a multicenter phase II study (n=124) investigating the feasibility and safety of a reduction in the overall treatment time of radiotherapy for prostate cancer patients, making use of hypofractionated…
- Conditions
- Prostate Adenocarcinoma, Prostate Cancer, Prostate Neoplasm
- Trial name
- NCT04045717
- Testing
- Hypo-FLAME 2.0 study
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 124 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spondyloarthropathies
The Characterization of Small Bowel and Colonic Involvement in Patients With Seronegative Spondyloarthritides
Up to 60% of patients with Seronegative Spondyloarthritides have inflammation in the colon or ileum. This is usually asymptomatic, but in 5 to 10% of patients with SA, Frank IBD will develop.
- Trial name
- SPONDILENDO (NCT00768950)
- Testing
- Capsule endoscopy examination, Colonoscopy
- Where
- Romania
- Volunteers
- 65 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Prostate Cancer
CyberKnife Ultra-hypofractionated SBRT for Localized PROStatE cancEr
This is a prospective observational study. The study will proceed with the enrollment of 60 patients in 2 years. he aim of the present study is to evaluate effectiveness of ultra-hypofractionated (UH) CyberKnife Stereotactic Body…
- Trial name
- PRO-SPEED (NCT06331013)
- Testing
- CyberKnife ultra-hypofractionated SBRT
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- European Institute of Oncology
Stomach Neoplasms
Enhanced Magnifying Endoscopy for Diagnosis of Early Gastric Cancer
When performing screening endoscopy, small focal gastric lesions are frequently encountered. Novel techniques in endoscopy, such as magnifying endoscopy (ME) with narrow-band imaging (NBI) and chromoendoscopy with acetic…
- Trial name
- NCT01617876
- Where
- China
- Volunteers
- 282 people
- Sponsor
- Peking Union Medical College Hospital
Oral Cancer
Erlotinib Prevention of Oral Cancer (EPOC)
The goal of this clinical research study is to learn if erlotinib hydrochloride (Tarcevaâ (OSI-774 ) can prevent cancer in the mouth of people with a high risk of developing cancer in the mouth.
- Trial name
- NCT00402779
- Testing
- Erlotinib
- Where
- 4 sites in United States
- Volunteers
- 303 people
- Sponsor
- M.D. Anderson Cancer Center
Atrial Fibrillation, Ischemic Stroke
Clinical Implication of Atrial Fibrillation Detection Using Wearable Device in Patients With Cryptogenic Stroke
Atrial fibrillation (AF) detected after ischemic stroke has immediate therapeutic implications, because it prompts a switch from antiplatelet to anticoagulant therapy.
- Conditions
- Atrial Fibrillation, Ischemic Stroke, Transient Ischemic Attack
- Trial name
- CANDLE-AF (NCT04624646)
- Testing
- Ambulatory Holter monitoring, Discontinuous monitoring, Continuous single-lead ECG Patch
- Where
- 7 sites in South Korea
- Volunteers
- 338 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Skin Lesions
The Validation of New Photographic Technology for Assessing Skin Lesions
The purpose of this study is to determine the validity of a new photographic technology in a dermatologic setting. The digital picture uses high levels of resolution to look at skin biopsy lesions.
- Trial name
- NCT06663241
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Wright State University
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