Clinical trials: Lesion
Coronary Artery Stenosis
Fractional Flow Reserve (FFR) Versus Intravascular Ultrasound (IVUS) in Intermediate Coronary Artery Disease
This study is a prospective, randomized, multi-center, open label trial to compare the clinical outcomes and effectiveness of Intravascular ultrasound (IVUS) versus Fractional Flow Reserve (FFR) guided Percutaneous coronary…
- Trial name
- FAVOR (NCT01175863)
- Testing
- Grey scale intravascular ultrasound (Galaxy or Virtual histology-Intravascular Ultrasound), Pressure wire(Radi Medical Systems)
- Where
- 8 sites in South Korea
- Volunteers
- 1,400 people
- Sponsor
- Ajou University School of Medicine
Melanoma
Analysis of Skin Lesions for Melanoma Presence by Volatile Spectroscopy Techniques
The purpose of this research study is to determine if a very sensitive chemistry lab analyzer can be used to smell a skin cancer (like melanoma) similar to some dogs.
- Trial name
- NCT02393001
- Testing
- Dermatology patients
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Florida
Colorectal Lesions, Endoscopic Submucosal Dissection (ESD)
Effect of Simplified Robot (FASTER) Assisted Versus Conventional Endoscopic Submucosal Dissection (ESD) for Colorectal Lesions
This study aims to compare the outcomes of Simplified Robot (FASTER) assisted Endoscopic Submucosal Dissection (ESD) with conventional ESD in the treatment of colorectal lesions.
- Conditions
- Colorectal Lesions, Endoscopic Submucosal Dissection (ESD), FASTER Robot
- Trial name
- NCT07354867
- Testing
- FASTER robot-assisted ESD group, Conventional ESD group
- Volunteers
- 40 people
- Sponsor
- Kaiyun Liu
Dental Caries, White Spot Lesions
QLF and Digital Imaging for Caries Activity Assessment After Orthodontic Treatment
This prospective longitudinal observational study aims to evaluate the diagnostic performance and agreement of Smartphone photography, intraoral 3D imaging, Quantitative Light-Induced Fluorescence Digital (QLF-D), and ICDAS…
- Conditions
- Dental Caries, White Spot Lesions, Caries Lesion Activity, Post-Orthodontic Enamel Demineralization
- Trial name
- NCT07608471
- Volunteers
- 30 people
- Sponsor
- Universidad El Bosque, Bogotá
Metastatic Bone Lesion
Phase 1/2 Study to Determine Optimal Dose for Treating Bone Metastases Using Novel STAT-RT Workflow
The purpose of this research study is to evaluate the safety and effectiveness of an experimental procedure called Focused Radiation that may result in a faster way to plan and deliver radiation for the treatment of pain caused…
- Trial name
- NCT02145286
- Testing
- Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Paul W. Read, MD
Ovarian Neoplasms, Ovarian Cancer
Improved Diagnosis of Ovarian Cancer
After implementation of systematic image description of adnexal masses, we aim to improve and evaluate our use of available imaging methods and biomarkers for classifying adnexal masses and distinguishing between benign and…
- Conditions
- Ovarian Neoplasms, Ovarian Cancer, Ovarian Cysts, Adnexal Mass
- Trial name
- NCT05842629
- Where
- Denmark
- Volunteers
- 1,700 people
- Sponsor
- University of Aarhus
Nutrition Related Neoplasm/Cancer
Dietary Factors Associated to Colorectal Premalignant Lesions (COLOMAR-1)
This study aims to find a correlation between fish protein intake and other dietary habits and colorectal premalignant lesions in healthy volunteers.
- Trial name
- NCT06368661
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fundación Vithas
Ischemic Heart Disease
Registry of Comprehensive Imaging and Physiological Evaluation of Deferred Lesions Based on FFR
1. To compare the risk of atherosclerotic lesion progression and subsequent patient-oriented composite outcomes (all-cause mortality, any MI, or any Ischemia-driven repeat revascularization) between deferred lesions with or…
- Trial name
- IMPACT-FFR (NCT03030495)
- Testing
- Comprehensive physiologic evaluation, Intravascular imaging devices
- Where
- 4 sites in South Korea
- Volunteers
- 1,400 people
- Sponsor
- Samsung Medical Center
Cardiovascular Disease, de Novo Coronary Lesions
TAXUS ARRIVE 2: A Multi-Center Safety Surveillance Program
The TAXUS ARRIVE 2 study is a multi-center safety and surveillance study designed to to compile safety surveillance and clinical outcomes data for the TAXUS™ Express2™ Paclitaxel-Eluting Coronary Stent System in routine clinical…
- Trial name
- ARRIVE 2 (NCT00569751)
- Testing
- TAXUS™ Express2™ Paclitaxel-Eluting Coronary Stent System
- Where
- 53 sites in United States
- Volunteers
- 5,016 people
- Sponsor
- Boston Scientific Corporation
Vascular Accident, Brain, Traumatic Brain Injury
Automated Versus Standard Physiotherapy for Upper Limb Rehabilitation in Patients With Acquired Brain Lesions
The Armeo Spring has proven its effectiveness in the rehabilitation of acute stroke patients. It neutralizes limb weight, enabling patients to use residual control in both arm and hand and to follow exercises guided by…
- Trial name
- NCT01398553
- Testing
- Armeo Spring, conventional physiotherapy
- Where
- 2 sites in Italy
- Sponsor
- Krankenhaus Bozen
Root Canal Obturation
Root Canal Obturation With a Ready-to-use Root Canal Sealer (PA1704) Versus BioRoot™ RCS: a Randomized Controlled Trial
The study design is a multicentric randomized controlled non-inferiority trial. 160 subjects (teeth) requiring a primary or a secondary root canal treatment will be enrolled in 2 groups (80 in each group).
- Trial name
- OPTIFILL (NCT04757753)
- Testing
- ready-to-use root canal sealer: PA1704, root canal sealer: BioRoot™ RCS
- Where
- 5 sites in Belgium, France
- Volunteers
- 160 people
- Sponsor
- Septodont
Normal, Sensitive Skin
To Assess Skin Safety of Test Product(s) by Patch Test on Adult Healthy Human Subjects
To Check Dermatological Safety of Test Products by 24 Hours Patch Testing
- Trial name
- NCT07109453
- Testing
- 18 Test Products along with positive and negative control
- Where
- India
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Invasive Breast Cancer
Evaluation of an Integrated Imaging System For In Vivo Detection of Fluorescently Labeled Lesions
This is a pilot study to test and characterize the ability of the Smart Goggles system to detect fluorescently labeled sentinel lymph nodes (SLNs).
- Trial name
- NCT02802553
- Testing
- Smart Goggle, Cardio-Green, SPY Elite Imaging system
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Case Comprehensive Cancer Center
Healthy Adult
Human Repeat Insult Patch Test to Evaluate Skin Irritation and Sensitization in Healthy Volunteers
This study evaluates skin irritation and sensitization following repeated application of a collagen-based material in healthy adult volunteers under controlled conditions.
- Trial name
- HRIPT (NCT07473661)
- Testing
- Collagen-Based Material
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- SerenaGroup, Inc.
Pancreatic Cystic Lesions
A Prospective Study To Identify Predictive Biological Markers In Blood And Cyst Fluid Aspirates From Patients With Pancreatic Cyst Lesions
The purpose To determine the diagnostic potential of various biological markers in blood and cyst fluid aspirates from patients with Pancreatic Cystic Lesions (PCLs).
- Trial name
- NCT02647177
- Testing
- Pancreatic Cyst Aspiration
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Coronary Syndrome
Drug-Coated Balloon Versus Drug-Eluting Stent for Treatment of De-Novo Coronary Lesions in Patients With High Bleeding Risk-2
A prospective, multi-center, open-label, randomized controlled, and superiority trial. The trial will compare clinical outcomes between discontinuation of antiplatelet agent and continuation of antiplatelet agent in HBR patients…
- Trial name
- DCB-HBR-2 (NCT06742931)
- Testing
- Discontinuation of antiplatelet agent group, Continuation of antiplatelet agent group
- Where
- 18 sites in South Korea
- Volunteers
- 1,200 people
- Sponsor
- Samsung Medical Center
Impetigo, Secondarily Infected Traumatic Lesions
Efficacy, Safety, and Tolerability of TD1414 2% Cream in Impetigo and Secondarily Infected Traumatic Lesions (SITL)
An international, multi-centre, prospective three arm parallel-group, phase II proof of concept study comparing the efficacy and safety of two dosage regimens (BID 7 days and TID 7 days) of TD1414 2% cream and one dosage regimen…
- Trial name
- NCT00626795
- Testing
- TD1414 2% cream, Bactroban® (mupirocin) 2% cream
- Where
- 2 sites in United States, South Africa
- Volunteers
- 773 people
- Sponsor
- LEO Pharma
Cancer, Lung, Perfusion Computed Tomography Target Lesion
DCE-CT of Thoracic Tumors as an Early Biomarker for Treatment Monitoring in Comparison With Morphologic Criteria
DCE-CT of thoracic tumors as an early biomarker for treatment monitoring in comparison with morphologic criteria. 1. Rationale of the clinical investigation For the evaluation of response to anti-tumoral therapy in thoracic…
- Conditions
- Cancer, Lung, Perfusion Computed Tomography Target Lesion, Cancer Liver, Metastatic Lung Cancer
- Trial name
- NCT04708483
- Testing
- Extra DCE-CT scan
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Hyperfusion
Head and Neck Cancer
Non-randomized, Open-label Study of Intralesional Nivolumab for High Risk Oral Premalignant Lesions
To characterize the safety and tolerability of nivolumab injected intralesionally in patients with high-risk oral premalignant lesions.
- Trial name
- NCT05327270
- Testing
- Nivolumab
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Sarcoidosis
Trial of Antimycobacterial Therapy in Sarcoidosis
Growing research from independent laboratories provide an association between mycobacteria and sarcoidosis. More recent immunologic and molecular studies demonstrate immune responses to mycobacteria virulence factors.
- Trial name
- CLEAR (NCT01074554)
- Testing
- Antibiotic Regimen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University
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