Clinical trials: Lesion
Atrial Fibrillation, Embolic Stroke of Undetermined Source
An Open-label Study of EZYPRO® in Atrial Fibrillation Detection on ESUS Patients
The aim of the study is to evaluate the effectiveness and safety of the 14-day continuous ECG patch monitor (EZYPRO®) compared with a 24-hour Holter monitor in the detection of atrial fibrillation (AF) among ESUS patients.
- Trial name
- NCT05089435
- Testing
- EZYPRO® ECG Recorder
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Sigknow Biomedical Co., Ltd.
Intermittent Claudication, Atherosclerotic Disease
Edwards Lifesciences Self-Expanding Stent Peripheral Vascular Disease Study
The main objective of this study is to assess the safety and effectiveness of the Edwards Lifesciences LifeStent nitinol self expandable stent device and its delivery system in the treatment of occlusive superficial femoral…
- Conditions
- Intermittent Claudication, Atherosclerotic Disease, Arterial Occlusive Disease
- Trial name
- RESILIENT (NCT00673985)
- Testing
- Percutaneous Transluminal Angioplasty, LifeStent NT™ Self-Expanding Peripheral Stent
- Volunteers
- 246 people
- Sponsor
- C. R. Bard
Colonic Polyp, Colonic Neoplasms
Endoscopic Surveillance in Serrated Polyposis Syndrome and Low-risk of Advanced Neoplasia
The aim of the study is to determine if Serrated Poliposis Syndrome (SPS) patients with SPS criteria, with clearing phase achieved and without any advanced lesion or less than 5 relevant lesions at last colonoscopy have the same…
- Conditions
- Colonic Polyp, Colonic Neoplasms, Colonic Cancer, Serrated Polyposis
- Trial name
- NCT04906343
- Testing
- Colonoscopy
- Where
- Spain
- Volunteers
- 144 people
- Sponsor
- Hospital Universitario de Móstoles
Lung Neoplasms, Diagnosis
Benefit of Cone-beam CT and Robotic-Assisted Bronchoscopy During Bronchoscopy
This randomized controlled trial evaluates the integration of cone-beam computed tomography (CBCT) and robotic-assisted bronchoscopy (RAB) for diagnosing pulmonary lesions, hypothesizing improved diagnostic yield compared to…
- Conditions
- Lung Neoplasms, Diagnosis, Lung Cancer
- Trial name
- NCT06489678
- Testing
- Robotic Assisted Bronchoscopy
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University of Zurich
Non-carious Cervical Lesions
Effect of Wet and Overwet Dentin on the Clinical Performance of Two Universal Adhesive Systems
The aim of this study will be to evaluate the effect of wet and overwet dentin on the long-term clinical performance of two universal adhesive systems used as etch-and-rinse application mode in non-carious cervical lesions…
- Trial name
- NCT07034235
- Testing
- Dentin Wet, Dentin Overwet, Ambar Universal APS Plus; FGM
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Osteochondral Lesions of the Talus
The Effect of Platelet Rich Plasma for the Treatment of Osteochondral Lesions of the Talus
Osteochondral lesion of the talus (OCL) results from the detachment of the talar cartilage which could also be associated with subchondral bone fragmentation due to trauma.
- Trial name
- NCT05795660
- Testing
- platelet rich plasma
- Volunteers
- 24 people
- Sponsor
- Ministry of Health, Kuwait
Hemodialysis, Ultrafiltration, Bioimpedance
Correlation of Ultrafiltered Volume (UFV) to Bioimpedance Changes
Patient submitted to hemodialysis are followed through a dialysis - interim - dialysis cycle. No intervention is done. Additional blood tests and clinical tests are used as pseudo-endpoints.
- Trial name
- CTR006 (NCT04937478)
- Testing
- Observation
- Where
- 2 sites in Norway
- Volunteers
- 31 people
- Sponsor
- Mode Sensors AS
Peripheral Arterial Disease, Stenosis
A Trail of Sperstent® Used for Residual Lesions of Femoropopliteal Arteries
This is a prospective, multi-center, randomized trial designed to investigate the efficacy and safety of Sperstent® peripheral spot stent system versus Everflex® self-expanding peripheral stent system in the endovascular…
- Conditions
- Peripheral Arterial Disease, Stenosis, Dissection
- Trial name
- SURF (NCT06539689)
- Testing
- Sperstent® peripheral spot stent system, Everflex® self-expanding peripheral stent system
- Where
- 12 sites in China
- Volunteers
- 240 people
- Sponsor
- FrontAce Scientific Co., Ltd
Coronary Diseases, Left Main Coronary Artery Disease
Clinical Efficacy and Safety of a Prospective, Multicenter Drug Coated Balloon for Left Main Artery Disease in China
This is a prospective and observational study. Patients with primary mediana 010 or 001 left main bifurcation lesions were treated with drug ball coated balloon from November 2018 to November 2020 in four hospitals in Huaihai…
- Conditions
- Coronary Diseases, Left Main Coronary Artery Disease, Bifurcation Lesions
- Trial name
- NCT04641468
- Testing
- DCB
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xuzhou Third People's Hospital
Caries,Dental
Clinical Evaluation of Silver Nanoparticles in Comparison to Silver Diamine Fluoride in Management of Deep Carious Lesions
this clinical study will be carried out to evaluate the effect of fluoride varnish with silver nanoparticles in comparison to silver diamine fluoride in management of deep carious lesions.
- Trial name
- NCT05231330
- Testing
- silvernanoparticles, SDF
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Brain Tumor, Brain Cancer
A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors
The neurosurgical standard of care for treating a patient with a tumor invading hand primary motor cortex (M1) includes performing a craniotomy with intraoperative direct electrical stimulation (DES) mapping and to resect as much…
- Conditions
- Brain Tumor, Brain Cancer, Motor Cortex; Lesion
- Trial name
- NCT05023434
- Testing
- Intraoperative Brain Simulation - Alternate Stimulation Parameters
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Retention
Restoration of Non-carious Cervical Lesions With Different Resin Composites and Universal Adhesive
patients with non carious cervical lesions suffer from dentin sensitivity and presence of cavitations and gingival recession. Restoring these lesions with different composites and evaluation of restorations every 6 months will be…
- Trial name
- NCT06393699
- Testing
- composite restoration
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Cutaneous Manifestations, Skin Manifestations
Cutaneous Manifestations of Coronavirus Disease 2019(COVID-19).
An outbreak of Corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-coV-2) occurred in Wuhan city, Hubei province, China in December 2019.
- Conditions
- Cutaneous Manifestations, Skin Manifestations, COVID-19, COVID-19 Pneumonia
- Trial name
- NCT05094687
- Where
- Pakistan
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Pancreatic Mucinous Cystic Neoplasm, Pancreatic Serous Cystic Neoplasm
AI-Assisted Differentiation of Pancreatic Cystic Lesions Using EUS Images and Clinical Features
Pancreatic mucinous cystic neoplasms (MCNs), serous cystic neoplasms (SCNs), and pancreatic pseudocysts (PPCs) often exhibit overlapping imaging features on endoscopic ultrasound (EUS).
- Conditions
- Pancreatic Mucinous Cystic Neoplasm, Pancreatic Serous Cystic Neoplasm, Pancreatic Pseudocyst
- Trial name
- NCT07919704
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Ruijin Hospital
Psoriasis
Pilot Studies Testing Levels of P63 in Psoriasis Skin Lesions
The purpose of this study is to understand the role of a specific protein, tumor protein p63 in the skin disease psoriasis. This study is to further understand how psoriasis lesions happens.
- Trial name
- NCT04560647
- Testing
- No intervention - Psoriasis Subject, No intervention - Control Subject
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Wright State University
Parkinson's Disease
Pharmacokinetic Profile of Neupro Patch Administrated at 2 mg, 4 mg, 6 mg and 8 mg/Day Weekly in Patients With Early-stage Parkinson's Disease
To study the profile of Neupro patch administrated at 2 mg, 4 mg, 6 mg and 8 mg/day weekly in patients with early-stage Parkinson's disease
- Trial name
- NCT02728947
- Testing
- ROTIGOTINE
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Luye Pharma Group Ltd.
High-Grade Squamous Intraepithelial Lesions
Association Between Surgical Timing and Route of Total Hysterectomy After LEEP and Perioperative Risk in Patients With Cervical HSIL
This study aimed to analyze perioperative information in patients with high-grade squamous intraepithelial lesion (HSIL) undergoing total hysterectomy (TH), offering insights into optimal surgery timing, selecting the operation…
- Trial name
- NCT06325592
- Testing
- surgical timing and operation path
- Where
- China
- Volunteers
- 826 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Primary Coronary Artery Calcification
SoniCrackerTM Single-use Intracoronary Shockwave Catheter
This study aims to observe the safety and effectiveness of the SoniCrackerTM single-use intracoronary shockwave catheter in the pretreatment and balloon dilation of primary coronary artery calcification lesions (coronary artery…
- Trial name
- NCT07873736
- Volunteers
- 390 people
- Sponsor
- Shanghai Bluesail Boyuan Medical Technology Co., Ltd.
Multivessel Coronary Artery Disease, Acute Myocardial Infarction (AMI)
Evolocumab in Patients With Multivessel Coronary Disease After Acute Myocardial Infarction: A Target Trial Emulation
The goal of this Target Trial Emulation (TTE) study is to evaluate the effect of evolocumab on clinical prognosis in patients with multivessel disease (MVD) following acute myocardial infarction (AMI) who have deferred…
- Trial name
- EVEREST (NCT06740552)
- Testing
- Evolocumab, Lipid Lowering Medication
- Where
- China
- Volunteers
- 1,862 people
- Sponsor
- Shanghai Zhongshan Hospital
Hypopharyngeal Cancer, Laryngeal Cancer
A Machine Learning-Based Risk Prediction Model for Head and Neck Cancerous Lesions
This study aims to develop and validate a clinical prediction model for the risk of head and neck cancerous lesions using deep learning combined with AI algorithms, based on multi-center clinical data.
- Conditions
- Hypopharyngeal Cancer, Laryngeal Cancer, Head and Neck Cancer
- Trial name
- ML-HNC-Risk (NCT07532538)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
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