Clinical trials: Lesion
Dental Erosion
12 Months Clinical Follow-up of Non-Carious Cervical Lesions Restored With New Injectable Composite
Non-carious cervical lesions are defined as loss of pathological material not associated with caries in the enamel-cement junction of the tooth.
- Trial name
- NCT04095520
- Testing
- Laser Etching, Phosphoric acid etching
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Remitting-Relapsing Multiple Sclerosis
TMP001 in Relapsing-remitting Multiple Sclerosis
The purpose of this study is to assess the impact of TMP001 in the treatment of patients with relapsing-remitting multiple sclerosis (RRMS).
- Trial name
- NCT02686788
- Testing
- TMP001
- Where
- 5 sites in Germany
- Volunteers
- 9 people
- Sponsor
- Dr. Frank Behrens
Healthy Volunteers
Study in Healthy Volunteers to Prove That Two Different Formulations of Rotigotine Patches Deliver Equivalent Drug Amount to the Body
The major aim of this study is to investigate and compare the drug amount delivered to the body after sequential application of two Rotigotine patches of two different formulations
- Trial name
- NCT01059903
- Testing
- Rotigotine transdermal patch
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- UCB Pharma
Coronary Artery Disease
Advanced NanoTherapies Dual-API DCB to Treat De-Novo Lesions in Patients With Symptomatic Coronary Artery Disease
This prospective, single-arm, multi-center, safety and feasibility first-in-human study will evaluate the safety and feasibility of the SirPlux Duo™ Dual-API Coated PTCA Balloon Catheter to treat de-novo lesions between ≥2.0 and…
- Trial name
- ADVANCE-DCB (NCT05521542)
- Testing
- SirPlux Duo™ Dual-API Coated PTCA Balloon Catheter
- Where
- 5 sites in Australia, Dominican Republic and 1 more
- Volunteers
- 28 people
- Sponsor
- Advanced NanoTherapies
Non-carious Cervical Lesions
Clinical Evaluation of a New Giomer Restorative System in Class V Restorations
The objective of this study is to evaluate the clinical effectiveness of a new composite resin (SHOFU Beautifil II LS) vs a control (3M/ESPE Filtek Supreme) for use in restoring non carious cervical lesions Class V lesions.
- Trial name
- NCT03153969
- Testing
- SHOFU Beautifil II LS, 3M/ESPE Filtek Supreme
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Tufts University
Febrile Neutropenia
ECM and Monitoring w/ Alio Smart Patch in Cancer Pts Receiving Chemotherapy
Undergoing cancer treatment comes with various risks and side effects. This clinical trial aims to reduce those risks and side effects through continuous monitoring of vital signs and blood levels.
- Trial name
- NCT06657183
- Testing
- Alio Smart Patch™
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Case Comprehensive Cancer Center
Cervical Cancer
Measurement of Digital Colposcopy for Fluorescence Spectroscopy of Cervical Intraepithelial Neoplasia
The overall objective of this study is to identify potential improvements for a noninvasive method of diagnosing dysplasia and neoplasia in the cervix using digital colposcopy for colposcopy for fluorescence spectroscopy.
- Trial name
- NCT00513123
- Testing
- Colposcopy
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Early Gastric Cancer
A Predictive Model Based on Narrow Band Imaging for Early Gastric Cancerous Lesions
Without high diagnostic efficacy of endoscopic forceps biopsy (EFB) and with low diagnostic efficacy of narrow band imaging (NBI) in novice endoscopists and endoscopists of community hospitals in China, it is urgent to improve…
- Trial name
- NCT02968069
- Testing
- NBI
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Small Bowel Neoplasia, Neuroendocrine (NE) Tumors
Use of 68Ga-DOTATOC PET/CT-enterography for Detection of the Primary Lesion in Neuroendocrine Tumors of the Small Bowel
The neuroendocrine neoplasms of the small intestine (Si-NENs) is a relatively rare malignancy. Surgical resection is the only curative treatment for the early-stage.
- Trial name
- NCT06773624
- Testing
- PET/CT-enterography with 68Ga-DOTATOC
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- European Institute of Oncology
Vascular Lesion, Pigmented Lesions
Evaluation of Safety and Efficacy of IPL Presets for Cutaneous Lesions
Single-center, Prospective, Open-Label with Before-After Study Design. Each subject will receive up to three (3) consecutive treatments at 1-month interval.
- Trial name
- NCT05630690
- Testing
- IPL with smart diagnostic handpiece
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lumenis Be Ltd.
Cardiac Arrhythmia
True Continuous ECG Monitoring (TCEM Study)
The purpose of this study is to compare short term (up to 48 hours) traditional cardiac rhythm monitoring using a standard ambulatory Holter monitor versus long term (up to 14 days), continuous ambulatory cardiac rhythm…
- Trial name
- TCEM (NCT01559246)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- iRhythm Technologies, Inc.
Bruxism, Noncarious Cervical Lesions
Clinical Performance of a Glass Hybrid Restorative in NCCL's of Patients With Bruxism
This is a double blinded, split mouth, randomized clinical study that evaluated the performance of a glass hybrid restorative material in non-carious servical lesions in patients with bruxism.
- Trial name
- NCT03713827
- Testing
- tooth restoration
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Coronary Artery Disease
Nordic-Baltic Coronary Revascularization Study in Patients With Proximal Left Descending Coronary Artery (LAD) Lesion.
The Nordic-Baltic Heart Team Initiative for improved long-term coronary artery revascularization outcome compares quality of life and survival after coronary bypass grafting (CABG) vs.
- Trial name
- NOBLE-LAD (NCT03538886)
- Testing
- Coronary artery bypass grafting (CABG), Percutaneous coronary intervention (PCI)
- Where
- Denmark
- Volunteers
- 4 people
- Sponsor
- Aalborg University Hospital
Brain Tumors
Fluorescence Guided Resection of Brain Tumors
Removing a tumor from your brain is hard to do because, very often, brain tumors do not have boundaries that are easy for your surgeon to find. In many cases, the surgeon can't tell exactly where the tumor begins or ends.
- Trial name
- FGR (NCT00870779)
- Testing
- 5-aminolevulinic acid
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- David W. Roberts
Umbilical Hernia
Self-Expanding Multi-Layered Partially Resorbable Lightweight Polypropylene Mesh Device (Proceed Ventral Patch® Or Pvp®) For The Treatment of Small and Medium Umbilical Ventral Hernias
Meshes-devices using dual-sided mesh technology have been developed for the specific indication of small ventral hernias. The design of these meshes allows introduction of a mesh of appropriate size to cover the hernia defect…
- Trial name
- NCT01307696
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Substance Abuse
Contingency Management for Smoking in Substance Abusers
The aim of this study is to determine whether contingent reinforcement for smoking abstinence, compared to noncontingent reinforcement, increases the effectiveness of brief counseling and nicotine replacement on smoking…
- Trial name
- SCMSUD (NCT00807742)
- Testing
- Nicotine Replacement Treatment (NRT), Brief Advice, Contingency Management
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- Brown University
Image Quality of Early Esophageal Squamous Neoplasia, Endoscopists'Subjective Assessments
Different Lugol's Solution Concentration for Image Quality of Esophageal Lesions in Chromoendoscopy With Iodine Staining
The purpose of this study is to assess whether lower Lugol's solution concentration can perceive the same image quality of early esophageal squamous neoplasia.
- Trial name
- NCT03180970
- Testing
- 1.2% Lugol's solution, 1.0% Lugol's solution, 0.8% Lugol's solution
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shandong University
Prostatic Neoplasms
Effectiveness of 68Ga-PSMA PET/MRI for Improving the Detection of csPCa in Lesions With PI-RADS Score 3
The purpose of this study was to explore the effectiveness of 68Ga-PSMA PET/MRI for improving the detection of csPCa in lesions with PI-RADS score 3. This study is a prospective, observational study, single-center research.
- Trial name
- NCT04573179
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Anal High Grade Squamous Intraepithelial Lesion, Anal Precancerous Condition
Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL
This is a phase II double blind, placebo-controlled, randomized study of Artesunate suppositories for the treatment of HIV-negative men and women who have anal high grade squamous intraepithelial lesions (anal HSIL)
- Conditions
- Anal High Grade Squamous Intraepithelial Lesion, Anal Precancerous Condition, AIN 2/3, HPV Infection
- Trial name
- anal HSIL HIV- (NCT05555862)
- Testing
- Artesunate
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Frantz Viral Therapeutics, LLC
Chronic Coronary Syndrome
CTFFR and Prediction of Non-Significant CAD Lesions
In this prospective cohort study, 250 patients with suspected or known CAD and at least one intermediate coronary lesion (50-70% stenosis) who had a NiFFR value greater than 0.80 underwent coronary computed tomography angiography…
- Trial name
- NCT06979427
- Testing
- NIFFR
- Where
- Iran
- Volunteers
- 250 people
- Sponsor
- Shiraz University of Medical Sciences
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