Clinical trials: Lesion
Generic Drug Quality, Generic Formulation Interchangeability
Generic Formulations of Commonly-used Oral Drugs in Saudi Arabia:Interchangeability & Post-marketing Quality
Generic formulations of prescription drugs can, through their relatively lower cost, improve healthcare as long as they maintain their registration-quality and public trust.
- Trial name
- NCT01344070
- Testing
- one of the 15 drugs listed below
- Where
- Saudi Arabia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King Faisal Specialist Hospital & Research Center
Colonic Polyp
Effect of Epinephrine on Post-polypectomy Pain
Epinephrine is widely used in endoscopic mucosal resection of large polyps to prevent post-polypectomy bleeding. No previous studies looked at increase in immediate post-polypectomy pain with the use of epinephrine.
- Trial name
- NCT04065451
- Testing
- Epinephrine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Indiana University
Prostate Cancer
Ex-vivo Investigation of Beta Probe for Prostate Cancer Resection and Evaluation of PSMA-PET for Diagnosis of Intraprostatic Lesions
68Ga-PSMA is a radiopharmaceutical used with PET imaging for the detection of prostate cancer under a compassionate IND in patients who have presented with biochemical failure.
- Trial name
- NCT03213951
- Testing
- Experimental beta probe, PSMA-PET
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Indiana University
Smokers
Oral Mucosal Lesions Among Smokers in an Egyptian Population.
This cross-sectional study will assess the prevalence of oral changes among smokers in an Egyptian cohort (patients attending to the hospital of Faculty of Dentistry - Cairo University), aiming that this study can serve as a…
- Trial name
- NCT03299595
- Testing
- printed questionnaire
- Where
- Egypt
- Volunteers
- 824 people, healthy volunteers welcome
- Sponsor
- Cairo University
Adenoma, Sessile Serrated Adenoma
Texture and Colour Enhancement Imaging in Improving Detection and Miss Rate of Premalignant Lesions
Texture and Color Enhancement Imaging (TXI) is a newly developed image-enhancing endoscopy technology that has show potential in improving detection of colorectal lesions.
- Trial name
- NCT06515977
- Testing
- TXI (Group A), TXI followed by WLI (Group B), WLI (Group C)
- Volunteers
- 2,964 people
- Sponsor
- Changhai Hospital
Stroke, Aphasia
Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe
This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on lexicosemantic impairments, to enhance recovery.
- Trial name
- ATLAS (NCT07608588)
- Testing
- continuous Theta Burst Stimulation, intermittent Theta Burst Stimulation, Semantic Feature Analysis
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of South Carolina
Spinal Cord Neoplasm
FDG PET-MRI for the Diagnosis of Spinal Cord Lesions
To compare the results and understand the possible benefits from FDG-PET/MRI during different scanning time points after FDG, a type of contrast drug, is given.
- Trial name
- NCT04219969
- Testing
- Fludeoxyglucose F-18, Magnetic Resonance Imaging, Positron Emission Tomography
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Neoplasm Metastasis
Zoledronic Acid Administration to Metastatic Breast Cancer Patients With Non-symptomatic Bone Lesions
This is an open-label, randomized, multicenter phase III trial to assess the efficacy of early administration of zoledronate versus observation in delaying bone-related symptoms in metastatic breast cancer patients.
- Trial name
- NCT00130494
- Testing
- Zoledronic acid
- Where
- Spain
- Volunteers
- 97 people
- Sponsor
- Spanish Breast Cancer Research Group
Hepatocellular Carcinoma
Study of ThermoDox With Standardized Radiofrequency Ablation (RFA) for Treatment of Hepatocellular Carcinoma (HCC)
The purpose of this study is to determine whether ThermoDox, a thermally sensitive liposomal doxorubicin, is effective in the treatment of non-resectable hepatocellular carcinoma when used in conjunction with standardized…
- Trial name
- OPTIMA (NCT02112656)
- Testing
- ThermoDox, Dummy infusion
- Where
- 61 sites in United States, Canada and 12 more
- Volunteers
- 554 people
- Sponsor
- Imunon
Cancer, Infection
Comparison of "Wet Suction" Technique to Contemporary "Dry Suction" Technique Using a 22 Gauge Needle for EUS FNA
ROLE OF SUCTION IN EUS-FNA: Current suction technique involves suctioning the aspirate into the needle that has an air column. The needle is not flushed with any liquid prior to passing into the desired solid lesion.
- Conditions
- Cancer, Infection, Inflammation, Tumor
- Trial name
- NCT01720745
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- University of Minnesota
Vitiligo
Deciphering the Vitiligo Transcriptomic Signature Between Repigmented and Non Repigmented Lesions
The purpose of this study is to perform an in-depth analysis of the molecular pathways involved in lesions responding to current treatment and lesions not responding to current treatment
- Trial name
- STRAVI (NCT05927272)
- Testing
- SKIN SAMPLES, BLOOD SAMPLES, narrowband UVB
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bordeaux
Endometrial Cancer, Cervical Cancer
Tachosil for the Prevention of Symptomatic Lymph Cysts
This is a randomized trial of 140 women with endometrial or cervical cancer undergoing removal of lymph tissue (lymphadenectomy).
- Trial name
- NCT01470677
- Testing
- Tachosil fibrin patch
- Where
- 2 sites in Austria, Germany
- Volunteers
- 220 people
- Sponsor
- Ruhr University of Bochum
Pressure Ulcers Prevention in Prone Positioning in Intensive Care
Pressure Sore Prevention Strategy for the Prone Position
The aim of this clinical trial is to determine whether 5-layer hydrocellular dressings are effective in preventing the development of pressure sores during prone positioning in the intensive care unit.
- Trial name
- DERM-H-PROTECT (NCT06442657)
- Testing
- Hydrocellular dressing, Hydrocolloids dressing
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Caen
Coronary Artery Disease
Impact of IntraVascular UltraSound Guidance on Outcomes of Xience Prime Stents in Long Lesions (IVUS-XPL Study)
This study is designed as a prospective, randomized, multi-center trial to demonstrate an inequality between IVUS-guided versus angiography-guided implantation of everolimus-eluting stents(EES) at long lesions(> 28 mm) in…
- Trial name
- NCT01308281
- Testing
- PCI with IVUS guidance, PCI without IVUS guidance
- Where
- South Korea
- Volunteers
- 1,079 people
- Sponsor
- Yonsei University
Trigeminal Neuralgia
An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia
This is a double blinded randomized control trial of a Surface Acoustic Wave Patch device for the treatment of Trigeminal Neuralgia. This will be a crossover study for the group that receives the sham device.
- Trial name
- NCT02801630
- Testing
- PainShield SAW Patch Device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rosenblum, Jonathan I., DPM
De Novo and Re-stenosed Coronary Artery Lesions
Long Term Safety Profile of the PRO-Kinetic ENERGY Coronary Stent System in Daily Clinical Practice
To evaluate the clinical performance of the PRO-Kinetic ENERGY® coronary bare metal stent system in a patient population within that defined in the Instructions for Use.
- Trial name
- ENERGY (NCT01056120)
- Testing
- Pro Kinetic Energy bare metal stent
- Where
- 50 sites in Austria, Belgium and 8 more
- Volunteers
- 1,026 people
- Sponsor
- Biotronik AG
Heart Diseases
Evaluate Safety and Effectiveness of XenoSure Biological Patch in the Application of Cardiac Repair
The purpose of this clinical trial is to collect safety and effectiveness data to support cardiac repair indication of XenoSure biologic patch. This trial is performed to meet the China FDA regulations for this kind of device.
- Trial name
- NCT03176225
- Testing
- Open heart surgery to address the heart disease, Close the defects with XenoSure Patch, Close the defects with Chest Polyester Patch
- Where
- China
- Volunteers
- 142 people
- Sponsor
- LeMaitre Vascular
Shoulder Lesions
Analgesic Efficacy of US-Guided Interscalene Block Versus Supraclavicular Block for Ambulatory Arthroscopic Rotator Cuff Repair
Ultrasound-guided interscalene block (ISB) is the reference technique for pain control after ambulatory upper limb surgery, but supraclavicular block (SCB) is an alternative procedure.
- Trial name
- BISBSC (NCT03743974)
- Testing
- arthroscopic shoulder surgery of rotary cuff (ISB), arthroscopic shoulder surgery of rotary cuff (CSB)
- Volunteers
- 108 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Periodontitis, Chronic, Periodontal Diseases
Effects of Antimicrobial Photodynamic Therapy on Regeneration of Class II Furcation Lesions
The aim of this study is to evaluate the additional effect of antimicrobial photodynamic therapy regeneration treatment of mandibular furcation lesions when associated to bovine bone and porcine collagen membrane.
- Conditions
- Periodontitis, Chronic, Periodontal Diseases, Periodontal Bone Loss
- Trial name
- NCT03264118
- Testing
- Scaling and root planing, Toluidine Blue O
- Where
- 2 sites in Brazil
- Volunteers
- 25 people
- Sponsor
- University of Sao Paulo
Healthy
Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Rotigotine Transdermal Patch in Healthy Chinese Subjects
This study is to characterize the Pharmacokinetics (PK) of unconjugated and total Rotigotine after single and multiple doses of Rotigotine transdermal patch, and also to investigate the safety and tolerability of Rotigotine…
- Trial name
- NCT01675024
- Testing
- Rotigotine, Period 1, Rotigotine, Period 2
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- UCB Pharma
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