Clinical trials: Lesion Skin, open to volunteers
Breast Cancer
Clinical Effectiveness of CEM in Diagnosis of Additional Findings at Preoperative Breast Magnetic Resonance Imaging
In order to explain the value of adding CESM into the clinical pathway, and also to obtain the relevant clinical data to support future update of clinical guideline, we plan to evaluate the detection rate of CESM for additional…
- Trial name
- COMBO-I (NCT06475066)
- Testing
- contrast-enhanced spectral mammography
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Breast Cancer, Ductal Carcinoma
Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer
The goal of this research study is to evaluate the efficacy and safety of low-dose exemestane versus low-dose tamoxifen in post-menopausal women at high risk for breast cancer.
- Conditions
- Breast Cancer, Ductal Carcinoma, Estrogen-receptor-positive Breast Cancer, Atypical Lobular Hyperplasia
- Trial name
- BabyTEARS (NCT07499999)
- Testing
- Exemestane, Tamoxifen
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Dana-Farber Cancer Institute
Giant Cell Arteritis
Association of Ultrasonographic Temporal Artery Lesions and Relapse in Patients With Giant Cell Arteritis
Ultrasound evaluation of the temporal and axillary arteries is currently well recognized in the field of giant cell arteritis (GCA), a disease primarily affecting medium- and large-caliber vessels.
- Trial name
- ALERT (NCT06894602)
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Cutaneous T Cell Lymphoma
Characterization of the Microbiome in Cutaneous T Cell Lymphoma Skin Lesions Before and After Use of APR-TD011® (RLF-TD011®) Spray Solution
This open-label, pilot study will evaluate the tolerance and change in the microbiome from the use of APR-TD011 ((RLF-TD011) wound cleansing spray for the treatment of CTCL skin lesions.
- Trial name
- NCT05728879
- Testing
- APR-TD011 (RLF-TD011)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Trachea Diseases, Tracheal Stenosis
Feasibility of Tracheobronchial Reconstruction Using Allogenic Aortic Patch in Children
Feasibility and safety of repairing tracheal and bronchial defects in infants and children using cryopreserved donor aortic patches.
- Conditions
- Trachea Diseases, Tracheal Stenosis, Tuberculosis; Tracheitis, Airway Disease
- Trial name
- NCT07240259
- Testing
- Cryopreserved aorta
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Oral Lichen Planus, Oral Lichen Planus Related Stress
Mucoadhesive Modified-Release Formulations for the Topical Treatment of Symptomatic Oral Lichen Planus
The goal of this clinical trial is to learn if a mucoadhesive patch containing clobetasol alone or in combination with resveratrol can reduce symptoms and improve quality of life in adults with Oral Lichen Planus (OLP).
- Conditions
- Oral Lichen Planus, Oral Lichen Planus Related Stress, Oral Mucosal Disease, Oral Pain
- Trial name
- EMPATIA (NCT07100613)
- Testing
- Clobetasol Patch, Clobetasol + Resveratrol Patch, Clobetasol in Orabase
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Palermo
Atopic Dermatitis
A Study to Observe How Pediatric Patients With Severe Atopic Dermatitis Despite Less Extensive Skin Lesions Respond to Dupilumab Treatment
In adolescents treated with dupilumab, clinical trials showed significant improvement of atopic dermatitis (AD) signs and symptoms, with a good safety profile.
- Trial name
- AD-BEASCUITS (NCT06192563)
- Testing
- Dupilumab
- Where
- 9 sites in Italy
- Volunteers
- 230 people
- Sponsor
- Sanofi
Acne Vulgaris
Comparing Nadifloxacin Plus Tretinoin Versus Clindamycin Plus Tretinoin Creams for Mild-to-Moderate Acne
The purpose of this randomized controlled trial is to compare the effectiveness of two topical combination treatments for mild-to-moderate acne vulgaris: 1% nadifloxacin with 0.025% tretinoin cream versus 1% clindamycin with…
- Trial name
- NCT07915648
- Testing
- nadifloxacin, Tretinoin Cream 0.025%, Clindamycin
- Where
- Pakistan
- Volunteers
- 158 people
- Sponsor
- Nishtar Medical University
Skin Lesion, Nevus
Genetic Risk Stratification of Pediatric Skin Lesions
A study to understand the clinical utility of noninvasive adhesive skin biopsies in pediatric patients by exploring whether DermTech Pigmented Lesion Assay (PLA) genetic risk analysis of suspicious lesions in children correlates…
- Trial name
- NCT05418959
- Testing
- DermTech PLA noninvasive adhesive biopsy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
DCIS, Breast Cancer
Delayed Sentinel Lymph Node Biopsy in Ductal Cancer in Situ
The trial aims to investigate the use of superparamagnetic iron oxide (SPIO) nanoparticles as a tracer for delayed sentinel lymph node dissection (d-SLND) in patients where upfront axillary surgery (SLND) is oncologically deemed…
- Conditions
- DCIS, Breast Cancer, Breast Neoplasms, Sentinel Lymph Node
- Trial name
- SENTINOT_2 (NCT04722692)
- Testing
- Delayed SLND, Late SLND
- Where
- 9 sites in United States, Hong Kong and 1 more
- Volunteers
- 500 people
- Sponsor
- Uppsala University
Oral Lichen Planus, Erosive Lichen Planus
Photobiomodulation, Photodynamic Therapy, and Clobetasol in the Treatment of Oral Lichen Planus.
This study aims to compare three treatment approaches for the erosive form of oral lichen planus, a chronic inflammatory condition that often causes pain, impaired oral function, and frequent relapses.
- Conditions
- Oral Lichen Planus, Erosive Lichen Planus, Mucosal Lesions
- Trial name
- NCT07278999
- Testing
- Photobiomodulation using 635 nm diode laser, Photodynamic therapy - laser mucosal treatment, Clobetasol propionate 0.05 percent topical application
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Silesia
Lichen Sclerosus Lesion
Identification of Genetic Variants Associated With Lichen Sclerosus
Lichen Sclerosus (LS) is a common genital skin condition that severely impacts on daily living. LS occurs worldwide but may be more common in the white population.
- Trial name
- GENITALS (NCT07720830)
- Testing
- No Interventions
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gudula Kirtschig
Warts
Randomized Controlled Clinical Trial of Hyperthermia and Hydrogen Peroxide 3% in the Treatment of Cutaneous Warts
Hyperthermia treatment (hyperthermia) refers to treating diseases with temperature (39-45 ° C) beyond normal body temperature,. It has been reported that local warming at 44 ° C is able to effectively mobilize the body's immunity…
- Trial name
- NCT06812065
- Testing
- Hydrogen Peroxide 3 % Topical Solution, Local Hyperthermia at 44℃
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- First Hospital of China Medical University
All Pigmented Skin Tumors
Dermoscopic and Histopathological Patterns of Pigmented Skin Lesions
1. To describe and analyze the characteristic dermoscopic features of various kinds of pigmented melanocytic and non-melanocytic skin lesions among patients attending the outpatient clinic in Sohag University Hospitals. 2.
- Trial name
- NCT07863076
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Sohag University
Warts
Hyperthermia Combined With Hydrogen Peroxide Microneedle Patch for Viral Warts
Hyperthermia treatment (hyperthermia) refers to treating diseases with temperature (39-45 ° C) beyond normal body temperature,. It has been reported that local warming at 44 ° C is able to effectively mobilize the body's immunity…
- Trial name
- NCT07534865
- Testing
- 3% hydrogen peroxide solution, 0.9 % saline, Hyperthermia at 44℃
- Where
- China
- Volunteers
- 210 people
- Sponsor
- First Hospital of China Medical University
Skin Lesions, Skin Care
Evaluation of the EF192B Protection Versus No Treatment
This study was designed with the objective of evaluating the protection potential provided by the experimental product EF192B by evaluating its barrier formation capacity.
- Trial name
- Spray B (NCT06752460)
- Testing
- EF192B
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Eurofarma Laboratorios S.A.
Breast Cancer
VisR Ultrasound for Noninvasively Interrogating Stromal Collagen Organization in Women as a Breast Cancer Biomarker: Evaluation of Anisotropy in Cancer Patients
Purpose: This study will evaluate how measurements of tissue stiffness, viscosity, and anisotropy using non-invasive ultrasound imaging correlate with breast tumor malignancy and response to chemotherapy.
- Trial name
- NCT06878547
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma
Two-photon Fluorescence Microscopy of Dermatologic Biopsies
The goal of this study is to investigate the ability of two-photon fluorescence microscopy to evaluate dermatologic biopsies. The main questions it aims to answer are: How well do two-photon fluorescence images of biopsies taken…
- Conditions
- Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma, Melanocytic Lesion, Adult
- Trial name
- NCT07773688
- Testing
- Two photon microscopy imaging
- Where
- United States
- Volunteers
- 644 people
- Sponsor
- University of Rochester
Oral Dysplasia, Leukoplakia Oral
Topical Imiquimod Treatment of Oral Dysplasia
The goal of this clinical trial is to determine the effectiveness of imiquimod in treating oral dysplasia in adult patients. Imiquimod 5% cream could be a safe and practical treatment for oral epithelial dysplasia (a precancerous…
- Conditions
- Oral Dysplasia, Leukoplakia Oral, Leukoplakia
- Trial name
- NCT07210775
- Testing
- Imiquimod (topical use)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Skin Cancer Prevention, Melanoma In Situ
Early Detection of Skin Tumors Using a Telemedicine Tool in Primary Care
The project is a national, prospective, multicenter, single-arm interventional pilot of screening skin tumors in the Czech Republic.
- Conditions
- Skin Cancer Prevention, Melanoma In Situ, Skin Lesions, Skin Cancer
- Trial name
- MEL (NCT07349940)
- Testing
- Intervention with telemedicine tool
- Where
- 5 sites in Czechia
- Volunteers
- 1,440 people
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic