Clinical trials: Lesion of Brain
Carotid Atherosclerosis, Carotid Artery Disease
ACCULINK for Revascularization of Carotids in High Risk Patients "The ARCHeR Trial"
1. To evaluate the safety and efficacy of the over-the-wire (OTW) ACCULINK (tm) System in patients deemed to be either at high risk or unsuitable for carotid endarterectomy (CEA) 2.
- Trial name
- NCT00180518
- Testing
- Over-the-wire & Rapid Exchange ACCULINK (tm) Carotid Stent & ACCUNET (tm) embolic protection system
- Volunteers
- 581 people
- Sponsor
- Abbott Medical Devices
Femoral Artery Stenosis, Iliac Artery Stenosis
Retrospective Study of the Uni-Graft® K DV Patch in the Clinical Routine
Uni-Graft® K DV Patch is marketed in Europe since 1999 for reconstructive interventions of the deep femoral, femoral and iliac artery and was also indicated for carotid interventions until 01/2020.
- Conditions
- Femoral Artery Stenosis, Iliac Artery Stenosis, Carotid Artery Stenosis
- Trial name
- RESTUGPA (NCT05117515)
- Testing
- Vascular reconstruction
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Aesculap AG
Idiopathic Parkinson's Disease
Rotigotine Versus Placebo, A Study To Evaluate The Efficacy In Advanced Stage Idiopathic Parkinson's Disease Patients
The primary objective of this study was to demonstrate that Rotigotine transdermal patch is efficacious in Chinese subjects with advanced-stage Idiopathic Parkinson's Disease as an adjuvant therapy.
- Trial name
- NCT01646255
- Testing
- Rotigotine, L-dopa
- Where
- 24 sites in China
- Volunteers
- 346 people
- Sponsor
- UCB Pharma
Alzheimer Disease
A Multinational, Multi-center, Randomized, Double-blind, Active Comparator, Phase III Clinical Trial to Evaluate the Efficacy and Safety of Donepezil Transdermal Patch in Patients With Alzheimer's Disease
The objective of this study is to evaluate the efficacy and safety of donepezil transdermal patch in patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT03197740
- Testing
- Donepezil patch, aricept Tab
- Where
- South Korea
- Volunteers
- 399 people
- Sponsor
- Icure Pharmaceutical Inc.
Brain Lesion
Effect of the Position of the Patient's Head
The position of the head of the patient influences the cerebral venous return and cerebral perfusion pressure (CPP). In our daily practice, it is almost routine to prescribe a Trendelenburg position 30 ° in all brain-damaged…
- Trial name
- NCT02549313
- Testing
- position changes of the head
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Intracerebral Hemorrhage
Prospective Cohort Study of Intracerebral Hemorrhage
The investigators design a prospective, observational cohort study to provide contemporary information on the prevalence, characteristics, risk stratification，cost-effective ,treatments and prognosis of Chinese hospitalised adult…
- Trial name
- POSTER (NCT04707105)
- Where
- China
- Volunteers
- 856 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alzheimer's Disease
Convenience, Tolerability, and Safety of Change in the Administration of Rivastigmine From Capsules to a Transdermal Patch in Patients With Mild to Moderate Alzheimer's Disease
This study used two doses of rivastigmine transdermal patch (5 cm^2, 10 cm^2) to establish the feasibility of 2 switch schedules (with transdermal patch one-step dose titration or without dose titration) from rivastigmine…
- Trial name
- KAPA (NCT00549601)
- Testing
- Rivastigmine patch (4.6 mg/day switch to 9.5 mg/day), Rivastigmine patch (9.5 mg/day), Rivastigmine capsules (6 mg to 12 mg/day)
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Novartis
Relapse Remitting Multiple Sclerosis
A Study to Assess the Effect of a Single Infusion of VAY736 on Disease Activity in Patients With Relapsing-remitting Multiple Sclerosis
This was a randomized, partially blinded, placebo-controlled, non-confirmatory study to assess the effects of a single infusion of VAY736 on disease activity as measured by brain MRI scans in patients with relapsing-remitting…
- Trial name
- NCT02038049
- Testing
- VAY736
- Where
- 5 sites in United States, Czechia and 1 more
- Volunteers
- 8 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson's Disease
Pharmacokinetic Profile of Neupro Patch Administrated at 2 mg, 4 mg, 6 mg and 8 mg/Day Weekly in Patients With Early-stage Parkinson's Disease
To study the profile of Neupro patch administrated at 2 mg, 4 mg, 6 mg and 8 mg/day weekly in patients with early-stage Parkinson's disease
- Trial name
- NCT02728947
- Testing
- ROTIGOTINE
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Luye Pharma Group Ltd.
Ischemic Stroke, Transient Ischemic Attack
Multiomics Targeting Microbiome Associated Changes in Stroke Patients (StrokeMicroBiomics)
Preclinical research has established a convincing connection between changes in the gut microbiota composition and stroke outcome. However clinical data on the gut-brain axis, and its chronic characteristics, is sparse.
- Trial name
- SMB (NCT04315922)
- Testing
- Microbiome and Plasma Characterisation
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Carotid Artery Disease, Stroke Prevention
Diffusion Weighted-MRI Based Evaluation of the Effectiveness of Endovascular Clamping During Carotid Artery Stenting With the Mo.Ma Device.
The purpose of this study is to detect new ischemic lesions after carotid artery stenting (with the Cristallo Ideale stent), in patients with high grade carotid artery stenosis, by diffusion-weighted magnetic resonance imaging…
- Trial name
- DESERVE (NCT00798512)
- Testing
- Carotid artery stenting
- Where
- 6 sites in Germany, Italy and 1 more
- Volunteers
- 127 people
- Sponsor
- Invatec S.p.A.
Brain Metastases, Generalized Malignancy, Primary
Fractionated Stereotactic Radiotherapy (FSRT) in Treatment of Brain Metastases
The main purpose of this study is to see whether addition of TPI 287 to FSRT is safe and tolerable. Researchers also want to find out if adding TPI 287 to FSRT can help with better controlling the growth of brain lesions in…
- Conditions
- Brain Metastases, Generalized Malignancy, Primary, Brain Lesions
- Trial name
- NCT02187822
- Testing
- TPI 287, Fractionated Stereotactic Radiotherapy (FSRT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Central Nervous System Disease, Cerebrovascular Accident
Influence of Area of Brain Damage on Brain Reorganization After Chronic Stroke
This study will examine how the brain rewires itself to make up for the lack of movement many people with stroke experience. It will try to determine if the rewiring differs depending on the location of the stroke and the amount…
- Conditions
- Central Nervous System Disease, Cerebrovascular Accident, Stroke
- Trial name
- NCT00474292
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alzheimer's Disease
A 12 Week, Multicenter, Open Label Evaluation of Caregiver Preference, Safety and Tolerability of Exelon® Patch (Rivastigmine Transdermal) in Patients With Alzheimer's Disease
This study is designed to evaluate caregiver preference for Exelon® patch (target patch size 10 cm²) treatment in patients with Alzheimer's disease (MMSE 10-26) who were under cholinesterase inhibitor treatment and experienced…
- Trial name
- BETTER (NCT01047579)
- Testing
- Rivastigmine transdermal
- Where
- 5 sites in Israel
- Volunteers
- 51 people
- Sponsor
- Novartis Pharmaceuticals
Spontaneous Intracranial Hypotension
Spontaneous Intracranial Hypotension Treatment "SIHT"
Spontaneous intracranial hypotension (SIH) is an infrequent disease, related to a leak of cerebrospinal fluid. There are not controlled studies for this treatment.The main of this study is to demonstrate the superiority of the…
- Trial name
- SIHT (NCT02261792)
- Testing
- 24 hours Trendelenburg position, 24 hours bed rest, EBP
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lesion of Brain
Comparison of Parameters Between a Frameless Brain Biopsy Method and the Standard Frame-based Stereotactic Biopsy
The purpose of the present study is to compare the characteristics, i.e. efficacy, duration, safety and hospital stay, of a frameless fiducial-less brain biopsy method with those of the standard frame-based stereotactic…
- Trial name
- NCT02723214
- Testing
- Brain biopsy
- Volunteers
- 56 people
- Sponsor
- University Hospital of Patras
Ischemic Stroke
A Phase 2b Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke
This Phase 2b study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke.
- Trial name
- MASTRE-2 (NCT07645560)
- Testing
- LNM-navigated cTBS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Prevention, Rehabilitation
Dysphagia and Cervical Spine Disorders in Patients With Brain Lesions
The research is about a prospective study conducted in patients suffering from dysphagia and cervical spine disorders and how they are interrelated.
- Trial name
- DysphagCerv (NCT01418105)
- Testing
- Videofluroscopic swallow study (VFSS), cervical spine isometric exercises, Fiberoptic endoscopic esophageal study (FEES)
- Where
- Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Ioannina
Brain Lesions
Study to Compare MultiHance With Gadovist in Magnetic Resonance Imaging (MRI) of the Brain
This study is being conducted as a phase IV, double-blind, multi-center, randomized, crossover trial aimed at a within-subject comparison of MULTIHANCE and GADOVIST at a dose of 0.1 mmol/kg, in terms of qualitative and…
- Trial name
- MERIT (NCT00907530)
- Testing
- MULTIHANCE:, GADOVIST
- Where
- Canada
- Volunteers
- 121 people
- Sponsor
- Bracco Diagnostics, Inc
Children Brain Injury
Quantitative Pupillometry in Brain Injury Children : Variation After Osmotherapy
Intracranial hypertension (ICH) is a common and serious complication in children admitted to pediatric intensive care units. It is primarily caused by traumatic brain injury but can also result from brain malformations, brain…
- Trial name
- OSMOPUPILLO (NCT06642896)
- Testing
- pupillometer
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Grenoble