Clinical trials: Lesion of Brain
Skin Lesion, Traumatic Ulcer
Clinical Investigation EUCLIDES-01 for the Calculation of the Area of Skin Lesions
The aim of this clinical investigation is to collect skin lesion area data for the comparison of the agreement among the results obtained between the following three wound area measurement methods: Ruler using the Kundin method…
- Conditions
- Skin Lesion, Traumatic Ulcer, Hematoma, Pressure Ulcer
- Trial name
- NCT05729334
- Testing
- Clinicgram Euclides
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Skilled Skin S.L.
Multiple Sclerosis
Magnetic Resonance Imaging to Detect Brain Damage in Patients With Multiple Sclerosis
This study will determine whether magnetic resonance imaging (MRI) can detect damage to certain parts of the brain and analyze the thickness of the brain's outer surface in patients with multiple sclerosis.
- Trial name
- NCT00099307
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Infectious Endocarditis
Long-term Clinico-radiological Evolution of Patients With Brain Lesions During Infectious Endocarditis
Primary objective: To describe the evolution of cerebral lesions in IE patients (number of patients with abnormal cerebral MRI in acute phase of IE and during follow-up).
- Trial name
- POST-IMAGE (NCT02252900)
- Testing
- Magnetic resonance imaging
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fabry Disease
Pulsatility Index, Vasomotor Reactivity and Leukoencephalopathy in Fabry Patients
We hypothesize that Fabry disease - FD is associated with elevated vascular resistance induced by cerebral small-vessel disease, indicating increased distal resistance to blood flow.
- Trial name
- NCT04577170
- Testing
- Transcranial Doppler (TCD) and Transcranial Color-Coded Duplex (TCCD) ultrasonography
- Where
- Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Cerebrovascular Disorders, Intracranial Neoplasms
Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions
This study focuses on implementing Yellow 560 for the direct intraoperative visualization of Fluorescein Sodium stained intracranial lesions to facilitate extend of surgery, develop better treatment protocols, and improve the…
- Trial name
- Fluoescein (NCT02478346)
- Testing
- Fluorescein Sodium
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- AdventHealth
Multiple Sclerosis
The Effect of Sildenafil Citrate (Viagra® (Registered Trademark)) on Brain Blood Flow in Multiple Sclerosis Patients
This study will determine whether sildenafil citrate, commonly known as Viagra, can cause increased blood flow to the brain in a wide range of multiple sclerosis (MS) patients, including women.
- Trial name
- NCT00094068
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Small/Large Bowel
PillCam SB3 Capsule- Feasibility Study
Study hypothesis: PillCam SB3 is a new capsule designed to provide an improved image quality, and improved SB and duodenum tissue coverage due to Adaptive Frame Rate (AFR) of 2-6 fps, which will create more images for evaluation…
- Trial name
- NCT01433042
- Testing
- capsule endoscopy
- Where
- 4 sites in Israel, Romania and 2 more
- Volunteers
- 225 people
- Sponsor
- Medtronic - MITG
Non-small Cell Lung Cancer
The Continuation of Erlotinib
Newly developed or progressive brain metastasis during erlotinib treatment is considered progressive disease requiring change of treatment regimens despite no progression in extracranial lesions.
- Trial name
- NCT01130779
- Testing
- Erlotinib (TARCEVA®)
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Samsung Medical Center
Stroke, Cognitive Symptoms
Cerebral Lesions and Outcome After Cardiac Surgery (CLOCS)
Between 1 and 5 percent of patients who have coronary artery bypass surgery suffer a stroke following surgery, and 30 percent have new brain lesions that do not produce symptoms and are seen only on MRI.
- Trial name
- NCT00391378
- Where
- United States
- Volunteers
- 363 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Atrial Fibrillation (AF)
A Prospective Observational Study Evaluating the Incidence of Silent Cerebral Lesions and Procedural Safety Following Atrial Fibrillation Ablation Using the VARIPULSE™ Pulsed Field Ablation System
Study Type: Observational Study Goal: The goal of this study is to evaluate the incidence and burden of silent cerebral lesions (SCLs) detected on brain magnetic resonance imaging (MRI) after pulsed field ablation (PFA) for…
- Trial name
- VARIACE (NCT07363278)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Fibromuscular Dysplasia
Cohort Follow-up of Patients With Renal or Craniocervical Fibromuscular Dysplasia
PROFILE is a cohort study evaluating the progression of fibromuscular dysplasia lesions. This study is the prospective dimension of ARCADIA registry (ClinicalTrials.gov Identifier: NCT02884141), which aims to document phenotypic…
- Trial name
- PROFILE (NCT02961868)
- Testing
- Abdominal and supra-aortic trunks vascular imaging, Blood sampling (genetic), Blood sampling (biomarkers)
- Where
- 17 sites in Belgium, France
- Volunteers
- 340 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alzheimer Disease
A Phase I Clinical Study, Randomized, Single-blind, Placebo-controlled, Multiple Doses, Dose Escalation Study of the Safety, Tolerability and Pharmacokinetics of Donepezil Patch in Healthy Male Subjects.
Study of the Safety, tolerability and pharmacokinetics with multiple doses of donepezil patch in healthy male subjects
- Trial name
- NCT02178124
- Testing
- Donepezil
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Icure Pharmaceutical Inc.
Arterial Stiffness, White Matter Lesions
Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers
The ACE Trial, funded by the National Institute on Ageing/National Institutes of Health (NIH), is a multicenter clinical trial. The ACE Trial will determine if taking the dietary supplement Equol could slow the progression of…
- Conditions
- Arterial Stiffness, White Matter Lesions, Cognitive Decline
- Trial name
- ACE (NCT05741060)
- Testing
- S-equol
- Where
- 3 sites in United States
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Akira Sekikawa
Intracranial Aneurysm
Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil
The primary objective of this study is to gather post market data on the Penumbra SMART COIL® System (Smart System) in the treatment of intracranial aneurysms and other malformations.
- Trial name
- SMART (NCT02729740)
- Testing
- Penumbra Smart Coil, Penumbra Coil 400TM (PC400), Penumbra Occlusion DeviceTM(POD)
- Where
- 72 sites in United States, Canada
- Volunteers
- 995 people
- Sponsor
- Penumbra Inc.
Coronary Disease
Comparison of the Risk of Stroke With On- Versus Off-Pump Coronary Artery Bypass Grafting
This study will compare the safety of coronary artery bypass grafting (CABG) with and without the use of heart-lung bypass during surgery (on- versus off-pump surgery).
- Trial name
- NCT00046410
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pituitary Tumors
Barrow Nasal Inventory Survey
The purpose of this study is to evaluate patient nasal outcome following endo-nasal surgery. This type of surgery is conducted for pituitary and skull base tumors.
- Trial name
- BNI (NCT01322945)
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Stroke
Contribution of a High-resolution Diffusion Sequence at 3T for the Detection of Acute Punctate Ischemic Brain Lesions
Stroke is a public health issue and a priority for our institution. MRI plays an essential role in the management of stroke, its contribution being diagnostic, etiological and prognostic.
- Trial name
- STROKE_HR (NCT05232500)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Verticality Perception, Self-motion Perception
Altered Vestibular Perception and Transcranial Magnetic Stimulation
The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences motion sensation.
- Trial name
- NCT02184130
- Testing
- transcranial magnetic stimulation and motion stimuli
- Where
- Switzerland
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Brain Tumor, Brain Lesion
Intraoperative Functional Ultrasound
A wide spectrum of methods is used to image brain activation in vivo. It can be directly detected by neurons electrical activity imaging (cortical simulation mapping, calcium imaging, voltage sensitive dyes) or indirectly by…
- Trial name
- FUSIMAGINE (NCT02656407)
- Testing
- Ultrasound device
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Idiopathic Parkinson's Disease
An Open-Label Extension Trial to Assess the Safety and Tolerability of Long Term Treatment of Rotigotine in Subjects With Idiopathic Parkinson's Disease
The objective of this open-label extension is to assess the safety and tolerability of long-term treatment of rotigotine in subjects with idiopathic PD.
- Trial name
- NCT00505687
- Testing
- Rotigotine
- Where
- 26 sites in United States, Austria and 6 more
- Volunteers
- 186 people
- Sponsor
- UCB Pharma