Clinical trials: Lesion of Brain
Acute Ischemic Stroke
Safety, Performance of CEREGLIDE 92 Intermediate Catheter in Treatment of Acute Ischemic Stroke
The device is indicated for use in the revascularization of patients with acute ischemic stroke secondary to intracranial large vessel occlusive disease
- Trial name
- SPLENDID (NCT06386289)
- Testing
- Cereglide 92
- Sponsor
- Cerenovus, Part of DePuy Synthes Products, Inc.
Enhancing Brain Lesions
MR Image Synthesis With Low Gadobutrol Dose and AI
Study 22403 is a Phase 1 / Proof of Concept exploratory investigation to assess the non-inferiority of low dose gadobutrol and SubtleGAD™, a software medical device using an Artificial Intelligence (AI) deep learning-based method…
- Trial name
- NCT06224543
- Testing
- SubtleGAD, Gadobutrol
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Subtle Medical
Parkinson Disease
Clinical Trial to Investigate Patch Adhesion of Rotigotine Containing Patches in Patients With Parkinson's Disease
The investigational medicinal product (IMP) to be tested in the clinical trial (Rotigotine (ROT)-Transdermal System (TDS) (8 mg/24 h)), which is subject to this submission, was designed as a generic of Neupro® 8 mg/24 h, which is…
- Trial name
- NCT06247410
- Testing
- Rotigotine 8Mg/24Hrs Patch
- Where
- 8 sites in Germany
- Volunteers
- 38 people
- Sponsor
- SocraTec R&D GmbH
Multiple Sclerosis
Sunphenon in Progressive Forms of Multiple Sclerosis
The investigators hypothesize that an oral Sunphenon EGCg (Epigallocatechin-Gallat, EGCG) treatment is - due to its antiinflamatoric and neuroprotective potence - significantly more effective than an oral placebo treatment…
- Trial name
- SUPREMES (NCT00799890)
- Testing
- Sunphenon EGCG
- Where
- Germany
- Volunteers
- 61 people
- Sponsor
- Friedemann Paul
Bipolar Disorder, Schizo Affective Disorder
Causal Lesion Network Guided Treatment of Bipolar Mania With Transcranial Electrical Stimulation
Mania is a core symptom of bipolar disorder involving periods of euphoria. Decreased inhibitory control, increased risk-taking behaviors, and aberrant reward processing are some of the more recognized symptoms of bipolar disorder…
- Trial name
- NCT05445466
- Testing
- High-Definition Transcranial Electrical-Current Stimulation, High-Definition Transcranial Alternate-Current Stimulation, High-Definition Personalized Beta-Gamma Electrical Stimulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Beth Israel Deaconess Medical Center
Patients With Brain Masses/Lesions
Register for Longitudinal Recording of Brain Function
The aim of this observational register study is to establish a registry that completely records and compiles the data from routinely performed technical examinations (navigated transcranial magnetic stimulation, intraoperative…
- Trial name
- NCT06401057
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Hospital Heidelberg
Postdural Puncture Headache
Pregabalin in Treatment of Postdural Puncture Headache
Lumbar puncture (LP), often known as a "spinal tap," is a standard medical technique pioneered in the late 1900s by Heinrich Quincke.
- Trial name
- NCT06271486
- Testing
- Pregabalin 75mg, An epidural blood patch (EBP), conservative treatment.
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Al-Azhar University
Carotid Stenosis
Predictive Value of Neovascularization Within Asymptomatic Carotis Stenosis on CEUS
Atherosclerosis is a chronic, systemic and progressive disease affecting different arterial blood vessels in the body. Atherosclerotic lesions silently progress from small plaques to severe stenosis and may remain asymptomatic…
- Trial name
- NCT01732523
- Testing
- Contrast enhanced carotid ultrasound
- Where
- Switzerland
- Volunteers
- 240 people
- Sponsor
- University Hospital, Basel, Switzerland
Orthopedic Equine Varus Deformity
Talonavicular Arthrodesis and Surgical Treatment of Ankle and Varus Foot
This study should refine our surgical indications and to establish a decision tree of medical and surgical treatment of this common and troublesome strain functionally which is equino-varus.
- Trial name
- talobot (NCT02790346)
- Testing
- arthrodesis talonavicular, tendon gestures
- Where
- France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Montpellier
Alzheimer's Disease
Randomized, Double-blind Study to Evaluate the Tolerability of 2 Different Titration Methods of Rivastigmine Patch in AD Patients (MMSE 10-20)
To evaluate the tolerability, safety and efficacy of 3-step titration versus 1-step titration of Rivastigmine patch in the Japanese population.
- Trial name
- NCT01614886
- Testing
- Active Comparator, ENA713
- Where
- 50 sites in Japan
- Volunteers
- 216 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson's Disease
A Trial of Neupro® (Rotigotine Transdermal Patch) in Patients With Parkinson's Disease Undergoing Surgery
Evaluation of efficacy and safety on the use of rotigotine in patients suffering from Parkinson's Disease during and after surgery requiring general anaesthesia.
- Trial name
- NEUPOS (NCT00594464)
- Testing
- Rotigotine
- Where
- 12 sites in Germany
- Volunteers
- 14 people
- Sponsor
- UCB Pharma
Intracranial Arterial Aneurysm
Analysis Of Intracranial Artery Lesions Using 2-D/3D Phase Contrast MR
Using phase contrast MR Angiography with NOVA® Software, this study intends to identify,evaluate and map intracranial aneurysm development as well as develope a predicator for future morphological changes of aneurysms and…
- Trial name
- NCT00710281
- Testing
- Additional scan time on standard MR angiography
- Where
- United States
- Sponsor
- Lahey Clinic
Vertigo, MRI
Brain Structural Abnormalities in Patients With Vertigo
Introduction: Dizziness is one of the most common complaints in medical practice and is associated with various underlying conditions, including neurological, otolaryngological, and psychological disorders.
- Trial name
- NCT06848712
- Testing
- Observational Study - No intervention
- Where
- Hungary
- Volunteers
- 464 people
- Sponsor
- University of Pecs
Secondary Progressive Multiple Sclerosis
Comparison of Clinical Effects of Rituximab and Glatiramer Acetate in Secondary Progressive Multiple Sclerosis Patients
The purpose of this study is to compare expanded disability status scale, annualized relapse rate, Gad-enhanced brain lesions, and side effects after administration of rituximab and glatiramer acetate among patients with active…
- Trial name
- NCT03315923
- Testing
- Rituximab, Glatiramer Acetate
- Where
- Iran
- Volunteers
- 84 people
- Sponsor
- Isfahan University of Medical Sciences
Post-Dural Puncture Headache, Chronic Headache
Long Term Outcomes After Accidental Dural Puncture ADP Study
Post Dural Puncture Headache (PDPH) causes significant short-term disability, prevents mobilisation, affects childcare activities and results in prolonged hospital stay.
- Conditions
- Post-Dural Puncture Headache, Chronic Headache, Chronic Low Back Pain
- Trial name
- NCT03080779
- Where
- 3 sites in United Kingdom
- Volunteers
- 270 people
- Sponsor
- University Hospitals, Leicester
Carotid Artery Thrombosis, Carotid Artery Stenosis
Randomized Clinical Trial of Polyester vs. Polyurethane Patch for Carotid Endarterectomy
This study examines the risk of thrombogenicity of the carotid patches in polyurethane compared to carotid patches in polyester including death, any stroke, carotid thrombosis at 30 days and long-term results including stroke and…
- Conditions
- Carotid Artery Thrombosis, Carotid Artery Stenosis, Stroke
- Trial name
- NCT02341196
- Testing
- CEA
- Volunteers
- 450 people
- Sponsor
- University of Poitiers
Acute Ischemic Stroke
Phase 2 Proof-of-Concept Study of the Safety and Efficacy of Alfimeprase to Rapidly Open Arteries and Restore Brain Function Following a Stroke
The purpose of this study is to identify a safe and effective bolus dose of intra-arterial/intra-thrombus alfimeprase in acute ischemic stroke (AIS) 3 to 9 hours from symptom onset.
- Trial name
- NCT00499902
- Testing
- alfimeprase
- Where
- 22 sites in United States, Canada
- Volunteers
- 7 people
- Sponsor
- ARCA Biopharma, Inc.
Malignant Central Nervous System Neoplasm
Study of Human Brain-Gut Axis and Gut Microbiome in Patients With Brain Lesions - Repository for Neuroscience Research
This study explores how microorganisms in the gut can affect the growth and progression of brain tumors.
- Trial name
- NCT06117930
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Intracranial Atherosclerosis
An International Registry of the Wingspan™ Stent System for the Treatment of Intracranial Atherosclerotic Stenosis
The IRISS study is designed to collect clinical and angiographic outcomes data when stenting intracranial atherosclerotic lesions using the Wingspan™ Stent System with Gateway™ PTA Balloon Catheter in routine clinical practice.
- Trial name
- IRISS (NCT00929383)
- Testing
- Wingspan Stent System with Gateway PTA Balloon Catheter
- Where
- 19 sites in France, Germany
- Volunteers
- 82 people
- Sponsor
- Stryker Neurovascular
Glioma, Glioma Intracranial
A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas
This study uses a cranial implant to deliver cortical stimulation that, when paired with physiotherapy, will remap the brain so that critical brain functions can be protected during brain tumor surgery.
- Conditions
- Glioma, Glioma Intracranial, Gliomas Benign, Brain Tumor
- Trial name
- NCT04745156
- Testing
- RNS System Implantation
- Volunteers
- 3 people
- Sponsor
- Medical College of Wisconsin