Clinical trials: Leukocytes
HIV Infections, Cytopenias
A Pilot Trial Evaluating an Alternating Schedule of Recombinant Human GM-CSF and Azidothymidine in Patients With HIV Infection and Leukopenia
To evaluate the safety of repeated courses of sargramostim ( recombinant granulocyte-macrophage colony-stimulating factor; GM-CSF ) administered subcutaneously to patients with HIV infection and leukopenia.
- Trial name
- NCT00002007
- Testing
- Zidovudine, Sargramostim
- Where
- United States
- Sponsor
- Sandoz
Immunity
Investigation of A Children's Beverage Containing Different Probiotics
Investigating different bioactive ingredients in children's beverages and the effect on blood serum markers.
- Trial name
- NCT00990002
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Wound Healing
Effect of Leucocyte- and Platelet-Rich Fibrin on Palatal Wound Healing After Free Gingival Graft Harvesting
Autogenous palatal free gingival graft harvesting presents challenges for patients due to the increased risk of postoperative morbidity related to a second intraoral surgical wound that heals with secondary intention.
- Trial name
- NCT06777069
- Testing
- Leucocyte and platelet rich fibrin membrane application
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Istanbul Medipol University Hospital
Brain and Central Nervous System Tumors
Bispecific Antibody Plus White Blood Cells in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme
RATIONALE: Bispecific antibodies plus white blood cells may be able to locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00005813
- Testing
- bispecific antibody MDX447, lymphokine-activated killer cells, conventional surgery
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Eosinophilic Esophagitis
Efficacy and Safety APT-1011 in Adolescent Subjects With Eosinophilic Esophagitis (EoE) - A Sub-Study of the FLUTE-2 Trial
This is a randomized, double-blind, placebo-controlled study of APT-1011, followed by an open-label extension (OLE) in adolescents (≥12 to <18 years) with EoE.
- Trial name
- FLUTEEN (NCT05083312)
- Testing
- APT-1011
- Where
- 3 sites in United States, Australia
- Volunteers
- 6 people
- Sponsor
- Ellodi Pharmaceuticals, LP
Septic Shock, Nonchemotherapy Drug-induced Neutropenia
Russian Clinical Trial of Mesenchymal Cells in Patients With Septic Shock and Severe Neutropenia
Septic shock remains a significant clinical problem associated with high rates of mortality among neutropenic patient despite antimicrobial therapy and supportive care.
- Conditions
- Septic Shock, Nonchemotherapy Drug-induced Neutropenia, Neutropenia After Chemotherapy in Oncohematological Patients, Neutropenia in Patients With Aplastic Anemia
- Trial name
- NCT01849237
- Testing
- Mesenchymal stromal cells, Standard therapy of septic shock
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- National Research Center for Hematology, Russia
Telomere Shortening, Telomere Length, Mean Leukocyte
Rosuvastatin Effect on Telomere-telomerase System in ACS
Coronary heart disease (CHD) is one of the diseases characterised by biological aging as one of the important risk factors in several epidemiological studies.
- Conditions
- Telomere Shortening, Telomere Length, Mean Leukocyte, 22q Telomere Deletion Syndrome
- Trial name
- NCT02299245
- Testing
- rosuvastatin
- Volunteers
- 400 people
- Sponsor
- Xiao-dong Zhuang
Acute Myeloid Leukemia, in Relapse
Analysis of the Immunobiology of Acute Myeloid Leukemia Relapses After Allogeneic Hematopoietic Stem Cell Transplant (HSCT) for the Generation of Guidelines and Personalized Therapeutic Pathways
This is a retrospective and prospective non-interventional multicenter observational study. Neither diagnostic approaches nor experimental drugs/procedure will be applied and the samples will take place at the same time as the…
- Trial name
- GITMO-RELAPSE (NCT05124288)
- Testing
- Observations on Relapsed AML Allogeneic Transplanted patients
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Ciceri Fabio
Solid Tumor
Safety Study of Vx006 Vaccine in Solid Tumor Patients
Patients with histologically proven malignancy with documented disease control (objective response or stable disease) or Not Evaluable Disease (NED) expectancy > 6 months; only HLA-A*02 positive patients.
- Trial name
- NCT02289196
- Testing
- Vx-006: 0,5mg, Vx-006: 1mg, Vx-006: 5mg
- Where
- 3 sites in Greece
- Volunteers
- 23 people
- Sponsor
- Vaxon Biotech
Food Allergy, Loeys-Dietz Syndrome
Natural History and Genetics of Food Allergy and Related Conditions
Background: About 15 million Americans have a food allergy. Because there are no cures or effective prevention or treatment for food allergies, researchers want to learn more about them.
- Conditions
- Food Allergy, Loeys-Dietz Syndrome, Atopic Dermatitis, Eosinophilic Esophagitis
- Trial name
- NCT02504853
- Where
- United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hereditary Haemorrhagic Telangiectasia
Immunological Effects of Iron Supplementation in HHT Disease
Hereditary haemorrhagic telangiectasia (HHT), is a rare genetic vascular disorder with autosomal dominant inheritance. Its prevalence is estimated at approximately 1 in 6,000 individuals in France.
- Trial name
- Fer&RO (NCT07111598)
- Testing
- Blood test at D0, Blood test at D+3 months
- Where
- France
- Volunteers
- 155 people
- Sponsor
- Hospices Civils de Lyon
Sarcoma, Solid Tumor, Adult
Trial of Nivolumab Following Partially Human Leukocyte Antigen (HLA) Mismatched BMT in Children & Adults With Sarcoma
This research is being done to find out if an investigational drug, Nivolumab, can be safely administered after a "half-matched" (haplo) bone marrow transplant (BMT), and if the investigational drug will help to prevent or delay…
- Conditions
- Sarcoma, Solid Tumor, Adult, Solid Tumor, Childhood
- Trial name
- NCT03465592
- Testing
- Nivolumab
- Where
- 4 sites in United States
- Volunteers
- 39 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
HIV Infections, Cytopenias
A Phase I/II Study of Recombinant Human GM-CSF in Patients With AIDS Virus Infection and Leukopenia
To determine the maximum tolerated dose (MTD) and toxicity of sargramostim (recombinant granulocyte-macrophage colony-stimulating factor; GM-CSF) given by continuous intravenous infusion (CIV) in patients with leukopenia in…
- Trial name
- NCT00002009
- Testing
- Sargramostim
- Where
- 2 sites in United States
- Sponsor
- Sandoz
Eosinophilic Esophagitis, Gastroesophageal Reflux
Phenotypic Characterization and Biomarkers Investigation for Eosinophilic Esophagitis in Pediatric Patients
The purpose of this study is to find out some potential biomarkers for the Eosinophilic Esophagitis (EoE) in pediatric patients through the prospective clinical characterization and assessment of samples collected during the…
- Trial name
- NCT03069573
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Federal University of Uberlandia
Sepsis, Disseminated Intravascular Coagulation (DIC)
Fluorescent Leukocytes as a Marker of Early Sepsis/Severity
Sepsis is a medical emergency whose prognosis depends on the early identification of patients at risk of septic shock, but the tools available in the Emergency Department remain insufficient.
- Conditions
- Sepsis, Disseminated Intravascular Coagulation (DIC), Septic Shock
- Trial name
- FLAMES (NCT07585942)
- Where
- France
- Volunteers
- 492 people
- Sponsor
- University Hospital, Strasbourg, France
COVID-19, SARS-CoV-2 Infection
Clinical Effect of Dialyzable Leukocyte Extract in Suspected or Confirmed Cases of COVID-19 (FUTURE-T)
Main goal: To generate information on the efficacy and safety of Dialyzable Leukocyte Extract (DLE) as an aid in the treatment of patients with acute respiratory infection (suspected or confirmed cases of COVID-19).
- Trial name
- FUTURE-T (NCT04379479)
- Testing
- Dialyzable Leukocyte Extract
- Where
- Mexico
- Volunteers
- 562 people
- Sponsor
- National Polytechnic Institute, Mexico
Non-small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma
A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
Phase I Study of NT-175, an autologous T cell therapy product genetically engineered to express an HLA-A*02:01-restricted T cell receptor (TCR), targeting TP53 R175H mutant malignancies
- Conditions
- Non-small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Colorectal Carcinoma, Pancreatic Adenocarcinoma
- Trial name
- NCT05877599
- Testing
- NT-175
- Where
- 20 sites in United States
- Volunteers
- 45 people
- Sponsor
- AstraZeneca
Eosinophilia, Hypereosinophilic Syndrome
A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression
Eosinophils are a type of white blood cell. Elevated eosinophil levels can damage the heart, nerves, and other organs, in the syndrome known as hypereosinophilic syndrome (HES).
- Trial name
- NCT00091871
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Eosinophilic Esophagitis
A Food Additive Removal Diet for Pediatric Eosinophilic Esophagitis
Prospective, pragmatic standard of care clinical trial comparing dietary therapies of standard dairy elimination diet alone (DED) to dairy elimination plus food additive elimination (FREE)
- Trial name
- FREE (NCT03657771)
- Testing
- DED, FREE
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Nemours Children's Clinic
Neutropenia
Pharmacokinetics and Pharmacodynamics Study of Pegfilgrastim in Chemotherapy Patients
The purpose of this study is to examine the safety,tolerability,pharmacokinetics and pharmacodynamics of Pegfilgrastim in patients with chemotherapy-induced neutropenia.
- Trial name
- NCT01637493
- Testing
- Pegfilgrastim
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Hangzhou Jiuyuan Gene Engineering Co. Ltd.,
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