Clinical trials: Leukocytes
Lymphoma
Peripheral Stem Cell Transplantation Followed By Infusion of White Blood Cells in Treating Patients With AIDS-Related Lymphoma
RATIONALE: Donor peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy. Sometimes the transplanted cells are rejected by the body's normal tissues.
- Trial name
- NCT00024128
- Testing
- anti-thymocyte globulin, therapeutic allogeneic lymphocytes, cyclophosphamide
- Sponsor
- AIDS Malignancy Consortium
Autoimmune Pancytopenia, Autoimmune Lymphoproliferative Syndrome (ALPS)
Sirolimus for Autoimmune Disease of Blood Cells
Treatment for patients with autoimmune destruction of blood cells is poor. The part of the body that fights infections is called the immune system and white blood cells (WBCs) are part of the immune system.
- Conditions
- Autoimmune Pancytopenia, Autoimmune Lymphoproliferative Syndrome (ALPS), Evans Syndrome, Idiopathic Thrombocytopenic Purpura
- Trial name
- NCT00392951
- Testing
- sirolimus
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Philadelphia
Neutropenia
Phase 2 Study of SPI-2012 or Pegfilgrastim for the Management of Neutropenia in Participants With Breast Cancer
The purpose of this study is to assess the effect of test doses of SPI-2012 on the duration of severe neutropenia (DSN) during Cycle 1 in participants with breast cancer who are candidates for adjuvant or neoadjuvant chemotherapy.
- Trial name
- NCT01724866
- Testing
- SPI-2012, Pegfilgrastim, Docetaxel
- Where
- 27 sites in United States, Australia and 4 more
- Volunteers
- 148 people
- Sponsor
- Spectrum Pharmaceuticals, Inc
COW'S MILK ALLERGY
Polymerized Beta-lactoglobulin Comparative Immunoreactivity
Bovine β-lactoglobulin (Bos d 5) is an allergen from cow's milk with relevance to human health. We employed β-lactoglobulin polymerized using microbial transglutaminase as a model of study to identify whether protein…
- Trial name
- ImmuneBLG (NCT01589731)
- Where
- Brazil
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Eosinophilic Esophagitis
Use of Esophageal String Test to Understand Symptoms, Inflammation, and Function in Eosinophilic Esophagitis
Presently, the only method available to monitor disease activity in Eosinophilic Esophagitis (EoE) is endoscopy with pathological review of biopsies.
- Trial name
- NCT03305653
- Testing
- Esophageal String Test (EST)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
COPD Exacerbation, Eosinophilia
Drivers of Eosinophilic COPD Exacerbations
Main objective: investigate gene expression differences in nasal epithelium and sputum between eosinophilic COPD exacerbations and other subtypes.
- Trial name
- DICE (NCT04961060)
- Where
- 2 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- University Medical Center Groningen
Sarcoma, Neutropenia
Pegfilgrastim as Support to Pediatric Sarcoma Patients Receiving Chemotherapy
Physicians are conducting a clinical trial for patients with pediatric sarcoma. Sarcoma is a type of bone cancer that can be treated with chemotherapy which can affect the bone marrow, where blood cells are produced.
- Trial name
- NCT00035620
- Testing
- pegfilgrastim, filgrastim
- Volunteers
- 44 people
- Sponsor
- Amgen
Malignant Otitis Externa
18F-FDG Tomography and Labeled Leukocyte Scintigraphy
The study will aim to show that there is a superiority of 18F-FDG PET/CT compared to labeled leukocyte scintigraphy in patients with a malignant otitis externa.
- Trial name
- OEN (NCT05994768)
- Testing
- 18F-FDG PET/CT
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Central Hospital, Nancy, France
Neutropenia, Fever
The Tobramycin Study
Evaluate if tobramycin given once a day is at least as efficacious as the traditional tobramycin given three times a day, given with penicillin G, til patients with febrile neutropenia.
- Conditions
- Neutropenia, Fever, Cancer
- Trial name
- NCT00257790
- Testing
- Tobramycin once a day
- Volunteers
- 210 people
- Sponsor
- Oslo University Hospital
Abortion, Missed
Research of Serum Procalcitonin, ESR, CRP And Leukocyte Levels in Fertile Missed Abortion Cases
Aim: The serum procalcitonin, erythrocyte sedimentation rate, c-reactive protein and leukocyte values will be compared between fertile missed abortion diagnosed pregnants and fertile normal pregnants to determine the presence of…
- Trial name
- NCT03767179
- Testing
- study
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Breast Cancer
Injection Regimen Trial of PEG-rhG-CSF During Breast Cancer Chemotherapy
The purpose of this study is to try to find a better injection regimen (including time and dose) of PEG-rhG-CSF, which is supposed to better prevent bone marrow suppression and/or FN in breast cancer patients who receive…
- Trial name
- NCT04477616
- Testing
- Day 7 regimen, Day 3 regimen
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Myocardial Infarction
Platelet Leukocyte Aggregates in Acute Cardiac Syndrome vs Healthy Volunteers
This project aims to refine previous studies including the investigators work recently published in August 2012 Journal Thrombosis and Thrombolysis.
- Trial name
- NCT01797016
- Where
- Israel
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Gingival Recession, Localized
L-PRF Versus Connective Tissue Graft Associated to Coronally Advanced Flap in Gingival Recession Treatment
Background: Nowadays, the use of connective tissue graft associated to the coronally advanced flap is considered the "gold standard" for localized gingival recession treatment.
- Trial name
- NCT04165044
- Testing
- Leukocyte and Platelet Rich Fibrin plus Coronally Advanced Flap, Connective tissue graft plus Coronally Advanced Flap
- Where
- Chile
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Eosinophilic Esophagitis
Trial of Montelukast in Eosinophilic Esophagitis
Evaluate clinical effectiveness of oral montelukast compared to placebo on prevention of dysphagia and food impaction in patients with EE. Also evaluate tolerance and safety of oral montelukast in treatment of EE.
- Trial name
- NCT00511316
- Testing
- Montelukast/ Singulair
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gerd, Eosinophilic Esophagitis
Utility of Mucosal Impedance Device in Chronic Esophageal Disorders:
Background \& Significance Chronic benign esophageal disorders such as Gastroesophageal reflux disease (GERD) and eosinophilic esophagitis are common gastrointestinal disorders affecting nearly 20% and 0.1% of the population…
- Trial name
- NCT07227506
- Testing
- MuVI Esophageal mucosal impedance testing
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Breast Cancer
Study on Efficacy and Safety of CBLB612 for Neutropenia Prophylaxis
Double blind, randomized, placebo-controlled, multicenter pilot study on efficacy and safety of CBLB612 following single administration for neutropenia prophylaxis in breast cancer patients receiving doxorubicin and…
- Trial name
- NCT02778763
- Testing
- CBLB612
- Volunteers
- 23 people
- Sponsor
- BioLab 612 LLC
Acquired Immunodeficiency Syndrome, HIV Infection
White Blood Cell Infusions to Treat HIV Infection
This study will evaluate the safety and immune system effects of infusing HIV-infected patients with multiple doses of lymphocytes (white blood cells) from their non-infected identical twin.
- Trial name
- NCT00001647
- Testing
- White blood cell infusion
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Eosinophilic Esophagitis
Evaluation of Efficacy, Safety and Patient' Satisfaction of Therapeutic Switch From Off-Steroids to Budesonide
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated, esophageal-restricted disease characterized clinically by symptoms related to esophageal dysfunction and histologically by an eosinophil-predominant inflammation.A…
- Trial name
- Switch (NCT05594849)
- Testing
- Budesonide Orodispersible Tablets (Jorveza)
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- Istituto Clinico Humanitas
Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)
This is a research protocol that will examine Hematopoietic Stem Cell Transplantation (HSCT) using a reduced conditioning regimen (RIC) with total body Irradiation (TBI) in those diagnosed with Common Variable Immunodeficiency…
- Conditions
- Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder, Immune Dysregulation, DiGeorge Syndrome
- Trial name
- CVID/PIRD (NCT07284641)
- Testing
- Hematopoietic stem cell transplant (HSCT)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Paul Szabolcs
Hematologic Malignacy, Autologous Hematopoietic Stem Cell Transplantation
Exercise in Patients Undergoing Autologous Stem Cell Transplantation: A Randomized Controlled Trial
This interventional study assigns participants undergoing autologous hematopoietic stem cell transplantation to a supervised exercise program or usual care.
- Trial name
- NCT07458854
- Testing
- Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- TC Erciyes University
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