Clinical trials: Leukoplakia, Oral
Oral Leukoplakia, Autofluorescence
Identification of Oral Lesions Through an Autofluorescence System
The aim of the study will be to evaluate the efficacy of a tissue autofluorescence detection system as an aid to clinical screening in identifying lesions of the oral mucosa.
- Conditions
- Oral Leukoplakia, Autofluorescence, Secondary Prevention, Keratosis
- Trial name
- NCT05942794
- Testing
- Screening examination
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Federico II University
Oral Dysplasia, Leukoplakia Oral
Topical Imiquimod Treatment of Oral Dysplasia
The goal of this clinical trial is to determine the effectiveness of imiquimod in treating oral dysplasia in adult patients. Imiquimod 5% cream could be a safe and practical treatment for oral epithelial dysplasia (a precancerous…
- Conditions
- Oral Dysplasia, Leukoplakia Oral, Leukoplakia
- Trial name
- NCT07210775
- Testing
- Imiquimod (topical use)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Squamous Cell Carcinoma of the Oral Cavity, Leukoplakia Oral
Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity
Recent studies estimated that 15 to 20% of all cancers in humans are associated with viruses. Among oral cancer about 90% are oral squamous cell carcinomas (OSCC).
- Trial name
- INECOC (NCT01636544)
- Testing
- contralateral healthy tissue biopsy
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut Pasteur
Leukoplakia, Oral
Safety and Efficacy of Nivolumab in Treating Oral Proliferative Verrucous Leukoplakia
This research study is studying an immunotherapy drug, as a possible treatment for oral proliferative verrucous leukoplakia (OPVL).
- Trial name
- NCT03692325
- Testing
- Nivolumab
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Dana-Farber Cancer Institute
Pneumonia, Pneumocystis Carinii, HIV Infections
Dapsone 100 Mg Versus 50 as Primary Prophylaxis for Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC)
To determine which of 2 doses of dapsone is effective prophylaxis for Pneumocystis carinii pneumonia (PCP) in patients with oral thrush or hairy leukoplakia and less than 400 CD4 lymphocytes per mm3.
- Trial name
- NCT00002043
- Testing
- Dapsone
- Where
- United States
- Sponsor
- Jacobus Pharmaceutical
Leukoplakia, Periodontal Disease
Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCR
In Phase II trials, treatment with ketorolac tromethamine oral rinse has been shown to block periodontal disease progression even in the absence of standard clinical intervention such as scaling and root planing which is…
- Trial name
- NCT00001698
- Testing
- Ketorolac Rinse
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Cancer Institute (NCI)
Oral Leukoplakia, Oral Cancer
Saliva and Plasma Exosomes for Oral Leukoplakia Malignant Transformation Diagnosis and Oral Cancer Prognosis Monitoring
The goal of this observational study is to test the expression levels of salivary and plasma exosomal miR-185 in patients with oral leukoplakia and oral squamous cell carcinoma.
- Trial name
- NCT06469892
- Testing
- Detect the expression level of miR-185 in salivary and plasma exosomes.
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Beijing Stomatological Hospital, Capital Medical University
Oral Leukoplakia, Oral Lichen Planus
Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy
Abstract Objective: To study the diagnostic efficiency of Rose Bengal with Toluidine blue in detecting the biopsy sites and thus establish an accurate diagnosis in oral premalignant lesions.
- Conditions
- Oral Leukoplakia, Oral Lichen Planus, Premalignant Lesion
- Trial name
- NCT03031899
- Testing
- Biopsy, Rose Bengal, toluidine blue
- Volunteers
- 27 people
- Sponsor
- The Oxford Dental College, Hospital and Research Center, Bangalore, India
Leukoplakia, Oral
Oral Potentially Malignant Disorders: Comparison Between Surgical Treatment and Wait and See Approach
This research protocol is comparing the effectiveness of surgical excision to the "wait and see" approach for the management of oral leukoplakia and erythroleukoplakia in prevention of oral squamous cell carcinoma onset.
- Trial name
- NCT04858100
- Testing
- Surgical excision of the lesion, Wait and see approach
- Where
- 2 sites in Italy
- Volunteers
- 310 people
- Sponsor
- University of Milan
Oral Cancer, Oral Lichen Planus
Artificial Intelligence Based Program to Classify Oral Cavity Findings Based on Clinical Image Analysis
This study aims to develop an AI program that can classify oral findings into Normal/variation of normal or an oral disease by clinical photos analysis, aiding in lowering the percentages of false positive and false negative…
- Conditions
- Oral Cancer, Oral Lichen Planus, Fordyce Granule, Leukoplakia
- Trial name
- NCT06325514
- Testing
- Artificial intelligence based program
- Where
- Egypt
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Cairo University
Potentially Malignant Lesions, Oral Lichen Planus
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
- Conditions
- Potentially Malignant Lesions, Oral Lichen Planus, Leukoplakia, Oral
- Trial name
- NCT05730855
- Testing
- Real-time Polymerase Chain Reaction technique
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Oral Leukoplakia
Comparison of Topical Photodynamic Therapy With Topical Calcipotriol in Management of Oral Leukoplakia
(i)Rationale/ gaps in existing knowledge,: Oral cancer, one of the top three common cancers in India is usually preceded by Oral potentially malignant disorders in nearly two thirds of the cases like Oral leukoplakia.
- Trial name
- PDT CALCI HOL (NCT07453472)
- Testing
- Non-invasive Photo Dynamic Therapy using LED of wavelength ranging from 630-660nm( Fluence 15 J/cm2) as light source and 2.5% TB as photosensitizer, Topical application of Calcipotriol ointment 0.005% twice a day for 4 weeks along with preventive and conventional therapy, Conventional non-invasive management : All subjects in the two groups will receive the same standard conventional non- invasive management advised for OL as per current scientific evidence
- Where
- India
- Volunteers
- 166 people
- Sponsor
- Dr. Shalini Gupta
Leukoplakia, Lichen
Photodynamic Therapy for Oral Precursor Lesions
Pre-malignant lesions are difficult to treat. Even after surgical removal they tend to re-appear. Often the lesions are to large and are apparent on many sites, therefore surgical removal is not always possible.
- Trial name
- PDT (NCT01497951)
- Testing
- Aminolaevulinic acid
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Medical University of Vienna
Oral Cancer, Oral Lichen Planus
Diagnostic Accuracy of Salivary Gamma-synuclein in Oral Malignant and Premalignant Lesions
Synucleins are a family of small, highly conserved proteins found in vertebrates and are specially abundant in neurons particularly in presynaptic terminals (Surguchov et al., 2001).
- Conditions
- Oral Cancer, Oral Lichen Planus, Oral Leukoplakia, Premalignant Lesion
- Trial name
- NCT04732741
- Testing
- Salivary Gamma-synuclein, Incisional biopsy, Conventional visual and tactile examination
- Volunteers
- 69 people
- Sponsor
- Cairo University
Oral Cancer, Oral Leukoplakia
Oral Cancer Screening and Education in Hong Kong
This study will be conducted to obtain data on oral cancer risk factors to generate machine learning models with good predictive accuracy for stratifying individuals with high-oral cancer risk and delineating high-risk and…
- Conditions
- Oral Cancer, Oral Leukoplakia, Oral Submucous Fibrosis, Proliferative Verrucous Leukoplakia
- Trial name
- NCT04487938
- Testing
- No intervention utilised
- Volunteers
- 3,190 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Oral Leukoplakia, Oral Dysplasia
Fenretinide Mucoadhesive Patch: Evaluation of Oral Cancer Prevention Efficacy in Adults With Premalignant Oral Lesions.
The goal of this clinical trial is to determine the effect of a mucoadhesive system that releases the vitamin A derivative, fenretinide (FMS), on precancerous surface epithelial (lining tissue inside your mouth) changes.
- Trial name
- FMS (NCT07149220)
- Testing
- Mucoadhesive fenretinide-releasing system (FMS)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Erythroleukoplakia, Leukoplakia
Pembrolizumab in Treating Participants With Leukoplakia
This phase II pilot trial studies how well pembrolizumab works in treating leukoplakia. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread.
- Conditions
- Erythroleukoplakia, Leukoplakia, Verrucous Oral Leukoplakia
- Trial name
- NCT03603223
- Testing
- Pembrolizumab
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Leukoplakic Lesions
Comparison Between Two Different High Power Ablative Lasers in the Treatment of Oral Leukoplakia
Oral leukoplakia is a precancerous lesion with relatively high malignant transformation potential. They are often treated by wide surgical excisions or conservative retinoids therapy.
- Trial name
- NCT03233165
- Testing
- Er:YAG laser, Er,Cr:YSGG laser
- Volunteers
- 54 people
- Sponsor
- University of Zagreb
Head and Neck Cancer
Celecoxib in Preventing Cancer in Patients With Oral Leukoplakia and/or Head and Neck Dysplasia
Patient at increased risk for developing a new head and neck squamous cell carcinoma are invited to take part in this study. The investigators of this trial will attempt to study the effectiveness of Celecoxib in preventing…
- Trial name
- NCT00052611
- Testing
- Celecoxib
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Dana-Farber Cancer Institute
Precancerous Conditions, Leukoplakia
Natural History of Oro-pharyngeal Cancer Precursors
Oro-pharyngeal cancers can develop from squamous dysplastic precursor lesions, which occur in a subset of common white (leukoplakia), red (erythroplasia), or mixed oro-pharyngeal plaques.
- Conditions
- Precancerous Conditions, Leukoplakia, Erythroplasia, Oral Papillomas
- Trial name
- NCT00179361
- Where
- United States
- Volunteers
- 374 people
- Sponsor
- Albert Einstein College of Medicine