Clinical trials: Leukoplakia
Leukoplakia, Oral, Benign Neoplasms
A Randomized Study of Sulindac in Oral Premalignant Lesions
The purpose of this study is to see if a drug called sulindac can prevent the development of changes in the mouth that are related to oral pre-cancer growths (oral epithelial dysplasia) or oral cancer.
- Trial name
- NCT00299195
- Testing
- sulindac
- Where
- 3 sites in United States, India
- Volunteers
- 63 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Oral Cancer, Oral Leukoplakia
Oral Cancer Screening and Education in Hong Kong
This study will be conducted to obtain data on oral cancer risk factors to generate machine learning models with good predictive accuracy for stratifying individuals with high-oral cancer risk and delineating high-risk and…
- Conditions
- Oral Cancer, Oral Leukoplakia, Oral Submucous Fibrosis, Proliferative Verrucous Leukoplakia
- Trial name
- NCT04487938
- Testing
- No intervention utilised
- Volunteers
- 3,190 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Oral Cancer, Oral Lichen Planus
Diagnostic Accuracy of Salivary DNA Integrity Index in Oral Malignant and Premalignant Lesions
This study aims to identify the accuracy of DNA integrity index in differentiating between oral premalignant lesions and oral cancer.
- Conditions
- Oral Cancer, Oral Lichen Planus, Oral Leukoplakia
- Trial name
- NCT03682562
- Testing
- DNA Integrity Index
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Cairo University
Oral Epithelial Dysplasia, Precancerous Conditions
Oral Epithelial Dysplasia Informational Needs Questionnaire
Background: Oral epithelial dysplasia (OED) is a condition with an increased risk of oral cancer. Due to the current changes in the factors associated with these diseases (because of human papillomavirus), it is expected that…
- Conditions
- Oral Epithelial Dysplasia, Precancerous Conditions, Precancerous Lesions, Oral Lichen Planus
- Trial name
- ODIN-Q (NCT04153266)
- Testing
- No intervention is planned for this study
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- University College, London
Oral Lichen Planus, Oral Cancer
Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions
investigating the level of malondialdehyde (MDA) \& nitric oxide (NO) in saliva in oral premalignant and malignant lesions in order to determine their diagnostic value for the malignant and potentially malignant lesions.
- Conditions
- Oral Lichen Planus, Oral Cancer, Leukoplakia, Oral Keratoses
- Trial name
- NCT04267419
- Testing
- salivary biomarker
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Oral Leukoplakia
Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia
Oral leukoplakia is the most commonly occurring oral premalignant disorder. It has an overall prevalence rate of 1-4% with highest prevalence rate of 10.54% in Asian countries.
- Trial name
- NCT04251845
- Testing
- topical melatonin
- Where
- India
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Oral Leukoplakia, Oral Leukoplakia of Tongue
Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore
Oral squamous cell carcinomas (OSCC) is among the most common malignancies worldwide. Early detection and prevention of OSCC is thought to have the highest potential to reduce morbidity and mortality.
- Conditions
- Oral Leukoplakia, Oral Leukoplakia of Tongue, Oral Leukoplakia of Gingiva, Oral Lichen Planus
- Trial name
- PREDICT-OLP (NCT03975322)
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Actinic Cheilitis, Leukoplakia
Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - Phase 2 Clinical Trial
Brazil is a tropical country, with high incidence of ultraviolet radiation throughout the year. Many Europeans migrated to Brazil escaping either war or economic crisis to live in the country searching for opportunities.
- Conditions
- Actinic Cheilitis, Leukoplakia, Erythroplakia
- Trial name
- PDTMALAC (NCT03990636)
- Testing
- Metil 5-aminolevulinate
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Pachyonychia Congenita
International Pachyonychia Congenita Research Registry
International Pachyonychia Congenita Research Registry (IPCRR) is a patient registry for those suffering from Pachyonychia Congenita (PC).
- Trial name
- IPCRR (NCT02321423)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Pachyonychia Congenita Project
Oral Leukoplakia, Oral Lichen Planus
Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy
Abstract Objective: To study the diagnostic efficiency of Rose Bengal with Toluidine blue in detecting the biopsy sites and thus establish an accurate diagnosis in oral premalignant lesions.
- Conditions
- Oral Leukoplakia, Oral Lichen Planus, Premalignant Lesion
- Trial name
- NCT03031899
- Testing
- Biopsy, Rose Bengal, toluidine blue
- Volunteers
- 27 people
- Sponsor
- The Oxford Dental College, Hospital and Research Center, Bangalore, India
Precancerous Conditions, Leukoplakia
Natural History of Oro-pharyngeal Cancer Precursors
Oro-pharyngeal cancers can develop from squamous dysplastic precursor lesions, which occur in a subset of common white (leukoplakia), red (erythroplasia), or mixed oro-pharyngeal plaques.
- Conditions
- Precancerous Conditions, Leukoplakia, Erythroplasia, Oral Papillomas
- Trial name
- NCT00179361
- Where
- United States
- Volunteers
- 374 people
- Sponsor
- Albert Einstein College of Medicine
Leukoplakic Lesions
Comparison Between Two Different High Power Ablative Lasers in the Treatment of Oral Leukoplakia
Oral leukoplakia is a precancerous lesion with relatively high malignant transformation potential. They are often treated by wide surgical excisions or conservative retinoids therapy.
- Trial name
- NCT03233165
- Testing
- Er:YAG laser, Er,Cr:YSGG laser
- Volunteers
- 54 people
- Sponsor
- University of Zagreb
Leukoplakia, Lichen
Photodynamic Therapy for Oral Precursor Lesions
Pre-malignant lesions are difficult to treat. Even after surgical removal they tend to re-appear. Often the lesions are to large and are apparent on many sites, therefore surgical removal is not always possible.
- Trial name
- PDT (NCT01497951)
- Testing
- Aminolaevulinic acid
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Medical University of Vienna
Head and Neck Cancer, Precancerous/Nonmalignant Condition
Photodynamic Therapy With Porfimer Sodium in Treating Patients With Precancerous Lesions, Cancer, or Other Disease of the Aerodigestive Tract
RATIONALE: Photodynamic therapy uses a drug that becomes active when it is exposed to a certain kind of light. When the drug is active, precancerous cells and cancer cells are killed.
- Trial name
- NCT00453336
- Testing
- Porfimer Sodium, Photodynamic Therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Miami
Smoking Cessation, Mouth Diseases
Tobacco Cessation Intervention Study for Oral Diseases
This study is to verify the efficacy of tobacco cessation in patients with oral diseases; periodontitis, dental implant and oral mucosal diseases by a multicenter prospective trial.
- Conditions
- Smoking Cessation, Mouth Diseases, Periodontal Diseases, Leukoplakia
- Trial name
- TISOD (NCT02737176)
- Testing
- Tobacco cessation intervention
- Where
- 2 sites in Japan
- Volunteers
- 812 people
- Sponsor
- Association for the Japanese Academy of Maxillofacial Implants
Oral Leukoplakia
Pioglitazone for Oral Premalignant Lesions
The goal of this clinical research study is to learn how Actos (pioglitazone) may affect oral premalignant lesions (OPLs) and/or the risk of mouth cancer. The safety of this drug will also be studied.
- Trial name
- NCT00951379
- Testing
- Pioglitazone hydrochloride, laboratory biomarker analysis
- Where
- 13 sites in United States, Canada and 1 more
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Leukoplakia, Erythroplakia
Treatment of Oral Premalignant Lesions With 5-ALA PDT
Oral leukoplakia within the mouth is a visible white patch which can develop into cancer if not treated. There is no good treatment for these lesions, apart from surgery which is associated with significant side effects and…
- Trial name
- NCT00571974
- Testing
- PDL-585, ScleroPLUS laser, 5-Aminolevulinic Acid (Levulan KerastickTM), Fluorescence Diagnosis Imaging
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Arkansas
Lip and Oral Cavity Cancer, Oral Leukoplakia
Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia
This randomized phase II trial is studying how well Bowman-Birk inhibitor concentrate works in preventing cancer in patients with oral leukoplakia.
- Conditions
- Lip and Oral Cavity Cancer, Oral Leukoplakia, Oropharyngeal Cancer, Tongue Cancer
- Trial name
- NCT00330382
- Testing
- Bowman-Birk inhibitor concentrate, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 325 people
- Sponsor
- National Cancer Institute (NCI)
Oral Leukoplakia
Photodynamic Therapy Using Aminolevulinic Acid in Treating Patients With Oral Leukoplakia
This phase I trial studies the side effects and best dose of photodynamic therapy using aminolevulinic acid in treating patients with oral leukoplakia.
- Trial name
- NCT00571558
- Testing
- aminolevulinic acid hydrochloride, photodynamic therapy, laboratory biomarker analysis
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Precancerous Condition
Aspirin Mouthwash in Treating Patients With Oral Leukoplakia
RATIONALE: Aspirin mouthwash may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I trial is studying the side effects and best dose of aspirin mouthwash in treating…
- Trial name
- NCT01238185
- Testing
- acetylsalicylic acid, gene expression analysis, protein expression analysis
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Institute of Head and Neck Studies and Education, United Kingdom